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Due to its complex pathological mechanism, its etiology is not yet clear. As one of the main pathological markers of AD, amyloid-\u03b2 (A\u03b2) plays an important role in the development of AD. The deposition of A\u03b2 is not only related to the degeneration of neurons, but also can activate a series of pathological events, including the activation of astrocytes and microglia, the breakdown of the blood\u2013brain barrier, and the change in microcirculation, which is the main cause of brain lesions and death in AD patients. Therefore, the development of efficient and reliable A\u03b2-specific probes is crucial for the early diagnosis and treatment of AD. This paper focuses on reviewing the application of small-molecule fluorescent probes in A\u03b2 imaging in vivo in recent years. These probes efficiently map the presence of A\u03b2 in vivo, providing a pathway for the early diagnosis of AD and providing enlightenment for the design of A\u03b2-specific probes in the future.<\/jats:p>","DOI":"10.3390\/bios13110990","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T01:54:12Z","timestamp":1700445252000},"page":"990","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Recent Research Progress in Fluorescent Probes for Detection of Amyloid-\u03b2 In Vivo"],"prefix":"10.3390","volume":"13","author":[{"given":"Zhen-Yu","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou 570228, China"},{"name":"Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze-Jun","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou 570228, China"},{"name":"Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Hao","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou 570228, China"},{"name":"Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou 570228, China"},{"name":"Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Teng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1837-8776","authenticated-orcid":false,"given":"Tian-Yi","family":"Qin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou 570228, China"},{"name":"Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1089-9358","authenticated-orcid":false,"given":"Ya-Long","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou 570228, China"},{"name":"Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou 570228, China"},{"name":"Wuhan National Laboratory for Optoelectronics, School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Haghighijoo, Z., Akrami, S., Saeedi, M., Zonouzi, A., Iraji, A., Larijani, B., Fakherzadeh, H., Sharifi, F., Arzaghi, S.M., and Mahdavi, M. 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