{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:25:21Z","timestamp":1780053921927,"version":"3.54.0"},"reference-count":71,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"N.I.H.\u2014NIBIB","award":["R03 EB027336"],"award-info":[{"award-number":["R03 EB027336"]}]},{"name":"A.J. and Sigismunda Palumbo Charitable Trust","award":["R03 EB027336"],"award-info":[{"award-number":["R03 EB027336"]}]},{"name":"Arizona Commerce Authority and Partnership for Economic Innovation (State of Arizona)","award":["R03 EB027336"],"award-info":[{"award-number":["R03 EB027336"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Ketones are well-known biomarkers of fat oxidation produced in the liver as a result of lipolysis. These biomarkers include acetoacetic acid and \u03b2-hydroxybutyric acid in the blood\/urine and acetone in our breath and skin. Monitoring ketone production in the body is essential for people who use caloric intake deficit to reduce body weight or use ketogenic diets for wellness or therapeutic treatments. Current methods to monitor ketones include urine dipsticks, capillary blood monitors, and breath analyzers. However, these existing methods have certain disadvantages that preclude them from being used more widely. In this work, we introduce a novel acetone sensor device that can detect acetone levels in breath and overcome the drawbacks of existing sensing approaches. The critical element of the device is a robust sensor with the capability to measure acetone using a complementary metal oxide semiconductor (CMOS) chip and convenient data analysis from a red, green, and blue deconvolution imaging approach. The acetone sensor device demonstrated sensitivity of detection in the micromolar-concentration range, selectivity for detection of acetone in breath, and a lifetime stability of at least one month. The sensor device utility was probed with real tests on breath samples using an established blood ketone reference method.<\/jats:p>","DOI":"10.3390\/bios14010004","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T04:44:40Z","timestamp":1703220280000},"page":"4","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Novel Acetone Sensor for Body Fluids"],"prefix":"10.3390","volume":"14","author":[{"given":"Oscar","family":"Osorio Perez","sequence":"first","affiliation":[{"name":"School of Engineering for Matter, Transport and Energy, Arizona State University, Tempe, AZ 85287, USA"},{"name":"Center for Bioelectronics and Biosensors, Biodesign Institute, Arizona State University, 1001 S McAllister Ave., Tempe, AZ 85281, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngan Anh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"School of Engineering for Matter, Transport and Energy, Arizona State University, Tempe, AZ 85287, USA"},{"name":"Center for Bioelectronics and Biosensors, Biodesign Institute, Arizona State University, 1001 S McAllister Ave., Tempe, AZ 85281, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asher","family":"Hendricks","sequence":"additional","affiliation":[{"name":"School of Engineering for Matter, Transport and Energy, Arizona State University, Tempe, AZ 85287, USA"},{"name":"Center for Bioelectronics and Biosensors, Biodesign Institute, Arizona State University, 1001 S McAllister Ave., Tempe, AZ 85281, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1922-6280","authenticated-orcid":false,"given":"Shaun","family":"Victor","sequence":"additional","affiliation":[{"name":"Center for Bioelectronics and Biosensors, Biodesign Institute, Arizona State University, 1001 S McAllister Ave., Tempe, AZ 85281, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina Jimena","family":"Mora","sequence":"additional","affiliation":[{"name":"Center for Bioelectronics and Biosensors, Biodesign Institute, Arizona State University, 1001 S McAllister Ave., Tempe, AZ 85281, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanxi","family":"Yu","sequence":"additional","affiliation":[{"name":"Center for Bioelectronics and Biosensors, Biodesign Institute, Arizona State University, 1001 S McAllister Ave., Tempe, AZ 85281, USA"},{"name":"School of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6561-5266","authenticated-orcid":false,"given":"Xiaojun","family":"Xian","sequence":"additional","affiliation":[{"name":"Center for Bioelectronics and Biosensors, Biodesign Institute, Arizona State University, 1001 S McAllister Ave., Tempe, AZ 85281, USA"},{"name":"Department of Electrical Engineering and Computer Science, South Dakota State University, Brookings, SD 57007, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2680-0503","authenticated-orcid":false,"given":"Shaopeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Bioelectronics and Biosensors, Biodesign Institute, Arizona State University, 1001 S McAllister Ave., Tempe, AZ 85281, USA"},{"name":"School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ 85287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doina","family":"Kulick","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Scottsdale, AZ 85289, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Forzani","sequence":"additional","affiliation":[{"name":"School of Engineering for Matter, Transport and Energy, Arizona State University, Tempe, AZ 85287, USA"},{"name":"Center for Bioelectronics and Biosensors, Biodesign Institute, Arizona State University, 1001 S McAllister Ave., Tempe, AZ 85281, USA"},{"name":"Mayo Clinic, Scottsdale, AZ 85289, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"ref_1","unstructured":"Tsow, F., Xian, X.J., Bridgeman, D., Forzani, E.S., and Tao, N.J. 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