{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:22:13Z","timestamp":1773350533032,"version":"3.50.1"},"reference-count":68,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T00:00:00Z","timestamp":1707609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["JP21H05006"],"award-info":[{"award-number":["JP21H05006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>A taste sensor employs various lipid\/polymer membranes with specific physicochemical properties for taste classification and evaluation. However, phosphoric acid di(2-ethylhexyl) ester (PAEE), employed as one of the lipids for the taste sensors, exhibits insufficient selectivity for umami substances. The pH of sample solutions impacts the dissociation of lipids to influence the membrane potential, and the response to astringent substances makes accurate measurement of umami taste difficult. This study aims to develop a novel taste sensor for detecting umami substances like monosodium L-glutamate (MSG) through surface modification, i.e., a methodology previously applied to taste sensors for non-charged bitter substance measurement. Four kinds of modifiers were tested as membrane-modifying materials. By comparing the results obtained from these modifiers, the modifier structure suitable for measuring umami substances was identified. The findings revealed that the presence of carboxyl groups at para-position of the benzene ring, as well as intramolecular H-bonds between the carboxyl group and hydroxyl group, significantly affect the effectiveness of a modifier in the umami substance measurement. The taste sensor treated with this type of modifier showed excellent selectivity for umami substances.<\/jats:p>","DOI":"10.3390\/bios14020095","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T06:19:59Z","timestamp":1707718799000},"page":"95","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Development of Taste Sensor with Lipid\/Polymer Membranes for Detection of Umami Substances Using Surface Modification"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4958-9441","authenticated-orcid":false,"given":"Wenhao","family":"Yuan","sequence":"first","affiliation":[{"name":"Graduate School of Information Science and Electrical Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Graduate School of Information Science and Electrical Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7314-5540","authenticated-orcid":false,"given":"Shunsuke","family":"Kimura","sequence":"additional","affiliation":[{"name":"Research and Development Center for Five-Sense Devices, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Toko","sequence":"additional","affiliation":[{"name":"Research and Development Center for Five-Sense Devices, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan"},{"name":"Institute for Advanced Study, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.snb.2018.03.004","article-title":"Label-Free Optical Biosensors for Food and Biological Sensor Applications","volume":"265","author":"Khansili","year":"2018","journal-title":"Sens. Actuators B Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.talanta.2015.08.071","article-title":"Sensory Intensity Assessment of Olive Oils Using an Electronic Tongue","volume":"146","author":"Veloso","year":"2016","journal-title":"Talanta"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1016\/j.foodchem.2012.06.021","article-title":"Discrimination of Mineral Waters by Electronic Tongue, Sensory Evaluation and Chemical Analysis","volume":"135","author":"Sipos","year":"2012","journal-title":"Food Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.snb.2008.09.025","article-title":"An Electronic Tongue Taste Evaluation: Identification of Goat Milk Adulteration with Bovine Milk","volume":"136","author":"Dias","year":"2009","journal-title":"Sens. Actuators B Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.snb.2005.05.003","article-title":"An Electronic Tongue in the Dairy Industry","volume":"111","author":"Winquist","year":"2005","journal-title":"Sens. Actuators B Chem."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Abu-Khalaf, N., Zaid, A.N., Jaradat, N., Alkilany, A., Rumaila, B.A., Al Ramahi, R., Shweiki, S., Nidal, S., and Surakhi, N. (2018). The Taste of Commercially Available Clarithromycin Oral Pharmaceutical Suspensions in the Palestinian Market: Electronic Tongue and in Vivo Evaluation. Sensors, 18.","DOI":"10.3390\/s18020454"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Podrazka, M., B\u00e1czy\u0144ska, E., Kundys, M., Jele\u0144, P.S., and Nery, E.W. (2017). Electronic Tongue-A Tool for All Tastes?. Biosensors, 8.","DOI":"10.3390\/bios8010003"},{"key":"ref_8","first-page":"136","article-title":"Taste Masking: A Novel Approach for Bitter and Obnoxious Drugs","volume":"1","author":"Tripathi","year":"2011","journal-title":"J. Pharm. Sci. Biosci. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1039\/b705107g","article-title":"Sensor Arrays for Liquid Sensing\u2014Electronic Tongue Systems","volume":"132","author":"Ciosek","year":"2007","journal-title":"Analyst"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.snb.2014.09.077","article-title":"Recent Achievements in Electronic Tongue and Bioelectronic Tongue as Taste Sensors","volume":"207","author":"Ha","year":"2015","journal-title":"Sens. Actuators B Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1039\/b801228h","article-title":"Electronic Integrated Multisensor Tongue Applied to Grape Juice and Wine Analysis","volume":"133","author":"Kloock","year":"2008","journal-title":"Analyst"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.talanta.2009.11.041","article-title":"Electronic Tongue as a Screening Tool for Rapid Analysis of Beer","volume":"81","author":"Polshin","year":"2010","journal-title":"Talanta"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1007\/s00216-010-3885-3","article-title":"Instrumental Measurement of Bitter Taste in Red Wine Using an Electronic Tongue","volume":"397","author":"Rudnitskaya","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.foodchem.2010.05.006","article-title":"Prediction of Bitterness and Alcoholic Strength in Beer Using an Electronic Tongue","volume":"123","author":"Arrieta","year":"2010","journal-title":"Food Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.snb.2006.11.011","article-title":"Multifrequency Large Amplitude Pulse Voltammetry: A Novel Electrochemical Method for Electronic Tongue","volume":"123","author":"Tian","year":"2007","journal-title":"Sens. Actuators B Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.snb.2010.06.028","article-title":"Accurate Concentration Determination of Anions Nitrate, Nitrite and Chloride in Minced Meat Using a Voltammetric Electronic Tongue","volume":"149","author":"Campos","year":"2010","journal-title":"Sens. Actuators B Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0925-4005(01)00583-4","article-title":"Discrimination of Tea by Means of a Voltammetric Electronic Tongue and Different Applied Waveforms","volume":"76","author":"Ivarsson","year":"2001","journal-title":"Sens. Actuators B Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"026107","DOI":"10.1063\/1.3084210","article-title":"Impedance E-Tongue Instrument for Rapid Liquid Assessment","volume":"80","author":"Cabral","year":"2009","journal-title":"Rev. Sci. Instrum."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.aca.2005.09.044","article-title":"Monitoring of the Ageing of Red Wines in Oak Barrels by Means of an Hybrid Electronic Tongue","volume":"563","author":"Parra","year":"2006","journal-title":"Anal. Chim. Acta"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Shimizu, F.M., Braunger, M.L., and Riul, A. (2021). Electronic Tongues: Fundamentals and Recent Advances, IOP Publishing.","DOI":"10.1088\/978-0-7503-3687-1"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Shimizu, F.M., Braunger, M.L., and Riul, A. (2021). Electronic Tongues Fundamentals and Recent Advances, IOP Publishing.","DOI":"10.1088\/978-0-7503-3687-1"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"116778","DOI":"10.1016\/j.trac.2022.116778","article-title":"Advances in Gustatory Biomimetic Biosensing Technologies: In Vitro and in Vivo Bioelectronic Tongue","volume":"157","author":"Tian","year":"2022","journal-title":"TrAC Trends Analyt. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"127949","DOI":"10.1016\/j.snb.2020.127949","article-title":"A Biomimetic Taste Biosensor Based on Bitter Receptors Synthesized and Purified on Chip from a Cell-Free Expression System","volume":"312","author":"Du","year":"2020","journal-title":"Sens. Actuators B Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/1521-4109(200104)13:6<471::AID-ELAN471>3.0.CO;2-1","article-title":"A New Potentiometric Photocurable Membrane Selective to Anionic Surfactants","volume":"13","year":"2001","journal-title":"Electroanalysis"},{"key":"ref_25","first-page":"11","article-title":"Measurement of Basic Taste Substances by a Fiber Optic Taste Sensor Using Evanescent Field Absorption","volume":"4","author":"Lee","year":"2002","journal-title":"Sens. Mater."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/j.2050-0416.2003.tb00590.x","article-title":"Adsorption and Desorption of Beer and Coffee on a Lipid Membrane as Related to Sensory Bitterness","volume":"109","author":"Kaneda","year":"2003","journal-title":"J. Inst. Brew."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s00216-006-0656-2","article-title":"L-Glutamate Biosensor for Estimation of the Taste of Tomato Specimens","volume":"386","author":"Pauliukaite","year":"2006","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/elan.201200299","article-title":"Assessment of Individual Polyphenol Content in Beer by Means of a Voltammetric BioElectronic Tongue","volume":"25","year":"2013","journal-title":"Electroanalysis"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"6035","DOI":"10.1073\/pnas.1520843113","article-title":"Taste Cell-Expressed \u03b1-Glucosidase Enzymes Contribute to Gustatory Responses to Disaccharides","volume":"113","author":"Sukumarana","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0928-4931(96)00134-8","article-title":"Taste Sensor with Global Selectivity","volume":"4","author":"Toko","year":"1996","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"126656","DOI":"10.1016\/j.foodchem.2020.126656","article-title":"Low-Temperature and Long-Time Heating Regimes on Non-Volatile Compound and Taste Traits of Beef Assessed by the Electronic Tongue System","volume":"320","author":"Ismail","year":"2020","journal-title":"Food Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"100693","DOI":"10.1016\/j.ijgfs.2023.100693","article-title":"Mining of Kokumi Peptides in Chicken Broth with Peptidomics","volume":"32","author":"Li","year":"2023","journal-title":"Int. J. Gastron. Food Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/j.1740-0929.2010.00773.x","article-title":"Effects of Muscle Type on Beef Taste-Traits Assessed by an Electric Sensing System","volume":"81","author":"Chikuni","year":"2010","journal-title":"Anim. Sci. J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/asj.12050","article-title":"Evaluation of Changes in the Taste of Cooked Meat Products during Curing Using an Artificial Taste Sensor","volume":"84","author":"Nodake","year":"2013","journal-title":"Anim. Sci. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"128228","DOI":"10.1016\/j.foodchem.2020.128228","article-title":"Bitterness Compounds in Coffee Brew Measured by Analytical Instruments and Taste Sensing System","volume":"342","author":"Fujimoto","year":"2021","journal-title":"Food Chem."},{"key":"ref_36","first-page":"2949","article-title":"Beer Taste Detection Based on Electronic Tongue","volume":"32","author":"Zhang","year":"2020","journal-title":"Sens. Mater."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"127784","DOI":"10.1016\/j.snb.2020.127784","article-title":"Quantification of Bitterness of Coffee in the Presence of High-Potency Sweeteners Using Taste Sensors","volume":"309","author":"Wu","year":"2020","journal-title":"Sens. Actuators B Chem."},{"key":"ref_38","first-page":"501","article-title":"Evaluation of the Taste of Tea with Different Degrees of Fermentation Using a Taste Sensing System","volume":"23","author":"Uchiyama","year":"2011","journal-title":"Sens. Mater."},{"key":"ref_39","first-page":"105","article-title":"Traditional Human Taste Panel and Taste Sensors Methods for Bitter Taste Masking Research on Combined Bitterness Suppressants of Berberine Hydrochloride","volume":"29","author":"Liu","year":"2017","journal-title":"Sens. Mater."},{"key":"ref_40","unstructured":"Kiyoshi, T. (2013). Biochemical Sensors: Mimicking Gustatory and Olfactory Senses, Pan Stanford Publishing."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1111\/jphp.12101","article-title":"Evaluation of Palatability of 10 Commercial Amlodipine Orally Disintegrating Tablets by Gustatory Sensation Testing, OD-Mate as a New Disintegration Apparatus and the Artificial Taste Sensor","volume":"65","author":"Uchida","year":"2013","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jpba.2011.02.002","article-title":"A Comparative Study on Two Electronic Tongues for Pharmaceutical Formulation Development","volume":"55","author":"Woertz","year":"2011","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1248\/cpb.c20-01014","article-title":"A New Bitterness Evaluation Index Obtained Using the Taste Sensor for 48 Active Pharmaceutical Ingredients of Pediatric Medicines","volume":"69","author":"Kojima","year":"2021","journal-title":"Chem. Pharm. Bull."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1248\/cpb.c17-00619","article-title":"The Utility of the Artificial Taste Sensor in Evaluating the Bitterness of Drugs: Correlation with Responses of Human TASTE2 Receptors (HTAS2Rs) Methods Taste Sensor Measurement The Taste Sensor SA402B (Intelligent Sensor Technol","volume":"66","author":"Haraguchi","year":"2018","journal-title":"Chem. Pharm. Bull."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"116874","DOI":"10.1016\/j.trac.2022.116874","article-title":"Taste Sensor with Multiarray Lipid\/Polymer Membranes","volume":"158","author":"Wu","year":"2022","journal-title":"TrAC Trends Analyt. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2183\/pjab.99.011","article-title":"Research and Development of Taste Sensors as a Novel Analytical Tool","volume":"99","author":"Toko","year":"2023","journal-title":"Proc. Jpn. Acad., Ser. B"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ijpharm.2010.08.042","article-title":"Rational Development of Taste Masked Oral Liquids Guided by an Electronic Tongue","volume":"400","author":"Woertz","year":"2010","journal-title":"Int. J. Pharm."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2116\/analsci.19R008","article-title":"Taste Sensor: Electronic Tongue with Lipid Membranes","volume":"36","author":"Wu","year":"2020","journal-title":"Anal. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Yoshimatsu, J., Toko, K., Tahara, Y., Ishida, M., Habara, M., Ikezaki, H., Kojima, H., Ikegami, S., Yoshida, M., and Uchida, T. (2020). Development of Taste Sensor to Detect Non-Charged Bitter Substances. Sensors, 20.","DOI":"10.3390\/s20123455"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/prot.20232","article-title":"Is Allostery an Intrinsic Property of All Dynamic Proteins?","volume":"57","author":"Gunasekaran","year":"2004","journal-title":"Proteins Struct. Funct. Genet."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41589-019-0407-2","article-title":"Computational Design of G Protein-Coupled Receptor Allosteric Signal Transductions","volume":"16","author":"Chen","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"20930","DOI":"10.1073\/pnas.0810174106","article-title":"Molecular Mechanism for the Umami Taste Synergism","volume":"105","author":"Zhang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Zhao, Z., Ishida, M., Onodera, T., and Toko, K. (2022). Effect of Hydroxybenzoic Acids on Caffeine Detection Using Taste Sensor with Lipid\/Polymer Membranes. Sensors, 22.","DOI":"10.3390\/s22041607"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Ishida, M., Ide, H., Arima, K., Zhao, Z., Matsui, T., and Toko, K. (2022). Identification of the Principle of Taste Sensors to Detect Non-Charged Bitter Substances by 1H-NMR Measurement. Sensors, 22.","DOI":"10.3390\/s22072592"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Xu, H., Zhao, Z., Kimura, S., Onodera, T., and Toko, K. (2023). Molecular Structure Underlying the Allosteric Mechanism of Caffeine Detection in Taste Sensor. Chemosensors, 11.","DOI":"10.3390\/chemosensors11020097"},{"key":"ref_56","first-page":"1","article-title":"Mini Review About Monosodium Glutamate","volume":"77","author":"Thuy","year":"2020","journal-title":"Bull. UASVM Food Sci. Technol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1111\/1541-4337.12291","article-title":"Potassium Chloride-based Salt Substitutes: A Critical Review with a Focus on the Patent Literature","volume":"16","author":"Cepanec","year":"2017","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1021\/jf072803c","article-title":"Studies on Umami Taste. Synthesis of New Guanosine 5\u2032-Phosphate Derivatives and Their Synergistic Effect with Monosodium Glutamate","volume":"56","author":"Cairoli","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/bip.360010408","article-title":"Dilatometric and Refractometric Studies of the Helix\u2014Coil Transition of Poly-L-glutamic Acid in Aqueous Solution","volume":"1","author":"Noguchi","year":"1963","journal-title":"Biopolymers"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s10953-007-9131-8","article-title":"Water Activity and Osmotic Coefficients in Solutions of Glycine, Glutamic Acid, Histidine and Their Salts at 298.15 K and 310.15 K","volume":"36","author":"Tsurko","year":"2007","journal-title":"J. Solution Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0925-4005(03)00087-X","article-title":"Peculiar Change in Membrane Potential of Taste Sensor Caused by Umami Substances","volume":"91","author":"Iiyama","year":"2003","journal-title":"Sens. Actuators B Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.3390\/s100403411","article-title":"Advanced Taste Sensors Based on Artificial Lipids with Global Selectivity to Basic Taste Qualities and High Correlation to Sensory Scores","volume":"10","author":"Kobayashi","year":"2010","journal-title":"Sensors"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"12792","DOI":"10.1021\/acs.iecr.1c02604","article-title":"Simple but Tricky: Investigations of Terephthalic Acid Purity Obtained from Mixed PET Waste","volume":"60","author":"Cosimbescu","year":"2021","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Matuszek, K., Pankalla, E., Grymel, A., Latos, P., and Chrobok, A. (2019). Studies on the Solubility of Terephthalic Acid in Ionic Liquids. Molecules, 25.","DOI":"10.3390\/molecules25010080"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0003-2670(01)01390-3","article-title":"Influence of Intramolecular Hydrogen Bond of Templates on Molecular Recognition of Molecularly Imprinted Polymers","volume":"450","author":"Zhang","year":"2001","journal-title":"Anal. Chim. Acta"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1139\/v66-188","article-title":"Effect of Intramolecular Hydrogen Bonding on Ionization Constants of Substituted Salicylic Acids","volume":"44","author":"Dunn","year":"1996","journal-title":"Can. J. Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"19562","DOI":"10.3390\/ijms151119562","article-title":"Competing Intramolecular vs. Intermolecular Hydrogen Bonds in Solution","volume":"15","author":"Nagy","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_68","first-page":"132","article-title":"Uses, Effects and Properties of Monosodium Glutamate (MSG) on Food & Nutrition","volume":"2","author":"Wijayasekara","year":"2017","journal-title":"Int. J. Food Sci. Nutr."}],"container-title":["Biosensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6374\/14\/2\/95\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:58:34Z","timestamp":1760104714000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6374\/14\/2\/95"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,11]]},"references-count":68,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["bios14020095"],"URL":"https:\/\/doi.org\/10.3390\/bios14020095","relation":{},"ISSN":["2079-6374"],"issn-type":[{"value":"2079-6374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,11]]}}}