{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T05:37:13Z","timestamp":1792388233776,"version":"4.4.0"},"reference-count":54,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011033","name":"Ministerio de Ciencia e Innovaci\u00f3n\/Agencia Estatal de Investigaci\u00f3n from Spanish Government","doi-asserted-by":"publisher","award":["PID2022-136566NB-I00"],"award-info":[{"award-number":["PID2022-136566NB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Ministerio de Ciencia e Innovaci\u00f3n\/Agencia Estatal de Investigaci\u00f3n from Spanish Government","doi-asserted-by":"publisher","award":["PID2019-105795RB-I00"],"award-info":[{"award-number":["PID2019-105795RB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Ministerio de Ciencia e Innovaci\u00f3n\/Agencia Estatal de Investigaci\u00f3n from Spanish Government","doi-asserted-by":"publisher","award":["PID2023-147959OB-I00"],"award-info":[{"award-number":["PID2023-147959OB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Random lasing (RL) is an optical phenomenon that arises from the combination of light amplification with optical feedback through multiple scattering events. In this paper, we present our investigations of RL generation from human blood samples. We tested mixtures of rhodamine B dye solutions with different blood components, including platelets, lymphocytes, erythrocytes, and whole blood. Intense coherent RL was obtained in all cases at relatively low pump thresholds, except for erythrocytes. We also studied the potential of RL signal analysis for biosensing applications using blood samples from healthy individuals and patients suffering from Chronic Lymphocytic Leukemia (CLL). CLL is a blood disease characterized by a high count of lymphocytes with significant morphological changes. A statistical analysis of the RL spectra based on principal component and linear discriminant analyses was conducted for classification purposes. RL-based sample discrimination was conducted for whole blood, platelet, and lymphocyte samples, being especially successful (86.7%) for the latter. Our results highlight the potential of RL analysis as a sensing tool in blood.<\/jats:p>","DOI":"10.3390\/bios14090441","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T05:31:44Z","timestamp":1726205504000},"page":"441","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Analysis of Random Lasing in Human Blood"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2084-3200","authenticated-orcid":false,"given":"Sergio","family":"de Armas-Rillo","sequence":"first","affiliation":[{"name":"Departamento de F\u00edsica, Instituto Universitario de Estudios Avanzados en F\u00edsica At\u00f3mica, Molecular y Fot\u00f3nica (IUdEA), Universidad de La Laguna (ULL), 38206 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0321-7662","authenticated-orcid":false,"given":"Beatriz","family":"Abdul-Jalbar","sequence":"additional","affiliation":[{"name":"Departamento de Matem\u00e1ticas, Estad\u00edstica e Investigaci\u00f3n Operativa, Universidad de La Laguna (ULL), 38206 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josmar","family":"Salas-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Instituto de Tecnolog\u00edas Biom\u00e9dicas (ITB), Universidad de La Laguna (ULL), 38071 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Mar\u00eda","family":"Raya-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Laboratorio de Hematolog\u00eda, Servicio de Hematolog\u00eda y Hemoterapia, Hospital Universitario de Canarias, 38320 La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2223-7434","authenticated-orcid":false,"given":"Tom\u00e1s","family":"Gonz\u00e1lez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Instituto de Tecnolog\u00edas Biom\u00e9dicas (ITB), Universidad de La Laguna (ULL), 38071 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Lahoz","sequence":"additional","affiliation":[{"name":"Departamento de F\u00edsica, Instituto Universitario de Estudios Avanzados en F\u00edsica At\u00f3mica, Molecular y Fot\u00f3nica (IUdEA), Universidad de La Laguna (ULL), 38206 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1109\/JQE.1966.1074123","article-title":"5A10(b)\u2014A Laser with a Nonresonant Feedback","volume":"2","author":"Ambartsumyan","year":"1966","journal-title":"IEEE J. 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