{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:22:04Z","timestamp":1788470524226,"version":"build-2803163510"},"reference-count":97,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Projects Supported by Shanxi Scholarship Council of China","award":["2024-079"],"award-info":[{"award-number":["2024-079"]}]},{"name":"Research Projects Supported by Shanxi Scholarship Council of China","award":["20240352"],"award-info":[{"award-number":["20240352"]}]},{"name":"Research Projects Supported by Shanxi Scholarship Council of China","award":["20210302123299"],"award-info":[{"award-number":["20210302123299"]}]},{"name":"Innovation and entrepreneurship training program for college students","award":["2024-079"],"award-info":[{"award-number":["2024-079"]}]},{"name":"Innovation and entrepreneurship training program for college students","award":["20240352"],"award-info":[{"award-number":["20240352"]}]},{"name":"Innovation and entrepreneurship training program for college students","award":["20210302123299"],"award-info":[{"award-number":["20210302123299"]}]},{"DOI":"10.13039\/501100004480","name":"Natural Science Foundation of Shanxi Province","doi-asserted-by":"publisher","award":["2024-079"],"award-info":[{"award-number":["2024-079"]}],"id":[{"id":"10.13039\/501100004480","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004480","name":"Natural Science Foundation of Shanxi Province","doi-asserted-by":"publisher","award":["20240352"],"award-info":[{"award-number":["20240352"]}],"id":[{"id":"10.13039\/501100004480","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004480","name":"Natural Science Foundation of Shanxi Province","doi-asserted-by":"publisher","award":["20210302123299"],"award-info":[{"award-number":["20210302123299"]}],"id":[{"id":"10.13039\/501100004480","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Parkinson\u2019s disease (PD) is the second most common neurodegenerative disorder, affecting the lives of millions of people worldwide. Although the mechanism underlying PD pathogenesis is largely undefined, increasing evidence indicates that oxidative and nitrosative stresses play a crucial role in PD occurrence and development. Among them, the role of oxidative stress has been widely acknowledged, but there is relatively less attention given to nitrosative stress, which is mainly derived from peroxynitrite. In the present review, after briefly introducing the background of PD, we discuss the physiopathological function of peroxynitrite and especially highlight how overloaded peroxynitrite is involved in PD pathogenesis. Then, we summarize the currently reported fluorescence imaging-based peroxynitrite detection probes. Moreover, we specifically emphasize the probes that have been applied in PD research. Finally, we propose perspectives on how to develop a more applicable peroxynitrite probe and leverage it for PD theranostics. Conclusively, the present review broadens the knowledge on the pathological role of peroxynitrite in the context of PD and sheds light on how to develop and utilize fluorescence imaging-based strategies for peroxynitrite detection.<\/jats:p>","DOI":"10.3390\/bios14100506","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T03:49:34Z","timestamp":1729136974000},"page":"506","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Role of Peroxynitrite in the Pathogenesis of Parkinson\u2019s Disease and Its Fluorescence Imaging-Based Detection"],"prefix":"10.3390","volume":"14","author":[{"given":"Jiye","family":"Lv","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Shanxi Medical University, 56 Xinjiannan Road, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyu","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, Tianjin University of Traditional Medicine, 10 Poyanghu Road, Tianjin 301617, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changchan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Shanxi Medical University, 56 Xinjiannan Road, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubing","family":"Kang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Shanxi Medical University, 56 Xinjiannan Road, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Shanxi Medical University, 56 Xinjiannan Road, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengwu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Shanxi Medical University, 56 Xinjiannan Road, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Guatteo, E., Berretta, N., Monda, V., Ledonne, A., and Mercuri, N.B. (2022). Pathophysiological Features of Nigral Dopaminergic Neurons in Animal Models of Parkinson\u2019s Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23094508"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1474-4422(18)30499-X","article-title":"GBD 2016 Neurology Collaborators Global, Regional, and National Burden of Neurological Disorders, 1990\u20132016: A Systematic Analysis for the Global Burden of Disease Study 2016","volume":"18","author":"Feigin","year":"2019","journal-title":"Lancet Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S1474-4422(18)30295-3","article-title":"GBD 2016 Parkinson\u2019s Disease Collaborators Global, Regional, and National Burden of Parkinson\u2019s Disease, 1990\u20132016: A Systematic Analysis for the Global Burden of Disease Study 2016","volume":"17","author":"Dorsey","year":"2018","journal-title":"Lancet Neurol."},{"key":"ref_4","first-page":"S3","article-title":"The Emerging Evidence of the Parkinson Pandemic","volume":"8","author":"Dorsey","year":"2018","journal-title":"J. Park. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1002\/mds.28762","article-title":"Prevalence of Parkinson\u2019s Disease: A Community-Based Study in China","volume":"36","author":"Qi","year":"2021","journal-title":"Mov. Disord. Off. J. Mov. Disord. Soc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/S1474-4422(18)30355-7","article-title":"The Burden of Parkinson\u2019s Disease: A Worldwide Perspective","volume":"17","author":"Rocca","year":"2018","journal-title":"Lancet Neurol."},{"key":"ref_7","first-page":"495","article-title":"Parkinson Matters","volume":"8","author":"Darweesh","year":"2018","journal-title":"J. Park. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1136\/jnnp.2007.131045","article-title":"Parkinson\u2019s Disease: Clinical Features and Diagnosis","volume":"79","author":"Jankovic","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson\u2019s Disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet Lond. Engl."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Melis, M., Haehner, A., Mastinu, M., Hummel, T., and Tomassini Barbarossa, I. (2021). Molecular and Genetic Factors Involved in Olfactory and Gustatory Deficits and Associations with Microbiota in Parkinson\u2019s Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22084286"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.parkreldis.2018.09.011","article-title":"The Importance of Preclinical Diagnostics in Parkinson Disease","volume":"64","author":"Mantri","year":"2019","journal-title":"Park. Relat. Disord."},{"key":"ref_12","first-page":"45","article-title":"Mitochondria and Parkinson\u2019s Disease: Clinical, Molecular, and Translational Aspects","volume":"11","author":"Borsche","year":"2021","journal-title":"J. Park. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cger.2019.08.002","article-title":"Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology","volume":"36","author":"Simon","year":"2020","journal-title":"Clin. Geriatr. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/S1474-4422(16)30230-7","article-title":"The Epidemiology of Parkinson\u2019s Disease: Risk Factors and Prevention","volume":"15","author":"Ascherio","year":"2016","journal-title":"Lancet Neurol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.amjmed.2019.03.001","article-title":"Parkinson\u2019s Disease and Parkinsonism","volume":"132","author":"Hayes","year":"2019","journal-title":"Am. J. Med."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Day, J.O., and Mullin, S. (2021). The Genetics of Parkinson\u2019s Disease and Implications for Clinical Practice. Genes, 12.","DOI":"10.3390\/genes12071006"},{"key":"ref_17","unstructured":"(2024, August 17). Tobacco Smoking and the Reduced Risk of Parkinson Disease: A Puzzle of 60 Years\u2014PubMed, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/32371449\/."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1001\/jama.2021.21011","article-title":"Effect of Urate-Elevating Inosine on Progression of Early Parkinson Disease-Reply","volume":"327","author":"Macklin","year":"2022","journal-title":"JAMA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.parkreldis.2022.08.009","article-title":"Risk Reduction of Parkinson\u2019s Disease by Caffeinated Beverage Consumption","volume":"103","author":"Kawada","year":"2022","journal-title":"Park. Relat. Disord."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e13031","DOI":"10.1111\/acel.13031","article-title":"Oxidative Stress in the Aging Substantia Nigra and the Etiology of Parkinson\u2019s Disease","volume":"18","author":"Trist","year":"2019","journal-title":"Aging Cell."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.bbapap.2019.03.001","article-title":"\u03b1-Synuclein misfolding and aggregation: Implications in Parkinson\u2019s Disease Pathogenesis","volume":"1867","author":"Mehra","year":"2019","journal-title":"Biochim. Biophys. Acta Proteins Proteom."},{"key":"ref_22","first-page":"485","article-title":"Inflammatory Mechanisms in Parkinson\u2019s Disease: From Pathogenesis to Targeted Therapies","volume":"28","author":"Lee","year":"2022","journal-title":"Neurosci. Rev. J. Bringing Neurobiol. Neurol. Psychiatry"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1136\/jnnp-2019-322338","article-title":"Parkinson\u2019s Disease: Etiopathogenesis and Treatment","volume":"91","author":"Jankovic","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13024-019-0332-6","article-title":"Impaired Dopamine Metabolism in Parkinson\u2019s Disease Pathogenesis","volume":"14","author":"Masato","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.mito.2023.05.007","article-title":"Mitochondrial Dysfunction and Oxidative Stress in Alzheimer\u2019s Disease, and Parkinson\u2019s Disease, Huntington\u2019s Disease and Amyotrophic Lateral Sclerosis\u2014An Updated Review","volume":"71","author":"Alqahtani","year":"2023","journal-title":"Mitochondrion"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41531-022-00370-3","article-title":"Nitrosative Stress in Parkinson\u2019s Disease","volume":"8","author":"Stykel","year":"2022","journal-title":"NPJ Park. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Prolo, C., Piacenza, L., and Radi, R. (2024). Peroxynitrite: A Multifaceted Oxidizing and Nitrating Metabolite. Curr. Opin. Chem. Biol., 80.","DOI":"10.1016\/j.cbpa.2024.102459"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"13779","DOI":"10.1039\/c2dt31526b","article-title":"Peroxynitrous Acid: Controversy and Consensus Surrounding an Enigmatic Oxidant","volume":"41","author":"Koppenol","year":"2012","journal-title":"Dalton Trans. Camb. Engl."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.brainresbull.2017.05.008","article-title":"Cellular Mechanisms of Peroxynitrite-Induced Neuronal Death","volume":"133","author":"Ramdial","year":"2017","journal-title":"Brain Res. Bull."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Iova, O.-M., Marin, G.-E., Lazar, I., Stanescu, I., Dogaru, G., Nicula, C.A., and Bulboac\u0103, A.E. (2023). Nitric Oxide\/Nitric Oxide Synthase System in the Pathogenesis of Neurodegenerative Disorders\u2014An Overview. Antioxidants, 12.","DOI":"10.3390\/antiox12030753"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.niox.2005.11.001","article-title":"Peroxynitrite-Induced Oxidation and Nitration Products of Guanine and 8-Oxoguanine: Structures and Mechanisms of Product Formation","volume":"14","author":"Niles","year":"2006","journal-title":"Nitric Oxide Biol. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Mahdi, A., Tengbom, J., Alvarsson, M., Wernly, B., Zhou, Z., and Pernow, J. (2020). Red Blood Cell Peroxynitrite Causes Endothelial Dysfunction in Type 2 Diabetes Mellitus via Arginase. Cells, 9.","DOI":"10.3390\/cells9071712"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1089\/152308603322110896","article-title":"Peroxynitrite and Mitochondrial Dysfunction in the Pathogenesis of Parkinson\u2019s Disease","volume":"5","author":"Ebadi","year":"2003","journal-title":"Antioxid. Redox Signal."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"26464","DOI":"10.1074\/jbc.R113.472936","article-title":"Peroxynitrite, a Stealthy Biological Oxidant","volume":"288","author":"Radi","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.bbrc.2004.03.122","article-title":"The Impact of Metal Catalysis on Protein Tyrosine Nitration by Peroxynitrite","volume":"317","author":"Daiber","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric Oxide and Peroxynitrite in Health and Disease","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiol. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s004010100428","article-title":"Increased Expression of Manganese Superoxide Dismutase Is Associated with That of Nitrotyrosine in Myopathies with Rimmed Vacuoles","volume":"103","author":"Tsuruta","year":"2002","journal-title":"Acta Neuropathol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1046\/j.1471-4159.1997.69051945.x","article-title":"Superoxide Dismutase Catalyzes Nitration of Tyrosines by Peroxynitrite in the Rod and Head Domains of Neurofilament-L","volume":"69","author":"Crow","year":"1997","journal-title":"J. Neurochem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1080\/00207454.2020.1713776","article-title":"3-Nitrotyrosine: A Versatile Oxidative Stress Biomarker for Major Neurodegenerative Diseases","volume":"130","author":"Bandookwala","year":"2020","journal-title":"Int. J. Neurosci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/cvr\/cvq028","article-title":"Cyclosporine A-Induced Nitration of Tyrosine 34 MnSOD in Endothelial Cells: Role of Mitochondrial Superoxide","volume":"87","author":"Romero","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"H3404","DOI":"10.1152\/ajpheart.00761.2007","article-title":"Enhanced Mitochondrial Superoxide in Hyperglycemic Endothelial Cells: Direct Measurements and Formation of Hydrogen Peroxide and Peroxynitrite","volume":"293","author":"Quijano","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"McCarty, M.F., and Lerner, A. (2020). Nutraceuticals Targeting Generation and Oxidant Activity of Peroxynitrite May Aid Prevention and Control of Parkinson\u2019s Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103624"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","article-title":"Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging","volume":"97","author":"Jomova","year":"2023","journal-title":"Arch. Toxicol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"120","DOI":"10.4103\/2319-4170.134084","article-title":"Pros and Cons of Current Approaches for Detecting Peroxynitrite and Their Applications","volume":"37","author":"Chen","year":"2014","journal-title":"Biomed. J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1021\/cr900263j","article-title":"New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging","volume":"110","author":"Kobayashi","year":"2010","journal-title":"Chem. Rev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1039\/D0CS00115E","article-title":"Fluorescent Probes for Bioimaging of Potential Biomarkers in Parkinson\u2019s Disease","volume":"50","author":"Gao","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Zheng, M., Wang, Y., Zhang, D., and Zhu, M. (2023). Fluorescent Materials with Excellent Biocompatibility and Their Application in Bio-Sensing, Bio-Imaging. Biosensors, 13.","DOI":"10.3390\/bios13100906"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1021\/acs.accounts.9b00302","article-title":"Reaction-Based Fluorescent Probes for the Detection and Imaging of Reactive Oxygen, Nitrogen, and Sulfur Species","volume":"52","author":"Wu","year":"2019","journal-title":"Acc. Chem. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e202200828","DOI":"10.1002\/chem.202200828","article-title":"Recent Progress of Small-Molecule Ratiometric Fluorescent Probes for Peroxynitrite in Biological Systems","volume":"28","author":"Ma","year":"2022","journal-title":"Chemistry"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Li, M., Han, H., Zhang, H., Song, S., Shuang, S., and Dong, C. (2020). Boronate Based Sensitive Fluorescent Probe for the Detection of Endogenous Peroxynitrite in Living Cells. Spectrochim. Acta A Mol. Biomol. Spectrosc., 243.","DOI":"10.1016\/j.saa.2020.118683"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Wang, M., Wang, C., Song, W., Zhong, W., Sun, T., Zhu, J., and Wang, J. (2021). A Novel Borate Fluorescent Probe for Rapid Selective Intracellular Peroxynitrite Imaging. Spectrochim. Acta A Mol. Biomol. Spectrosc., 251.","DOI":"10.1016\/j.saa.2020.119398"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Li, M., Han, H., Song, S., Shuang, S., and Dong, C. (2021). AIE-Based Fluorescent Boronate Probe and Its Application in Peroxynitrite Imaging. Spectrochim. Acta A Mol. Biomol. Spectrosc., 261.","DOI":"10.1016\/j.saa.2021.120044"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Li, M., Huang, Y., Song, S., Shuang, S., and Dong, C. (2022). A Bifunctional Fluorescence Probe for Dual-Channel Detecting of Mitochondrial Viscosity and Endogenous\/Exogenous Peroxynitrite. Bioorganic Chem., 119.","DOI":"10.1016\/j.bioorg.2021.105484"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4661","DOI":"10.1039\/D3OB00637A","article-title":"Human Serum Albumin-based Supramolecular Host-guest Boronate Probe for Enhanced Peroxynitrite Sensing","volume":"21","author":"Tian","year":"2023","journal-title":"Org. Biomol. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Qin, S., Ran, Y., He, Y., Lu, X., Wang, J., Zhao, W., and Zhang, J. (2023). Near-Infrared Fluorescence Probe for Visualizing Fluctuations of Peroxynitrite in Living Cells and Inflammatory Mouse Models. Chemosensors, 11.","DOI":"10.3390\/chemosensors11060316"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Xu, Z., Qian, J., Ge, Y., Wang, Y., and Chen, H. (2022). A Two-Photon Fluorescent Probe for the Visual Detection of Peroxynitrite in Living Cells and Zebrafish. Molecules, 27.","DOI":"10.3390\/molecules27154858"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3581","DOI":"10.1021\/acsbiomaterials.3c00307","article-title":"Multifunctional Mitochondria-Targeting Near-Infrared Fluorescent Probe for Viscosity, ONOO-, Mitophagy, and Bioimaging","volume":"9","author":"Lei","year":"2023","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"6496","DOI":"10.1021\/acs.analchem.3c01124","article-title":"A Chemiluminescent Probe for Imaging Peroxynitrite in Inflammatory Cells and Tissues","volume":"95","author":"Deng","year":"2023","journal-title":"Anal. Chem."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Wu, X., Shen, Y., Tan, S., Jiang, X., Chen, Z., Yu, Q., Chen, H., Zhuang, Y., Zeng, H., and Fu, X. (2023). Multiscale Imaging of Peroxynitrite in Gliomas with a Blood-brain Barrier Permeable Probe Reveals Its Potential as a Biomarker and Target for Glioma Treatment. Biosens. Bioelectron., 236.","DOI":"10.1016\/j.bios.2023.115415"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Weber, M., Yamada, N., Tian, X., Bull, S.D., Minoshima, M., Kikuchi, K., Mackenzie, A.B., and James, T.D. (2020). Sensing Peroxynitrite in Different Organelles of Murine RAW264.7 Macrophages with Coumarin-Based Fluorescent Probes. Front. Chem., 8.","DOI":"10.3389\/fchem.2020.00039"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.7150\/thno.82323","article-title":"Ratiometric Optical Probes for Biosensing","volume":"13","author":"Yang","year":"2023","journal-title":"Theranostics"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1039\/C4CS00280F","article-title":"Small Molecule-Based Ratiometric Fluorescence Probes for Cations, Anions, and Biomolecules","volume":"44","author":"Lee","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Xu, J.-Q., Gao, M.-J., Guo, J.-S., Wang, Y.-H., Wei, R., Meng, Y.-L., and Kang, Y.-F. (2022). A Highly Selective Probe for Ratiometric Imaging Peroxynitrite in Living Cells and in Vivo. Bioorganic Chem., 128.","DOI":"10.1016\/j.bioorg.2022.106055"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1021\/acsabm.0c01178","article-title":"Nanoliposomal Ratiometric Fluorescent Probe toward ONOO- Flux","volume":"4","author":"Zhang","year":"2021","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"339652","DOI":"10.1016\/j.aca.2022.339652","article-title":"A Deep Red Ratiometric Fluorescent Probe for Accurate Detection of Peroxynitrite in Mitochondria","volume":"1203","author":"Han","year":"2022","journal-title":"Anal. Chim. Acta"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Liang, C., Shu, W., Han, R., Kang, H., Zhang, X., Jing, J., Zhang, R., and Zhang, X. (2022). A Xanthene-Based Fluorescent Probe for Detection of Peroxynitrite in Living Cells and Zebrafish. Spectrochim. Acta A Mol. Biomol. Spectrosc., 277.","DOI":"10.1016\/j.saa.2022.121264"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e202200388","DOI":"10.1002\/asia.202200388","article-title":"Construction of a Mitochondria-Endoplasmic Reticulum Dual-Targeted Red-Emitting Fluorescent Probe for Imaging Peroxynitrite in Living Cells and Zebrafish","volume":"17","author":"He","year":"2022","journal-title":"Chem. Asian J."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Liu, Z., Mo, S., Hao, Z., and Hu, L. (2023). Recent Progress of Spectroscopic Probes for Peroxynitrite and Their Potential Medical Diagnostic Applications. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241612821"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Shen, Y., Dai, L., Zhang, Y., Li, H., Chen, Y., and Zhang, C. (2020). A Novel Pyridinium-Based Fluorescent Probe for Ratiometric Detection of Peroxynitrite in Mitochondria. Spectrochim. Acta A Mol. Biomol. Spectrosc., 228.","DOI":"10.1016\/j.saa.2019.117762"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"27530","DOI":"10.1021\/acsomega.0c04073","article-title":"Application of a Colorimetric and Near-Infrared Fluorescent Probe in Peroxynitrite Detection and Imaging in Living Cells","volume":"5","author":"Gu","year":"2020","journal-title":"ACS Omega"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Zhang, Y., and Ma, D. (2021). Selective Detection of Peroxynitrite in Living Cells by a Near-Infrared Diphenyl Phosphinate-Based Dicyanoisophorone Probe. Spectrochim. Acta A Mol. Biomol. Spectrosc., 244.","DOI":"10.1016\/j.saa.2020.118890"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Sonawane, P.M., Lee, W., Kim, Y., Roychaudhury, A., Bhosale, V.K., Kim, D., Park, H.-S., Kim, C.-H., and Churchill, D.G. (2022). Phosphinate-Benzoindocyanin Fluorescent Probe for Endogenous Mitochondrial Peroxynitrite Detection in Living Cells and Gallbladder Access in Inflammatory Zebrafish Animal Models. Spectrochim. Acta A Mol. Biomol. Spectrosc., 267.","DOI":"10.1016\/j.saa.2021.120568"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"120100","DOI":"10.1016\/j.saa.2021.120100","article-title":"A Morpholino Hydrazone-based Lysosome-targeting Fluorescent Probe With Fast Response and High Sensitivity for Imaging Peroxynitrite in Living Cells","volume":"262","author":"Gu","year":"2021","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"27933","DOI":"10.1039\/D2RA04549D","article-title":"Highly Sensitive Benzothiazole-based Chemosensors for Detection and Bioimaging of Peroxynitrite in Living Cells","volume":"12","author":"Kong","year":"2022","journal-title":"RSC Adv."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Lu, Z., Dong, C., Wang, Y., Liu, Q., Wei, H., Zhao, B., Xu, X., Dong, B., and Fan, C. (2023). A Near-Infrared Fluorescent Probe with Remarkably Large Stokes Shift for Specifical Imaging of Peroxynitrite Fluctuations in Hela Cells. Bioorganic Chem., 141.","DOI":"10.1016\/j.bioorg.2023.106866"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1021\/acs.analchem.0c04854","article-title":"Activity-Based Fluorescent Molecular Logic Gate Probe for Dynamic Tracking of Mitophagy Induced by Oxidative Stress","volume":"93","author":"Liu","year":"2021","journal-title":"Anal. Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s00775-022-01954-3","article-title":"A Ratiometric Fluorescent Nanoprobe for Ultrafast Imaging of Peroxynitrite in Living Cells","volume":"27","author":"Cui","year":"2022","journal-title":"J. Biol. Inorg. Chem. JBIC Publ. Soc. Biol. Inorg. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"6003","DOI":"10.1021\/acs.analchem.0c00259","article-title":"Lysosome-Targeting Iridium(III) Probe with Near-Infrared Emission for the Visualization of NO\/O2\u2022- Crosstalk via In Vivo Peroxynitrite Imaging","volume":"92","author":"Wu","year":"2020","journal-title":"Anal. Chem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"339784","DOI":"10.1016\/j.aca.2022.339784","article-title":"Development of a Fluorescein Modified Ruthenium(II) Complex Probe for Lysosome-Targeted Ratiometric Luminescence Detection and Imaging of Peroxynitrite in Living Cells","volume":"1205","author":"Ren","year":"2022","journal-title":"Anal. Chim. Acta"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1039\/D2CC06425A","article-title":"Selective Detection of Peroxynitrite Using an Isatin Receptor and a Naphthalimide Fluorophore","volume":"59","author":"Wu","year":"2023","journal-title":"Chem. Commun. Camb. Engl."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"7278","DOI":"10.1021\/acs.analchem.3c00282","article-title":"New \u201cDestruction Seek to Survive\u201d Strategy Based on a Serum Albumin Assembly with a Squaraine Molecule for the Detection of Peroxynitrite","volume":"95","author":"Han","year":"2023","journal-title":"Anal. Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.1039\/D3AY01416A","article-title":"A Dihydro-benzo[4,5]imidazo[1,2-c]quinazoline-based Probe with Aggregation-induced Ratiometric Emission for the Ratiometric Fluorescent Detection of Peroxynitrite in Living Cells and Zebrafish","volume":"15","author":"Yan","year":"2023","journal-title":"Anal Methods."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1039\/D2TB02568J","article-title":"A Therapeutic Probe for Detecting and Inhibiting ONOO- in Senescent Cells","volume":"11","author":"Huang","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1021\/acsinfecdis.9b00357","article-title":"Liposomes for Antibiotic Encapsulation and Delivery","volume":"6","author":"Hosseinidoust","year":"2020","journal-title":"ACS Infect. Dis."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"12380","DOI":"10.1021\/acs.analchem.6b03632","article-title":"Using Nanoliposomes to Construct a FRET-Based Ratiometric Fluorescent Probe for Sensing Intracellular pH Values","volume":"88","author":"Zhang","year":"2016","journal-title":"Anal. Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"122421","DOI":"10.1016\/j.talanta.2021.122421","article-title":"A Mitochondria-targeted Ratiometric Fluorescent Nanoprobe for Imaging of Peroxynitrite in Living Cells","volume":"231","author":"Yang","year":"2021","journal-title":"Talanta"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Shao, J., Sun, S., Zhan, D., Pan, L., Min, G., Li, X., Huang, K., Chen, W., Yang, L., and Liu, X.-Y. (2022). Phycocyanin - Carbon Dots Nanoprobe for the Ratiometric Fluorescence Determination of Peroxynitrite. Spectrochim. Acta A Mol. Biomol. Spectrosc., 275.","DOI":"10.1016\/j.saa.2022.121177"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1039\/D3SC05010F","article-title":"Selective FRET Nano Probe Based on Carbon Dots and Naphthalimide-isatin for the Ratiometric Detection of Peroxynitrite in Drug-induced Liver Injury","volume":"15","author":"Wu","year":"2023","journal-title":"Chem. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4038","DOI":"10.1021\/acs.analchem.9b05599","article-title":"Ultrafast Detection of Peroxynitrite in Parkinson\u2019s Disease Models Using a Near-Infrared Fluorescent Probe","volume":"92","author":"Sun","year":"2020","journal-title":"Anal. Chem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"129003","DOI":"10.1016\/j.snb.2020.129003","article-title":"A Two-Photon Fluorescent Probe for Visualizing Endoplasmic Reticulum Peroxynitrite in Parkinson\u2019s Disease Models","volume":"328","author":"Yan","year":"2021","journal-title":"Sens. Actuators B Chem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2250039","DOI":"10.1142\/S1793545822500390","article-title":"A Novel \u03b1-Ketoamide Reactivity-Based Two-Photon Fluorogenic Probe for Visualizing Peroxynitrite in Parkinson\u2019s Disease Models","volume":"16","author":"Shao","year":"2023","journal-title":"J. Innov. Opt. Health Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"131393","DOI":"10.1016\/j.snb.2022.131393","article-title":"A Near-Infrared Fluorescent Probe for Ratiometric Imaging Peroxynitrite in Parkinson\u2019s Disease Model","volume":"359","author":"Kang","year":"2022","journal-title":"Sens. Actuators B Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"7138","DOI":"10.1021\/acs.analchem.4c00591","article-title":"A Sequentially Activated Probe for Imaging of Superoxide Anion and Peroxynitrite in PC12 Cells under Oxidative Stress","volume":"96","author":"Li","year":"2024","journal-title":"Anal. Chem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"15088","DOI":"10.1021\/acs.analchem.1c03334","article-title":"Dual-Channel Imaging of Amyloid-\u03b2 Plaques and Peroxynitrite To Illuminate Their Correlations in Alzheimer\u2019s Disease Using a Unimolecular Two-Photon Fluorescent Probe","volume":"93","author":"Xie","year":"2021","journal-title":"Anal. Chem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"6300","DOI":"10.1039\/D2CC01744J","article-title":"Two-Photon Fluorescence Imaging of the Cerebral Peroxynitrite Stress in Alzheimer\u2019s Disease","volume":"58","author":"Xie","year":"2022","journal-title":"Chem. Commun. Camb. Engl."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e202206894","DOI":"10.1002\/anie.202206894","article-title":"An Activity-Based Fluorescent Probe for Imaging Fluctuations of Peroxynitrite (ONOO-) in the Alzheimer\u2019s Disease Brain","volume":"61","author":"Wang","year":"2022","journal-title":"Angew. Chem. Int. Ed Engl."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1039\/D3AN00956D","article-title":"A Large Stokes Shift NIR Fluorescent Probe for Visual Monitoring of Mitochondrial Peroxynitrite during Inflammation and Ferroptosis and in an Alzheimer\u2019s Disease Model","volume":"148","author":"Chen","year":"2023","journal-title":"Analyst"}],"container-title":["Biosensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6374\/14\/10\/506\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:14:48Z","timestamp":1760112888000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6374\/14\/10\/506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,17]]},"references-count":97,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["bios14100506"],"URL":"https:\/\/doi.org\/10.3390\/bios14100506","relation":{},"ISSN":["2079-6374"],"issn-type":[{"value":"2079-6374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,17]]}}}