{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T12:11:25Z","timestamp":1781093485549,"version":"3.54.1"},"reference-count":60,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of Chongqing","award":["cstc2021jcyj-msxmX0635"],"award-info":[{"award-number":["cstc2021jcyj-msxmX0635"]}]},{"name":"Natural Science Foundation of Chongqing","award":["61503309"],"award-info":[{"award-number":["61503309"]}]},{"name":"Natural Science Foundation of Chongqing","award":["No. 2020CDJYGRH-1001"],"award-info":[{"award-number":["No. 2020CDJYGRH-1001"]}]},{"name":"National Natural Science Foundation of China through the Young Program","award":["cstc2021jcyj-msxmX0635"],"award-info":[{"award-number":["cstc2021jcyj-msxmX0635"]}]},{"name":"National Natural Science Foundation of China through the Young Program","award":["61503309"],"award-info":[{"award-number":["61503309"]}]},{"name":"National Natural Science Foundation of China through the Young Program","award":["No. 2020CDJYGRH-1001"],"award-info":[{"award-number":["No. 2020CDJYGRH-1001"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["cstc2021jcyj-msxmX0635"],"award-info":[{"award-number":["cstc2021jcyj-msxmX0635"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["61503309"],"award-info":[{"award-number":["61503309"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["No. 2020CDJYGRH-1001"],"award-info":[{"award-number":["No. 2020CDJYGRH-1001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>In this study, we have proposed an electrochemiluminescence (ECL) signal amplification system which is based on two-dimensional (2D) flower-like CdS@Co\/Mo-MOF composites as a co-reaction accelerator of the g-C3N4\/S2O82\u2212 system for ultrasensitive detection of chlorpromazine hydrochloride (CPH). Specifically, the 2D flower-like Co\/Mo-MOF with mesoporous alleviated the aggregation of CdS NPs while simultaneously fostering reactant-active site contact and improving the reactant\u2013product transport rate. This allowed the material to act as a novel co-reaction accelerator, speeding up the transformation of the S2O82\u2212 into SO4\u2022\u2212 and enhancing the cathodic ECL emission of g-C3N4. Moreover, the signal probe which was synthesized by coupling the 2D CdS@Co\/Mo-MOF and graphitic carbon nitride (g-C3N4) achieved the generation of SO4\u2022\u2212 in situ and reduced energy loss. The results confirmed that the ECL signal was enhanced 6.2-fold and stabilized by CdS@Co\/Mo-MOF. Based on the extremely strong quenching effect of chlorpromazine hydrochloride (CPH) on this system, a \u201csignal-off\u201d type sensor was constructed. The sensor demonstrated excellent sensitivity and linear response to CPH concentrations ranging from 1 pmol L\u22121 to 100 \u03bcmol L\u22121, with a low detection limit of 0.4 pmol L\u22121 (S\/N = 3).<\/jats:p>","DOI":"10.3390\/bios14120586","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T10:52:30Z","timestamp":1733223150000},"page":"586","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["2D Flower-like CdS@Co\/Mo-MOF as Co-Reaction Accelerator of g-C3N4-Based Electrochemiluminescence Sensor for Chlorpromazine Hydrochloride"],"prefix":"10.3390","volume":"14","author":[{"given":"Xiaowei","family":"Fan","sequence":"first","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, No. 174, Shapingba Main Street, Chongqing 400030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, No. 174, Shapingba Main Street, Chongqing 400030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodi","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, No. 174, Shapingba Main Street, Chongqing 400030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, No. 174, Shapingba Main Street, Chongqing 400030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, No. 174, Shapingba Main Street, Chongqing 400030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilei","family":"Hao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, No. 174, Shapingba Main Street, Chongqing 400030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6981-1755","authenticated-orcid":false,"given":"Defang","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, No. 174, Shapingba Main Street, Chongqing 400030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.coelec.2019.04.018","article-title":"Advanced carbon nanomaterials for electrochemiluminescent biosensor applications","volume":"16","author":"Fiorani","year":"2019","journal-title":"Curr. Opin. Electrochem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.bios.2017.09.017","article-title":"Electrochemiluminescence resonance energy transfer system between GNRs and Ru(bpy)32+: Application in magnetic aptasensor for \u03b2-amyloid","volume":"100","author":"Ke","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1021\/acs.analchem.7b05137","article-title":"Strong electrochemiluminescence from MOF accelerator enriched quantum dots for enhanced sensing of trace cTnI","volume":"90","author":"Yang","year":"2018","journal-title":"Anal. Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"101621","DOI":"10.1016\/j.cocis.2022.101621","article-title":"Strategies of tailored nanomaterials for electrochemiluminescence signal enhancements","volume":"61","author":"Alemu","year":"2022","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4188","DOI":"10.1021\/ac403635f","article-title":"Gold nanoparticle-graphite-like C3N4 nanosheet nanohybrids used for electrochemiluminescent immunosensor","volume":"86","author":"Chen","year":"2014","journal-title":"Anal. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.electacta.2017.12.124","article-title":"Detection of cyanide by etching-induced electrochemiluminescence recovery","volume":"261","author":"Feng","year":"2018","journal-title":"Electrochim. Acta."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4754","DOI":"10.1021\/ac300205w","article-title":"Electrogenerated chemiluminescence behavior of graphite-like carbon nitride and its application in selective sensing Cu2+","volume":"84","author":"Cheng","year":"2012","journal-title":"Anal. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"15636","DOI":"10.1021\/jacs.6b09020","article-title":"Co-reactant-on-demand ECL: Electrogenerated chemiluminescence by the in situ production of S2O82\u2013 at boron-doped diamond electrodes","volume":"138","author":"Irkham","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.1007\/s00216-021-03247-1","article-title":"Advances in electrochemiluminescence co-reaction accelerator and its analytical applications","volume":"413","author":"Wang","year":"2021","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"126767","DOI":"10.1016\/j.snb.2019.126767","article-title":"Fe-Co-Co Prussian blue analogues as a novel co-reaction accelerator for ultrasensitive electrochemiluminescent biosensor construction","volume":"297","author":"Wu","year":"2019","journal-title":"Sens. Actuat. B Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"112820","DOI":"10.1016\/j.bios.2020.112820","article-title":"A synergistic promotion strategy remarkably accelerated electrochemiluminescence of SnO2 QDs for microRNA detection using 3D DNA walker amplification","volume":"173","author":"Yang","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"108588","DOI":"10.1016\/j.microc.2023.108588","article-title":"Highly efficient synthesis of CeO2@g-C3N4 double-shelled hollow spheres for ultrasensitive self-enhanced electrochemiluminescence biosensors","volume":"190","author":"Lin","year":"2023","journal-title":"Microchem. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.bios.2018.10.068","article-title":"CuS as co-reaction accelerator in PTCA-K2S2O8 system for enhancing electrochemiluminescence behavior of PTCA and its application in the detection of amyloid-\u03b2 protein","volume":"126","author":"Song","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"8992","DOI":"10.1021\/acs.analchem.0c01075","article-title":"High-efficiency CNNS@NH2-MIL(Fe) electrochemiluminescence emitters coupled with Ti3C2 nanosheets as a matrix for a highly sensitive cardiac troponin I assay","volume":"92","author":"Jiang","year":"2020","journal-title":"Anal. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1126\/science.aaf9135","article-title":"Coordinative alignment of molecules in chiral metal-organic frameworks","volume":"353","author":"Lee","year":"2016","journal-title":"Science"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ccr.2017.09.001","article-title":"Metal\u2013organic frameworks for electrocatalysis","volume":"373","author":"Liao","year":"2018","journal-title":"Coord. Chem. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.1039\/C8CS00268A","article-title":"Two-dimensional metal-organic framework nanosheets: Synthesis and applications","volume":"47","author":"Zhao","year":"2018","journal-title":"Chem. Soc. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"10787","DOI":"10.1002\/ange.201907002","article-title":"A phthalocyanine-based layered two-dimensional conjugated metal-organic framework as a highly efficient electrocatalyst for the oxygen reduction reaction","volume":"131","author":"Zhong","year":"2019","journal-title":"Angew. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/s00604-020-04634-8","article-title":"In situ deposition of MOF-74(Cu) nanosheet arrays onto carbon cloth to fabricate a sensitive and selective electrocatalytic biosensor and its application for the determination of glucose in human serum","volume":"187","author":"Hu","year":"2020","journal-title":"Microchim. Acta."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"132854","DOI":"10.1016\/j.snb.2022.132854","article-title":"A bottom-up sonication-assisted synthesis of Zn-BTC MOF nanosheets and the ppb-level acetone detection of their derived ZnO nanosheets","volume":"375","author":"Du","year":"2023","journal-title":"Sensor. Actuat B Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"107708","DOI":"10.1016\/j.cclet.2022.07.051","article-title":"Modification strategies on 2D Ni-Fe MOF-based catalysts in peroxy-disulfate activation for efficient organic pollutant removal","volume":"34","author":"Liu","year":"2023","journal-title":"Chin. Chem. Lett."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"127919","DOI":"10.1016\/j.snb.2020.127919","article-title":"A highly sensitive and stable electrochemiluminescence immunosensor for alpha-fetoprotein detection based on luminol-AgNPs@Co\/Ni-MOF nanosheet microflowers","volume":"311","author":"Wang","year":"2020","journal-title":"Sensor. Actuat B Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.gee.2020.12.023","article-title":"Recent progress on the synthesis of ZIF-67-based materials and their application to heterogeneous catalysis","volume":"7","author":"Duan","year":"2022","journal-title":"Green Energy Environ."},{"key":"ref_24","first-page":"1887","article-title":"The application of ZIF-67 and its derivatives: Adsorption, separation, electrochemistry, and catalysts","volume":"6","author":"Zhong","year":"2018","journal-title":"J. Mater."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"41960","DOI":"10.1021\/acsami.0c11269","article-title":"One-Step Electrodeposition of Silver Nanostructures on 2D\/3D Metal-Organic Framework ZIF-67: Comparison and Application in Electrochemical Detection of Hydrogen Peroxide","volume":"12","author":"Sun","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"100448","DOI":"10.1016\/j.mtadv.2023.100448","article-title":"Superhydrophobic ZIF-67 with exceptional hydrostability","volume":"20","author":"Butt","year":"2023","journal-title":"Mater. Today Adv."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"143156","DOI":"10.1016\/j.cej.2023.143156","article-title":"Two-dimensional metal-organic framework nanosheets: An efficient two-electron oxygen reduction reaction electrocatalyst for boosting cathodic luminol electrochemiluminescence","volume":"466","author":"Zhao","year":"2023","journal-title":"Chem. Eng. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.apcatb.2019.03.007","article-title":"Bottom-up MOF-intermediated synthesis of 3D hierarchical flower-like cobalt-based homobimetallic phophide composed of ultrathin nanosheets for highly efficient oxygen evolution reaction","volume":"249","author":"Li","year":"2019","journal-title":"Appl. Catal. B Environ."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"134815","DOI":"10.1016\/j.cej.2022.134815","article-title":"Design of hydrangea-type Co\/Mo bimetal MOFs and MOF-derived Co\/Mo2C embedded carbon composites for highly efficient oxygen evolution reaction","volume":"435","author":"Ahn","year":"2022","journal-title":"Chem. Eng. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"19224","DOI":"10.1039\/C8NR06956E","article-title":"Multi-segmented CdS-Au nanorods for electrochemiluminescence bioanalysis","volume":"10","author":"Huo","year":"2018","journal-title":"Nanoscale"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1021\/acsami.7b13557","article-title":"Spatial-resolved photoelectrochemical biosensing array based on CdS@g-C3N4 heterojunction: A universal immunosensing platform for accurate detection","volume":"10","author":"Dong","year":"2018","journal-title":"ACS Appl. Mater."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00604-020-4125-y","article-title":"Electrochemiluminescence immunoassay for the prostate-specific antigen by using a CdS\/chitosan\/g-C3N4 nanocomposite","volume":"187","author":"Huang","year":"2020","journal-title":"Microchim. Acta."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.jcis.2023.10.006","article-title":"Nanosheet-assembled transition metal sulfides nanoflowers derived from CoMo-MOF for efficient oxygen evolution reaction","volume":"653","author":"Yu","year":"2024","journal-title":"J. Colloid Interface Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1021\/acs.energyfuels.2c03882","article-title":"Synthesis and application of mesoporous materials: Process status, technical problems, and development prospects: A mini-review","volume":"37","author":"Li","year":"2023","journal-title":"Energy Fuel."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"105886","DOI":"10.1016\/j.microc.2020.105886","article-title":"Electrochemical detection of antipsychotic drug in water samples based on nano\/sub-microrod-like CuBi2-xInxO4 electrocatalysts","volume":"163","author":"Kaleeswarran","year":"2021","journal-title":"Microchem. J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"663","DOI":"10.4088\/JCP.v64n0607","article-title":"Chlorpromazine equivalent doses for the newer atypical antipsychotics","volume":"64","author":"Woods","year":"2003","journal-title":"J. Clin. Psychiatry"},{"key":"ref_37","first-page":"CD007778","article-title":"Chlorpromazine dose for people with schizophrenia","volume":"4","author":"Dudley","year":"2017","journal-title":"Cochrane Db. Syst. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"6483","DOI":"10.1039\/C4AY00898G","article-title":"Electrochemiluminescence detection of chlorpromazine hydrochloride at bare and graphene oxide modified glassy carbon electrodes","volume":"6","author":"Liu","year":"2014","journal-title":"Anal. Methods"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.aca.2020.08.066","article-title":"A novel \u201coff-on\u201d electrochemiluminescence sensor based on highly efficient resonance energy transfer in C-g-C3N4\/CuO nanocomposite","volume":"1138","author":"Li","year":"2020","journal-title":"Anal. Chim. Acta."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"12533","DOI":"10.1021\/am4038307","article-title":"Facile fabrication of highly efficient g-C3N4\/Ag2O heterostructured photocatalysts with enhanced visible-light photocatalytic activity","volume":"5","author":"Miao","year":"2013","journal-title":"ACS Appl. Mater."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"11615","DOI":"10.1021\/acscatal.8b03233","article-title":"Unveiling charge-separation dynamics in CdS\/metal-organic framework composites for enhanced photocatalysis","volume":"8","author":"Xu","year":"2018","journal-title":"ACS Catal."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"151792","DOI":"10.1016\/j.apsusc.2021.151792","article-title":"Fabricated hierarchical CdS\/Ni-MOF heterostructure for promoting the photocatalytic reduction of CO2","volume":"576","author":"Xu","year":"2022","journal-title":"Appl. Surf. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"5669","DOI":"10.1039\/C9NR10473A","article-title":"Mechanistic insight into bimetallic CoNi-MOF arrays with enhanced performance for supercapacitors","volume":"12","author":"Chu","year":"2020","journal-title":"Nanoscale"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"13708","DOI":"10.1021\/jp3041692","article-title":"Synthesis and efficient visible light photocatalytic hydrogen evolution of polymeric g-C3N4 coupled with CdS quantum dots","volume":"116","author":"Ge","year":"2012","journal-title":"J. Phys. Chem. C"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"122053","DOI":"10.1016\/j.cej.2019.122053","article-title":"Novel phosphidated MoS2 nanosheets modified CdS semiconductor for an efficient photocatalytic H2 evolution","volume":"375","author":"Xu","year":"2019","journal-title":"Chem. Eng. J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"127810","DOI":"10.1016\/j.colsurfa.2021.127810","article-title":"Application of two-dimensional layered Mo-MOF@ppy with high valency molybdenum in lithium-ion batteries","volume":"632","author":"Du","year":"2022","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_47","first-page":"15074","article-title":"Interface modulation of Mo2C@foam Nickel via MoS2 quantum dots for the electrochemical oxygen evolution reaction","volume":"8","author":"Lei","year":"2020","journal-title":"J. Mater."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"107097","DOI":"10.1016\/j.microc.2021.107097","article-title":"Bimetal-organic frameworks MnCo-MOF-74 derived Co\/MnO@HC for the construction of a novel enzyme-free glucose sensor","volume":"175","author":"Zhang","year":"2022","journal-title":"Microchem. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"13219","DOI":"10.1021\/acs.analchem.1c02272","article-title":"Plasmon-driven interfacial catalytic reactions in plasmonic MOF nanoparticles","volume":"93","author":"Xie","year":"2021","journal-title":"Anal. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"6851","DOI":"10.1021\/acs.analchem.8b01018","article-title":"Silver ions as novel co-reaction accelerator for remarkably enhanced electrochemiluminescence in a PTCA-S2O82\u2212 system and its application in an ultrasensitive assay for mercury ions","volume":"90","author":"Lei","year":"2018","journal-title":"Anal. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"106784","DOI":"10.1016\/j.microc.2021.106784","article-title":"A sensitive electrochemical detection of hydrazine based on SnO2\/CeO2 nanostructured oxide","volume":"171","author":"Mohammad","year":"2021","journal-title":"Microchem. J."},{"key":"ref_52","first-page":"2786","article-title":"Recent advances in the development of phenothiazine and its fluorescent derivatives for optoelectronic applications","volume":"11","author":"Khana","year":"2023","journal-title":"J. Mater."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1002\/elan.202060011","article-title":"Determination of chlorpromazine hydrochloride with a layered double hydroxide modified glassy carbon electrode as a nanocatalyst","volume":"32","author":"Jaberi","year":"2020","journal-title":"Electroanalysis"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1021\/acs.analchem.6b00760","article-title":"Polypeptide functional surface for the aptamer immobilization: Electrochemical cocaine biosensing","volume":"88","author":"Bozokalfa","year":"2016","journal-title":"Anal. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"111918","DOI":"10.1016\/j.jphotochem.2019.111918","article-title":"Cost-effective and facile fluorescent probes for label-free recognition of chlorpromazine hydrochloride and logic gate operation","volume":"382","author":"Zhang","year":"2019","journal-title":"J. Photochem. Photobiol. A Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jpba.2004.05.003","article-title":"Ion-pair complex-based solvent extraction combined with chemiluminescence determination of chlorpromazine hydrochloride with luminol in reverse micelles","volume":"36","author":"Shi","year":"2004","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"100982","DOI":"10.1016\/j.mtchem.2022.100982","article-title":"Preparation and fabrication of porous-Fe2O3\/carbon black nanocomposite: A portable electrochemical sensor for psychotropic drug detection in environmental samples","volume":"25","author":"Shanmugam","year":"2022","journal-title":"Mater. Today Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"108396","DOI":"10.1016\/j.microc.2023.108396","article-title":"Highly sensitive amperometric determination of chlorpromazine hydrochloride in blood serum sample employing antimony vanadate nanospheres as electrode modifier","volume":"187","author":"Priscillal","year":"2023","journal-title":"Microchem. J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"100268","DOI":"10.1016\/j.cdc.2019.100268","article-title":"Electrochemical determination of Chlorpromazine using l-Cysteine modified carbon paste electrode","volume":"23","author":"Purushothama","year":"2019","journal-title":"Chem. Data Collect."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1007\/s00216-023-04621-x","article-title":"Ultrasensitive SERS substrate for label-free therapeutic drug monitoring of chlorpromazine hydrochloride and aminophylline in human serum","volume":"415","author":"Chen","year":"2023","journal-title":"Anal. Bioanal. Chem."}],"container-title":["Biosensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6374\/14\/12\/586\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:44:30Z","timestamp":1760114670000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6374\/14\/12\/586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,2]]},"references-count":60,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["bios14120586"],"URL":"https:\/\/doi.org\/10.3390\/bios14120586","relation":{},"ISSN":["2079-6374"],"issn-type":[{"value":"2079-6374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,2]]}}}