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Although broadband fingerprint enhancement compensates for limitations in detection capability and sensitivity, the complex optical path design in operation restricts its broader adoption. This paper proposes a multi-degree-of-freedom stretchable metasurface that supports magnetic dipole resonance to enhance the broadband THz fingerprint detection of trace analytes. The metasurface substrate and unit cell structures are constructed using polydimethylsiloxane. By adjusting the sensor\u2019s geometric dimensions or varying the incident angle within a narrow range, the practical optical path is significantly simplified. Simultaneously, the resonance frequency of the transmission curve is tuned, achieving high sensitivity for effectively detecting cinnamoylglycine. The results demonstrate that the metasurface achieves a high-quality factor of 770.6 and an excellent figure of merit of 777.2, significantly enhancing the THz sensing capability. Consequently, the detection sensitivity for cinnamoylglycine can reach 24.6 \u00b5g\u00b7cm\u22122. This study offers critical foundations for applying THz technology to biomedical fields, particularly detecting urinary biomarkers for diseases like gestational diabetes.<\/jats:p>","DOI":"10.3390\/bios14120602","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T10:11:47Z","timestamp":1733739107000},"page":"602","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Multi-Degree-of-Freedom Stretchable Metasurface Terahertz Sensor for Trace Cinnamoylglycine Detection"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6821-4957","authenticated-orcid":false,"given":"Huanyu","family":"Li","sequence":"first","affiliation":[{"name":"School of Integrated Circuits, Shandong University, Jinan 250100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyao","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Integrated Circuits, Shandong University, Jinan 250100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengya","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Integrated Circuits, Shandong University, Jinan 250100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Integrated Circuits, Shandong University, Jinan 250100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9968-1059","authenticated-orcid":false,"given":"Wanxin","family":"Nie","sequence":"additional","affiliation":[{"name":"School of Integrated Circuits, Shandong University, Jinan 250100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6077-8525","authenticated-orcid":false,"given":"Yifei","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Integrated Circuits, Shandong University, Jinan 250100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1970-5783","authenticated-orcid":false,"given":"Yanpeng","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Integrated Circuits, Shandong University, Jinan 250100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"19292","DOI":"10.3390\/molecules191219292","article-title":"Natural cinnamic acids, synthetic derivatives and hybrids with antimicrobial activity","volume":"19","author":"Guzman","year":"2014","journal-title":"Molecules"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1073\/pnas.0812874106","article-title":"Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites","volume":"106","author":"Wikoff","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/0278-6915(94)90085-X","article-title":"Metabolism of trans-cinnamic acid in the rat and the mouse and its variation with dose","volume":"32","author":"Nutley","year":"1994","journal-title":"Food Chem. Toxicol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e00477-17","DOI":"10.1128\/AAC.00477-17","article-title":"Targeted metabolomics analysis identifies intestinal microbiota-derived urinary biomarkers of colonization resistance in antibiotic-treated mice","volume":"61","author":"Obrenovich","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1256S","DOI":"10.1093\/ajcn\/71.5.1256s","article-title":"Carbohydrate and lipid metabolism in pregnancy: Normal compared with gestational diabetes mellitus","volume":"71","author":"Butte","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.siny.2008.09.004","article-title":"Normal and abnormal maternal metabolism during pregnancy","volume":"14","author":"Hadden","year":"2009","journal-title":"Semin. Fetal Neonatal Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.earlhumdev.2011.08.004","article-title":"Gestational diabetes and preeclampsia\u2014Similar risk factor profiles?","volume":"88","author":"Schneider","year":"2012","journal-title":"Early Hum. Dev."},{"key":"ref_8","first-page":"850","article-title":"Gestational diabetes mellitus and lesser degrees of pregnancy hyperglycemia: Association with increased risk of spontaneous preterm birth","volume":"102","author":"Hedderson","year":"2003","journal-title":"Obstet. Gynecol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.2337\/diacare.25.10.1862","article-title":"Gestational diabetes and the incidence of type 2 diabetes: A systematic review","volume":"25","author":"Kim","year":"2002","journal-title":"Diabetes Care"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1039\/C5AN01790D","article-title":"Biomarker detection technologies and future directions","volume":"141","author":"Nimse","year":"2016","journal-title":"Analyst"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Fu, X., Liu, Y., Chen, Q., Fu, Y., and Cui, T.J. (2022). Applications of terahertz spectroscopy in the detection and recognition of substances. Front. Phys., 10.","DOI":"10.3389\/fphy.2022.869537"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.dit.2013.03.009","article-title":"Terahertz technology and its applications","volume":"5","author":"Pawar","year":"2013","journal-title":"Drug Invent. Today"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1364\/OL.452131","article-title":"Enhanced trace-amount terahertz vibrational absorption spectroscopy using surface spoof polarization in metasurface structures","volume":"47","author":"Li","year":"2022","journal-title":"Opt. Lett."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"133635","DOI":"10.1016\/j.snb.2023.133635","article-title":"Dimethyl ether gas sensing using rotational absorption spectroscopy in the THz frequency region from 220 to 330 GHz","volume":"384","author":"Powers","year":"2023","journal-title":"Sens. Actuators B Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"9681","DOI":"10.1039\/D2NR01561G","article-title":"A pixelated frequency-agile metasurface for broadband terahertz molecular fingerprint sensing","volume":"14","author":"Sun","year":"2022","journal-title":"Nanoscale"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/bip.10106","article-title":"Collective vibrational modes in biological molecules investigated by terahertz time-domain spectroscopy","volume":"67","author":"Walther","year":"2002","journal-title":"Biopolymers"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1109\/TMTT.2010.2050184","article-title":"Qualitative and quantitative detection of pesticides with terahertz time-domain spectroscopy. IEEE Trans. Microw","volume":"58","author":"Hua","year":"2010","journal-title":"Theory Tech."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"107060","DOI":"10.1016\/j.isci.2023.107060","article-title":"Terahertz technology and its applications in head and neck diseases","volume":"26","author":"Shi","year":"2023","journal-title":"iScience"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7146","DOI":"10.1021\/acs.jpclett.0c02046","article-title":"Terahertz signatures of hydrate formation in alkali halide solutions","volume":"11","author":"Chen","year":"2020","journal-title":"J. Phys. Chem. Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"7382","DOI":"10.1364\/OE.16.007382","article-title":"Material thickness optimization for transmission-mode terahertz time-domain spectroscopy","volume":"16","author":"Withayachumnankul","year":"2008","journal-title":"Opt. Express"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.mattod.2019.08.002","article-title":"Terahertz plasmonics: The rise of toroidal metadevices towards immunobiosensing","volume":"32","author":"Ahmadivand","year":"2020","journal-title":"Mater. Today"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"116888","DOI":"10.1016\/j.trac.2022.116888","article-title":"Recent progress in terahertz biosensors based on artificial electromagnetic subwavelength structures","volume":"158","author":"Wang","year":"2023","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1364\/OL.29.001617","article-title":"Waveguide terahertz time-domain spectroscopy of nanometer water layers","volume":"29","author":"Zhang","year":"2004","journal-title":"Opt. Lett."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1364\/OPEX.12.001004","article-title":"Resonantly enhanced transmission of terahertz radiation through a periodic array of subwavelength apertures","volume":"12","author":"Cao","year":"2004","journal-title":"Opt. Express"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.carbon.2019.11.026","article-title":"Tunable localized surface plasmon graphene metasurface for multiband superabsorption and terahertz sensing","volume":"158","author":"Islam","year":"2020","journal-title":"Carbon"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1126\/science.1133628","article-title":"Metamaterial electromagnetic cloak at microwave frequencies","volume":"314","author":"Schurig","year":"2006","journal-title":"Science"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1021\/acs.nanolett.8b00475","article-title":"Active tuning of spontaneous emission by Mie-resonant dielectric metasurfaces","volume":"18","author":"Bohn","year":"2018","journal-title":"Nano Lett."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nnano.2015.304","article-title":"All-dielectric metamaterials","volume":"11","author":"Jahani","year":"2016","journal-title":"Nat. Nanotechnol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"036617","DOI":"10.1103\/PhysRevE.71.036617","article-title":"Electromagnetic parameter retrieval from inhomogeneous metamaterials","volume":"71","author":"Smith","year":"2005","journal-title":"Phys. Rev. E Stat. Nonlin. Soft Matter Phys."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"eaaw2871","DOI":"10.1126\/sciadv.aaw2871","article-title":"Angle-multiplexed all-dielectric metasurfaces for broadband molecular fingerprint retrieval","volume":"5","author":"Leitis","year":"2019","journal-title":"Sci. Adv."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Liu, P., Li, W., Chen, N., Ma, C., Li, X., and Yan, D. (2022). Enhancing the terahertz absorption spectrum based on the low refractive index all-dielectric metasurface. Photonics, 9.","DOI":"10.3390\/photonics9110848"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1515\/nanoph-2020-0180","article-title":"Ultra-wideband enhancement on mid-infrared fingerprint sensing for 2D materials and analytes of monolayers by a metagrating","volume":"9","author":"Xie","year":"2020","journal-title":"Nanophotonics"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1364\/OL.389045","article-title":"Enhancing terahertz molecular fingerprint detection by a dielectric metagrating","volume":"45","author":"Zhu","year":"2020","journal-title":"Opt. Lett."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"105766","DOI":"10.1016\/j.rinp.2022.105766","article-title":"Study on the enhancement mechanism of terahertz molecular fingerprint sensing","volume":"39","author":"Meng","year":"2022","journal-title":"Results Phys."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1364\/PRJ.472114","article-title":"Enhancing THz fingerprint detection on the planar surface of an inverted dielectric metagrating","volume":"10","author":"Liu","year":"2022","journal-title":"Photonics Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"33018","DOI":"10.1039\/D0RA06463G","article-title":"Ultrasensitive specific sensor based on all-dielectric metasurfaces in the terahertz range","volume":"10","author":"Zhong","year":"2020","journal-title":"RSC Adv."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1039\/D2NA00837H","article-title":"A terahertz metasurface sensor with fingerprint enhancement in a wide spectrum band for thin film detection","volume":"5","author":"Zhang","year":"2023","journal-title":"Nanoscale Adv."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1039\/D2MA00910B","article-title":"Recent advances in strongly-resonant and gradient all-dielectric metasurfaces","volume":"4","author":"Zografopoulos","year":"2022","journal-title":"Mater. Adv."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s00339-023-07205-9","article-title":"Enhancement of the terahertz absorption spectroscopy based on the stretchable dielectric metasurface","volume":"130","author":"Li","year":"2024","journal-title":"Appl. Phys. A"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"124976","DOI":"10.1016\/j.polymer.2022.124976","article-title":"Synergistic thermodynamic compatibility of polydimethylsiloxane block in thermoplastic polyurethane for flame retardant materials: Super flexible, highly flame retardant and low smoke release","volume":"253","author":"Cui","year":"2022","journal-title":"Polymer"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"035009","DOI":"10.1088\/0960-1317\/25\/3\/035009","article-title":"Mechanical properties of bulk polydimethylsiloxane for microfluidics over a large range of frequencies and aging times","volume":"25","author":"Placet","year":"2015","journal-title":"J. Micromech. Microeng."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"9869","DOI":"10.1007\/s10965-012-9869-6","article-title":"Accelerated thermal ageing studies of polydimethylsiloxane (PDMS) rubber","volume":"19","author":"Xiang","year":"2012","journal-title":"J. Polym. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.sna.2015.04.011","article-title":"Extended PDMS stiffness range for flexible systems","volume":"230","author":"Seghir","year":"2015","journal-title":"Sens. Actuators A Phys."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1021\/acs.nanolett.0c04660","article-title":"From Fano to Quasi-BIC Resonances in Individual Dielectric Nanoantennas","volume":"21","author":"Koshelev","year":"2021","journal-title":"Nano Lett."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1021\/acsphotonics.8b00098","article-title":"All-dielectric resonant metasurfaces with a strong toroidal response","volume":"5","author":"Tuz","year":"2018","journal-title":"ACS Photonics"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1364\/JOSAA.18.001562","article-title":"Material parameter estimation with terahertz time-domain spectroscopy","volume":"18","author":"Dorney","year":"2001","journal-title":"J. Opt. Soc. Am. A"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1706031","DOI":"10.1002\/adma.201706031","article-title":"Ultrafast broadband coherent control of photoluminescence from single semiconductor quantum dots","volume":"30","author":"Liu","year":"2018","journal-title":"Adv. Mater."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"156408","DOI":"10.1016\/j.apsusc.2023.156408","article-title":"Toroidal dipole bound states in the continuum in all-dielectric metasurface for high-performance refractive index and temperature sensing","volume":"615","author":"Guo","year":"2023","journal-title":"Appl. Surf. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/pssb.19680290125","article-title":"Transient effects in the room-temperature F-colouring of NaCl irradiated with X-or \u03b3-rays","volume":"29","year":"1968","journal-title":"Phys. Status Solidi B"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Qu, Q., Sun, M., Wang, W., and Shi, Y. (2024). All-dielectric metasurface-based terahertz molecular fingerprint sensor for trace cinnamoylglycine detection. Biosensors, 14.","DOI":"10.3390\/bios14090440"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"16501","DOI":"10.1039\/D3TC03554A","article-title":"A mid-IR tunable graphene metasurface for ultrasensitive molecular fingerprint retrieval and refractive index sensing","volume":"11","author":"Wei","year":"2023","journal-title":"J. Mater. Chem. 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