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Extracellular amyloid-\u03b2 peptides (A\u03b2), intracellular tau proteins, and their phosphorylated forms have gained prominence as critical biomarkers for early and precise diagnosis of AD, correlating with disease progression and response to therapy. The high costs and invasiveness of conventional diagnostic methods, such as positron emission tomography (PET) and magnetic resonance imaging (MRI), limit their suitability for large-scale or routine screening. However, electrochemical (EC) analysis methods have made significant progress in disease detection due to their high sensitivity, excellent specificity, portability, and cost-effectiveness. This article reviews the progress in EC biosensing technologies, focusing on the detection of tau protein biomarkers in the blood (a low-invasive, accessible diagnostic medium). The article then discusses various EC sensing platforms, including their fabrication processes, limit of detection (LOD), sensitivity, and clinical potential to show the role of these sensors as transformers changing the face of AD diagnostics.<\/jats:p>","DOI":"10.3390\/bios15020085","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T05:13:43Z","timestamp":1738646023000},"page":"85","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Electrochemical Technology for the Detection of Tau Proteins as a Biomarker of Alzheimer\u2019s Disease in Blood"],"prefix":"10.3390","volume":"15","author":[{"given":"Jianman","family":"Wang","sequence":"first","affiliation":[{"name":"Macao Translational Medicine Center, Macau University of Science and Technology, Taipa 999078, Macau SAR, China"},{"name":"School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Taipa 999078, Macau SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Lu","sequence":"additional","affiliation":[{"name":"Macao Translational Medicine Center, Macau University of Science and Technology, Taipa 999078, Macau SAR, China"},{"name":"Macao Institute of Materials Science and Engineering, Macau University of Science and Technology, Taipa 999078, Macau SAR, China"},{"name":"Suzhou Key Laboratory of Nanotechnology and Biomedicine, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, Suzhou 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"He","sequence":"additional","affiliation":[{"name":"Macao Translational Medicine Center, Macau University of Science and Technology, Taipa 999078, Macau SAR, China"},{"name":"Macao Institute of Materials Science and Engineering, Macau University of Science and Technology, Taipa 999078, Macau SAR, China"},{"name":"Suzhou Key Laboratory of Nanotechnology and Biomedicine, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, Suzhou 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/s13195-024-01607-4","article-title":"Exploring easily accessible neurophysiological biomarkers for predicting Alzheimer\u2019s disease progression: A systematic review","volume":"16","author":"Costanzo","year":"2024","journal-title":"Alzheimers Res. 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