{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:51:49Z","timestamp":1791870709562,"version":"4.3.4"},"reference-count":100,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Pusan National University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Neurodegenerative diseases, such as Parkinson\u2019s disease (PD) and Alzheimer\u2019s disease (AD), represent a growing global health challenge with overlapping biomarkers. Key biomarkers, including \u03b1-synucleins, amyloid-\u03b2, and Tau proteins, are critical for accurate detection but are often assessed using conventional methods like enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR), which are invasive, costly, and time-intensive. Electrochemical biosensors have emerged as promising tools for biomarker detection due to their high sensitivity, rapid response, and potential for miniaturization. The integration of nanomaterials has further enhanced their performance, improving sensitivity, specificity, and practical application. To this end, this review provides a comprehensive overview of recent advances in electrochemical biosensors for detecting neurodegenerative disease biomarkers, highlighting their strengths, limitations, and future opportunities. By addressing the challenges of early diagnosis, this work aims to stimulate interdisciplinary innovation and improve clinical outcomes for neurodegenerative disease patients.<\/jats:p>","DOI":"10.3390\/bios15030151","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T10:46:46Z","timestamp":1740739606000},"page":"151","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Recent Advances in Electrochemical Biosensors for Neurodegenerative Disease Biomarkers"],"prefix":"10.3390","volume":"15","author":[{"given":"Mingyu","family":"Bae","sequence":"first","affiliation":[{"name":"Department of Information Convergence Engineering, Pusan National University, Yangsan 50612, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Information Convergence Engineering, Pusan National University, Yangsan 50612, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Euni","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Information Convergence Engineering, Pusan National University, Yangsan 50612, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taek","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Kwangwoon University, Seoul 01897, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5877-0222","authenticated-orcid":false,"given":"Jin-Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Information Convergence Engineering, Pusan National University, Yangsan 50612, Republic of Korea"},{"name":"School of Biomedical Convergence Engineering, Pusan National University, Yangsan 50612, Republic of Korea"},{"name":"Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/s41591-021-01382-x","article-title":"Biomarkers for neurodegenerative diseases","volume":"27","author":"Hansson","year":"2021","journal-title":"Nat. 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