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however, its adaptation for cerebrovascular applications remains constrained by the narrow, tortuous anatomical structure of cerebral vessels. To address these limitations, this study introduces a cerebrovascular-specific OCT (bOCT) catheter, an advanced adaptation of the cardiovascular OCT (cOCT) catheter, with significant structural modifications for improved access to brain blood vessels. The bOCT catheter incorporates a braided wire within a braided tube, strategically reinforcing axial strength. The distal shaft was reconfigured as a single-lumen structure, facilitating unified movement of the rotating fiber optic core and guidewire, thereby reducing guidewire bending and augmenting force transmission stability. Additionally, the anterior protrusion was removed and replaced with a dual-lumen configuration, significantly enhancing lesion accessibility. The bOCT catheter\u2019s performance was validated in a 3D physical model and an animal model, demonstrating pronounced enhancements in flexibility, pushability, and navigability. Notably, the pushability through curved flow paths significantly improved, enhancing access to cerebral blood vessels. Therefore, this innovation promises to revolutionize cerebrovascular diagnostics with high-resolution imaging suited to the complex brain vasculature, setting a new standard in intravascular imaging technology.<\/jats:p>","DOI":"10.3390\/bios15030170","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T09:59:17Z","timestamp":1741255157000},"page":"170","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Development of a Brain Catheter for Optical Coherence Tomography in Advanced Cerebrovascular Diagnostics"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6420-9759","authenticated-orcid":false,"given":"Tae-Mi","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Keimyung University, Daegu 42601, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1624-0671","authenticated-orcid":false,"given":"Tahsin","family":"Nairuz","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Keimyung University, Daegu 42601, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Keimyung University Dongsan Hospital, Daegu 42601, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5756-1621","authenticated-orcid":false,"given":"Jong-Ha","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Keimyung University, Daegu 42601, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.3174\/ajnr.A4848","article-title":"Wall apposition is a key factor for aneurysm occlusion after flow diversion: A histologic evaluation in 41 rabbits","volume":"37","author":"Rouchaud","year":"2016","journal-title":"Am. 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