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The distribution and magnitude of the electric field generated within the brain may directly affect the results of neural modulation. Therefore, it is important to clarify the change trend of the cortical electric field and the determinants of the induced electric field in the endodermis at different ages during the adult life cycle. In this study, we used SimNIBS software to perform MR image segmentation and realistic head model reconstruction on 476 individuals (aged 18 to 88 years old) and calculated the cortical electric field of four electrode montages commonly used in cognitive tasks. We divided all participants into groups by age with a span of 10 years for each group and compared the electric field distribution patterns, electric field intensities, and focalities of the cortexes and regions of interest related to cognitive tasks within groups. The degree of influence of global and local anatomical parameters on the electric field was analyzed using a stepwise regression model. The results showed that, in the cortexes and regions of interest, the variability of electric field distribution patterns was highest in adolescents (&lt;20 years old) and elderly individuals (&gt;80 years old). Moreover, throughout the adult lifespan, the electric field induced by transcranial electrical stimulation did not decrease linearly with age but rather presented a U-shaped pattern. In terms of the entire adult life cycle, compared with global anatomical parameters (intracranial brain tissue volume), local anatomical parameters (such as scalp or skull thickness below the electrode) have a greater impact on the amplitude of the intracranial electric field. Our research results indicated that it is necessary to consider the effects caused by different brain tissues when using transcranial electrical stimulation to modulate or treat individuals of different ages.<\/jats:p>","DOI":"10.3390\/bios15030185","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T12:06:59Z","timestamp":1741867619000},"page":"185","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Amplitude of Intracranial Induced Electric Fields Does Not Linearly Decrease with Age: A Computational Study of Anatomical Effects in Adults"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7611-2418","authenticated-orcid":false,"given":"Jianxu","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Mechatronical Engineering, Beijing Institute of Technology, Beijing 100081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zilong","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Mechatronical Engineering, Beijing Institute of Technology, Beijing 100081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anshun","family":"Kang","sequence":"additional","affiliation":[{"name":"School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Ouyang","sequence":"additional","affiliation":[{"name":"School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Mechatronical Engineering, Beijing Institute of Technology, Beijing 100081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyue","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinglong","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingjie","family":"Suo","sequence":"additional","affiliation":[{"name":"School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Funahashi","sequence":"additional","affiliation":[{"name":"Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology, Beijing 100081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3745-4036","authenticated-orcid":false,"given":"Wei","family":"Meng","sequence":"additional","affiliation":[{"name":"Radiology Department, Harbin Medical University, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin 150081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9819-9051","authenticated-orcid":false,"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1327-7896","authenticated-orcid":false,"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Gu, X., and Ren, H. 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