{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:32:31Z","timestamp":1791685951392,"version":"4.3.4"},"reference-count":36,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"TaiShan Scholars Talent Project","award":["tsqn202312255"],"award-info":[{"award-number":["tsqn202312255"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Micron-sized, ultrathin metal\u2013organic framework (MOF) sheet is a two-dimensional (2D) hybrid material with a large specific surface area, which can be used not only in the fields of energy and biomedicine, but also in electrode modification to improve the electrochemical detection effect. In this work, the 2D-structured Co-TCPP(Fe) MOF sheets were synthesized from porphyrin molecules and cobalt ions and then combined with reduced graphene oxide (rGO) and perfluorosulfonic acid polymer (Nafion) solution to construct Co-TCPP(Fe)\/rGO\/Nafion-modified electrodes capable of sensitively capturing dopamine (DA). The 2D ultrathin lamellar structure of this electrode-modified material is beneficial to the formation of \u03c0-\u03c0 stacking effect with DA molecules, and the oxygen-containing groups carried on its surface can also form electrostatic attraction with the amino groups of DA molecules. Therefore, the Co-TCPP(Fe)\/rGO\/Nafion-modified electrode under the synergistic effect shows a specific adsorption effect on DA molecules, resulting in high anti-interference ability and a low detection limit of 0.014 \u00b5M in the concentration range of 0.1\u2013100 \u00b5M. Furthermore, the Co-TCPP(Fe)\/rGO\/Nafion composite material composed of micron-sized, ultrathin lamellar structures also shows high reusability due to the stability of its coordination structure and can demonstrate good results when applied to the actual sample detection of human urine.<\/jats:p>","DOI":"10.3390\/bios15060348","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T08:34:13Z","timestamp":1748853253000},"page":"348","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Electrochemical Sensor Capable of Enhancing Dopamine Sensitivity Based on Micron-Sized Metal\u2013Organic Frameworks"],"prefix":"10.3390","volume":"15","author":[{"given":"Ruhui","family":"Yan","sequence":"first","affiliation":[{"name":"School of Science, Shenyang University of Chemical Technology, Shenyang 110042, China"},{"name":"Shandong Provincial Engineering Laboratory of Novel Pharmaceutical Excipients, College of Pharmacy, Sustained and Controlled Release Preparations, Dezhou University, Dezhou 253023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuewu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shandong Provincial Engineering Laboratory of Novel Pharmaceutical Excipients, College of Pharmacy, Sustained and Controlled Release Preparations, Dezhou University, Dezhou 253023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaixiao","family":"Geng","sequence":"additional","affiliation":[{"name":"School of Science, Shenyang University of Chemical Technology, Shenyang 110042, China"},{"name":"Shandong Provincial Engineering Laboratory of Novel Pharmaceutical Excipients, College of Pharmacy, Sustained and Controlled Release Preparations, Dezhou University, Dezhou 253023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxia","family":"Yan","sequence":"additional","affiliation":[{"name":"Shandong Provincial Engineering Laboratory of Novel Pharmaceutical Excipients, College of Pharmacy, Sustained and Controlled Release Preparations, Dezhou University, Dezhou 253023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jine","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong Provincial Engineering Laboratory of Novel Pharmaceutical Excipients, College of Pharmacy, Sustained and Controlled Release Preparations, Dezhou University, Dezhou 253023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Han","sequence":"additional","affiliation":[{"name":"School of Science, Shenyang University of Chemical Technology, Shenyang 110042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1000120","DOI":"10.4172\/2471-271X.1000120","article-title":"Dopamine: Receptors, functions, synthesis, pathways, locations and mental disorders: Review of literatures","volume":"2","author":"Ayano","year":"2016","journal-title":"J. Ment. Disord. Treat."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0893-133X(87)90004-2","article-title":"Human brain D1 and D2 dopamine receptors in schizophrenia, Alzheimer\u2019s, Parkinson\u2019s, and Huntington\u2019s diseases","volume":"1","author":"Seeman","year":"1987","journal-title":"Neuropsychopharmacology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1159\/000495238","article-title":"Association of dopamine beta-hydroxylase polymorphisms with Alzheimer\u2019s disease, Parkinson\u2019s disease and schizophrenia: Evidence based on currently available loci","volume":"51","author":"Tang","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"ref_4","unstructured":"GBD 2021 Nervous System Disorders Collaborators (2024). Global, regional, and national burden of disorders affecting the nervous system, 1990\u20132021: A systematic analysis for the Global Burden of Disease Study 2021. Lancet Neurol., 23, 344\u2013381."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S2666-7568(24)00094-1","article-title":"Temporal trends in the prevalence of Parkinson\u2019s disease from 1980 to 2023: A systematic review and meta-analysis","volume":"5","author":"Zhu","year":"2024","journal-title":"Lancet Healthy Longev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"10571","DOI":"10.1038\/s41467-024-54604-4","article-title":"Synaptotagmin-11 deficiency mediates schizophrenia-like behaviors in mice via dopamine over-transmission","volume":"15","author":"Chen","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.cca.2021.08.009","article-title":"Dopamine in Parkinson\u2019s disease","volume":"522","author":"Latif","year":"2021","journal-title":"Clin. Chim. Acta"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bios.2012.01.007","article-title":"Electrochemical detection of dopamine using porphyrin-functionalized graphene","volume":"34","author":"Wu","year":"2012","journal-title":"Biosens. Bioelectron."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1039\/C5DT04025F","article-title":"A lead-porphyrin metal-organic framework: Gas adsorption properties and electrocatalytic activity for water oxidation","volume":"45","author":"Dai","year":"2016","journal-title":"Dalton Trans."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"215764","DOI":"10.1016\/j.ccr.2024.215764","article-title":"Polyoxometalate-based porphyrinic metal-organic frameworks as heterogeneous catalysts","volume":"508","author":"Ebrahimi","year":"2024","journal-title":"Coordin. Chem. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"145389","DOI":"10.1016\/j.electacta.2024.145389","article-title":"Electrochemical CO2 reduction by heterogeneous catalysts of 2D metal-organic frameworks comprising metal-coordinated porphyrins","volume":"511","author":"Chiu","year":"2025","journal-title":"Electrochim. Acta"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2306364","DOI":"10.1002\/smll.202306364","article-title":"Mn (II) Optimized Sono\/Chemodynamic Effect of Porphyrin-Metal\u2013Organic Framework Nanosheets for MRI-Guided Colon Cancer Therapy and Metastasis Suppression","volume":"20","author":"Hang","year":"2024","journal-title":"Small"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"10706","DOI":"10.1039\/D3TB01592K","article-title":"A metal\u2013organic framework complex for enhancing tumor treatments through synergistic effect of chemotherapy and photodynamic therapy","volume":"11","author":"Jiang","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Bai, Y., Wang, J., Yan, R., Zhao, Y., Han, S., Zhang, Z., and Zhao, Y. (2025). Progress of metal-organic frameworks in improving the effect of sonodynamic therapy. Biomed. Technol., 9.","DOI":"10.1016\/j.bmt.2025.100070"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"20551","DOI":"10.1002\/anie.202107860","article-title":"Porphyrinic MOF film for multifaceted electrochemical sensing","volume":"60","author":"Zhou","year":"2021","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"119058","DOI":"10.1016\/j.jelechem.2025.119058","article-title":"Synthesis of porphyrin-based metal-organic framework and biomass-derived carbon composite for electrochemical detection of Rutin","volume":"984","author":"Liu","year":"2025","journal-title":"J. Electroanal. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"131492","DOI":"10.1016\/j.snb.2022.131492","article-title":"Copper porphyrin metal-organic framework modified carbon paper for electrochemical sensing of glyphosate","volume":"358","author":"Jiang","year":"2022","journal-title":"Sens. Actuators B-Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1021\/acs.jpcc.4c07265","article-title":"Localized nanoscale formation of vanadyl porphyrin 2D MOF nanosheets and their optimal coupling to lumped element superconducting resonators","volume":"129","author":"Gimeno","year":"2025","journal-title":"J. Phys. Chem. C"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"9713","DOI":"10.1039\/c3cp55431g","article-title":"Porphyrin-based sensor nanoarchitectonics in diverse physical detection modes","volume":"21","author":"Ishihara","year":"2014","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"142139","DOI":"10.1016\/j.cej.2023.142139","article-title":"A general way to manipulate electrical conductivity of graphene","volume":"462","author":"Chen","year":"2023","journal-title":"Chem. Eng. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"118800","DOI":"10.1016\/j.carbon.2024.118800","article-title":"Recent progress in utilizing carbon nanotubes and graphene to relieve volume expansion and increase electrical conductivity of Si-based composite anodes for lithium-ion batteries","volume":"219","author":"Kang","year":"2024","journal-title":"Carbon"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1021\/ja01539a017","article-title":"Functionalized graphene and graphene oxide: Materials synthesis","volume":"80","author":"Hummers","year":"1958","journal-title":"J. Am. Chem. Soc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"23697","DOI":"10.1021\/acsami.0c04363","article-title":"Metal\u2013organic frameworks with enhanced photodynamic therapy: Synthesis, erythrocyte membrane camouflage, and aptamer-targeted aggregation","volume":"12","author":"Zhao","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"7511","DOI":"10.1021\/acs.chemmater.8b02467","article-title":"Synthesis of metal\u2013organic framework nanosheets with high relaxation rate and singlet oxygen yield","volume":"30","author":"Zhao","year":"2018","journal-title":"Chem. Mater."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s00604-021-05122-3","article-title":"Electrochemical dopamine sensor based on bi-metallic Co\/Zn porphyrin metal\u2013organic framework","volume":"189","author":"Ma","year":"2022","journal-title":"Microchim. Acta"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"11693","DOI":"10.1039\/D2NR02828J","article-title":"Dimensionality reduction boosts the peroxidase-like activity of bimetallic MOFs for enhanced multidrug-resistant bacteria eradication","volume":"14","author":"Sun","year":"2022","journal-title":"Nanoscale"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1021\/acsanm.2c05402","article-title":"Defective Metal-Organic Framework Nanocrystals as Signal Amplifiers for Electrochemical Dopamine Sensing","volume":"65","author":"Chang","year":"2023","journal-title":"ACS Appl. Nano Mater."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1039\/D4NR04714A","article-title":"Advances in precise synthesis of metal nanoclusters and their applications in electrochemical biosensing of disease biomarkers","volume":"17","author":"Han","year":"2025","journal-title":"Nanoscale"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"107206","DOI":"10.1016\/j.elecom.2022.107206","article-title":"Cerium-based metal-organic framework as an electrocatalyst for the reductive detection of dopamine","volume":"135","author":"Chiang","year":"2022","journal-title":"Electrochem. Commun."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"128225","DOI":"10.1016\/j.matchemphys.2023.128225","article-title":"Synthesis of manganese porphyrins\/electrochemical reduction of graphene oxide nanocomposite to simultaneously detect dopamine and uric acid under the interference of ascorbic acid","volume":"307","author":"Zhang","year":"2023","journal-title":"Mater. Chem. Phys."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"116945","DOI":"10.1016\/j.jelechem.2022.116945","article-title":"Synthesis and characterization of graphene oxide- Cu NPs-Fe-MOF nanocomposite and its application to simultaneous determination of Eskazina and Dopamine in real samples","volume":"926","author":"Khoshraftar","year":"2022","journal-title":"J. Electroanal. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s12678-022-00806-7","article-title":"Simultaneous detection of dopamine and paracetamol on electroreduced graphene oxide-cobalt phthalocyanine polymer nanocomposite electrode","volume":"14","author":"Luhana","year":"2023","journal-title":"Electrocatalysis"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Roostaee, M., Beitollahi, H., and Sheikhshoaie, I. (2022). Simultaneous determination of dopamine and uric acid in real samples using a voltammetric nanosensor based on Co-MOF, Graphene Oxide, and 1-Methyl-3-butylimidazolium Bromide. Micromachines, 13.","DOI":"10.3390\/mi13111834"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e202200229","DOI":"10.1002\/cnma.202200229","article-title":"A porphyrin-functionalized graphene oxide nanocomposite for simultaneous detection of dopamine and uric Acid","volume":"8","author":"Wei","year":"2022","journal-title":"Chemnanomat"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1126\/science.1067020","article-title":"The molecular biology of memory storage: A dialogue between genes and synapses","volume":"294","author":"Kandel","year":"2001","journal-title":"Science"},{"key":"ref_36","first-page":"201","article-title":"A multifunctional luminescence Metal-Organic Framework sensor for the neuropathy biomarker glutamic Acid","volume":"52","author":"Zhang","year":"2021","journal-title":"Chem. Lett."}],"container-title":["Biosensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6374\/15\/6\/348\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:44:28Z","timestamp":1760031868000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6374\/15\/6\/348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,30]]},"references-count":36,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["bios15060348"],"URL":"https:\/\/doi.org\/10.3390\/bios15060348","relation":{},"ISSN":["2079-6374"],"issn-type":[{"value":"2079-6374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,30]]}}}