{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:29:19Z","timestamp":1791203359250,"version":"4.2.0"},"reference-count":91,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hong Kong Research Grants Council\u2014Early Career Scheme","award":["25100523"],"award-info":[{"award-number":["25100523"]}]},{"name":"Hong Kong Research Grants Council\u2014Early Career Scheme","award":["P0050739"],"award-info":[{"award-number":["P0050739"]}]},{"name":"Research Institute for Smart Ageing, The Hong Kong Polytechnic University","award":["25100523"],"award-info":[{"award-number":["25100523"]}]},{"name":"Research Institute for Smart Ageing, The Hong Kong Polytechnic University","award":["P0050739"],"award-info":[{"award-number":["P0050739"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>This study investigated the effect of wearable ultrasound-imaging-based visual feedback (UVF) on assisting paretic ankle dorsiflexion training of chronic stroke survivors. Thirty-three participants with unilateral hemiplegia performed maximal isometric contractions on an isokinetic dynamometer in randomized conditions with and without UVF that provided by a wearable ultrasound imaging system. Torque parameters (mean, peak, percentage of maximal voluntary contraction) and tibialis anterior muscle thickness were analyzed across different contraction phases. Statistical comparisons were conducted using paired t-tests or Wilcoxon tests. Correlation analyses were performed using Pearson\u2019s or Spearman\u2019s tests. Results demonstrated that UVF significantly improved torque output, as evidence by the increased percentage of maximal voluntary contraction (%MVC) during entire contractions (p = 0.007), increased mean (p \u2264 0.022) and peak (p \u2264 0.044) torque and the %MVC (p \u2264 0.004) during mid and end phases, and larger muscle thickness during mid contraction (p = 0.045). Moderate correlations were found between torque and muscle thickness (r \u2265 0.30, p \u2264 0.049). These findings preliminarily supported the positive outcomes of real-time wearable UVFs in enhancing paretic ankle dorsiflexion strength and force control during isometric contractions in chronic stroke survivors. While the developed and validated new training protocol may potentially serve as a practical adjunct to existing rehabilitation approaches, further investigations emphasizing the functional outcomes and clinical translations are still needed to verify the clinical utility.<\/jats:p>","DOI":"10.3390\/bios15060365","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T09:43:14Z","timestamp":1749202994000},"page":"365","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Wearable Ultrasound-Imaging-Based Visual Feedback (UVF) Training for Ankle Rehabilitation of Chronic Stroke Survivors: A Proof-of-Concept Randomized Crossover Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5544-7101","authenticated-orcid":false,"given":"Yu-Yan","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2035-2420","authenticated-orcid":false,"given":"Zhen","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaheh","family":"Nazari","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5911-5756","authenticated-orcid":false,"given":"Arnold Yu-Lok","family":"Wong","sequence":"additional","affiliation":[{"name":"Research Institute for Smart Ageing, The Hong Kong Polytechnic University, Hong Kong SAR, China"},{"name":"Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5964-3233","authenticated-orcid":false,"given":"Lin","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5303-3899","authenticated-orcid":false,"given":"Mingjie","family":"Dong","sequence":"additional","affiliation":[{"name":"Faculty of Materials and Manufacturing, Beijing University of Technology, Beijing 100124, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3407-9226","authenticated-orcid":false,"given":"Yong-Ping","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China"},{"name":"Research Institute for Smart Ageing, The Hong Kong Polytechnic University, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy Siu-Ngor","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6507-2329","authenticated-orcid":false,"given":"Christina Zong-Hao","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China"},{"name":"Research Institute for Smart Ageing, The Hong Kong Polytechnic University, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1161\/CIRCRESAHA.116.308413","article-title":"Global Burden of Stroke","volume":"120","author":"Feigin","year":"2017","journal-title":"Circ. Res."},{"key":"ref_2","first-page":"100550","article-title":"Prevalence of Stroke in China, 2013-2019: A Population-Based Study","volume":"28","author":"Tu","year":"2022","journal-title":"Lancet Reg. Health\u2014West. Pac."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1161\/CIRCULATIONAHA.116.025250","article-title":"Prevalence, Incidence, and Mortality of Stroke in China","volume":"135","author":"Wang","year":"2017","journal-title":"Circulation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jamda.2014.12.007","article-title":"Stroke-Related Sarcopenia: Specific Characteristics","volume":"16","author":"Scherbakov","year":"2015","journal-title":"J. Am. Med. Dir. assoc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"105092","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105092","article-title":"Prevalence of Stroke-Related Sarcopenia: A Systematic Review and Meta-Analysis","volume":"29","author":"Su","year":"2020","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1939.19.1.1","article-title":"The Reaction of Muscle to Denervation","volume":"19","author":"Tower","year":"1939","journal-title":"Physiol. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/mus.20085","article-title":"Muscle Molecular Phenotype After Stroke is Associated with Gait Speed","volume":"30","author":"Ivey","year":"2004","journal-title":"Muscle Nerve"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s13539-011-0024-8","article-title":"Sarcopenia in Stroke\u2014Facts and Numbers on Muscle Loss Accounting for Disability After Stroke","volume":"2","author":"Scherbakov","year":"2011","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1212\/WNL.30.12.1303","article-title":"The Control of Muscle Tone, Reflexes, and Movement: Robert Wartenberg Lecture","volume":"30","author":"Lance","year":"1980","journal-title":"Neurology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1212\/WNL.0b013e3182764c86","article-title":"Poststroke Spasticity","volume":"80","author":"Zorowitz","year":"2013","journal-title":"Neurology"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Zeng, H., Chen, J., Guo, Y., and Tan, S. (2021). Prevalence and Risk Factors for Spasticity After Stroke: A Systematic Review and Meta-Analysis. Front. Neurol., 11.","DOI":"10.3389\/fneur.2020.616097"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1161\/01.STR.0000105386.05173.5E","article-title":"Spasticity After Stroke: Its Occurrence and association with Motor Impairments and Activity Limitations","volume":"35","author":"Sommerfeld","year":"2004","journal-title":"Stroke"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1519\/JPT.0000000000000044","article-title":"The association Between Knee Extensor Force Steadiness, Force Accuracy, and Mobility in Older Adults Who Have Fallen","volume":"39","author":"Tracy","year":"2016","journal-title":"J. Geriatr. Phys. Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"313","DOI":"10.5014\/ajot.43.5.313","article-title":"Weakness in Patients with Hemiparesis","volume":"43","author":"Bourbonnais","year":"1989","journal-title":"Am. J. Occup. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1177\/1545968317721974","article-title":"Lower Extremity Motor Impairments in Ambulatory Chronic Hemiparetic Stroke: Evidence for Lower Extremity Weakness and Abnormal Muscle and Joint Torque Coupling Patterns","volume":"31","author":"Acosta","year":"2017","journal-title":"Neurorehabilit. Neural Repair"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1152\/japplphysiol.00968.2017","article-title":"Effects of Stroke Injury on the Shear Modulus of the Lower Leg Muscle During Passive Dorsiflexion","volume":"126","author":"Nordez","year":"2019","journal-title":"J. Appl. Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/j.clinph.2008.02.016","article-title":"Rhythmic Arm Cycling Suppresses Hyperactive Soleus H-Reflex Amplitude After Stroke","volume":"119","author":"Barzi","year":"2008","journal-title":"Clin. Neurophysiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.apmr.2011.12.016","article-title":"Contribution of Ankle Dorsiflexor Strength to Walking Endurance in People with Spastic Hemiplegia After Stroke","volume":"93","author":"Ng","year":"2012","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1600-0838.2009.01084.x","article-title":"Role of the Nervous System in Sarcopenia and Muscle Atrophy with Aging: Strength Training as a Countermeasure","volume":"20","author":"Aagaard","year":"2010","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1177\/0269215518815220","article-title":"Effects of Isokinetic Muscle Strengthening on Muscle Strength, Mobility, and Gait in Post-Stroke Patients: A Systematic Review and Meta-Analysis","volume":"33","author":"Pontes","year":"2019","journal-title":"Clin. Rehabil."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1161\/STROKEAHA.110.602441","article-title":"Skeletal Muscle Hypertrophy and Muscle Myostatin Reduction After Resistive Training in Stroke Survivors","volume":"42","author":"Ryan","year":"2011","journal-title":"Stroke"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1191\/0269215504cr843oa","article-title":"The Impact of Physical Therapy on Functional Outcomes After Stroke: What\u2019s the Evidence?","volume":"18","author":"Kwakkel","year":"2004","journal-title":"Clin. Rehabil."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1310\/tsr1503-177","article-title":"Strengthening to Promote Functional Recovery Poststroke: An Evidence-Based Review","volume":"15","author":"Pak","year":"2008","journal-title":"Top. Stroke Rehabil."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1177\/0269215520932964","article-title":"Resistance Training in Stroke Rehabilitation: Systematic Review and Meta-Analysis","volume":"34","author":"Veldema","year":"2020","journal-title":"Clin. Rehabil."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neulet.2014.12.028","article-title":"Bimanual Force Variability in Chronic Stroke: With and Without Visual Information","volume":"587","author":"Kang","year":"2015","journal-title":"Neurosci. Lett."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1080\/09638280500534937","article-title":"Extrinsic Feedback for Motor Learning After Stroke: What Is the Evidence?","volume":"28","author":"Wulf","year":"2006","journal-title":"Disabil. Rehabil."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1093\/ptj\/61.6.886","article-title":"Evaluation of Electromyographic Biofeedback as An Adjunct to Therapeutic Exercise in Treating the Lower Extremities of Hemiplegic Patients","volume":"61","author":"Binder","year":"1981","journal-title":"Phys. Ther."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Kim, H.J., Lee, J.H., Kang, N., and Cauraugh, J.H. (2021). Visual Feedback Improves Bimanual Force Control Performances at Planning and Execution Levels. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-00721-9"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.apmr.2010.08.016","article-title":"Use of Visual Force Feedback to Improve Digit Force Direction During Pinch Grip in Persons with Stroke: A Pilot Study","volume":"92","author":"Seo","year":"2011","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.gaitpost.2010.07.017","article-title":"Comparison of Visual and Haptic Feedback During Training of Lower Extremities","volume":"32","author":"Koritnik","year":"2010","journal-title":"Gait Posture"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Liu, W., Wu, H.-D., Li, Y.-Y., Zhu, R.T.-L., Luo, Y.-Y., Ling, Y.T., Wang, L.-K., Wang, J.-F., Zheng, Y.-P., and Ma, C.Z.-H. (2024). Effect of Ankle-Foot Orthosis on Paretic Gastrocnemius and Tibialis Anterior Muscle Contraction of Stroke Survivors During Walking: A Pilot Study. Biosensors, 14.","DOI":"10.21203\/rs.3.rs-4217969\/v1"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Lyu, P.-Z., Zhu, R.T.-L., Ling, Y.T., Wang, L.-K., Zheng, Y.-P., and Ma, C.Z.-H. (2022). How Paretic and Non-Paretic Ankle Muscles Contract During Walking in Stroke Survivors: New Insight Using Novel Wearable Ultrasound Imaging and Sensing Technology. Biosensors, 12.","DOI":"10.3390\/bios12050349"},{"key":"ref_33","first-page":"38","article-title":"A Randomised Controlled Trial of Transabdominal Ultrasound Biofeedback for Pelvic Floor Muscle Training in Older Women with Urinary Incontinence","volume":"19","author":"Galea","year":"2013","journal-title":"Aust. N. Z. Cont. J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"293","DOI":"10.12965\/jer.2040380.190","article-title":"Effects of Spinal Stabilization Exercise with Real-Time Ultrasound Imaging Biofeedback in Individuals with Chronic Nonspecific Low Back Pain: A Pilot Study","volume":"16","author":"Sarafadeen","year":"2020","journal-title":"J. Exerc. Rehabil."},{"key":"ref_35","first-page":"612","article-title":"Training of Transversus Abdominis Activation in the Supine Position with Ultrasound Biofeedback Translated to Increased Transversus Abdominis Activation During Upright Loaded Functional Tasks","volume":"6","author":"McPherson","year":"2014","journal-title":"PmR"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"627","DOI":"10.2519\/jospt.2007.2555","article-title":"Ultrasound Imaging as A Feedback Tool in the Rehabilitation of Trunk Muscle Dysfunction for People with Low Back Pain","volume":"37","author":"Henry","year":"2007","journal-title":"J. Orthop. Sports Phys. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Valera-Calero, J.A., Fern\u00e1ndez-de-Las-Pe\u00f1as, C., Varol, U., Ortega-Santiago, R., Gallego-Sendarrubias, G.M., and Arias-Bur\u00eda, J.L. (2021). Ultrasound Imaging as A Visual Biofeedback Tool in Rehabilitation: An Updated Systematic Review. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18147554"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Sosnowska, A., Vuckovic, A., and Gollee, H. (2019). Training Towards Precise Control Over Muscle Activity with Real Time Biofeedback Based on Ultrasound Imaging, Springer Nature.","DOI":"10.1007\/978-981-10-9035-6_9"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1519\/JSC.0000000000004230","article-title":"Real-Time Visual Biofeedback Via Wearable Ultrasound Imaging Can Enhance the Muscle Contraction Training Outcome of Young Adults","volume":"36","author":"Huang","year":"2022","journal-title":"J. Strength Cond. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/NPT.0b013e31819824f0","article-title":"Reorganization of Brain Function During Force Production After Stroke: A Systematic Review of the Literature","volume":"33","author":"Kokotilo","year":"2009","journal-title":"J. Neurol. Phys. Ther."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"l4378","DOI":"10.1136\/bmj.l4378","article-title":"Consort 2010 Statement: Extension to Randomised Crossover Trials","volume":"366","author":"Dwan","year":"2019","journal-title":"BMJ"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jcm.2016.02.012","article-title":"A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research","volume":"15","author":"Koo","year":"2016","journal-title":"J. Chiropr. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s41999-020-00433-9","article-title":"Application of Ultrasound for Muscle assessment in Sarcopenia: 2020 Sarcus Update","volume":"12","author":"Perkisas","year":"2021","journal-title":"Eur. Geriatr. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1152\/japplphysiol.00835.2019","article-title":"Ultrasound Imaging to assess Skeletal Muscle Architecture During Movements: A Systematic Review of Methods, Reliability, and Challenges","volume":"128","author":"Teratsias","year":"2020","journal-title":"J. Appl. Physiol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Wu, W.-T., Chang, K.-V., Hsu, Y.-C., Hsu, P.-C., Ricci, V., and \u00d6z\u00e7akar, L. (2020). Artifacts in Musculoskeletal Ultrasonography: From Physics to Clinics. Diagnostics, 10.","DOI":"10.3390\/diagnostics10090645"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/S0003-9993(96)90184-7","article-title":"The Reliability of the Functional Independence Measure: A Quantitative Review","volume":"77","author":"Ottenbacher","year":"1996","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1016\/j.apmr.2019.01.027","article-title":"Cutoff Score of the Lower-Extremity Motor Subscale of Fugl-Meyer assessment in Chronic Stroke Survivors: A Cross-Sectional Study","volume":"100","author":"Kwong","year":"2019","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1097\/PHM.0000000000001705","article-title":"A Comparison Between the Effect of Combined Chain Exercises Plus Kinesio Taping with Combined Chain Exercises Alone in Knee Osteoarthritis: A Randomized Clinical Trial","volume":"100","author":"Danazumi","year":"2021","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/sms.13920","article-title":"Reliability of Isokinetic Tests of Velocity-and Contraction Intensity-Dependent Plantar Flexor Mechanical Properties","volume":"31","author":"Pinto","year":"2021","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/mus.20663","article-title":"Hip Joint Position Modulates Volitional Knee Extensor Muscle Activity After Stroke","volume":"34","author":"Lewek","year":"2006","journal-title":"Muscle Nerve"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Moraux, A., Canal, A., Ollivier, G., Ledoux, I., Doppler, V., Payan, C., and Hogrel, J.-Y. (2013). Ankle Dorsi- and Plantar-Flexion Torques Measured By Dynamometry in Healthy Subjects From 5 to 80 Years. BMC Musculoskelet. Disord., 14.","DOI":"10.1186\/1471-2474-14-104"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Olsen, S., Signal, N., Niazi, I.K., Rashid, U., Alder, G., Mawston, G., Nedergaard, R.B., Jochumsen, M., and Taylor, D. (2020). Peripheral Electrical Stimulation Paired with Movement-Related Cortical Potentials Improves Isometric Muscle Strength and Voluntary Activation Following Stroke. Front. Hum. Neurosci., 14.","DOI":"10.3389\/fnhum.2020.00156"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1109\/TUFFC.2024.3445434","article-title":"Synthesizing Real-Time Ultrasound Images of Muscle Based on Biomechanical Simulation and Conditional Diffusion Network","volume":"71","author":"Song","year":"2024","journal-title":"IEEE Trans. Ultrason. Ferroelectr. Freq. Control"},{"key":"ref_54","first-page":"2055668319831631","article-title":"Investigating the Feasibility and Acceptability of Real-Time Visual Feedback in Reducing Compensatory Motions During Self-Administered Stroke Rehabilitation Exercises: A Pilot Study with Chronic Stroke Survivors","volume":"6","author":"Lin","year":"2019","journal-title":"J. Rehabil. Assist. Technol. Eng."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jelekin.2015.10.006","article-title":"Measuring Voluntary Quadriceps Activation: Effect of Visual Feedback and Stimulus Delivery","volume":"26","author":"Luc","year":"2016","journal-title":"J. Electromyogr. Kinesiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1016\/j.clinph.2014.03.019","article-title":"Activation Deficit Correlates with Weakness in Chronic Stroke: Evidence From Evoked and Voluntary Emg Recordings","volume":"125","author":"Li","year":"2014","journal-title":"Clin. Neurophysiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.nicl.2017.11.012","article-title":"Visual Feedback Alters Force Control and Functional Activity in the Visuomotor Network After Stroke","volume":"17","author":"Archer","year":"2018","journal-title":"Neuroimage Clin."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1093\/cercor\/bhl084","article-title":"Activation of Area Mt\/V5 and the Right Inferior Parietal Cortex During the Discrimination of Transient Direction Changes in Translational Motion","volume":"17","author":"Cheyne","year":"2007","journal-title":"Cereb. Cortex"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/cercor\/6.3.319","article-title":"The Sources of Visual Information to the Primate Frontal Lobe: A Novel Role for the Superior Parietal Lobule","volume":"6","author":"Caminiti","year":"1996","journal-title":"Cereb. Cortex"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev.neuro.20.1.25","article-title":"Premotor and Parietal Cortex: Corticocortical Connectivity and Combinatorial Computations","volume":"20","author":"Wise","year":"1997","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_61","unstructured":"Hyde, M., Scott, J., and Harrison, R. (2011). Clinical Neuroanatomy and Neuroscience, Elsevier\u2014Health Sciences Division. [6th ed.]."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1152\/jn.00675.2003","article-title":"Differential Cortical and Subcortical Activations in Learning Rotations and Gains for Reaching: A Pet Study","volume":"91","author":"Krakauer","year":"2004","journal-title":"J. Neurophysiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.neuroimage.2004.08.031","article-title":"Human Medial Intraparietal Cortex Subserves Visuomotor Coordinate Transformation","volume":"23","author":"Grefkes","year":"2004","journal-title":"Neuroimage"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"pzaa208","DOI":"10.1093\/ptj\/pzaa208","article-title":"The Addition of Real-Time Ultrasound Visual Feedback to Manual Facilitation Increases Serratus Anterior Activation in Adults with Painful Shoulders: A Randomized Crossover Trial","volume":"101","author":"McKenna","year":"2021","journal-title":"Phys. Ther."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Warneke, K., Brinkmann, A., Hillebrecht, M., and Schiemann, S. (2022). Influence of Long-Lasting Static Stretching on Maximal Strength, Muscle Thickness and Flexibility. Front. Physiol., 13.","DOI":"10.3389\/fphys.2022.878955"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Wang, R., Zhang, L., Jalo, H., Tarassova, O., Pennati, G.V., and Arndt, A. (2024). Individualized Muscle Architecture and Contractile Properties of Ankle Plantarflexors and Dorsiflexors in Post-Stroke Individuals. Front. Bioeng. Biotechnol., 12.","DOI":"10.3389\/fbioe.2024.1453604"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/mus.10375","article-title":"Measurement of Muscle Contraction with Ultrasound Imaging","volume":"27","author":"Hodges","year":"2003","journal-title":"Muscle Nerve"},{"key":"ref_68","first-page":"115","article-title":"The Functional Significance of Muscle Architecture\u2014A Theoretical Analysis","volume":"38","author":"Gans","year":"1965","journal-title":"Ergeb. Der Anat. Und Entwicklungsgeschichte"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1249\/00003677-198800160-00006","article-title":"Concepts and Models of Functional Architecture in Skeletal Muscle","volume":"16","author":"Otten","year":"1988","journal-title":"Exerc. Sport Sci. Rev."},{"key":"ref_70","first-page":"359","article-title":"Muscle and Tendon: Properties, Models, Scaling, and Application to Biomechanics and Motor Control","volume":"17","author":"Zajac","year":"1989","journal-title":"Crit. Rev. Biomed. Eng."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s12541-013-0112-0","article-title":"Pennation Angles of Ankle Dorsiflexor and Plantarflexors Depending on Muscle Contraction Intensity","volume":"14","author":"Kim","year":"2013","journal-title":"Int. J. Precis. Eng. Manuf."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s004210050510","article-title":"Predictability of in Vivo Changes in Pennation Angle of Human Tibialis Anterior Muscle From Rest to Maximum Isometric Dorsiflexion","volume":"79","author":"Maganaris","year":"1999","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1123\/jab.22.4.255","article-title":"Optimal Pennation Angle of the Primary Ankle Plantar and Dorsiflexors: Variations with Sex, Contraction Intensity, and Limb","volume":"22","author":"Manal","year":"2006","journal-title":"J. Appl. Biomech."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s10237-019-01196-4","article-title":"Mechanical and Microstructural Changes of Skeletal Muscle Following Immobilization and\/or Stroke","volume":"19","author":"Jalal","year":"2020","journal-title":"Biomech. Model. Mechanobiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.clinbiomech.2017.08.009","article-title":"Passive Material Properties of Stroke-Impaired Plantarflexor and Dorsiflexor Muscles","volume":"49","author":"Jakubowski","year":"2017","journal-title":"Clin. Biomech."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1152\/japplphysiol.00587.2014","article-title":"Muscle-Specific Changes in Length-Force Characteristics of the Calf Muscles in the Spastic Han-Wistar Rat","volume":"117","author":"Olesen","year":"2014","journal-title":"J. Appl. Physiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1589\/jpts.28.2596","article-title":"Effects of Ankle Biofeedback Training on Strength, Balance, and Gait in Patients with Stroke","volume":"28","author":"Kim","year":"2016","journal-title":"J. Phys. Ther. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Patel, P., Casamento-Moran, A., Christou, E.A., and Lodha, N. (2021). Force-Control Vs. Strength Training: The Effect on Gait Variability in Stroke Survivors. Front. Neurol., 12.","DOI":"10.3389\/fneur.2021.667340"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00002060-200007000-00009","article-title":"High Intensity Strength Training Improves Strength and Functional Performance After Stroke","volume":"79","author":"Weiss","year":"2000","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.gaitpost.2006.04.007","article-title":"Abnormalities in the Temporal Patterning of Lower Extremity Muscle Activity in Hemiparetic Gait","volume":"25","author":"Geurts","year":"2007","journal-title":"Gait Posture"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12984-019-0487-y","article-title":"Altered Muscle Activation Patterns (Amap): An Analytical Tool to Compare Muscle Activity Patterns of Hemiparetic Gait with A Normative Profile","volume":"16","author":"Srivastava","year":"2019","journal-title":"J. Neuroeng. Rehabil."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1743-0003-8-48","article-title":"Gait Training with Partial Body Weight Support During Overground Walking for Individuals with Chronic Stroke: A Pilot Study","volume":"8","author":"Sousa","year":"2011","journal-title":"J. Neuroeng. Rehabil."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1177\/1545968309349940","article-title":"Segmental Muscle Vibration Improves Walking in Chronic Stroke Patients with Foot Drop: A Randomized Controlled Trial","volume":"24","author":"Paoloni","year":"2010","journal-title":"Neurorehabilit. Neural Repair"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1682\/JRRD.2007.09.0145","article-title":"Falls in Individuals with Stroke","volume":"45","author":"Weerdesteijn","year":"2008","journal-title":"J. Rehabil. Res. Dev."},{"key":"ref_85","unstructured":"Brooks, J. (1996). Sus-A \u201cQuick and Dirty\u201d Usability Scale. Usability Evaluation in Industry, Digital Equipment Corporation. [1st ed.]."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Held, J.P., Klaassen, B., van Beijnum, B.-J.F., Luft, A.R., and Veltink, P.H. (2017). Usability Evaluation of a Vibrotactile Feedback System in Stroke Subjects. Front. Bioeng. Biotechnol., 4.","DOI":"10.3389\/fbioe.2016.00098"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Lewis, J.R. (1992, January 12\u201316). Psychometric Evaluation of the Post-Study System Usability Questionnaire: The Pssuq. Proceedings of the Human Factors and Ergonomics Society 36th Annual Meeting, Atlanta, GA, USA.","DOI":"10.1177\/154193129203601617"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"7802180210","DOI":"10.5014\/ajot.2024.050501","article-title":"Pre-Implementation Analysis of the Usability and Acceptability of A Poststroke Complex Telehealth Biofeedback Intervention","volume":"78","author":"Donnelly","year":"2024","journal-title":"Am. J. Occup. Ther."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1016\/j.ultrasmedbio.2017.12.012","article-title":"Quantitative Ultrasound Imaging to assess the Biceps Brachii Muscle in Chronic Post-Stroke Spasticity: Preliminary Observation","volume":"44","author":"Gao","year":"2018","journal-title":"Ultrasound Med. Biol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"105543","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105543","article-title":"Changes in Quadriceps Thickness and Echo Intensity in Chronic Stroke Survivors: A 3-Year Longitudinal Study","volume":"30","author":"Akazawa","year":"2021","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Lv, S., Ling, L., Shi, H., Chen, X., Chen, S., Zhu, S., Lin, W., Lv, R., and Ding, G. (2022). Application of Muscle Thickness and Quality Measured by Ultrasound in Frailty assessment in China. Front. Med., 9.","DOI":"10.3389\/fmed.2022.859555"}],"container-title":["Biosensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6374\/15\/6\/365\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:47:51Z","timestamp":1760032071000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6374\/15\/6\/365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,6]]},"references-count":91,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["bios15060365"],"URL":"https:\/\/doi.org\/10.3390\/bios15060365","relation":{},"ISSN":["2079-6374"],"issn-type":[{"value":"2079-6374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,6]]}}}