{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:36:43Z","timestamp":1787027803218,"version":"build-2736575974"},"reference-count":28,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chulabhorn International College of Medicine, Thammasat University","award":["F 4\/2566"],"award-info":[{"award-number":["F 4\/2566"]}]},{"name":"Chulabhorn International College of Medicine, Thammasat University","award":["N42A671041"],"award-info":[{"award-number":["N42A671041"]}]},{"name":"National Research Council of Thailand (NRCT)","award":["F 4\/2566"],"award-info":[{"award-number":["F 4\/2566"]}]},{"name":"National Research Council of Thailand (NRCT)","award":["N42A671041"],"award-info":[{"award-number":["N42A671041"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Microalbuminemia, characterized by a urinary albumin concentration between 20 and 200 mg\/L, is a critical marker in assessing the risk of chronic kidney disease (CKD), diabetic nephropathy, and various other chronic conditions. Previously, we developed and validated the MyACR point-of-care (PoC) device, which facilitates the monitoring of CKD progression through real-time data transmission, thus enhancing patient management. This device utilizes a spectrophotometric dye-binding assay to measure albumin and creatinine concentrations in urine samples, providing an albumin-to-creatinine ratio (ACR) result. In the present study, we introduced a refined version of the PoC device, My\u03bcAlbumin, designed to offer a simple, accurate, specific, sensitive, and rapid method for detecting microalbumin in urine as an early indicator of CKD and related diseases. The measurement is based on a specific immunoturbidimetric assay in a microcuvette, using a total solution volume of 125 \u00b5L (n = 5 for each validation test). The My\u03bcAlbumin device demonstrated excellent performance, achieving high accuracy (%DMV \u2264 4.67) and precision (%CV &lt; 5) and a strong correlation (R2 &gt; 0.995) with laboratory spectrophotometry (dye-binding assay) and reference hospital-based immunoturbidimetric assay. Its high sensitivity (LOQ = 5 mg\/L) positions My\u03bcAlbumin as a highly viable and cost-effective tool for clinical use. Additionally, the device supports real-time, seamless data transmission, making it ideal for integration into remote healthcare settings.<\/jats:p>","DOI":"10.3390\/bios15060391","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T11:53:14Z","timestamp":1750161194000},"page":"391","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["My\u03bcAlbumin: A Cutting-Edge Immunoturbidity-Based Device with Real-Time and Seamless Data Transmission for Early Detection of Chronic Kidney Disease at the Point of Care"],"prefix":"10.3390","volume":"15","author":[{"given":"Wanna","family":"Chaijaroenkul","sequence":"first","affiliation":[{"name":"Graduate Program in Bioclinical Sciences, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Napaporn","family":"Youngvises","sequence":"additional","affiliation":[{"name":"Drug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University, Pathum Thani 12120, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artitaya","family":"Thiengsusuk","sequence":"additional","affiliation":[{"name":"Drug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University, Pathum Thani 12120, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tullayakorn","family":"Plengsuriyakarn","sequence":"additional","affiliation":[{"name":"Graduate Program in Bioclinical Sciences, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakkrapong","family":"Suwanboriboon","sequence":"additional","affiliation":[{"name":"Bangkok High Lab Co., Ltd., Bang Khen District, Bangkok 10220, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kridsada","family":"Sirisabhabhorn","sequence":"additional","affiliation":[{"name":"Department of Medical Technology Laboratory, Thammasat University Hospital, Pathum Thani 12120, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanchai","family":"Meesiri","sequence":"additional","affiliation":[{"name":"Bangkok High Lab Co., Ltd., Bang Khen District, Bangkok 10220, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kesara","family":"Na-Bangchang","sequence":"additional","affiliation":[{"name":"Graduate Program in Bioclinical Sciences, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, Thailand"},{"name":"Drug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University, Pathum Thani 12120, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American Diabetes Association Professional Practice Committee (2022). 11. 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