{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:29:08Z","timestamp":1760059748692,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad Nacional de San Luis","award":["PROICO 02-2220","PICT-2021-GRF-TII-0390","PICT-2020-2347","PIP11220200100033CO","IF-2023-85161983-APN-DNOYPI#MCT"],"award-info":[{"award-number":["PROICO 02-2220","PICT-2021-GRF-TII-0390","PICT-2020-2347","PIP11220200100033CO","IF-2023-85161983-APN-DNOYPI#MCT"]}]},{"name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","award":["PROICO 02-2220","PICT-2021-GRF-TII-0390","PICT-2020-2347","PIP11220200100033CO","IF-2023-85161983-APN-DNOYPI#MCT"],"award-info":[{"award-number":["PROICO 02-2220","PICT-2021-GRF-TII-0390","PICT-2020-2347","PIP11220200100033CO","IF-2023-85161983-APN-DNOYPI#MCT"]}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PROICO 02-2220","PICT-2021-GRF-TII-0390","PICT-2020-2347","PIP11220200100033CO","IF-2023-85161983-APN-DNOYPI#MCT"],"award-info":[{"award-number":["PROICO 02-2220","PICT-2021-GRF-TII-0390","PICT-2020-2347","PIP11220200100033CO","IF-2023-85161983-APN-DNOYPI#MCT"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003033","name":"Ministerio de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n, Argentina","doi-asserted-by":"publisher","award":["PROICO 02-2220","PICT-2021-GRF-TII-0390","PICT-2020-2347","PIP11220200100033CO","IF-2023-85161983-APN-DNOYPI#MCT"],"award-info":[{"award-number":["PROICO 02-2220","PICT-2021-GRF-TII-0390","PICT-2020-2347","PIP11220200100033CO","IF-2023-85161983-APN-DNOYPI#MCT"]}],"id":[{"id":"10.13039\/501100003033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Celiac disease (CD), a human leukocyte antigen-associated disorder, is caused by gluten sensitivity and is characterized by mucosal alterations in the small intestine. Currently, its diagnosis involves the determination of serological markers. The traditional method for clinically determining these markers is the enzyme-linked immunosorbent assay. However, immunosensors offer sensitivity and facilitate the development of miniaturized and portable analytical systems. This work focuses on developing an amperometric immunosensor for the quantification of IgA antibodies against tissue transglutaminase (IgA anti-TGA) in human serum samples, providing information on a critical biomarker for CD diagnosis. The electrochemical device was designed on a polyimide substrate using a novel solid ink of wax and carbon nanofibers (CNFs). The working electrode microzone was defined by incorporating aminofunctionalized TiO2 nanoparticles (TiO2NPs). The interactions and morphology of CNFs\/wax and TiO2NPs\/CNFs\/wax electrodes were assessed through different characterization techniques. Furthermore, the device was electrochemically characterized, demonstrating that the incorporation of CNFs into the wax matrix significantly enhanced its conductivity and increased the active surface area of the electrode, while TiO2NPs contributed to the immunoreaction area. The developed device exhibited remarkable sensitivity, selectivity, and reproducibility. These results indicate that the fabricated device is a robust and reliable tool for the precise serological diagnosis of CD.<\/jats:p>","DOI":"10.3390\/bios15070431","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T05:54:52Z","timestamp":1751608492000},"page":"431","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A New Sensing Platform Based in CNF-TiO2NPs-Wax on Polyimide Substrate for Celiac Disease Diagnostic"],"prefix":"10.3390","volume":"15","author":[{"given":"Evelyn","family":"Mar\u00edn-Barroso","sequence":"first","affiliation":[{"name":"Instituto de Qu\u00edmica de San Luis (INQUISAL), Departamento de Qu\u00edmica, Facultad de Qu\u00edmica Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis, Avenida Ej\u00e9rcito de los Andes 950, San Luis D5700HHW, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Av. Rivadavia 1917, Buenos Aires C1033AAJ, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Ferroni-Martini","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica de San Luis (INQUISAL), Departamento de Qu\u00edmica, Facultad de Qu\u00edmica Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis, Avenida Ej\u00e9rcito de los Andes 950, San Luis D5700HHW, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Av. Rivadavia 1917, Buenos Aires C1033AAJ, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo A.","family":"Takara","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Av. Rivadavia 1917, Buenos Aires C1033AAJ, Argentina"},{"name":"Instituto de F\u00edsica Aplicada (INFAP), Departamento de Qu\u00edmica, Facultad de Qu\u00edmica Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis, Avenida Ej\u00e9rcito de los Andes 950, San Luis D5700HHW, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9255-6222","authenticated-orcid":false,"given":"Matias","family":"Regiart","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica de San Luis (INQUISAL), Departamento de Qu\u00edmica, Facultad de Qu\u00edmica Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis, Avenida Ej\u00e9rcito de los Andes 950, San Luis D5700HHW, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Av. Rivadavia 1917, Buenos Aires C1033AAJ, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0385-2391","authenticated-orcid":false,"given":"Mart\u00edn A.","family":"Fern\u00e1ndez-Baldo","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica de San Luis (INQUISAL), Departamento de Qu\u00edmica, Facultad de Qu\u00edmica Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis, Avenida Ej\u00e9rcito de los Andes 950, San Luis D5700HHW, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Av. 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