{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:44:28Z","timestamp":1792035868699,"version":"4.4.0"},"reference-count":151,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Key Research and Development Program of China","award":["2023YFC3011802"],"award-info":[{"award-number":["2023YFC3011802"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82472102"],"award-info":[{"award-number":["82472102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["T2541072"],"award-info":[{"award-number":["T2541072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Zhejiang Provincial Natural Science Foundation of China","award":["LMS25H180006"],"award-info":[{"award-number":["LMS25H180006"]}]},{"name":"the Sanming Project of Medicine in Shenzhen","award":["SZSM202411032"],"award-info":[{"award-number":["SZSM202411032"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Plasmonic nanoparticles (NPs) exhibit exceptional optical and electromagnetic (EM) properties that are, however, confined to their near\u2013field region, limiting effective interactions with non-adsorbed species. Metal\u2013organic frameworks (MOFs), renowned for their high surface area and tunable pores, provide an ideal complement through surface enrichment and subsequent molecular enrichment within their pores. The integration of plasmonic NPs with MOFs into nanohybrids overcomes this spatial constraint. This architectural synergy creates a synergistic effect, yielding properties superior to either component alone. This review summarizes recent advances in NP\u2013MOF nanohybrids, with a focus on synthesis strategies for diverse architectures and their emergent functionalities. We highlight how this synergistic effect enables breakthrough applications in chemical sensing, cancer therapy, and catalysis. Finally, we conclude our discussion and present a critical outlook that explores the challenges and future opportunities in the design and applications of NP\u2013MOF nanohybrids.<\/jats:p>","DOI":"10.3390\/bios16010053","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:20:37Z","timestamp":1768206037000},"page":"53","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Functionalized Metal\u2013Organic Frameworks Integrated with Plasmonic Nanoparticles: From Synthesis to Applications"],"prefix":"10.3390","volume":"16","author":[{"given":"Songsong","family":"Huang","sequence":"first","affiliation":[{"name":"School of Disaster and Emergency Medicine, Tianjin University, Tianjin 300072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1587-2729","authenticated-orcid":false,"given":"Qian","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Disaster and Emergency Medicine, Tianjin University, Tianjin 300072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Li","sequence":"additional","affiliation":[{"name":"School of Disaster and Emergency Medicine, Tianjin University, Tianjin 300072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyang","family":"Duan","sequence":"additional","affiliation":[{"name":"School of Disaster and Emergency Medicine, Tianjin University, Tianjin 300072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuexing","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Disaster and Emergency Medicine, Tianjin University, Tianjin 300072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Disaster and Emergency Medicine, Tianjin University, Tianjin 300072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9820-3177","authenticated-orcid":false,"given":"Zetao","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Disaster and Emergency Medicine, Tianjin University, Tianjin 300072, China"},{"name":"Wenzhou Safety (Emergency) Institute of Tianjin University, Wenzhou 325026, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"161637","DOI":"10.1016\/j.apsusc.2024.161637","article-title":"Label-free detection of formaldehyde in water by titanium doped MoS2 gold nanoislands LSPR sensor","volume":"682","author":"Wang","year":"2025","journal-title":"Appl. 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