{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:18:38Z","timestamp":1787872718444,"version":"build-2784847793"},"reference-count":63,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22474114"],"award-info":[{"award-number":["22474114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["22474114"],"award-info":[{"award-number":["22474114"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Graduate Research and Innovation Foundation of Chongqing, China","award":["CYB240044"],"award-info":[{"award-number":["CYB240044"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["2024CDJXY010"],"award-info":[{"award-number":["2024CDJXY010"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Laccase plays an important role in the detection and degradation of phenolic compounds, but it is limited by its cost and stability. In this study, the laccase-like property of copper peptide (GHK-Cu) has been revealed. In terms of enzymatic reaction kinetics, GHK-Cu has a Vmax of 1.735 \u00d7 10\u22124 mM\u00b7s\u22121 and a Km of 0.061 mM, demonstrating good substrate affinity and excellent catalytic efficiency. Then, a colorimetry was developed for rapid detection of epinephrine (EP) and 2-aminophenol (2-AP). The linear response range of EP is 20\u2013240 \u03bcM, with a limit of detection (LOD) of 9.5 \u03bcM. The linear response ranges of 2-AP are 14\u2013100 \u03bcM (in ultrapure water) and 2\u2013120 \u03bcM (in seawater), with LODs of 2.56 \u03bcM and 1.65 \u03bcM. In addition, combined with a smartphone platform, a cotton-based sensor has been developed for the detection of 2-AP in seawater. The linear response ranges are 0\u20130.2 mM and 0.2\u20131 mM, with LOD of 0.033 mM. The structure of GHK-Cu provides a reference for the development of novel laccase mimetic enzymes. The constructed colorimetry offers an option for the rapid detection of phenolic compounds, and the developed cotton-based sensor enabled rapid and portable detection of 2-AP.<\/jats:p>","DOI":"10.3390\/bios16040217","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T07:29:29Z","timestamp":1776065369000},"page":"217","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Laccase-like Property of GHK-Cu and Its Applications in Colorimetric Sensing of Phenolic Compounds"],"prefix":"10.3390","volume":"16","author":[{"given":"Jiang-Shan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong-Qing","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9300-5710","authenticated-orcid":false,"given":"Feng-Qing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"12713","DOI":"10.1021\/jf203372w","article-title":"Analysis of nonextractable phenolic compounds in foods: The current state of the art","volume":"59","author":"Torres","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"137142","DOI":"10.1016\/j.jhazmat.2025.137142","article-title":"Metal covalent organic frameworks-based laccase-like nanozyme for oxidative degradation and identification of phenolic pollutants","volume":"487","author":"Liu","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"126033","DOI":"10.1016\/j.chemosphere.2020.126033","article-title":"Radical attack and mineralization mechanisms on electrochemical oxidation of p-substituted phenols at boron-doped diamond anodes","volume":"248","author":"Jiang","year":"2020","journal-title":"Chemosphere"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1016\/j.envpol.2011.04.047","article-title":"Comparison of competitive and synergetic adsorption of three phenolic compounds on river sediment","volume":"159","author":"Gao","year":"2011","journal-title":"Environ. Pollut."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"129404","DOI":"10.1016\/j.chemosphere.2020.129404","article-title":"Preferential and efficient degradation of phenolic pollutants with cooperative hydrogen-bond interactions in photocatalytic process","volume":"269","author":"Zhang","year":"2021","journal-title":"Chemosphere"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"133906","DOI":"10.1016\/j.jhazmat.2024.133906","article-title":"Biodegradation of phenolic pollutants and bioaugmentation strategies: A review of current knowledge and future perspectives","volume":"469","author":"Wang","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"102423","DOI":"10.1016\/j.eti.2022.102423","article-title":"A comprehensive review on eco-toxicity and biodegradation of phenolics: Recent progress and future outlook","volume":"27","author":"Panigrahy","year":"2022","journal-title":"Environ. Technol. Innov."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10895-016-1944-7","article-title":"Surface molecular imprinting on silica-coated cdte quantum dots for selective and sensitive fluorescence detection of p-aminophenol in water","volume":"27","author":"Lu","year":"2017","journal-title":"J. Fluoresc."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.talanta.2014.11.015","article-title":"Microextraction with polyethersulfone for bisphenol-A, alkylphenols and hormones determination in water samples by means of gas chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry analysis","volume":"134","author":"Ros","year":"2015","journal-title":"Talanta"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"115067","DOI":"10.1016\/j.jelechem.2021.115067","article-title":"Aluminium MOF fabricated electrochemical sensor for the ultra-sensitive detection of hydroquinone in water samples","volume":"883","author":"Ming","year":"2021","journal-title":"J. Electroanal. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"136887","DOI":"10.1016\/j.foodchem.2023.136887","article-title":"Gold nanoparticles as colorimetric probes in food analysis: Progress and challenges","volume":"429","author":"Liu","year":"2023","journal-title":"Food Chem."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Janusz, G., Pawlik, A., Swiderska-Burek, U., Polak, J., Sulej, J., Jarosz-Wilkolazka, A., and Paszczynski, A. (2020). Laccase Properties, Physiological Functions, and Evolution. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21030966"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s00253-009-1869-z","article-title":"Fungal laccases as tools for the synthesis of new hybrid molecules and biomaterials","volume":"82","author":"Mikolasch","year":"2009","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/btpr.713","article-title":"Structure\/Redox potential relationship of simple organic compounds as potential precursors of dyes for laccase-mediated transformation","volume":"28","author":"Polak","year":"2012","journal-title":"Biotechnol. Prog."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0376-7388(00)00522-6","article-title":"Immobilization of laccase from Trametes versicolor on a modified PVDF microfiltration membrane: Characterization of the grafted support and application in removing a phenylurea pesticide in wastewater","volume":"180","author":"Jolivalt","year":"2000","journal-title":"J. Membr. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"8404","DOI":"10.1002\/chem.201504394","article-title":"Enzyme mimics: Advances and applications","volume":"22","author":"Kuah","year":"2016","journal-title":"Chem.-Eur. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1021\/acsami.6b15124","article-title":"Multicopper laccase mimicking nanozymes with nucleotides as ligands","volume":"9","author":"Liang","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1039\/D1CY00074H","article-title":"Preparation of laccase mimicking nanozymes and their catalytic oxidation of phenolic pollutants","volume":"11","author":"Xu","year":"2021","journal-title":"Catal. Sci. Technol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"124340","DOI":"10.1016\/j.jhazmat.2020.124340","article-title":"Biodegradation of malachite green by a novel laccase-mimicking multicopper BSA-Cu complex: Performance optimization, intermediates identification and artificial neural network modeling","volume":"406","author":"Rashtbari","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1007\/s10562-017-2106-5","article-title":"Catalytic performance of oligonucleotide-templated Pt nanozyme evaluated by laccase substrates","volume":"147","author":"Wang","year":"2017","journal-title":"Catal. Lett."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"7756","DOI":"10.1038\/s41598-017-07913-2","article-title":"The laccase-like reactivity of manganese oxide nanomaterials for pollutant conversion: Rate analysis and cyclic voltammetry","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"132972","DOI":"10.1016\/j.snb.2022.132972","article-title":"Single-atom Rh nanozyme: An efficient catalyst for highly sensitive colorimetric detection of acetylcholinesterase activity and adrenaline","volume":"375","author":"Guan","year":"2023","journal-title":"Sens. Actuators B Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1002\/elps.202400047","article-title":"Novel applications of ce-icp-ms\/ms: Monitoring of antiaging ghk-cu cosmetic component encapsulation in liposomes","volume":"45","author":"Zajda","year":"2024","journal-title":"Electrophoresis"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/BF02002806","article-title":"Growth-modulating serum tripeptide is glycyl-histidyl-lysine","volume":"33","author":"Schlesinger","year":"1977","journal-title":"Experientia"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"107265","DOI":"10.1016\/j.compbiolchem.2020.107265","article-title":"Theoretical study of copper binding to GHK peptide","volume":"86","author":"Alshammari","year":"2020","journal-title":"Comput. Biol. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Pickart, L., and Margolina, A. (2018). Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19071987"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"152154","DOI":"10.1016\/j.cej.2024.152154","article-title":"GHK-Cu\/Pionin-loaded in situ electrospun PVB\/PVP smart dressing promotes wound healing via anti-oxidant, anti-inflammatory, antimicrobial, and tissue regenerative effects","volume":"492","author":"Wang","year":"2024","journal-title":"Chem. Eng. J."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Wang, F., Yu, X., Yu, Z., Cui, Y., Xu, L., Huo, S., Ding, Z., Zhao, L., Du, L., and Qiu, Y. (2023). Improved laccase production by Trametes versicolor using Copper-Glycyl-L-Histidyl-L-Lysine as a novel and high-efficient inducer. Front. Bioeng. Biotechnol., 11.","DOI":"10.3389\/fbioe.2023.1176352"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"130198","DOI":"10.1016\/j.jhazmat.2022.130198","article-title":"Supramolecular assembly of benzophenone alanine and copper presents high laccase-like activity for the degradation of phenolic pollutants","volume":"443","author":"Liu","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Chai, T.Q., Wang, J.L., Chen, G.Y., Chen, L.X., and Yang, F.Q. (2023). Tris-Copper Nanozyme as a Novel Laccase Mimic for the Detection and Degradation of Phenolic Compounds. Sensors, 23.","DOI":"10.3390\/s23198137"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"343298","DOI":"10.1016\/j.aca.2024.343298","article-title":"A novel dual-ligand copper-based nanoflower for the colorimetric and fluorescence detection of 2,4-dichlorophenol, epinephrine and hydrogen peroxide","volume":"1330","author":"Li","year":"2024","journal-title":"Anal. Chim. Acta"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1800420","DOI":"10.1002\/ppsc.201800420","article-title":"Self-assembled fluorescent and antibacterial GHK-Cu nanoparticles for wound healing applications","volume":"36","author":"Sun","year":"2019","journal-title":"Part. Part. Syst. Charact."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"137112","DOI":"10.1016\/j.snb.2024.137112","article-title":"Deciphering of laccase-like activity ruthenium single-atom nanozyme for identification\/quantification and remediation of phenolic pollutants","volume":"426","author":"Wang","year":"2025","journal-title":"Sens. Actuators B Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1007\/s12010-024-05172-2","article-title":"Excellent Laccase Mimic Activity of Cu-Melamine and Its Applications in the Degradation of Congo Red","volume":"197","author":"Chai","year":"2025","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"110559","DOI":"10.1016\/j.microc.2024.110559","article-title":"MOF-818(Cu)-derived bi-nanozymes of laccase and catecholase mimics and colorimetric sensing to epinephrine","volume":"201","author":"Liu","year":"2024","journal-title":"Microchem. J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s00604-025-07314-7","article-title":"Unraveling the modulation of covalently bonded carbon matrix on Fe-N4 active sites for enhanced laccase-like activity: Toward advanced detection and degradation of phenolic pollutants","volume":"192","author":"Zhang","year":"2025","journal-title":"Microchim. Acta"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"131429","DOI":"10.1016\/j.snb.2022.131429","article-title":"Colorimetric logic gate for protamine and trypsin based on the Bpy-Cu nanozyme with laccase-like activity","volume":"357","author":"Li","year":"2022","journal-title":"Sens. Actuators B Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"116275","DOI":"10.1016\/j.bios.2024.116275","article-title":"Perovskite hydroxide-based laccase mimics with controllable activity for environmental remediation and biosensing","volume":"256","author":"Liu","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"135445","DOI":"10.1016\/j.colsurfa.2024.135445","article-title":"Bioinspired coassembly of peptide, imidazolecarboxaldehyde, and copper for nanozyme with laccase-like activity for colorimetric detection of epinephrine","volume":"704","author":"Dong","year":"2025","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"134165","DOI":"10.1016\/j.snb.2023.134165","article-title":"Construction of platinum nanozyme by using carboxymethylcellulose with improved laccase-like activity for phenolic compounds detection","volume":"393","author":"Yang","year":"2023","journal-title":"Sens. Actuators B Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"127862","DOI":"10.1016\/j.talanta.2025.127862","article-title":"Bioinspired Cu\/Zn-ZIF nanozyme with excellent laccase-like activity for selective colorimetric detection of phenolic pollutants","volume":"291","author":"Wei","year":"2025","journal-title":"Talanta"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"33610","DOI":"10.1039\/D5RA05134G","article-title":"Spherical nanoflower-shaped Co-2MI with laccase-like activity for colorimetric detection of salbutamol","volume":"15","author":"Xu","year":"2025","journal-title":"RSC Adv."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"111380","DOI":"10.1016\/j.microc.2024.111380","article-title":"Synthesis of phenylalanine\/manganese-copper supramolecular sheets with laccase-like activity for the detection of phenolic pollutants","volume":"206","author":"Chen","year":"2024","journal-title":"Microchem. J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"7526","DOI":"10.1021\/acs.analchem.5c00743","article-title":"S-modified MOF nanozyme cascade system with multi-enzyme activity for dual-mode antibiotic assay","volume":"97","author":"Wang","year":"2025","journal-title":"Anal. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s00894-020-04389-2","article-title":"A DFT study of isolated histidine interactions with metal ions (Ni2+, Cu2+, Zn2+) in a six-coordinated octahedral complex","volume":"26","author":"Franklin","year":"2020","journal-title":"J. Mol. Model."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"19771","DOI":"10.1021\/acsanm.5c03086","article-title":"2D Nb2C MXene\/COF Composite as Electrochemical Platform for the Stress Marker Epinephrine Detection","volume":"8","author":"Punniyamoorthy","year":"2025","journal-title":"ACS Appl. Nano Mater."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1021\/acssuschemeng.1c06340","article-title":"Robust and reusable laccase mimetic copper oxide nanozyme for phenolic oxidation and biosensing","volume":"10","author":"Maity","year":"2022","journal-title":"ACS Sustain. Chem. Eng."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.apcatb.2019.05.012","article-title":"Construction of a bioinspired laccase-mimicking nanozyme for the degradation and detection of phenolic pollutants","volume":"254","author":"Wang","year":"2019","journal-title":"Appl. Catal. B Environ."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"341771","DOI":"10.1016\/j.aca.2023.341771","article-title":"Adenine phosphate-Cu nanozyme with multienzyme mimicking activity for efficient degrading phenolic compounds and detection of hydrogen peroxide, epinephrine and glutathione","volume":"1279","author":"Chai","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1039\/D1AN01817E","article-title":"Copper fumarate with high-bifunctional nanozyme activities at different pH values for glucose and epinephrine colorimetric detection in human serum","volume":"147","author":"Ying","year":"2021","journal-title":"Analyst"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"126105","DOI":"10.1016\/j.colsurfa.2020.126105","article-title":"Laccase-like catalytic activity of Cu-tannic acid nanohybrids and their application for epinephrine detection","volume":"613","author":"Ma","year":"2021","journal-title":"Colloids Surf. A"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"J375","DOI":"10.1149\/1.3223664","article-title":"Simultaneous electrochemical determination of adrenaline and ascorbic acid: Influence of [CTAB]","volume":"156","year":"2009","journal-title":"J. Electrochem. Soc."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"111366","DOI":"10.1016\/j.envres.2021.111366","article-title":"Synthesis of porous 2D layered nickel oxide-reduced graphene oxide (NiO-rGO) hybrid composite for the efficient electrochemical detection of epinephrine in biological fluid","volume":"200","author":"Ramu","year":"2021","journal-title":"Environ. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"47921","DOI":"10.1021\/acsami.3c09586","article-title":"Synthesis of 2D VO2 nanosheets for the dual optical sensor method by colorimetric and fluorometric sensing of catecholamines","volume":"15","author":"Weerasinghe","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"110920","DOI":"10.1016\/j.microc.2024.110920","article-title":"Construction of COF@MOF composite-based electrochemical sensor for rapid detection of 2-Aminophenol","volume":"203","author":"Song","year":"2024","journal-title":"Microchem. J."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1034\/j.1600-0536.2001.450610.x","article-title":"Contact anaphylaxis due to para-aminophenol and para-methylaminophenol in hair dye","volume":"45","author":"Oshima","year":"2001","journal-title":"Contact Dermat."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1006\/abbi.2001.2302","article-title":"Oxidative DNA damage induced by a metabolite of carcinogenic o-anisidine: Enhancement of DNA damage and alteration in its sequence specificity by superoxide dismutase","volume":"389","author":"Ohkuma","year":"2001","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"116539","DOI":"10.1016\/j.jece.2025.116539","article-title":"Detection and degradation of phenolic pollutants using a highly effective and stable biomimetic laccase-mimicking Cys-Cu\/NH2-ZIF-8 nanozyme: Toxicity assessment and artificial neural network modeling","volume":"13","author":"Rashtbari","year":"2025","journal-title":"J. Environ. Chem. Eng."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/elan.201500477","article-title":"Fabrication of hierarchical hollow manganese silicate spheres for the simultaneous enhanced determination of 2-aminophenol and 4-aminophenol","volume":"28","author":"Sun","year":"2016","journal-title":"Electroanalysis"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.electacta.2015.02.207","article-title":"Polyelectrolyte functionalized gold nanoparticles-reduced graphene oxide nanohybrid for electrochemical determination of aminophenol isomers","volume":"164","author":"Li","year":"2015","journal-title":"Electrochim. Acta"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.bios.2015.09.052","article-title":"Highly sensitive and simultaneous electrochemical determination of 2-aminophenol and 4-aminophenol based on poly (L-arginine)-\u03b2-cyclodextrinicarbon nanotubes@graphene nanoribbons modified electrode","volume":"77","author":"Yi","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"113182","DOI":"10.1016\/j.fct.2022.113182","article-title":"Tailoring the heterojunction of TiO2 with multivalence CeO2 nanocrystals\u2014For detection of toxic 2-aminophenol","volume":"165","author":"Manoj","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"10429","DOI":"10.1039\/D5NJ01535A","article-title":"Highly active silver-based laccase-like nanozyme for colorimetric distinction and detection of phenylenediamine isomers","volume":"49","author":"Wang","year":"2025","journal-title":"New J. Chem."}],"container-title":["Biosensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6374\/16\/4\/217\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T04:17:13Z","timestamp":1776140233000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6374\/16\/4\/217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,12]]},"references-count":63,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["bios16040217"],"URL":"https:\/\/doi.org\/10.3390\/bios16040217","relation":{},"ISSN":["2079-6374"],"issn-type":[{"value":"2079-6374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,12]]}}}