{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:22:05Z","timestamp":1785435725906,"version":"3.56.0"},"reference-count":72,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013129","name":"Ministry of SMEs and Startups","doi-asserted-by":"crossref","award":["RS-2024-00508642"],"award-info":[{"award-number":["RS-2024-00508642"]}],"id":[{"id":"10.13039\/501100013129","id-type":"DOI","asserted-by":"crossref"}]},{"award":["RS-2024-00508642"],"award-info":[{"award-number":["RS-2024-00508642"]}],"id":[{"id":"https:\/\/ror.org\/022c4zk48","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Structurally complex plasmonic nanoarchitectures represent an emerging class of nanomaterials with properties that extend beyond those of conventional spherical nanoparticles. Their distinctive structural motifs generate dense near field electromagnetic hot spots, expand interfacial surface area, and create biophysical environments at the nano\u2013bio interface that can actively engage cellular signaling networks relevant to neural regeneration and aging. Despite growing interest in these platforms, a systematic, omics-guided synthesis that links nanoparticle structural features to transcriptomic programs and regenerative outcomes has been lacking. In this review, we summarize recent advances in high complexity plasmonic nanoparticle engineering and integrate published omics-based evidence of their cellular effects, organizing the discussion. Across these studies, transcriptomic analyses of nanoparticle treated neural systems consistently highlight three convergent biological themes: mitigation of oxidative stress and activation of antioxidant pathways, suppression of neuroinflammatory signaling, and induction of neuronal developmental and plasticity programs. Collectively, the omics-guided findings synthesized here suggest that structural complexity in plasmonic nanoarchitectures is not merely a synthetic achievement but a tunable determinant of cellular state, with important implications for the rational design of regenerative nanomedicines targeting neurodegenerative diseases and age-related neuronal decline.<\/jats:p>","DOI":"10.3390\/bios16050239","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T12:29:11Z","timestamp":1777033751000},"page":"239","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Omics-Guided Insights into Nanoparticle Complexity and Neural Regeneration"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8371-8784","authenticated-orcid":false,"given":"Yujung","family":"Chang","sequence":"first","affiliation":[{"name":"Laboratory of Regenerative Medicine for Neurodegenerative Disease, Stand Up Therapeutics Inc., Hannamdaero 98, Seoul 04418, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5411-0366","authenticated-orcid":false,"given":"Sungwoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Yonsei University, Seoul 03722, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garam","family":"Yang","sequence":"additional","affiliation":[{"name":"Laboratory of Regenerative Medicine for Neurodegenerative Disease, Stand Up Therapeutics Inc., Hannamdaero 98, Seoul 04418, Republic of Korea"},{"name":"Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Seon","family":"Yang","sequence":"additional","affiliation":[{"name":"Laboratory of Regenerative Medicine for Neurodegenerative Disease, Stand Up Therapeutics Inc., Hannamdaero 98, Seoul 04418, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Biochemistry, Northeastern University, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Regenerative Medicine for Neurodegenerative Disease, Stand Up Therapeutics Inc., Hannamdaero 98, Seoul 04418, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon","family":"Ha","sequence":"additional","affiliation":[{"name":"Spine & Spinal Cord Center, Department of Neurosurgery, College of Medicine, Yonsei University, Seoul 03722, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungho","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Yonsei University, Seoul 03722, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junsang","family":"Yoo","sequence":"additional","affiliation":[{"name":"Laboratory of Regenerative Medicine for Neurodegenerative Disease, Stand Up Therapeutics Inc., Hannamdaero 98, Seoul 04418, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e00467-19","DOI":"10.1128\/MCB.00467-19","article-title":"Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer\u2019s Disease Model Mice","volume":"40","author":"Uruno","year":"2020","journal-title":"Mol. Cell. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Buck, A.C., Maarman, G.J., Dube, A., and Bardien, S. (2025). Mitochondria targeted nanoparticles for the treatment of mitochondrial dysfunction-associated brain disorders. Front. Bioeng. Biotechnol., 13.","DOI":"10.3389\/fbioe.2025.1563701"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-bioeng-071811-150124","article-title":"The effect of nanoparticle size, shape, and surface chemistry on biological systems","volume":"14","author":"Albanese","year":"2012","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"673","DOI":"10.2217\/nnm.16.5","article-title":"The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction","volume":"11","author":"Hoshyar","year":"2016","journal-title":"Nanomedicine"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1039\/C6CS00636A","article-title":"Cellular uptake of nanoparticles: Journey inside the cell","volume":"46","author":"Behzadi","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1021\/nn300223w","article-title":"Effects of the presence or absence of a protein corona on silica nanoparticle uptake and impact on cells","volume":"6","author":"Lesniak","year":"2012","journal-title":"ACS Nano"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Chang, Y., Lee, S., Kim, J., Kim, C., Shim, H.S., Lee, S.E., Park, H.J., Kim, J., Lee, S., and Lee, Y.K. (2023). Gene Therapy Using Efficient Direct Lineage Reprogramming Technology for Neurological Diseases. Nanomaterials, 13.","DOI":"10.3390\/nano13101680"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/nnano.2017.133","article-title":"Electromagnetized gold nanoparticles mediate direct lineage reprogramming into induced dopamine neurons in vivo for Parkinson\u2019s disease therapy","volume":"12","author":"Yoo","year":"2017","journal-title":"Nat. Nanotechnol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.actbio.2022.07.058","article-title":"Elongated nanoporous Au networks improve somatic cell direct conversion into induced dopaminergic neurons for Parkinson\u2019s disease therapy","volume":"151","author":"Lee","year":"2022","journal-title":"Acta Biomater."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Lundstrom, K. (2020). The Current Status of COVID-19 Vaccines. Front. Genome Ed., 2.","DOI":"10.3389\/fgeed.2020.579297"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1039\/C1CS15237H","article-title":"The golden age: Gold nanoparticles for biomedicine","volume":"41","author":"Dreaden","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1039\/b517615h","article-title":"Gold nanostructures: Engineering their plasmonic properties for biomedical applications","volume":"35","author":"Hu","year":"2006","journal-title":"Chem. Soc. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.2147\/IJN.S199781","article-title":"Green synthesis of gold nanoparticles using Euphrasia officinalisleaf extract to inhibit lipopolysaccharide-induced inflammation through NF-\u03baB and JAK\/STAT pathways in RAW 264.7 macrophages","volume":"14","author":"Liu","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"10648","DOI":"10.1073\/pnas.1806908115","article-title":"Functional muscle recovery with nanoparticle-directed M2 macrophage polarization in mice","volume":"115","author":"Raimondo","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1021\/acs.nanolett.5c05754","article-title":"Plasmonic Truncated Satellite Octahedral Nanoparticles: Interior Nanocavities and Exterior Nanotrenches Synergistically Maximize Near-Field Focus","volume":"26","author":"Lee","year":"2026","journal-title":"Nano Lett."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7202","DOI":"10.1021\/acs.jpcc.4c01170","article-title":"Plasmonic Nanoantenna: Enhanced Near-Field Focusing with Branched Gold Dual-Rim Nanorings","volume":"128","author":"Lee","year":"2024","journal-title":"J. Phys. Chem. C"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e2409814","DOI":"10.1002\/smll.202409814","article-title":"Hot Nanogap Networks-In-Triangular Nanoframes: A Strategy for Positioning Adsorbates Near Hot Spots","volume":"21","author":"Lee","year":"2025","journal-title":"Small"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"7321","DOI":"10.1021\/acs.chemrev.4c00897","article-title":"Colloidal Synthesis of Plasmonic Complex Metal Nanoparticles: Sequential Execution of Multiple Chemical Toolkits Increases Morphological Complexity","volume":"125","author":"Jung","year":"2025","journal-title":"Chem. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7656","DOI":"10.1021\/acsnano.4c00734","article-title":"Octahedron in a cubic nanoframe: Strong near-field focusing and surface-enhanced Raman scattering","volume":"18","author":"Oh","year":"2024","journal-title":"ACS Nano"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1039\/df9511100055","article-title":"A study of the nucleation and growth processes in the synthesis of colloidal gold","volume":"11","author":"Turkevich","year":"1951","journal-title":"Discuss. Faraday Soc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"9399","DOI":"10.1021\/ja048789r","article-title":"Synthesis and optical properties of nanorattles and multiple-walled nanoshells\/nanotubes made of metal alloys","volume":"126","author":"Sun","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"8410","DOI":"10.1021\/jp9917648","article-title":"Spectral properties and relaxation dynamics of surface plasmon electronic oscillations in gold and silver nanodots and nanorods","volume":"103","author":"Link","year":"1999","journal-title":"J. Phys. Chem. B"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"7093","DOI":"10.1021\/acsami.5b00410","article-title":"Nanoporous gold as a neural interface coating: Effects of topography, surface chemistry, and feature size","volume":"7","author":"Chapman","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"18165","DOI":"10.1021\/ja3076132","article-title":"Single-crystalline octahedral Au-Ag nanoframes","volume":"134","author":"Hong","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.1038\/s41467-022-32549-w","article-title":"Three-dimensional nanoframes with dual rims as nanoprobes for biosensing","volume":"13","author":"Hilal","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"7402","DOI":"10.1021\/acsnano.3c09844","article-title":"Step-by-Step Nanoscale Top-Down Blocking and Etching Lead to Nanohexapods with Cartesian Geometry","volume":"18","author":"Park","year":"2024","journal-title":"ACS Nano"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6355","DOI":"10.1039\/D1SC00202C","article-title":"Au nanolenses for near-field focusing","volume":"12","author":"Lee","year":"2021","journal-title":"Chem. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1038\/s41467-022-32261-9","article-title":"Nesting of multiple polyhedral plasmonic nanoframes into a single entity","volume":"13","author":"Yoo","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Ganguly, S., and Margel, S. (2025). Magnetic Polymeric Conduits in Biomedical Applications. Micromachines, 16.","DOI":"10.3390\/mi16020174"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"53177","DOI":"10.1021\/acsami.3c08756","article-title":"Enhanced Nose-to-Brain Delivery of Combined Small Interfering RNAs Using Lesion-Recognizing Nanoparticles for the Synergistic Therapy of Alzheimer\u2019s Disease","volume":"15","author":"Li","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000519534","article-title":"The Effect of Cannabidiol Coated by Nano-Chitosan on Learning and Memory, Hippocampal CB1 and CB2 Levels, and Amyloid Plaques in an Alzheimer\u2019s Disease Rat Model","volume":"81","author":"Amini","year":"2022","journal-title":"Neuropsychobiology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"40","DOI":"10.9734\/indj\/2025\/v22i3479","article-title":"Advances in Understanding and Treating Alzheimer\u2019s Disease: From Pathogenesis to Novel Therapeutics and Biomarkers","volume":"22","author":"Yashwanth","year":"2025","journal-title":"Int. Neuropsychiatr. Dis. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1166\/jnn.2021.18636","article-title":"Explore the Effects of Fe(3)O(4) Nanoparticles and Oxidative Stress and Neuroinflammatory Responses on the Intestinal Flora Based on a Parkinson Rat Model","volume":"21","author":"Xu","year":"2021","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"111302","DOI":"10.1016\/j.colsurfb.2020.111302","article-title":"Effects of gold nanoparticles administration through behavioral and oxidative parameters in animal model of Parkinson\u2019s disease","volume":"196","author":"Scussel","year":"2020","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"102119","DOI":"10.1016\/j.nano.2019.102119","article-title":"Enriched chitosan nanoparticles loaded with siRNA are effective in lowering Huntington\u2019s disease gene expression following intranasal administration","volume":"24","author":"Sava","year":"2020","journal-title":"Nanomedicine"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1021\/acschemneuro.8b00545","article-title":"Biodegradable Nanoparticles Containing Mechanism Based Peptide Inhibitors Reduce Polyglutamine Aggregation in Cell Models and Alleviate Motor Symptoms in a Drosophila Model of Huntington\u2019s Disease","volume":"10","author":"Joshi","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.15252\/emmm.201505413","article-title":"Cholesterol-loaded nanoparticles ameliorate synaptic and cognitive function in Huntington\u2019s disease mice","volume":"7","author":"Valenza","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1002\/ptr.8488","article-title":"Research Progress of Flavonoids in Spinal Cord Injury: Therapeutic Mechanisms and Drug Delivery Strategies","volume":"39","author":"Li","year":"2025","journal-title":"Phytother. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"8953","DOI":"10.18632\/aging.103125","article-title":"Valproic acid-labeled chitosan nanoparticles promote recovery of neuronal injury after spinal cord injury","volume":"12","author":"Wang","year":"2020","journal-title":"Aging"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Gwak, S.-J., Yun, Y., Yoon, D.H., Kim, K.N., and Ha, Y. (2016). Therapeutic use of 3\u03b2-[N-(N\u2032,N\u2032-dimethylaminoethane)carbamoyl] cholesterol-modified PLGA nanospheres as gene delivery vehicles for spinal cord injury. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0147389"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e2100059","DOI":"10.1002\/adhm.202100059","article-title":"Antioxidant Activity and Toxicity Study of Cerium Oxide Nanoparticles Stabilized with Innovative Functional Copolymers","volume":"10","author":"Goujon","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"ref_42","first-page":"38","article-title":"ROS-responsive 18\u03b2-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation","volume":"19","author":"Jin","year":"2023","journal-title":"Bioact. Mater."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/10717544.2021.1879315","article-title":"Targeted nano-delivery strategies for facilitating thrombolysis treatment in ischemic stroke","volume":"28","author":"Ma","year":"2021","journal-title":"Drug Deliv."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12951-025-03251-y","article-title":"Responsive nanoparticles synergize with Curcumin to break the \u201creactive oxygen Species-Neuroinflammation\u201d vicious cycle, enhancing traumatic brain injury outcomes","volume":"23","author":"Fu","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"65850","DOI":"10.1021\/acsami.4c14389","article-title":"Targeted Pyroptosis with Resveratrol Nanoparticles to Reduce Secondary Brain Injury and Post-Traumatic Epilepsy","volume":"16","author":"Han","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"102586","DOI":"10.1016\/j.nano.2022.102586","article-title":"Ultrasmall polymer-coated cerium oxide nanoparticles as a traumatic brain injury therapy","volume":"45","author":"Kang","year":"2022","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1038\/s41467-022-31368-3","article-title":"Light-induced charge generation in polymeric nanoparticles restores vision in advanced-stage retinitis pigmentosa rats","volume":"13","author":"Francia","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1167\/tvst.10.9.6","article-title":"Retinal protection by sustained nanoparticle delivery of oncostatin M and ciliary neurotrophic factor into rodent models of retinal degeneration","volume":"10","author":"Yang","year":"2021","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"11823","DOI":"10.1021\/acsnano.4c14061","article-title":"Intravitreally Injected Plasmonic Nanorods Activate Bipolar Cells with Patterned Near-Infrared Laser Projection","volume":"19","author":"Nie","year":"2025","journal-title":"ACS Nano"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s40199-025-00561-2","article-title":"Synthesis and optimization of fluoxetine-loaded polymeric nanoparticles for dual therapeutic applications in cancer and depression","volume":"33","author":"Shoaib","year":"2025","journal-title":"Daru"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1080\/17425247.2019.1690452","article-title":"In vivo biodistribution of venlafaxine-PLGA nanoparticles for brain delivery: Plain vs. functionalized nanoparticles","volume":"16","author":"Gomes","year":"2019","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1080\/03639045.2020.1851240","article-title":"Polymer-based prolonged-release nanoformulation of duloxetine: Fabrication, characterization and neuropharmacological assessments","volume":"47","author":"Singh","year":"2021","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1016\/j.apsb.2023.06.011","article-title":"Mitochondrial-targeted and ROS-responsive nanocarrier via nose-to-brain pathway for ischemic stroke treatment","volume":"13","author":"Zhang","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"122063","DOI":"10.1016\/j.biomaterials.2023.122063","article-title":"Cerium oxide nanozymes confer a cytoprotective and bio-friendly surface micro-environment to methacrylate based oro-facial prostheses","volume":"296","author":"Jin","year":"2023","journal-title":"Biomaterials"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e2520119123","DOI":"10.1073\/pnas.2520119123","article-title":"Endogenous ATP-powered nanomotors directing neural stem cell differentiation for Parkinson\u2019s disease treatment","volume":"123","author":"Ding","year":"2026","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Ma, L., Zhou, K., Wang, X., Wang, J., Zhao, R., Zhang, Y., and Cheng, F. (2024). Recent Progress in the Synthesis of 3D Complex Plasmonic Intragap Nanostructures and Their Applications in Surface-Enhanced Raman Scattering. Biosensors, 14.","DOI":"10.3390\/bios14090433"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"26239","DOI":"10.1021\/acsnano.5c10119","article-title":"Complex Plasmonic Hot Nanocavity: Vertically Nested Au Quintuple Nanorings Produce a Strong Cavity-Enhanced Near-Field Focus","volume":"19","author":"Kim","year":"2025","journal-title":"ACS Nano"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e2410296","DOI":"10.1002\/smll.202410296","article-title":"Gold Tetrahedral Nanoframes with Mono-Rim or Dual-Rim Morphologies for Enhanced Near-Field Focusing in SERS","volume":"21","author":"Kwon","year":"2025","journal-title":"Small"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"13285","DOI":"10.1021\/jacs.2c04514","article-title":"All-Hot-Spot Bulk Surface-Enhanced Raman Scattering (SERS) Substrates: Attomolar Detection of Adsorbates with Designer Plasmonic Nanoparticles","volume":"144","author":"Zhao","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.1021\/acs.nanolett.4c00451","article-title":"Plasmonic Annular Nanotrenches with 1 nm Nanogaps for Detection of SARS-CoV-2 Using SERS-Based Immunoassay","volume":"24","author":"Lee","year":"2024","journal-title":"Nano Lett."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.biomaterials.2014.12.049","article-title":"Nanogrooved substrate promotes direct lineage reprogramming of fibroblasts to functional induced dopaminergic neurons","volume":"45","author":"Yoo","year":"2015","journal-title":"Biomaterials"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2105346","DOI":"10.1002\/adfm.202105346","article-title":"Electromagnetized Graphene Facilitates Direct Lineage Reprogramming into Dopaminergic Neurons","volume":"31","author":"Chang","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"16744","DOI":"10.1021\/acsnano.5c01457","article-title":"Electromagnetized MXenes Enhance the Efficient Direct Reprogramming of Dopamine Neurons for Parkinson\u2019s Disease Therapy","volume":"19","author":"Kim","year":"2025","journal-title":"ACS Nano"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"5577","DOI":"10.1021\/acsnano.1c10344","article-title":"Predictive biophysical cue mapping for direct cell reprogramming using combinatorial nanoarrays","volume":"16","author":"Yang","year":"2022","journal-title":"ACS Nano"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"7365","DOI":"10.1002\/adma.201601900","article-title":"Triboelectric Nanogenerator Accelerates Highly Efficient Nonviral Direct Conversion and In Vivo Reprogramming of Fibroblasts to Functional Neuronal Cells","volume":"28","author":"Jin","year":"2016","journal-title":"Adv. Mater."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"13730","DOI":"10.1039\/C6NR04400J","article-title":"Directing lineage specification of human mesenchymal stem cells by decoupling electrical stimulation and physical patterning on unmodified graphene","volume":"8","author":"Balikov","year":"2016","journal-title":"Nanoscale"},{"key":"ref_67","first-page":"29","article-title":"Novel Gene Therapies Technology for Spinal Cord Injury (SCI) Therapy: Efficient Direct Lineage Reprogramming","volume":"3","author":"Kim","year":"2022","journal-title":"J. Clin. Pharmacol. Ther."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"121157","DOI":"10.1016\/j.biomaterials.2021.121157","article-title":"Electromagnetized gold nanoparticles improve neurogenesis and cognition in the aged brain","volume":"278","author":"Chang","year":"2021","journal-title":"Biomaterials"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1021\/acsnano.0c08727","article-title":"Immunomodulatory Layered Double Hydroxide Nanoparticles Enable Neurogenesis by Targeting Transforming Growth Factor-beta Receptor 2","volume":"15","author":"Zhu","year":"2021","journal-title":"ACS Nano"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12951-023-01853-y","article-title":"Combination therapy with ultrasound and 2D nanomaterials promotes recovery after spinal cord injury via Piezo1 downregulation","volume":"21","author":"Zhang","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"122873","DOI":"10.1016\/j.biomaterials.2024.122873","article-title":"LDH nanoparticles-doped cellulose nanofiber scaffolds with aligned microchannels direct high-efficiency neural regeneration and organized neural circuit remodeling through RhoA\/Rock\/Myosin II pathway","volume":"314","author":"Pang","year":"2025","journal-title":"Biomaterials"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1186\/s12951-024-02587-1","article-title":"Microfluidics-enabled mesenchymal stem cell derived Neuron like cell membrane coated nanoparticles inhibit inflammation and apoptosis for Parkinson\u2019s Disease","volume":"22","author":"Lei","year":"2024","journal-title":"J. Nanobiotechnol."}],"container-title":["Biosensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6374\/16\/5\/239\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T04:12:00Z","timestamp":1777176720000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6374\/16\/5\/239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,24]]},"references-count":72,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["bios16050239"],"URL":"https:\/\/doi.org\/10.3390\/bios16050239","relation":{},"ISSN":["2079-6374"],"issn-type":[{"value":"2079-6374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,24]]}}}