{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:23:10Z","timestamp":1785435790446,"version":"3.56.0"},"reference-count":60,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Science, Technology and Innovation","award":["DSTI-TIA Nano Technology Platform"],"award-info":[{"award-number":["DSTI-TIA Nano Technology Platform"]}]},{"award":["DSTI-TIA Nano Technology Platform"],"award-info":[{"award-number":["DSTI-TIA Nano Technology Platform"]}],"id":[{"id":"https:\/\/ror.org\/048kh7197","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"crossref","award":["NRF-CPRR"],"award-info":[{"award-number":["NRF-CPRR"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001333","name":"Rhodes University","doi-asserted-by":"crossref","award":["RRG"],"award-info":[{"award-number":["RRG"]}],"id":[{"id":"10.13039\/501100001333","id-type":"DOI","asserted-by":"crossref"}]},{"award":["RRG"],"award-info":[{"award-number":["RRG"]}],"id":[{"id":"https:\/\/ror.org\/016sewp10","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Ascorbic acid (AA) or vitamin C is an important biomolecule that plays a crucial role in biological and physiological systems. Deficiency and\/or excess of AA in the body can lead to severe diseases such as scurvy and gastrointestinal complications. Therefore, it is crucial to monitor the levels of AA in the body and supplements. Polyvinylpyrrolidone nickel oxide nanoparticles (PVP-NiONPs) are prepared and evaluated for their potential as nanozymes with peroxidase-like activity. o-Phenylenediamine (OPD) was used as a chromogen in the presence of hydrogen peroxide. The oxidized OPD was produced by ROS from PVP-NiONPs and H2O2. This was monitored using UV-vis spectra and by colour changes using the naked eye. AA reduced the oxidized OPD during its sensing. The UV-vis signal was linear for AA concentrations ranging from 40 \u00b5M to 400 \u03bcM. The limit of detection (LOD) for AA was calculated to be 0.11 \u03bcM using 3\u03c3 and the limit of quantification (LOQ) was 0.36 \u03bcM using 10\u03c3 indicating a very high sensitivity. The colorimetric sensor showed good reproducibility and a recovery rate between 92.3% and 102.6%, indicating high accuracy and reliability. The findings of this work confirmed that PVP-NiONPs possess enzyme-like activity and are a promising alternative for the quantitative, on-site detection of ascorbic acid.<\/jats:p>","DOI":"10.3390\/bios16050299","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:02:27Z","timestamp":1779375747000},"page":"299","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Catalytic Reduction of H2O2 by Polyvinylpyrrolidone Nickel Oxide Nanozymatic Activity and Colorimetric Sensing of Ascorbic Acid"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7227-7872","authenticated-orcid":false,"given":"Mosebudi","family":"Rambevha","sequence":"first","affiliation":[{"name":"Institute for Nanotechnology Innovation, Rhodes University, P.O. Box 94, Makhanda 6140, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1538-6087","authenticated-orcid":false,"given":"Ridge","family":"Chavalala","sequence":"additional","affiliation":[{"name":"Institute for Nanotechnology Innovation, Rhodes University, P.O. Box 94, Makhanda 6140, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4815-6146","authenticated-orcid":false,"given":"Philani","family":"Mashazi","sequence":"additional","affiliation":[{"name":"Institute for Nanotechnology Innovation, Rhodes University, P.O. Box 94, Makhanda 6140, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kurkut, A., and Gelen, V. (2024). Antioxidant roles\/functions of ascorbic acid (Vitamin C). 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