{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:01:25Z","timestamp":1785427285225,"version":"3.56.0"},"reference-count":30,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2022ZD0208600"],"award-info":[{"award-number":["2022ZD0208600"]}]},{"name":"National Key Research and Development Program of China","award":["2022ZD0208602"],"award-info":[{"award-number":["2022ZD0208602"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["62466015"],"award-info":[{"award-number":["62466015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"award":["62466015"],"award-info":[{"award-number":["62466015"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Key Research and Development Program of Hainan Province","award":["ZDYF2025SHFZ023"],"award-info":[{"award-number":["ZDYF2025SHFZ023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>High-channel-count neural recording requires wireless links with high throughput, low power, and compact implementation, yet commercial protocols and phase-locked loop (PLL)-based transmitters often trade data rate against power and complexity. We present a low-power, PLL-less wideband on\u2013off keying (OOK) neural-signal transmitter fabricated in a 180 nm CMOS process. The transmitter employs a free-running inductor\u2013capacitor voltage-controlled oscillator (LC-VCO), a Gilbert mixer for OOK modulation and reverse isolation, and a current-reuse stacked power amplifier. It consumes 8 mA from a 3.3 V supply (26.4 mW), demonstrates modulation and receiver frame acquisition at a maximum raw input rate of 90 Mbps, corresponding to a 180 Mbps Manchester-coded line rate, and tunes from 3.266 to 3.445 GHz. End-to-end bit error rate (BER) was measured at raw rates of 15 and 31.2 Mbps, corresponding to encoded rates of 30 and 62.4 Mbps; the latter matches the in vivo data stream. The transmitter was integrated with a 128-channel recording chip and evaluated in freely moving adult C57 mice. Wireless hippocampal spike and local field potential (LFP) recordings, wired-system comparison, and event-locked LFP analysis support its feasibility for untethered neural recording.<\/jats:p>","DOI":"10.3390\/bios16080405","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T08:15:56Z","timestamp":1785140156000},"page":"405","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Low-Power PLL-Less Wideband OOK Wireless Neural-Signal Transmitter for Miniaturized Neural Interfaces with In Vivo Validation in Freely Moving Mice"],"prefix":"10.3390","volume":"16","author":[{"given":"Guijun","family":"Shu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou 570100, China"},{"name":"Key Laboratory of Biomedical Engineering of Hainan Province, One Health Institute, Hainan University, Haikou 570100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangning","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou 570100, China"},{"name":"Key Laboratory of Biomedical Engineering of Hainan Province, One Health Institute, Hainan University, Haikou 570100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou 570100, China"},{"name":"Key Laboratory of Biomedical Engineering of Hainan Province, One Health Institute, Hainan University, Haikou 570100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Jia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou 570100, China"},{"name":"Key Laboratory of Biomedical Engineering of Hainan Province, One Health Institute, Hainan University, Haikou 570100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5546-5647","authenticated-orcid":false,"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou 570100, China"},{"name":"Key Laboratory of Biomedical Engineering of Hainan Province, One Health Institute, Hainan University, Haikou 570100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou 570100, China"},{"name":"Key Laboratory of Biomedical Engineering of Hainan Province, One Health Institute, Hainan University, Haikou 570100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Rosenthal, J., Pike, A., and Reynolds, M.S. 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