{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:29:09Z","timestamp":1787632149640,"version":"build-2736575974"},"reference-count":42,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Jilin Provincial Department of Science and Technology","award":["20250102239JC"],"award-info":[{"award-number":["20250102239JC"]}]},{"name":"the 2025 Industry-Academia Collaboration Project","award":["25JBH005L033"],"award-info":[{"award-number":["25JBH005L033"]}]},{"name":"the Changchun University Institutional Research","award":["25JBE005L010"],"award-info":[{"award-number":["25JBE005L010"]}]},{"award":["25JBE005L010"],"award-info":[{"award-number":["25JBE005L010"]}],"id":[{"id":"https:\/\/ror.org\/02an57k10","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Multimodal medical image fusion combines anatomical and functional information from different imaging modalities. However, existing methods often struggle to preserve fine anatomical structures while incorporating complementary functional information. To address this problem, we propose TAPGFusion, an anatomy-aware multimodal medical image fusion network. It employs a Multi-Scale Encoder to capture fine local details and broad anatomical structures through parallel convolutions with different receptive fields. A Detail-Enhanced Attention Block further refines the extracted features through channel, spatial, and pixel attention. In addition, a Physiological Prior-Guided Attention Block dynamically balances anatomical and functional features using MRI-conditioned prior information and edge constraints. The main contribution of TAPGFusion is a unified framework that jointly addresses multi-scale feature representation, fine-grained feature selection, and spatially adaptive anatomical\u2013functional fusion. Extensive experiments on three public medical imaging datasets demonstrate the effectiveness and robustness of the proposed method. TAPGFusion achieves CC values above 0.83 and SSIM values above 0.78 on the CT\u2013MRI, PET\u2013MRI, and SPECT\u2013MRI fusion tasks. These results indicate that the proposed method effectively preserves anatomical structures while integrating complementary functional information.<\/jats:p>","DOI":"10.3390\/bios16090458","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:07:53Z","timestamp":1787566073000},"page":"458","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["TAPGFusion: Anatomy-Aware Triple-Attention and MRI-Conditioned Prior Learning for Multimodal Medical Image Fusion"],"prefix":"10.3390","volume":"16","author":[{"given":"Liu","family":"Wang","sequence":"first","affiliation":[{"name":"School of Computer Science and Technology, Changchun University, 6543 Weixing Road, Changchun 130022, China"},{"name":"Jilin Provincial Key Laboratory of Human Health Status Identification Function & Enhancement, 6543 Weixing Road, Changchun 130022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2459-357X","authenticated-orcid":false,"given":"Yang","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Computer Science and Technology, Changchun University, 6543 Weixing Road, Changchun 130022, China"},{"name":"Jilin Provincial Key Laboratory of Human Health Status Identification Function & Enhancement, 6543 Weixing Road, Changchun 130022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjia","family":"Li","sequence":"additional","affiliation":[{"name":"School of Computer Science and Technology, Changchun University, 6543 Weixing Road, Changchun 130022, China"},{"name":"Jilin Provincial Key Laboratory of Human Health Status Identification Function & Enhancement, 6543 Weixing Road, Changchun 130022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3265-6461","authenticated-orcid":false,"given":"Jian","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Computer Science and Technology, Changchun University, 6543 Weixing Road, Changchun 130022, China"},{"name":"Jilin Provincial Key Laboratory of Human Health Status Identification Function & Enhancement, 6543 Weixing Road, Changchun 130022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Gu, X., Xia, Y., and Zhang, J. 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