{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:17:05Z","timestamp":1788236225064,"version":"build-2803163510"},"reference-count":125,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PNU\u2019s Tenure-track Faculty"},{"id":[{"id":"https:\/\/ror.org\/01an57a31","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Cancer continues to pose a major global burden because of the high incidence and mortality, underscoring the urgent need for innovative and highly sensitive diagnostic technologies. Conducting polymer\u2013nanomaterial (CP\u2013NM) hybrid biosensors have become promising platforms for cancer biomarker detection, integrating the redox-active and biocompatible nature of conducting polymers such as polyaniline (PANI), polypyrrole (PPy), and poly(3,4-ethylenedioxythiophene) (PEDOT) with the high surface area and charge transport properties of nanomaterials, including metallic nanoparticles, metal oxides, carbon-based nanostructures, and two-dimensional materials. The synergistic interfaces in these hybrids enable efficient electron transfer, signal amplification, and stable biomolecular immobilization, facilitating ultrasensitive and multiplexed detection of proteins, nucleic acids, and metabolites associated with tumor progression. This review highlights recent advances in CP\u2013NM hybrid biosensors for cancer diagnostics, focusing on material design strategies, sensing mechanisms, and representative applications across electrochemical, optical, and mechanical modalities. Finally, key challenges and future perspectives are discussed, emphasizing the potential of CP\u2013NM hybrid platforms to drive next-generation approaches for early cancer detection, therapeutic monitoring, and personalized healthcare.<\/jats:p>","DOI":"10.3390\/bios16090479","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:19:26Z","timestamp":1788232766000},"page":"479","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Conducting Polymer\u2013Nanomaterial Hybrids for Cancer Diagnostics"],"prefix":"10.3390","volume":"16","author":[{"given":"Mingyu","family":"Bae","sequence":"first","affiliation":[{"name":"Department of Information Convergence Engineering, Pusan National University, Yangsan 50612, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5877-0222","authenticated-orcid":false,"given":"Jin-Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Information Convergence Engineering, Pusan National University, Yangsan 50612, Republic of Korea"},{"name":"School of Biomedical Convergence Engineering, Pusan National University, 49 Busandaehak-ro, Yangsan 50612, Republic of Korea"},{"name":"Research Institute of Convergence of Biomedical Science and Technology, Pusan National University of Yangsan Hospital, Yangsan 50612, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/s41571-021-00514-z","article-title":"Planning for tomorrow: Global cancer incidence and the role of prevention 2020\u20132070","volume":"18","author":"Soerjomataram","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Mills, S., Donnan, P., Buchanan, D., and Smith, B.H. (2023). Age and cancer type: Associations with increased odds of receiving a late diagnosis in people with advanced cancer. BMC Cancer, 23.","DOI":"10.1186\/s12885-023-11652-1"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1002\/cncr.32887","article-title":"Breast cancer early detection: A phased approach to implementation","volume":"126","author":"Ginsburg","year":"2020","journal-title":"Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/nature22079","article-title":"T-cell invigoration to tumour burden ratio associated with anti-PD-1 response","volume":"545","author":"Huang","year":"2017","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"eaay9040","DOI":"10.1126\/science.aay9040","article-title":"Early detection of cancer","volume":"375","author":"Crosby","year":"2022","journal-title":"Science"},{"key":"ref_7","first-page":"409","article-title":"Cancer treatment and survivorship statistics, 2022","volume":"72","author":"Miller","year":"2022","journal-title":"CA Cancer J. Clin."},{"key":"ref_8","first-page":"e1764","article-title":"Technological advancements in cancer diagnostics: Improvements and limitations","volume":"6","author":"Pulumati","year":"2023","journal-title":"Cancer Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"111416","DOI":"10.1016\/j.bios.2019.111416","article-title":"Recent advances in biosensor for detection of lung cancer biomarkers","volume":"141","author":"Yang","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.bios.2016.08.028","article-title":"Biosensors for breast cancer diagnosis: A review of bioreceptors, biotransducers and signal amplification strategies","volume":"88","author":"Mittal","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrclinonc.2017.166","article-title":"Tumour heterogeneity and resistance to cancer therapies","volume":"15","author":"Shaw","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"192","DOI":"10.5230\/jgc.2025.25.e3","article-title":"Spatial and Temporal Tumor Heterogeneity in Gastric Cancer: Discordance of Predictive Biomarkers","volume":"25","author":"Lee","year":"2024","journal-title":"J. Gastric Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12967-023-03960-8","article-title":"Liquid biopsies: The future of cancer early detection","volume":"21","author":"Connal","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12943-022-01505-z","article-title":"Liquid biopsy in lung cancer: Significance in diagnostics, prediction, and treatment monitoring","volume":"21","author":"Li","year":"2022","journal-title":"Mol. Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.7150\/thno.40677","article-title":"Refining Cancer Management Using Integrated Liquid Biopsy","volume":"10","author":"Qiu","year":"2020","journal-title":"Theranostics"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s40364-024-00697-4","article-title":"Microfluidic biosensors for biomarker detection in body fluids: A key approach for early cancer diagnosis","volume":"12","author":"Liu","year":"2024","journal-title":"Biomark. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"5691","DOI":"10.1021\/acs.iecr.2c04097","article-title":"Recent Advances and Emerging Trends in Cancer Biomarker Detection Technologies","volume":"62","author":"Kumar","year":"2023","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1038\/s41416-022-01881-9","article-title":"Blood-based liquid biopsies for prostate cancer: Clinical opportunities and challenges","volume":"127","author":"Trujillo","year":"2022","journal-title":"Br. J. Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1158\/2159-8290.CD-20-1311","article-title":"Liquid Biopsy: From Discovery to Clinical Application","volume":"11","author":"Pantel","year":"2021","journal-title":"Cancer Discov."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1021\/cbmi.5c00043","article-title":"Recent Progress in Small Molecule-Based Chemiluminescent Probes for Reactive Oxygen and Nitrogen Species","volume":"3","author":"Cao","year":"2025","journal-title":"Chem. Biomed. Imaging"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e2004433","DOI":"10.1002\/advs.202004433","article-title":"Cytokines: From Clinical Significance to Quantification","volume":"8","author":"Liu","year":"2021","journal-title":"Adv. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1158\/1055-9965.EPI-14-0064","article-title":"A review of the application of inflammatory biomarkers in epidemiologic cancer research","volume":"23","author":"Brenner","year":"2014","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12943-022-01543-7","article-title":"Liquid biopsy: A step closer to transform diagnosis, prognosis and future of cancer treatments","volume":"21","author":"Lone","year":"2022","journal-title":"Mol. Cancer"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/s41392-024-02021-w","article-title":"Liquid biopsy in cancer current: Status, challenges and future prospects","volume":"9","author":"Ma","year":"2024","journal-title":"Signal Transduct. Target Ther."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Le, C.V., and Yoon, H. (2024). Advances in the Use of Conducting Polymers for Healthcare Monitoring. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25031564"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1039\/C5TB00090D","article-title":"Rational design and applications of conducting polymer hydrogels as electrochemical biosensors","volume":"3","author":"Li","year":"2015","journal-title":"J. Mater. Chem. B"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1039\/D3MH00056G","article-title":"Conductive polymer based hydrogels and their application in wearable sensors: A review","volume":"10","author":"Liu","year":"2023","journal-title":"Mater. Horiz."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1021\/acs.chemmater.1c04196","article-title":"Naphthobispyrazine bisimide: A strong acceptor unit for conjugated polymers enabling highly coplanar backbone, short \u03c0\u2013\u03c0 stacking, and high electron transport","volume":"34","author":"Mikie","year":"2022","journal-title":"Chem. Mater."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Ramanavicius, S., and Ramanavicius, A. (2020). Conducting Polymers in the Design of Biosensors and Biofuel Cells. Polymers, 13.","DOI":"10.3390\/polym13010049"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1038\/ncomms4002","article-title":"An ultra-sensitive resistive pressure sensor based on hollow-sphere microstructure induced elasticity in conducting polymer film","volume":"5","author":"Pan","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.tsf.2018.04.022","article-title":"Influence of galvanostatic electrodeposition parameters on the structure-property relationships of polyaniline thin films and their use as potentiometric and optical pH sensors","volume":"656","author":"Mello","year":"2018","journal-title":"Thin Solid Films"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1039\/C6CS00555A","article-title":"Polyaniline nanofibers: Broadening applications for conducting polymers","volume":"46","author":"Baker","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4954","DOI":"10.1002\/adma.201400753","article-title":"High performance conducting polymer nanofiber biosensors for detection of biomolecules","volume":"26","author":"Yang","year":"2014","journal-title":"Adv. Mater."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/s41563-023-01569-2","article-title":"3D printable high-performance conducting polymer hydrogel for all-hydrogel bioelectronic interfaces","volume":"22","author":"Zhou","year":"2023","journal-title":"Nat. Mater."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"6232","DOI":"10.1039\/C9SC02033K","article-title":"Doping engineering of conductive polymer hydrogels and their application in advanced sensor technologies","volume":"10","author":"Ma","year":"2019","journal-title":"Chem. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e2007318","DOI":"10.1002\/adma.202007318","article-title":"Nanoarchitectured Porous Conducting Polymers: From Controlled Synthesis to Advanced Applications","volume":"33","author":"Luo","year":"2021","journal-title":"Adv. Mater."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"10088","DOI":"10.1021\/jacs.6b05552","article-title":"Nanostructuration of PEDOT in Porous Coordination Polymers for Tunable Porosity and Conductivity","volume":"138","author":"Boudot","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"130674","DOI":"10.1016\/j.snb.2021.130674","article-title":"A conducting polymer PEDOT: PSS hydrogel based wearable sensor for accurate uric acid detection in human sweat","volume":"348","author":"Xu","year":"2021","journal-title":"Sens. Actuators B Chem."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Zhao, Z., Mi, Y., Lu, Y., Zhu, Q., Cao, X., and Wang, N. (2023). From Biochemical Sensor to Wearable Device: The Key Role of the Conductive Polymer in the Triboelectric Nanogenerator. Biosensors, 13.","DOI":"10.3390\/bios13060604"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"5659","DOI":"10.1039\/D0RA07800J","article-title":"Conducting polymers: A comprehensive review on recent advances in synthesis, properties and applications","volume":"11","author":"Namsheer","year":"2021","journal-title":"RSC Adv."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"6766","DOI":"10.1021\/acs.chemrev.6b00275","article-title":"Conductive Polymers: Opportunities and Challenges in Biomedical Applications","volume":"118","author":"Nezakati","year":"2018","journal-title":"Chem. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Park, Y., Jung, J., and Chang, M. (2019). Research progress on conducting polymer-based biomedical applications. Appl. Sci., 9.","DOI":"10.3390\/app9061070"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1021\/acs.accounts.7b00191","article-title":"Multifunctional Nanostructured Conductive Polymer Gels: Synthesis, Properties, and Applications","volume":"50","author":"Zhao","year":"2017","journal-title":"Acc. Chem. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"10193","DOI":"10.1039\/D1TC02240G","article-title":"High performance 2D MXene based conducting polymer hybrids: Synthesis to emerging applications","volume":"9","author":"Faruk","year":"2021","journal-title":"J. Mater. Chem. C"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"27493","DOI":"10.1039\/D5RA04634C","article-title":"Design, structure, and application of conductive polymer hybrid materials: A comprehensive review of classification, fabrication, and multifunctionality","volume":"15","author":"Aljabali","year":"2025","journal-title":"RSC Adv."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e202300819","DOI":"10.1002\/slct.202300819","article-title":"Recent Advances in Biosensors Based on Conducting Polymers for Biomedical Applications","volume":"8","author":"Acar","year":"2023","journal-title":"ChemistrySelect"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Park, C.S., Lee, C., and Kwon, O.S. (2016). Conducting Polymer Based Nanobiosensors. Polymers, 8.","DOI":"10.3390\/polym8070249"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Pan, Y., Zhang, J., Guo, X., Li, Y., Li, L., and Pan, L. (2024). Recent Advances in Conductive Polymers-Based Electrochemical Sensors for Biomedical and Environmental Applications. Polymers, 16.","DOI":"10.3390\/polym16111597"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1016\/j.bios.2010.10.017","article-title":"Recent advances in polyaniline based biosensors","volume":"26","author":"Dhand","year":"2011","journal-title":"Biosens. Bioelectron."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"8594","DOI":"10.1039\/D0RA00016G","article-title":"Flexible potentiometric pH sensors for wearable systems","volume":"10","author":"Manjakkal","year":"2020","journal-title":"RSC Adv."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5300","DOI":"10.1007\/s10853-025-10759-z","article-title":"Highly porous polyaniline (PANI): A novel green catalytic method for morphology control","volume":"60","author":"Galloni","year":"2025","journal-title":"J. Mater. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Beygisangchin, M., Abdul Rashid, S., Shafie, S., Sadrolhosseini, A.R., and Lim, H.N. (2021). Preparations, Properties, and Applications of Polyaniline and Polyaniline Thin Films-A Review. Polymers, 13.","DOI":"10.3390\/polym13122003"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/s41598-025-29897-0","article-title":"Role of rGO in improving the mechanical and thermal performance of PANI\/graphene nanocomposites","volume":"16","author":"Mustafa","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.trac.2017.10.009","article-title":"Polypyrrole based next generation electrochemical sensors and biosensors: A review","volume":"97","author":"Jain","year":"2017","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Dzulkurnain, N.A., Mokhtar, M., Rashid, J.I.A., Knight, V.F., Wan Yunus, W.M.Z., Ong, K.K., Mohd Kasim, N.A., and Mohd Noor, S.A. (2021). A Review on Impedimetric and Voltammetric Analysis Based on Polypyrrole Conducting Polymers for Electrochemical Sensing Applications. Polymers, 13.","DOI":"10.3390\/polym13162728"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.colsurfa.2012.10.052","article-title":"Electrochemical stability and repulsion of polypyrrole film","volume":"418","author":"Ratautaite","year":"2013","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_58","first-page":"49","article-title":"Pushing the Electrochemical Performance Limits of Polypyrrole Toward Stable Microelectronic Devices","volume":"15","author":"Tahir","year":"2023","journal-title":"Nanomicro Lett."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1021\/acsami.1c21591","article-title":"Conductivity and Stability Enhancement of PEDOT:PSS Electrodes via Facile Doping of Sodium 3-Methylsalicylate for Highly Efficient Flexible Organic Light-Emitting Diodes","volume":"14","author":"Liu","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"10493","DOI":"10.1039\/C6TA03537J","article-title":"High-performance free-standing PEDOT:PSS electrodes for flexible and transparent all-solid-state supercapacitors","volume":"4","author":"Cheng","year":"2016","journal-title":"J. Mater. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"02004","DOI":"10.11605\/j.pnrs.201802004","article-title":"A Review on Tailoring PEDOT:PSS Layer for Improved Performance of Perovskite Solar Cells","volume":"2","author":"Reza","year":"2018","journal-title":"Proc. Nat. Res. Soc."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Hu, L., Song, J., Yin, X., Su, Z., and Li, Z. (2020). Research Progress on Polymer Solar Cells Based on PEDOT:PSS Electrodes. Polymers, 12.","DOI":"10.3390\/polym12010145"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1900813","DOI":"10.1002\/advs.201900813","article-title":"PEDOT:PSS for Flexible and Stretchable Electronics: Modifications, Strategies, and Applications","volume":"6","author":"Fan","year":"2019","journal-title":"Adv. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4811","DOI":"10.1039\/C9TB01028A","article-title":"PEDOT:PSS interfaces stabilised using a PEGylated crosslinker yield improved conductivity and biocompatibility","volume":"7","author":"Solazzo","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1039\/D3TB00014A","article-title":"PEDOT:PSS hydrogels with high conductivity and biocompatibility for in situ cell sensing","volume":"11","author":"Yang","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1039\/c0cs00103a","article-title":"Electronic conduction in polymers, carbon nanotubes and graphene","volume":"40","author":"Kaiser","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1800561","DOI":"10.1002\/macp.201800561","article-title":"Progress in the Development of Intrinsically Conducting Polymer Composites as Biosensors","volume":"220","author":"Prajapati","year":"2019","journal-title":"Macromol. Chem. Phys."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Rahman, S.U., Bilal, S., and Ul Haq Ali Shah, A. (2020). Synthesis and Characterization of Polyaniline-Chitosan Patches with Enhanced Stability in Physiological Conditions. Polymers, 12.","DOI":"10.3390\/polym12122870"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2201860","DOI":"10.1002\/admt.202201860","article-title":"Nanomaterials-Based Biosensors for the Detection of Prostate Cancer Biomarkers: Recent Trends and Future Perspective","volume":"8","author":"Singh","year":"2023","journal-title":"Adv. Mater. Technol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/med.21931","article-title":"Nanotechnology-based electrochemical biosensors for monitoring breast cancer biomarkers","volume":"43","author":"Nasrollahpour","year":"2023","journal-title":"Med. Res. Rev."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.compositesb.2018.05.015","article-title":"Plasmonic polyaniline\/gold nanorods hybrid composites for selective NIR photodetection: Synthesis and characterization","volume":"149","author":"Abdelrasoul","year":"2018","journal-title":"Compos. Part B Eng."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1021\/cm990537f","article-title":"Conducting polymer nanocomposites: A brief overview","volume":"12","author":"Gangopadhyay","year":"2000","journal-title":"Chem. Mater."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cej.2014.07.078","article-title":"Facile fabrication of polyaniline nanotubes\/gold hybrid nanostructures as substrate materials for biosensors","volume":"258","author":"Bao","year":"2014","journal-title":"Chem. Eng. J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.microc.2019.02.061","article-title":"Role of conducting polymer and metal oxide-based hybrids for applications in ampereometric sensors and biosensors","volume":"147","author":"Dakshayini","year":"2019","journal-title":"Microchem. J."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1021\/acs.chemrev.3c00392","article-title":"Electrochemical and Electrical Biosensors for Wearable and Implantable Electronics Based on Conducting Polymers and Carbon-Based Materials","volume":"124","author":"Zhang","year":"2024","journal-title":"Chem. Rev."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.nantod.2012.12.005","article-title":"Hybridized conducting polymer chemiresistive nano-sensors","volume":"8","author":"Hangarter","year":"2013","journal-title":"Nano Today"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s40089-018-0238-2","article-title":"Recent progress in nanocomposites based on conducting polymer: Application as electrochemical sensors","volume":"8","author":"Majid","year":"2018","journal-title":"Int. Nano Lett."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"6794","DOI":"10.1021\/acs.inorgchem.3c00534","article-title":"Boosted Charge Transfer via Coordinate Bond Construction in Porphyrin Metal-Organic Framework\/ZnIn2S4 Core-Shell Heterostructures","volume":"62","author":"Hu","year":"2023","journal-title":"Inorg. Chem."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Rivero, P.J., Goicoechea, J., and Arregui, F.J. (2019). Layer-by-Layer Nano-assembly: A Powerful Tool for Optical Fiber Sensing Applications. Sensors, 19.","DOI":"10.3390\/s19030683"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"40133","DOI":"10.1021\/acsami.0c12074","article-title":"Platinum Nanozyme-Triggered Pressure-Based Immunoassay Using a Three-Dimensional Polypyrrole Foam-Based Flexible Pressure Sensor","volume":"12","author":"Yu","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"105780","DOI":"10.1016\/j.microc.2020.105780","article-title":"An ultrasensitive biosensor based on three-dimensional nanoporous conducting polymer decorated with gold nanoparticles for microRNA detection","volume":"161","author":"Ma","year":"2021","journal-title":"Microchem. J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e2405099","DOI":"10.1002\/advs.202405099","article-title":"Recent Advances in Transparent Electrodes and Their Multimodal Sensing Applications","volume":"11","author":"Althumayri","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1074\/mcp.R200007-MCP200","article-title":"The human plasma proteome: History, character, and diagnostic prospects","volume":"1","author":"Anderson","year":"2002","journal-title":"Mol. Cell. Proteom."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s40824-023-00388-5","article-title":"Molecularly imprinted polymers (MIPs): Emerging biomaterials for cancer theragnostic applications","volume":"27","author":"Kang","year":"2023","journal-title":"Biomater. Res."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Das, S., Dey, M.K., Devireddy, R., and Gartia, M.R. (2024). Biomarkers in Cancer Detection, Diagnosis, and Prognosis. Sensors, 24.","DOI":"10.3390\/s24010037"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.aca.2020.07.010","article-title":"RF plasma-enhanced conducting Polymer\/W5O14 based self-propelled micromotors for miRNA detection","volume":"1138","author":"Cogal","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"119008","DOI":"10.1016\/j.jelechem.2025.119008","article-title":"Sensitive detection of \u03b1-Fetoprotein using an electrochemiluminescence sensor combining molecular imprinting and aptamer recognition on a graphite carbon nitride\/polypyrrole platform","volume":"981","author":"Wang","year":"2025","journal-title":"J. Electroanal. Chem."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Feng, F., Tian, Y., Xu, G., Liu, Z., Liu, S., Zheng, G., Guo, M., Lian, X., Fan, D., and Zhang, H. (2017). Diagnostic and prognostic value of CEA, CA19-9, AFP and CA125 for early gastric cancer. BMC Cancer, 17.","DOI":"10.1186\/s12885-017-3738-y"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"8789","DOI":"10.2147\/OTT.S221335","article-title":"Prognostic Values of Preoperative Serum CEA and CA125 Levels and Nomograms for Young Breast Cancer Patients","volume":"12","author":"Li","year":"2019","journal-title":"OncoTargets Ther."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1016\/S0140-6736(16)32417-5","article-title":"HER2-positive breast cancer","volume":"389","author":"Loibl","year":"2017","journal-title":"Lancet"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"21792","DOI":"10.1038\/s41598-023-48838-3","article-title":"Ag nanorod@PEI-Ag nanohybrid as an excellent signal label for sensitive and rapid detection of serum HER2","volume":"13","author":"Hakimian","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"9945","DOI":"10.1021\/acsanm.1c02677","article-title":"Electrodes Based on PEDOT Nanotubes Decorated with Gold Nanoparticles for Biosensing and Energy Storage","volume":"4","author":"Soares","year":"2021","journal-title":"ACS Appl. Nano Mater."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"116388","DOI":"10.1016\/j.bios.2024.116388","article-title":"Exploring various carbon nanomaterials-based electrodes modified with polymelamine for the reagentless electrochemical immunosensing of Claudin18.2","volume":"259","author":"Kanagavalli","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trac.2018.08.017","article-title":"Current advancement on diagnosis of ovarian cancer using biosensing of CA 125 biomarker: Analytical approaches","volume":"108","author":"Razmi","year":"2018","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.procbio.2023.02.004","article-title":"An electrochemical aptasensor based on g-C3N4\/Fe3O4\/PANI nanocomposite applying cancer antigen_125 biomarkers detection","volume":"127","author":"Foroozandeh","year":"2023","journal-title":"Process Biochem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1039\/D0AY01225D","article-title":"A magneto-controlled microfluidic device for voltammetric immunoassay of carbohydrate antigen-125 with silver-polypyrrole nanotags","volume":"12","author":"Huang","year":"2020","journal-title":"Anal. Methods"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.aca.2019.07.050","article-title":"Molecularly imprinted polymer SPE sensor for analysis of CA-125 on serum","volume":"1082","author":"Rebelo","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"138480","DOI":"10.1016\/j.snb.2025.138480","article-title":"Engineering a multifunctional hybrid polymer-hydrogel nanocomposite for high-sensitivity, anti-fouling electrochemical immunodetection in early cancer diagnosis","volume":"444","author":"Santiago","year":"2025","journal-title":"Sens. Actuators B Chem."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00604-021-04859-1","article-title":"Free-standing electrochemical biosensor for carcinoembryonic antigen detection based on highly stable and flexible conducting polypyrrole nanocomposite","volume":"188","author":"Song","year":"2021","journal-title":"Mikrochim. Acta"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Bouras, E., Karhunen, V., Gill, D., Huang, J., Haycock, P.C., Gunter, M.J., Johansson, M., Brennan, P., Key, T., and Lewis, S.J. (2022). Circulating inflammatory cytokines and risk of five cancers: A Mendelian randomization analysis. BMC Med., 20.","DOI":"10.1186\/s12916-021-02193-0"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"6914","DOI":"10.1039\/C9AN01450K","article-title":"Single droplet detection of immune checkpoints on a multiplexed electrohydrodynamic biosensor","volume":"144","author":"Wuethrich","year":"2019","journal-title":"Analyst"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40364-020-00228-x","article-title":"Roles of IFN-gamma in tumor progression and regression: A review","volume":"8","author":"Jorgovanovic","year":"2020","journal-title":"Biomark. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"134739","DOI":"10.1016\/j.snb.2023.134739","article-title":"Ultrasensitive interferon-gamma sensor with a bifunctionalized conducting polymer nanobioconjugate for therapy-progress monitoring of cancer patients","volume":"398","author":"Saputra","year":"2024","journal-title":"Sens. Actuators B Chem."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Rahman, M.A., Pal, R.K., Islam, N., Freeman, R., Berthiaume, F., Mazzeo, A., and Ashraf, A. (2023). A Facile Graphene Conductive Polymer Paper Based Biosensor for Dopamine, TNF-alpha, and IL-6 Detection. Sensors, 23.","DOI":"10.3390\/s23198115"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00109-007-0214-1","article-title":"Molecular determinants of immunogenic cell death: Surface exposure of calreticulin makes the difference","volume":"85","author":"Chaput","year":"2007","journal-title":"J. Mol. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"3773","DOI":"10.1021\/acsbiomaterials.2c00499","article-title":"Impedimetric Detection of Calreticulin by a Disposable Immunosensor Modified with a Single-Walled Carbon Nanotube-Conducting Polymer Nanocomposite","volume":"8","author":"Aydin","year":"2022","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"115733","DOI":"10.1016\/j.bios.2023.115733","article-title":"A nanobody based ultrasensitive electrochemical biosensor for the detection of soluble CTLA-4 -A candidate biomarker for cancer development and progression","volume":"242","author":"Pandey","year":"2023","journal-title":"Biosens. Bioelectron."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nrc3066","article-title":"Cell-free nucleic acids as biomarkers in cancer patients","volume":"11","author":"Schwarzenbach","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Kim, N., Bae, M., Cho, E., Kim, K.S., and Lee, J.H. (2025). Plasmonic Biosensors in Cancer-Associated miRNA Detection. Biosensors, 15.","DOI":"10.3390\/bios15030165"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Silva, S.H., Avelino, K.Y.P.d.S., Lucena-Silva, N., Errachid, A., de Oliveira, M.D.L., and de Andrade, C.A.S. (2025). An Attomolar-Level Biosensor Based on Polypyrrole and TiO2@Pt Nanocomposite for Electrochemical Detection of TCF3-PBX1 Oncogene in Acute Lymphoblastic Leukemia. Sensors, 25.","DOI":"10.3390\/s25175313"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"7567","DOI":"10.1039\/D4AY01215A","article-title":"A label-free and ultrasensitive electrochemical biosensor using hybrid polypyrrole\/gold nanoelectrocatalyst mediated signal amplification for the detection of miRNA-21","volume":"16","author":"Zhang","year":"2024","journal-title":"Anal. Methods"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"4896","DOI":"10.1021\/acs.analchem.2c04656","article-title":"PEDOT\/FeOOH\/BiVO4 Nanohybrids with Excellent Photoelectric Performance Promoted by Photothermal Effects for the Ultrasensitive Detection of MicroRNA-375-3p","volume":"95","author":"Wang","year":"2023","journal-title":"Anal. Chem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.aca.2018.12.033","article-title":"Highly efficient Polyaniline-MoS2 hybrid nanostructures based biosensor for cancer biomarker detection","volume":"1055","author":"Soni","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.bios.2017.08.035","article-title":"Gold nanoparticles superlattices assembly for electrochemical biosensor detection of microRNA-21","volume":"99","author":"Tian","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1039\/D1AN00116G","article-title":"A highly sensitive electrochemical microRNA-21 biosensor based on intercalating methylene blue signal amplification and a highly dispersed gold nanoparticles\/graphene\/polypyrrole composite","volume":"146","author":"Pothipor","year":"2021","journal-title":"Analyst"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/s41573-025-01227-z","article-title":"Metabolites as agents and targets for cancer immunotherapy","volume":"24","author":"Trefny","year":"2025","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"11009","DOI":"10.1039\/D2SC02981B","article-title":"Emerging nanosensor platforms and machine learning strategies toward rapid, point-of-need small-molecule metabolite detection and monitoring","volume":"13","author":"Leong","year":"2022","journal-title":"Chem. Sci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/elan.201900568","article-title":"A Sensor for Serotonin and Dopamine Detection in Cancer Cells Line Based on the Conducting Polymer\u2212Pd Complex Composite","volume":"32","author":"Chung","year":"2019","journal-title":"Electroanalysis"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"4838","DOI":"10.1021\/acs.analchem.9b00478","article-title":"Conductive Polymer Coated Scaffold to Integrate 3D Cell Culture with Electrochemical Sensing","volume":"91","author":"Zhang","year":"2019","journal-title":"Anal. Chem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1007\/s00216-023-04818-0","article-title":"Point-of-care diagnostics for rapid determination of prostate cancer biomarker sarcosine: Application of disposable potentiometric sensor based on oxide-conductive polymer nanocomposite","volume":"415","author":"Yamani","year":"2023","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.1172\/JCI67228","article-title":"Oncometabolites: Linking altered metabolism with cancer","volume":"123","author":"Yang","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1002\/1878-0261.12439","article-title":"Sarcosine is a prostate epigenetic modifier that elicits aberrant methylation patterns through the SAMe-Dnmts axis","volume":"13","author":"Strmiska","year":"2019","journal-title":"Mol. Oncol."},{"key":"ref_123","first-page":"187","article-title":"miRNA Regulation of Glutathione Homeostasis in Cancer Initiation, Progression and Therapy Resistance","volume":"9","author":"Marengo","year":"2020","journal-title":"Microrna"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s12257-020-0065-y","article-title":"Au Nanoparticle-decorated Nanoporous PEDOT Modified Glassy Carbon Electrode: A New Electrochemical Sensing Platform for the Detection of Glutathione","volume":"25","author":"Rajaram","year":"2020","journal-title":"Biotechnol. Bioprocess Eng."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1016\/j.cell.2023.01.035","article-title":"From patterns to patients: Advances in clinical machine learning for cancer diagnosis, prognosis, and treatment","volume":"186","author":"Swanson","year":"2023","journal-title":"Cell"}],"container-title":["Biosensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6374\/16\/9\/479\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:45:10Z","timestamp":1788234310000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6374\/16\/9\/479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":125,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["bios16090479"],"URL":"https:\/\/doi.org\/10.3390\/bios16090479","relation":{},"ISSN":["2079-6374"],"issn-type":[{"value":"2079-6374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]}}}