{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:06:40Z","timestamp":1789189600565,"version":"build-2803163510"},"reference-count":42,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Basic Research Funding of Universities in the Autonomous Region","award":["XJEDU2025P052"],"award-info":[{"award-number":["XJEDU2025P052"]}]},{"DOI":"10.13039\/100009110","name":"Natural Science Foundation of Xinjiang Uygur Autonomous Region","doi-asserted-by":"crossref","award":["2024D01C140"],"award-info":[{"award-number":["2024D01C140"]}],"id":[{"id":"10.13039\/100009110","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004880","name":"Xinjiang Medical University","doi-asserted-by":"crossref","award":["XYD2024Q02"],"award-info":[{"award-number":["XYD2024Q02"]}],"id":[{"id":"10.13039\/501100004880","id-type":"DOI","asserted-by":"crossref"}]},{"award":["XYD2024Q02"],"award-info":[{"award-number":["XYD2024Q02"]}],"id":[{"id":"https:\/\/ror.org\/01p455v08","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Noncommunicable Chronic Diseases","award":["2024ZD0528300"],"award-info":[{"award-number":["2024ZD0528300"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Salvianolic acid B is an important bioactive biomarker in traditional Chinese medicines (TCMs). Current methods for its quantitation are time- and cost-consuming; a rapid and reliable method is urgently needed. In this work, we have developed a simple and sensitive electrochemical (EC) sensor on screen-printed carbon electrode (SPCE) that was modified with three-dimensional hierarchical Au\u2013Pt nanostructured film. This highly conductive structure facilitates direct electron transfer when the sample solution containing salvianolic acid B is dropped, thereby amplifying its generated current response. Under optimized conditions, the fabricated label-free EC sensor exhibited a wide linear range (4\u2013500 \u03bcg\/mL) with excellent conductivity and a detection limit as low as 3.76 \u03bcg\/mL for salvianolic acid B, as well as high reproducibility and outstanding stability. Furthermore, the practical applicability was validated by satisfactory spiked recovery rates (97.5\u2013101.4%) in complex Salvia miltiorrhiza matrices. These findings indicated that the Au\u2013Pt nanostructure-modified SPCE could achieve reliable and stable quantitation of salvianolic acid B. The developed EC sensor provided an economical, efficient, user-friendly, and reliable on-site strategy for accurate determination of salvianolic acid B and other components in more TCMs.<\/jats:p>","DOI":"10.3390\/bios16090508","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:13:03Z","timestamp":1789031583000},"page":"508","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hierarchical Au\u2013Pt Nanostructured Film-Enabled Electrochemical Sensor for Highly-Sensitive Determination of Salvianolic Acid B"],"prefix":"10.3390","volume":"16","author":[{"given":"Yujiao","family":"Hou","sequence":"first","affiliation":[{"name":"College of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830017, China"},{"name":"Institute of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830017, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"}]},{"given":"Fang","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Xinjiang Medical University, Urumqi 830017, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Xinjiang Medical University, Urumqi 830017, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Jianhua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China"},{"name":"Xinjiang Key Laboratory of Clinical Drug Research, Urumqi 830011, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"given":"Longfei","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830017, China"},{"name":"Cardiovascular Center, Affiliated Traditional Chinese Medicine Hospital of Xinjiang Medical University, Urumqi 830099, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"given":"Weijun","family":"Kong","sequence":"additional","affiliation":[{"name":"Xinjiang Key Laboratory of Clinical Drug Research, Urumqi 830011, China"},{"name":"School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/aps.2017.193","article-title":"Salvia miltiorrhizaBurge (Danshen): A golden herbal medicine in cardiovascular therapeutics","volume":"39","author":"Li","year":"2018","journal-title":"Acta Pharmacol. 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