{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T17:37:11Z","timestamp":1768412231479,"version":"3.49.0"},"reference-count":47,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2018,6,16]],"date-time":"2018-06-16T00:00:00Z","timestamp":1529107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Celiac disease is a chronic gluten-initiated autoimmune disorder that predominantly damages the mucosa of the small intestine in genetically-susceptible individuals. It affects a large and increasing number of the world\u2019s population. The diagnosis of this disease and monitoring the response of patients to the therapy, which is currently a life-long gluten-free diet, require the application of reliable, rapid, sensitive, selective, simple, and cost-effective analytical tools. Celiac disease biomarker detection in full blood, serum, or plasma offers a non-invasive way to do this and is well-suited to being the first step of diagnosis. Biosensors provide a novel and alternative way to perform conventional techniques in biomarker sensing, in which electrode material and architecture play important roles in achieving sensitive, selective, and stable detection. There are many opportunities to build and modify biosensor platforms using various materials and detection methods, and the aim of the present review is to summarize developments in this field.<\/jats:p>","DOI":"10.3390\/bios8020055","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T10:57:11Z","timestamp":1529319431000},"page":"55","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Biosensors for Non-Invasive Detection of Celiac Disease Biomarkers in Body Fluids"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7558-8230","authenticated-orcid":false,"given":"Tibor","family":"Pasinszki","sequence":"first","affiliation":[{"name":"Department of Chemistry, School of Sciences, College of Engineering, Science &amp; Technology (CEST), Fiji National University, P.O. Box 7222, Nasinu, Fiji"},{"name":"Institute of Chemistry, Faculty of Science, ELTE E\u00f6tv\u00f6s Lor\u00e1nd University, P\u00e1zm\u00e1ny P. s\u00e9t\u00e1ny 1\/A, H-1117 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9961-6988","authenticated-orcid":false,"given":"Melinda","family":"Krebsz","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Faculty of Science, ELTE E\u00f6tv\u00f6s Lor\u00e1nd University, P\u00e1zm\u00e1ny P. s\u00e9t\u00e1ny 1\/A, H-1117 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,6,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMra071600","article-title":"Celiac disease","volume":"357","author":"Green","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/ajg.2013.60","article-title":"Increasing incidence of celiac disease in a North American Population","volume":"108","author":"Ludvigsson","year":"2013","journal-title":"Am. J. Gastroenterol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3109\/07853890.2010.505931","article-title":"The prevalence of celiac disease in Europe: Results of a centralized, international mass screening project","volume":"42","author":"Mustalahti","year":"2010","journal-title":"Ann. Med."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Rodrigo, L., and Pe\u00f1a, A.S. (2014). A History of Celiac Disease. Celiac Disease and Non-Celiac Gluten Sensitvity, OmniaScience.","DOI":"10.3926\/oms.223"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Koehler, P., Weiser, H., and Konitzer, K. (2014). Celiac Disease\u2014A Complex Disorder. Celiac Disease and Gluten: Multidisciplinary Challenges and Opportunities, Academic Press, Elsevier Inc.","DOI":"10.1016\/B978-0-12-420220-7.00001-8"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Rodrigo, L., and Pe\u00f1a, A.S. (2014). The Role of Endoscopy in Celiac Disease and its Complications: Advances in Imaging Techniques and Computerization. Celiac Disease and Non-Celiac Gluten Sensitivity, OmniaScience.","DOI":"10.3926\/oms.223"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Rodrigo, L., and Pe\u00f1a, A.S. (2014). Genetic Markers in Celiac Disease. Celiac Disease and Non-Celiac Gluten Sensitivity, OmniaScience.","DOI":"10.3926\/oms.223"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Rodrigo, L., and Pe\u00f1a, A.S. (2014). The Role of Serology in Celiac Disease Screening, Diagnosis and Follow-Up. Celiac Disease and Non-Celiac Gluten Sensitivity, OmniaScience.","DOI":"10.3926\/oms.223"},{"key":"ref_9","first-page":"375","article-title":"Immunofluorescent antibodies against gliadin: A screening test for coeliac disease","volume":"31","author":"Hernandez","year":"1976","journal-title":"Helv. Paediatr. Acta"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/01971520009349533","article-title":"Enzyme-Linked Immunosorbent Assay","volume":"21","author":"Butler","year":"2000","journal-title":"J. Immunoass. Immunochem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1136\/bmj.286.6383.2007","article-title":"Alpha gliadin antibody levels: A serological test for coeliac disease","volume":"286","author":"Kelly","year":"1983","journal-title":"Br. Med. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s12033-016-9940-3","article-title":"Biosensors for the Diagnosis of Celiac Disease: Current Status and Future Perspectives","volume":"58","author":"Scherf","year":"2016","journal-title":"Mol. Biotechnol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.3390\/s80314000","article-title":"Electrochemical Biosensors\u2014Sensor Principles and Architectures","volume":"8","author":"Grieshaber","year":"2008","journal-title":"Sensors"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.aca.2007.06.041","article-title":"Screen-printed electrodes as impedimetric immunosensors for the detection of anti-transglutaminase antibodies in human sera","volume":"597","author":"Balkenhohl","year":"2007","journal-title":"Anal. Chim. Acta"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/MCG.0b013e31827874e3","article-title":"Biomarkers for Diagnosis and Monitoring of Celiac Disease","volume":"47","author":"Takasawa","year":"2013","journal-title":"Clin. Gastroenterol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1038\/ajg.2010.276","article-title":"Update on serologic testing in celiac disease","volume":"105","author":"Leffler","year":"2010","journal-title":"Am. J. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1053\/j.gastro.2005.02.012","article-title":"What are the sensitivity and specificity of serologic tests for celiac disease? Do sensitivity and specificity vary in different populations?","volume":"128","author":"Hill","year":"2005","journal-title":"Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.trsl.2011.04.004","article-title":"Regenerating gene I\u03b1 is a biomarker for diagnostic and monitoring of celiac disease: A preliminary study","volume":"158","author":"Planas","year":"2011","journal-title":"Transl. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/nri2670","article-title":"Tissue-mediated control of immunopathology in coeliac disease","volume":"9","author":"Jabri","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.giec.2012.07.004","article-title":"Diagnosis of celiac disease","volume":"22","author":"Lebwohl","year":"2012","journal-title":"Gastrointest. Endosc. Clin. N. Am."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Pasinszki, T., Krebsz, M., Tung, T.T., and Losic, D. (2017). Carbon Nanomaterial Based Biosensors for Non-Invasive Detection of Cancer and Disease Biomarkers for Clinical Diagnosis. Sensors, 17.","DOI":"10.3390\/s17081919"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4471","DOI":"10.1016\/j.bios.2011.05.004","article-title":"Electrochemical immunosensor detection of antigliadin antibodies from real human serum","volume":"26","author":"Katakis","year":"2011","journal-title":"Biosens. Bioelectron."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1021\/ac102956p","article-title":"Detection of Antigliadin Autoantibodies in Celiac Patient Samples Using a Cyclodextrin-Based Supramolecular Biosensor","volume":"83","author":"Ortiz","year":"2011","journal-title":"Anal. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.1039\/C6AN00532B","article-title":"Supramolecular biosensors based on electropolymerised pyrrole\u2013cyclodextrin modified surfaces for antibody detection","volume":"141","author":"Wajs","year":"2016","journal-title":"Analyst"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Corres, J.M., Matias, I.R., Goicoechea, J., Arregui, F.J., Viegas, D., Ara\u00fajo, F.M., and Santos, J.L. (2008, January 14\u201318). Experimental Results of Antigliadin Antibodies Detection using Long Period Fiber Grating. Proceedings of the 19th International Conference on Optical Fibre Sensors, Perth, WA, Australia.","DOI":"10.1117\/12.786076"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.snb.2008.08.008","article-title":"Tapered optical fiber biosensor for the detection of anti-gliadin antibodies","volume":"135","author":"Corres","year":"2008","journal-title":"Sens. Actuators B Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1702891","DOI":"10.1002\/adfm.201702891","article-title":"Recent Advances in Sensing Applications of Graphene Assemblies and Their Composites","volume":"27","author":"Tung","year":"2017","journal-title":"Adv. Funct. Mater."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.snb.2014.04.017","article-title":"Spectral width reduction in lossy mode resonance-based sensors by means of tapered optical fibre structures","volume":"200","author":"Socorro","year":"2014","journal-title":"Sens. Actuators B Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1039\/c3an36728b","article-title":"An electrochemical deamidated gliadin antibody immunosensor for celiac disease clinical diagnosis","volume":"138","author":"Neves","year":"2013","journal-title":"Analyst"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ab.2009.02.026","article-title":"Electrochemical immunosensor for the diagnosis of celiac disease","volume":"388","author":"Pividori","year":"2009","journal-title":"Anal. Biochem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1016\/j.bios.2011.02.045","article-title":"Electrochemical detection of celiac disease-related anti-tissue transglutaminase antibodies using thiol based surface chemistry","volume":"26","author":"Dulay","year":"2011","journal-title":"Biosens. Bioelectron."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.bios.2011.09.044","article-title":"Celiac disease detection using a transglutaminase electrochemical immunosensor fabricated on nanohybrid screen-printed carbon electrodes","volume":"31","author":"Neves","year":"2012","journal-title":"Biosens. Bioelectron."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bios.2013.04.012","article-title":"Electrochemical magneto immunosensor for the detection of anti-TG2 antibody in celiac disease","volume":"48","author":"Kergaravat","year":"2013","journal-title":"Biosens. Bioelectron."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.talanta.2014.07.010","article-title":"Electrochemical immunosensor for anti-tissue transglutaminase antibodies based on the in situ detection of quantum dots","volume":"130","year":"2014","journal-title":"Talanta"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"13931","DOI":"10.1021\/la202546a","article-title":"Nanoparticle-Enhanced Sensitivity of a Nanogap-Interdigitated Electrode Array Impedimetric Biosensor","volume":"27","author":"Singh","year":"2011","journal-title":"Langmuir"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1177\/0883911512472277","article-title":"Highly sensitive gold-overoxidized polypyrrole nanocomposite immunosensor for antitransglutaminase antibody","volume":"28","author":"West","year":"2013","journal-title":"J. Bioact. Compat. Polym."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1016\/S1452-3981(23)06532-X","article-title":"Electrochemical Immunosensor Based on the Interactions Between Polypyrrole and Cobalt (II) Salicylaldiimine Dendrimer","volume":"10","author":"Wilson","year":"2015","journal-title":"Int. J. Electrochem. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.bioelechem.2015.05.014","article-title":"Towards a blocking-free electrochemical immunosensing strategy for anti-transglutaminase antibodies using screen-printed electrodes","volume":"105","year":"2015","journal-title":"Bioelectrochem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1039\/C7AN00086C","article-title":"Enhanced detection of quantum dots by the magnetohydrodynamic effect for electrochemical biosensing","volume":"142","year":"2017","journal-title":"Analyst"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.ijbiomac.2017.07.126","article-title":"Ultrasensitive transglutaminase based nanosensor for early detection of celiac disease in human","volume":"105","author":"Gupta","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1007\/s00216-017-0322-x","article-title":"Disulfide-modified antigen for detection of celiac disease-associated anti-tissue transglutaminase autoantibodies","volume":"409","author":"Dulay","year":"2017","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"12080","DOI":"10.1021\/acs.analchem.5b02801","article-title":"A Sensitive Electrochemiluminescence Immunosensor for Celiac Disease Diagnosis Based on Nanoelectrode Ensembles","volume":"87","author":"Habtamu","year":"2015","journal-title":"Anal. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.snb.2012.10.055","article-title":"An innovative plastic optical fiber-based biosensor for new bio\/applications. The case of celiac disease","volume":"176","author":"Cennamo","year":"2013","journal-title":"Sens. Actuators B Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.snb.2014.05.018","article-title":"Piezoelectric immunosensor based on antibody recognition of immobilized open-tissue transglutaminase: An innovative perspective on diagnostic devices for celiac disease","volume":"201","author":"Manfredi","year":"2014","journal-title":"Sens. Actuators B Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1007\/s00216-014-7650-x","article-title":"Medium-high resolution electrochemical genotyping of HLA-DQ2\/DQ8 for detection of predisposition to coeliac disease","volume":"406","author":"Joda","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.bios.2015.05.048","article-title":"Modified primers for rapid and direct electrochemical analysis of coeliac disease associated HLA alleles","volume":"73","author":"Joda","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s00216-011-5493-2","article-title":"Gold nanoparticle fluorescent molecular beacon for low-resolution DQ2 gene HLA typing","volume":"402","author":"Beni","year":"2012","journal-title":"Anal. Bioanal. Chem."}],"container-title":["Biosensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6374\/8\/2\/55\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:09:02Z","timestamp":1760195342000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6374\/8\/2\/55"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,16]]},"references-count":47,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,6]]}},"alternative-id":["bios8020055"],"URL":"https:\/\/doi.org\/10.3390\/bios8020055","relation":{},"ISSN":["2079-6374"],"issn-type":[{"value":"2079-6374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,16]]}}}