{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:34:27Z","timestamp":1787027667019,"version":"build-2736575974"},"reference-count":87,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioTech"],"abstract":"<jats:p>Helicobacter pylori, the gastric pathogen which colonizes the gastric mucosa of more than half of the world\u2019s population, is considered a risk factor for peptic ulcers and is epidemiologically associated with gastric cancer. Antimicrobial eradication of this pathogen has now become a central concern because of its growing resistance to frontline antibiotics such as clarithromycin and metronidazole. Moreover, these antibiotics can have adverse effects on the normal human gut flora and can lead to several health complications. Most times, the antibiotic doses become intolerable to the elderly population and they reject the therapy. This has impelled us to think about alternate effective and safe antimicrobials which can replace antibiotic usage or may reduce their dosage when used together with the antibiotics. Plant and microbial natural products, in view of this, offer an excellent source of novel and potential antimicrobial agents. Herein, we review anti-H. pylori natural compounds from diverse plant and microbial sources and highlight their role in the management of H. pylori infection.<\/jats:p>","DOI":"10.3390\/biotech14040094","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T13:56:34Z","timestamp":1764165394000},"page":"94","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Comprehensive Review of Plant and Microbial Natural Compounds as Sources of Potential Helicobacter pylori-Inhibiting Agents"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4196-1599","authenticated-orcid":false,"given":"Srichandan","family":"Padhi","sequence":"first","affiliation":[{"name":"University Centre for Research and Development, Chandigarh University, Mohali 140413, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Sharma","sequence":"additional","affiliation":[{"name":"Advanced Centre of Research and Innovation, Chandigarh Group of Colleges Jhanjeri, Mohali 140307, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puja","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Food and Nutrition Biotechnology, BRIC-National Agri-Food and Biomanufacturing Institute (NABI), Mohali 140306, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0609-8902","authenticated-orcid":false,"given":"Marco","family":"Masi","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte S. Angelo, Via Cintia, 80126 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1551-4237","authenticated-orcid":false,"given":"Alessio","family":"Cimmino","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte S. Angelo, Via Cintia, 80126 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4496-7585","authenticated-orcid":false,"given":"Amit Kumar","family":"Rai","sequence":"additional","affiliation":[{"name":"Food and Nutrition Biotechnology, BRIC-National Agri-Food and Biomanufacturing Institute (NABI), Mohali 140306, India"},{"name":"Department of Botany, University of Delhi, New Delhi 110007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.biotechadv.2015.08.001","article-title":"Discovery and resupply of pharmacologically active plant-derived natural products: A review","volume":"33","author":"Atanasov","year":"2015","journal-title":"Biotechnol. 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