{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:04:06Z","timestamp":1770062646235,"version":"3.49.0"},"reference-count":60,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioTech"],"abstract":"<jats:p>Prostate cancer (PCa) is a leading cause of cancer-related mortality in men and is often characterized by aggressive growth and bone metastasis. Angiogenesis plays a central role in tumor progression and dissemination. This study aimed to explore the regulatory roles of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in angiogenesis and metastasis during PCa progression. Publicly available RNA-seq datasets were analyzed to identify differentially expressed miRNAs between metastatic (N1) and nonmetastatic (N0) PCa. Bioinformatic tools were used to reconstruct co-regulatory networks involving miRNAs, lncRNAs, and angiogenesis-related mRNAs. RT-qPCR was performed on serum-derived liquid biopsies from N0 and N1 patients and healthy controls to validate the key regulatory axes. Transcriptomic analysis revealed that miRNAs such as hsa-miR-183-5p and hsa-miR-216a-5p were upregulated in N1 PCa and associated with pro-angiogenic signaling, whereas hsa-miR-206 and hsa-miR-184, known for their anti-angiogenic functions, were downregulated. Network analysis identified the LINC00261\u2013miR-206\u2013HIF1A axis as the central regulatory module. RT-qPCR validation confirmed the significant downregulation of LINC00261 and miR-206, along with HIF1A overexpression in N1 samples compared to N0 and controls (p &lt; 0.001), supporting in silico predictions. These findings highlight the role of ncRNA-mediated regulation of PCa angiogenesis and metastasis. The LINC00261\u2013miR-206\u2013HIF1A axis may serve as a promising noninvasive biomarker and potential therapeutic target. The integration of computational and experimental data provides a strong rationale for the further functional validation of advanced PCa.<\/jats:p>","DOI":"10.3390\/biotech15010012","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T09:00:33Z","timestamp":1770022833000},"page":"12","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcriptomic Insights into lncRNA\u2013miRNA\u2013mRNA Networks Regulating Angiogenesis and Metastasis in Prostate Cancer"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6941-6248","authenticated-orcid":false,"given":"Jonathan","family":"Puente-Rivera","sequence":"first","affiliation":[{"name":"Laboratorio de Patog\u00e9nesis Celular Humana y Veterinaria, Posgrado en Ciencias Gen\u00f3micas, Universidad Aut\u00f3noma de la Ciudad de M\u00e9xico (UACM), San Lorenzo 290, Col. Del Valle, Mexico City 09790, Mexico"},{"name":"Divisi\u00f3n de Investigaci\u00f3n, Hospital Ju\u00e1rez de M\u00e9xico, Instituto Polit\u00e9cnico Nacional 5160, Col. Magdalena de las Salinas, Mexico City 07760, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9323-7159","authenticated-orcid":false,"given":"Stephanie I.","family":"Nu\u00f1ez Olvera","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ameyatzin Ereth","family":"Robles-Ch\u00e1vez","sequence":"additional","affiliation":[{"name":"Laboratorio de Patog\u00e9nesis Celular Humana y Veterinaria, Posgrado en Ciencias Gen\u00f3micas, Universidad Aut\u00f3noma de la Ciudad de M\u00e9xico (UACM), San Lorenzo 290, Col. Del Valle, Mexico City 09790, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5354-9900","authenticated-orcid":false,"given":"Nayeli Goreti","family":"Nieto-Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Investigaci\u00f3n, Hospital Ju\u00e1rez de M\u00e9xico, Instituto Polit\u00e9cnico Nacional 5160, Col. Magdalena de las Salinas, Mexico City 07760, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9212-4451","authenticated-orcid":false,"given":"Mar\u00eda Elizbeth","family":"Alvarez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Laboratorio de Patog\u00e9nesis Celular Humana y Veterinaria, Posgrado en Ciencias Gen\u00f3micas, Universidad Aut\u00f3noma de la Ciudad de M\u00e9xico (UACM), San Lorenzo 290, Col. Del Valle, Mexico City 09790, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,1]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1017\/erm.2023.7","article-title":"MicroRNAs in cancer metastasis: Biological and therapeutic implications","volume":"25","author":"Sell","year":"2023","journal-title":"Expert Rev. Mol. 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