{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:25:18Z","timestamp":1791894318234,"version":"4.3.4"},"reference-count":78,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["FZSR-2024-0008"],"award-info":[{"award-number":["FZSR-2024-0008"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioTech"],"abstract":"<jats:p>In this work, Filipendula ulmaria (L.) Maxim, a perennial herbaceous plant from the Rosaceae family, was considered a novel source of obtaining rutin for pharmaceutical purposes. Rutin was extracted from the plant parts collected in the flowering summer period and dried at 40 \u00b1 3 \u00b0C. The process was carried out using the ethanol extraction and fractionation of extracted compounds, and it yields the 95 wt% purity crystalline product. The phase composition of the extracted rutin was verified by the XRD analysis and NMR measurements. It was found that 2.85% of rutin could be extracted from Filipendula ulmaria, which is 1.2 times higher than the results of similar studies. The biological activity of the isolated rutin was tested on rats. It was established in vivo that the extracted rutin normalizes blood glucose levels (glucose and glycosylated hemoglobin), insulin resistance (HOMA-IR index) and reduces the severity of dystrophic changes in the liver caused by high-fat and high-carbohydrate diets. The introduction of rutin corrects lipid profile indicators (triglycerides, cholesterol, cholesterol fractions in lipoproteins and atherogenic indices), cytolysis indicators of hepatocytes, and liver steatosis (ALT, AST\/ALT, triglycerides). Thus, the novel source of rutin opens the possibility for a wide use of this flavonoid in the food technology and pharmaceutical industry.<\/jats:p>","DOI":"10.3390\/biotech15010025","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:59:36Z","timestamp":1774267176000},"page":"25","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characterization and Biological Activity of Rutin Extracted from Filipendula ulmaria (L.) Maxim"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4552-7418","authenticated-orcid":false,"given":"Anna","family":"Vesnina","sequence":"first","affiliation":[{"name":"Natural Nutraceutical Biotesting Laboratory, Kemerovo State University, Kemerovo 650000, Russia"},{"name":"DNA Sequencing and Genomics Laboratory, Kemerovo State University, Krasnaya Street, 6, Kemerovo 650000, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"Le","sequence":"additional","affiliation":[{"name":"Natural Nutraceutical Biotesting Laboratory, Kemerovo State University, Kemerovo 650000, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1252-9572","authenticated-orcid":false,"given":"Svetlana","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Institute of NBICS-Technologies, Kemerovo State University, Krasnaya Street, 6, Kemerovo 650000, Russia"},{"name":"Department of TNSMD Theory and Methods, Kemerovo State University, Krasnaya Street, 6, Kemerovo 650000, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3988-8521","authenticated-orcid":false,"given":"Anna","family":"Frolova","sequence":"additional","affiliation":[{"name":"Natural Nutraceutical Biotesting Laboratory, Kemerovo State University, Kemerovo 650000, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3536-562X","authenticated-orcid":false,"given":"Irina","family":"Milentyeva","sequence":"additional","affiliation":[{"name":"Natural Nutraceutical Biotesting Laboratory, Kemerovo State University, Kemerovo 650000, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7424-5604","authenticated-orcid":false,"given":"Victor","family":"Atuchin","sequence":"additional","affiliation":[{"name":"Research and Development Department, Kemerovo State University, Krasnaya Street, 6, Kemerovo 650000, Russia"},{"name":"Department of Industrial Machinery Design, Novosibirsk State Technical University, Novosibirsk 630073, Russia"},{"name":"Laboratory of Optical Materials and Structures, Institute of Semiconductor Physics, SB RAS, Novosibirsk 630090, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5630-3196","authenticated-orcid":false,"given":"Alexander","family":"Prosekov","sequence":"additional","affiliation":[{"name":"Laboratory of Biocatalysis, Kemerovo State University, Kemerovo 650043, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"ref_1","first-page":"87","article-title":"The potential use of the metabolite of the bearded roots of Scutellaria baicalensis as a geroprotector","volume":"12","author":"Chekushkina","year":"2024","journal-title":"Bull. 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