{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:26:27Z","timestamp":1790803587410,"version":"4.1.0"},"reference-count":234,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["BioTech"],"abstract":"<jats:p>Hantaviruses are zoonotic RNA viruses responsible for two severe human diseases: hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). Worldwide case fatality rates vary from 1% to 40%. Although single-layer genomics, transcriptomics, proteomics, and metabolomics studies have advanced our understanding of hantavirus biology, true multi-omics integration remains scarce, leaving systems-level mechanisms of disease severity and host\u2013pathogen interactions unresolved. High-throughput omics technologies have greatly advanced the study of hantavirus\u2013host interactions. This review summarizes genomic, transcriptomic, proteomic, metabolomic, and AI-enabled approaches in hantavirus research. Genomic studies have clarified viral diversity, evolution, and reassortment, while transcriptomics has identified regulatory networks governing endothelial and innate immune responses. Proteomics has revealed host proteins involved in immune regulation, endothelial dysfunction, and potential therapeutic targeting, whereas metabolomics indicates substantial metabolic reprogramming during infection, although dedicated studies remain limited. AI-based approaches are increasingly applied to outbreak prediction, surveillance, and risk modeling. Drawing on successful multi-omics frameworks developed for other viral infections, we discuss opportunities to improve biomarker discovery, surveillance, therapeutic development, and future precision medicine strategies for hantavirus infections.<\/jats:p>","DOI":"10.3390\/biotech15030058","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:13:17Z","timestamp":1784826797000},"page":"58","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Omics Approaches in Hantavirus Research: Current Advances, Challenges, and Future Perspectives"],"prefix":"10.3390","volume":"15","author":[{"given":"Soroosh","family":"Najafi","sequence":"first","affiliation":[{"name":"Scientific and Production Center \u201cArmbiotechnology\u201d NAS RA, 14 Gyurjyan Str., Yerevan 0056, Armenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5160-1336","authenticated-orcid":false,"given":"Maryam","family":"Jojani","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery, University of Naples \u2018Federico II\u2019, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9680-3896","authenticated-orcid":false,"given":"Kianoosh","family":"Najafi","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery, University of Naples \u2018Federico II\u2019, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6065-2367","authenticated-orcid":false,"given":"Giovanni N.","family":"Roviello","sequence":"additional","affiliation":[{"name":"Institute of Biostructures and Bioimaging (IBB), CNR National Research Council of Italy, 80145 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kuhn, J.H., and Schmaljohn, C.S. (2023). A Brief History of Bunyaviral Family Hantaviridae. Diseases, 11.","DOI":"10.3390\/diseases11010038"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1128\/CMR.00062-09","article-title":"A global perspective on hantavirus ecology, epidemiology, and disease","volume":"23","author":"Jonsson","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Santini, M., Ljubi\u0107, J., \u0160o\u0161tar, N., Vilibi\u0107-\u010cavlek, T., Bogdani\u0107, M., Zakotnik, S., Av\u0161i\u010d-\u017dupanc, T., Korva, M., Kurolt, I.C., and Radmani\u0107, L. (2023). Hantavirus pulmonary syndrome caused by Puumala orthohantavirus\u2014A case report and literature review. Microorganisms, 11.","DOI":"10.3390\/microorganisms11122963"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Bellomo, C.M., Kehl, S., Alonso, D.O., L\u00f3pez, W., Cassinelli, F., Coelho, R.M., Bravo, G., Aguirre, S., Dib, M., and Periolo, N. (2025). Novel Orthohantavirus Associated with Hantavirus Pulmonary Syndrome in Northern Argentina. Viruses, 17.","DOI":"10.3390\/v17050717"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Ter\u00e7as-Trettel, A.C.P., Oliveira, E.C.d., Fontes, C.J.F., Melo, A.V.G.d., Oliveira, R.C.d., Guterres, A., Fernandes, J., Silva, R.G.d., Atanaka, M., and Espinosa, M.M. (2019). Malaria and Hantavirus Pulmonary Syndrome in Gold Mining in the Amazon Region, Brazil. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16101852"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Ferro, I., Lopez, W., Cassinelli, F., Aguirre, S., Cuyckens, G.A.E., Kehl, S., Ab\u00e1n-Moreyra, D., Castillo, P., Bellomo, C., and Gil, J. (2024). Hantavirus Pulmonary Syndrome Outbreak Anticipation by a Rapid Synchronous Increase in Rodent Abundance in the Northwestern Argentina Endemic Region: Towards an Early Warning System for Disease Based on Climate and Rodent Surveillance Data. Pathogens, 13.","DOI":"10.3390\/pathogens13090753"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.virusres.2013.12.036","article-title":"Hemorrhagic Fever with Renal Syndrome in the New, and Hantavirus Pulmonary Syndrome in the Old World: Paradi(se)gm lost or regained?","volume":"187","author":"Clement","year":"2014","journal-title":"Virus Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.3201\/eid1610.100242","article-title":"Mortality rate patterns for hemorrhagic fever with renal syndrome caused by Puumala virus","volume":"16","author":"Hjertqvist","year":"2010","journal-title":"Emerg. Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"001975","DOI":"10.1099\/jgv.0.001975","article-title":"ICTV Virus Taxonomy Profile: Hantaviridae 2024","volume":"105","author":"Bradfute","year":"2024","journal-title":"J. Gen. Virol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.virusres.2014.01.015","article-title":"Hantaviruses and cardiopulmonary syndrome in South America","volume":"187","author":"Figueiredo","year":"2014","journal-title":"Virus Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1056\/NEJMoa2009040","article-title":"\u201cSuper-Spreaders\u201d and Person-to-Person Transmission of Andes Virus in Argentina","volume":"383","author":"Paola","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Guo, W.-P., Lin, X.-D., Wang, W., Tian, J.-H., Cong, M.-L., Zhang, H.-L., Wang, M.-R., Zhou, R.-H., Wang, J.-B., and Li, M.-H. (2013). Phylogeny and Origins of Hantaviruses Harbored by Bats, Insectivores, and Rodents. PLoS Pathog., 9.","DOI":"10.1371\/journal.ppat.1003159"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10393-017-1305-2","article-title":"Global Diversity and Distribution of Hantaviruses and Their Hosts","volume":"15","author":"Milholland","year":"2018","journal-title":"Ecohealth"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/molbev\/msn234","article-title":"Hantavirus evolution in relation to its rodent and insectivore hosts: No evidence for codivergence","volume":"26","author":"Ramsden","year":"2009","journal-title":"Mol. Biol. Evol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0966-842X(99)01658-3","article-title":"Persistent hantavirus infections: Characteristics and mechanisms","volume":"8","author":"Meyer","year":"2000","journal-title":"Trends Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Tian, H., and Stenseth, N.C. (2019). The ecological dynamics of hantavirus diseases: From environmental variability to disease prevention largely based on data from China. PLoS Neglected Trop. Dis., 13.","DOI":"10.1371\/journal.pntd.0006901"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Jiang, H., Du, H., Wang, L.M., Wang, P.Z., and Bai, X.F. (2016). Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture. Front. Cell. Infect. Microbiol., 6.","DOI":"10.3389\/fcimb.2016.00001"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.3201\/eid1707.101306","article-title":"Hantavirus pulmonary syndrome, United States, 1993\u20132009","volume":"17","author":"MacNeil","year":"2011","journal-title":"Emerg. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nrmicro3066","article-title":"Uncovering the mysteries of hantavirus infections","volume":"11","author":"Vaheri","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Brocato, R.L., and Hooper, J.W. (2019). Progress on the Prevention and Treatment of Hantavirus Disease. Viruses, 11.","DOI":"10.3390\/v11070610"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Mayor, J., Engler, O., and Rothenberger, S. (2021). Antiviral Efficacy of Ribavirin and Favipiravir against Hantaan Virus. Microorganisms, 9.","DOI":"10.3390\/microorganisms9061306"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1086\/425007","article-title":"Placebo-Controlled, Double-Blind Trial of Intravenous Ribavirin for the Treatment of Hantavirus Cardiopulmonary Syndrome in North America","volume":"39","author":"Mertz","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"366","DOI":"10.23876\/j.krcp.18.0044","article-title":"Effectiveness of inactivated hantavirus vaccine on the disease severity of hemorrhagic fever with renal syndrome","volume":"37","author":"Yi","year":"2018","journal-title":"Kidney Res. Clin. Pract."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/ckj\/sfac008","article-title":"The kidney in hantavirus infection-epidemiology, virology, pathophysiology, clinical presentation, diagnosis and management","volume":"15","author":"Koehler","year":"2022","journal-title":"Clin. Kidney J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.ejcts.2011.01.089","article-title":"Extracorporeal membrane oxygenation support improves survival of patients with Hantavirus cardiopulmonary syndrome refractory to medical treatment","volume":"40","author":"Wernly","year":"2011","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Scognamiglio, P.L., Tesauro, D., and Roviello, G.N. (2025). Metallogels as Supramolecular Platforms for Biomedical Applications: A Review. Processes, 13.","DOI":"10.20944\/preprints202511.0700.v1"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Sargsyan, T., Simonyan, H.M., Stepanyan, L., Tsaturyan, A., Vicidomini, C., Pastore, R., Guerra, G., and Roviello, G.N. (2025). Neuroprotective Properties of Clove (Syzygium aromaticum): State of the Art and Future Pharmaceutical Applications for Alzheimer\u2019s Disease. Biomolecules, 15.","DOI":"10.20944\/preprints202503.1063.v1"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Bandyopadhyay, A., Shah, S., and Roviello, G.N. (2026). Forest bathing (Shinrin-yoku) and preventive medicine: Immune modulation, stress regulation, neurocognitive resilience, and neurological health. Med. Sci., 14.","DOI":"10.3390\/medsci14010095"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Sargsyan, T., Stepanyan, L., Tsaturyan, A., Palumbo, R., Vicidomini, C., and Roviello, G.N. (2025). Intracellular Parasitic Infections Caused by Plasmodium falciparum, Leishmania spp., Toxoplasma gondii, Echinococcus multilocularis, Among Key Pathogens: Global Burden, Transmission Dynamics, and Vaccine Advances\u2014A Narrative Review with Contextual Insights from Armenia. Vaccines, 13.","DOI":"10.3390\/vaccines13111082"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Najafi, S., Jojani, M., Najafi, K., Costanzo, V., Vicidomini, C., and Roviello, G.N. (2026). West Nile Virus: Epidemiology, Surveillance, and Prophylaxis with a Comparative Insight from Italy and Iran. Vaccines, 14.","DOI":"10.3390\/vaccines14010057"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Najafi, K., Jojani, M., Najafi, S., and Roviello, G.N. (2026). Plant-Based Strategies for Vaccine Development: A Narrative Review of Recombinant Biofactories, Phytochemical Adjuvants, Innovative Delivery Systems, and Insights on Oral and Edible Vaccines. Vaccines, 14.","DOI":"10.20944\/preprints202604.0910.v1"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"128001","DOI":"10.1016\/j.saa.2026.128001","article-title":"Spectroscopic and computational characterization of the nucleopeptide WWT reveals supramolecular organization, selective biomolecular interactions, and potential regenerative relevance","volume":"359","author":"Palumbo","year":"2026","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Costanzo, M., and Roviello, G.N. (2025). Precision Therapeutics Through Bioactive Compounds: Metabolic Reprogramming, Omics Integration, and Drug Repurposing Strategies. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms262010047"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Vicidomini, C., and Roviello, G.N. (2025). Therapeutic Convergence in Neurodegeneration: Natural Products, Drug Repurposing, and Biomolecular Targets. Biomolecules, 15.","DOI":"10.3390\/biom15091333"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Sargsyan, T., Stepanyan, L., Panosyan, H., Hakobyan, H., Israyelyan, M., Tsaturyan, A., Hovhannisyan, N., Vicidomini, C., Mkrtchyan, A., and Saghyan, A. (2025). Synthesis and antifungal activity of Fmoc-protected 1, 2, 4-triazolyl-\u03b1-amino acids and their dipeptides against Aspergillus species. Biomolecules, 15.","DOI":"10.20944\/preprints202412.1740.v1"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Ferrara, B.T., Thompson, E.P., Roviello, G.N., and Gale, T.F. (2025). C-Terminal Analogues of Camostat Retain TMPRSS2 Protease Inhibition: New Synthetic Directions for Antiviral Repurposing of Guanidinium-Based Drugs in Respiratory Infections. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26146761"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Stepanyan, L., Israyelyan, M., Gori, A., Tsaturyan, A., Saribekyan, Z., Hovsepyan, K., Sargsyan, T., Pastore, R., De Luca, A., and Roviello, G.N. (2026). Natural and Synthetic Peptides as Alternatives to Antibiotics in Intestinal Infections\u2014A Review. Antibiotics, 15.","DOI":"10.20944\/preprints202601.0037.v1"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"128700","DOI":"10.1016\/j.molliq.2025.128700","article-title":"Biomacromolecular interactions and antioxidant properties of novel synthetic amino acids targeting DNA and serum albumin","volume":"440","author":"Sargsyan","year":"2025","journal-title":"J. Mol. Liq."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Stepanyan, L., Sargsyan, T., Mittova, V., Tsetskhladze, Z.R., Motsonelidze, N., Gorgoshidze, E., Nova, N., Israyelyan, M., Simonyan, H., and Bisceglie, F. (2025). The Synthesis, characterization, and biological evaluation of a fluorenyl-methoxycarbonyl-containing thioxo-triazole-bearing dipeptide: Antioxidant, antimicrobial, and BSA\/DNA binding studies for potential therapeutic applications in ROS scavenging and drug transport. Biomolecules, 15.","DOI":"10.20944\/preprints202506.1217.v1"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"102478","DOI":"10.1016\/j.omtn.2025.102478","article-title":"Binding of G-quadruplex DNA and serum albumins by synthetic non-proteinogenic amino acids: Implications for c-Myc-related anticancer activity and drug delivery","volume":"36","author":"Simonyan","year":"2025","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"35379","DOI":"10.1039\/D5RA04554A","article-title":"A 3-Mannich coupling reaction via chiral propargylglycine Ni (ii) complex: An approach for synthesizing enantiomerically enriched unnatural \u03b1-amino acids","volume":"15","author":"Hayriyan","year":"2025","journal-title":"RSC Adv."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"11640","DOI":"10.1039\/D5NJ00764J","article-title":"Strategy for synthesizing O-protected (S)-\u03b1-substituted serine analogs via sequential Ni (ii)-complex-mediated cross-coupling and cycloaddition reactions","volume":"49","author":"Tovmasyan","year":"2025","journal-title":"New J. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e202303249","DOI":"10.1002\/slct.202303249","article-title":"Unnatural Phosphorus-Containing \u03b1-Amino Acids and Their N-FMOC Derivatives: Synthesis and In Vitro Investigation of Anticholinesterase Activity","volume":"9","author":"Dadayan","year":"2024","journal-title":"ChemistrySelect"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Tovmasyan, A.S., Mkrtchyan, A.F., Khachatryan, H.N., Hayrapetyan, M.V., Hakobyan, R.M., Poghosyan, A.S., Tsaturyan, A.H., Minasyan, E.V., Maleev, V.I., and Larionov, V.A. (2023). Synthesis, characterization, and study of catalytic activity of chiral Cu (II) and Ni (II) salen complexes in the \u03b1-Amino Acid C-\u03b1 alkylation reaction. Molecules, 28.","DOI":"10.3390\/molecules28031180"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"11927","DOI":"10.1039\/D0NJ02072A","article-title":"Using the Ni-[(benzylprolyl) amino] benzophenone complex in the Glaser reaction for the synthesis of bis \u03b1-amino acids","volume":"44","author":"Mkrtchyan","year":"2020","journal-title":"New J. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"127850","DOI":"10.1016\/j.molstruc.2020.127850","article-title":"Asymmetric synthesis, biological activity and molecular docking studies of some unsaturated \u03b1-amino acids, derivatives of glycine, allylglycine and propargylglycine","volume":"1208","author":"Mkrtchyan","year":"2020","journal-title":"J. Mol. Struct."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"107400","DOI":"10.1039\/C5RA22407A","article-title":"Synthesis of optically pure (S)-2-amino-5-arylpent-4-ynoic acids by Sonogashira reactions and their potential use as highly selective potent inhibitors of aldose reductase","volume":"5","author":"Parpart","year":"2015","journal-title":"RSC Adv."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"110244","DOI":"10.1016\/j.compbiomed.2025.110244","article-title":"Resting-state functional MRI metrics to detect freezing of gait in Parkinson\u2019s disease: A machine learning approach","volume":"192","author":"Vicidomini","year":"2025","journal-title":"Comput. Biol. Med."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Fontanella, F., D\u2019Alessandro, T., Nardone, E., De Stefano, C., Vicidomini, C., and Roviello, G.N. (2026). Artificial Intelligence for Natural Products Drug Discovery in Neurodegeneration Therapies: A Review. Biomolecules, 16.","DOI":"10.3390\/biom16010129"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Roviello, G.N. (2025). Nature-Inspired Pathogen and Cancer Protein Covalent Inhibitors: From Plants and Other Natural Sources to Drug Development. Pathogens, 14.","DOI":"10.3390\/pathogens14111153"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Mittova, V., Tsetskhladze, Z.R., Motsonelidze, N., Palumbo, R., and Roviello, G.N. (2026). Georgian Grapes and Wines as a Source of Phenolic Compounds: Composition, Antioxidant Activity, and Traditional Winemaking. Molecules, 31.","DOI":"10.3390\/molecules31020303"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"854","DOI":"10.31989\/ffhd.v15i11.1745","article-title":"Yeast whey-enriched bread: Nutritional profile and potential functional relevance","volume":"15","author":"Bagiyan","year":"2025","journal-title":"Funct. Foods Health Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"635","DOI":"10.4067\/s0718-58392025000500635","article-title":"Valorization of grape pomace through melanin extraction and its biostimulant effects on yield and development of winter barley","volume":"85","author":"Aghajanyan","year":"2025","journal-title":"Chil. J. Agric. Res."},{"key":"ref_54","first-page":"450","article-title":"Safety evaluation of bacterial melanin as a plant growth stimulant for agricultural and food industry applications","volume":"5","author":"Hovsepyan","year":"2025","journal-title":"Funct. Food Sci."},{"key":"ref_55","first-page":"204","article-title":"Isolation, purification, identification of melanin from grape pomace extracts, and its application areas","volume":"8","author":"Aghajanyan","year":"2025","journal-title":"Bioact. Compd. Health Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1007\/s12088-023-01155-9","article-title":"Antimicrobial activity of melanin isolated from wine waste","volume":"64","author":"Minasyan","year":"2024","journal-title":"Indian J. Microbiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1111\/ijfs.17016","article-title":"Efficient isolation and characterization of functional melanin from various plant sources","volume":"59","author":"Aghajanyan","year":"2024","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"100209","DOI":"10.1016\/j.foohum.2023.100209","article-title":"Baker\u2019s yeast of the ttkhmor with high \u03b1-glucosidase activity for cultivation on whey","volume":"2","author":"Bagiyan","year":"2024","journal-title":"Food Humanit."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1007\/s00253-023-12609-x","article-title":"Valorization of whey-based side streams for microbial biomass, molecular hydrogen, and hydrogenase production","volume":"107","author":"Poladyan","year":"2023","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.31925\/farmacia.2023.5.21","article-title":"Study of the chemical composition, antibacterial and antioxidant activity of various extracts of the aerial part of Leonurus cardiaca","volume":"71","author":"Stepanyan","year":"2023","journal-title":"Farmacia"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.3897\/pharmacia.70.e109086","article-title":"Development of an efficient method for obtaining lactose and lactulose from whey","volume":"70","author":"Tsaturyan","year":"2023","journal-title":"Pharmacia"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00217-021-03894-9","article-title":"Development of the technology for producing water-soluble melanin from waste of vinary production and the study of its physicochemical properties","volume":"248","author":"Aghajanyan","year":"2022","journal-title":"Eur. Food Res. Technol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3897\/pharmacia.71.e135658","article-title":"Ion-chromatographic determination of common anions in drinking water in some regions of the Republic of Armenia","volume":"71","author":"Tsaturyan","year":"2024","journal-title":"Pharmacia"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3897\/pharmacia.69.e76247","article-title":"Detection and development of a quantitation method for undeclared compounds in antidiabetic biologically active additives and its validation by high performance liquid chromatography","volume":"69","author":"Kirakosyan","year":"2022","journal-title":"Pharmacia"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Pinu, F.R., Beale, D.J., Paten, A.M., Kouremenos, K., Swarup, S., Schirra, H.J., and Wishart, D. (2019). Systems Biology and Multi-Omics Integration: Viewpoints from the Metabolomics Research Community. Metabolites, 9.","DOI":"10.3390\/metabo9040076"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"107739","DOI":"10.1016\/j.biotechadv.2021.107739","article-title":"Using machine learning approaches for multi-omics data analysis: A review","volume":"49","author":"Reel","year":"2021","journal-title":"Biotechnol. Adv."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12943-026-02637-2","article-title":"Machine learning model on multi-omics data enables risk stratification and identifies molecular heterogeneity and therapeutic targets in glioblastoma","volume":"25","author":"Zhang","year":"2026","journal-title":"Mol. Cancer"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/s41586-021-04278-5","article-title":"Multi-omic machine learning predictor of breast cancer therapy response","volume":"601","author":"Sammut","year":"2022","journal-title":"Nature"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1038\/s41588-024-01898-1","article-title":"Disease prediction with multi-omics and biomarkers empowers case\u2013control genetic discoveries in the UK Biobank","volume":"56","author":"Garg","year":"2024","journal-title":"Nat. Genet."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e43075","DOI":"10.7554\/eLife.43075","article-title":"High resolution cryo-EM structure of the helical RNA-bound Hantaan virus nucleocapsid reveals its assembly mechanisms","volume":"8","author":"Arragain","year":"2019","journal-title":"eLife"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/B978-0-12-387022-3.00006-9","article-title":"Recent advances in hantavirus molecular biology and disease","volume":"74","author":"Hussein","year":"2011","journal-title":"Adv. Appl. Microbiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.3390\/v6041801","article-title":"Hantavirus Gn and Gc Envelope Glycoproteins: Key Structural Units for Virus Cell Entry and Virus Assembly","volume":"6","author":"Tischler","year":"2014","journal-title":"Viruses"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Meier, K., Thorkelsson, S.R., Quemin, E.R.J., and Rosenthal, M. (2021). Hantavirus Replication Cycle\u2014An Updated Structural Virology Perspective. Viruses, 13.","DOI":"10.3390\/v13081561"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1002\/jmv.20948","article-title":"Tula and Puumala hantavirus NSs ORFs are functional and the products inhibit activation of the interferon-beta promoter","volume":"79","author":"Kaukinen","year":"2007","journal-title":"J. Med. Virol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1038\/s41467-023-38555-w","article-title":"Structures of active Hantaan virus polymerase uncover the mechanisms of Hantaviridae genome replication","volume":"14","author":"Arragain","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Muyangwa, M., Martynova, E.V., Khaiboullina, S.F., Morzunov, S.P., and Rizvanov, A.A. (2015). Hantaviral Proteins: Structure, Functions, and Role in Hantavirus Infection. Front. Microbiol., 6.","DOI":"10.3389\/fmicb.2015.01326"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"199678","DOI":"10.1016\/j.virusres.2025.199678","article-title":"Characterization of minigenome systems for Hantaan and Seoul hantaviruses","volume":"363","author":"Jain","year":"2026","journal-title":"Virus Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0042-6822(86)90223-0","article-title":"Coding strategy of the S genome segment of Hantaan virus","volume":"155","author":"Schmaljohn","year":"1986","journal-title":"Virology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"6299","DOI":"10.1093\/nar\/15.15.6299","article-title":"Nucleotide sequence of the M segment of the genomic RNA of Hantaan virus 76\u2013118","volume":"15","author":"Yoo","year":"1987","journal-title":"Nucleic Acids Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"6728","DOI":"10.1093\/nar\/18.22.6728","article-title":"Nucleotide sequence of the L genome segment of Hantaan virus","volume":"18","author":"Schmaljohn","year":"1990","journal-title":"Nucleic Acids Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"13853","DOI":"10.1128\/JVI.02668-12","article-title":"Complete genome sequence of Seoul virus isolated from Rattus norvegicus in the Democratic People\u2019s Republic of Korea","volume":"86","author":"Yao","year":"2012","journal-title":"J. Virol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0168-1702(91)90093-B","article-title":"Molecular characterization of the M genomic segment of the Seoul 80-39 virus; nucleotide and amino acid sequence comparisons with other hantaviruses reveal the evolutionary pathway","volume":"19","author":"Antic","year":"1991","journal-title":"Virus Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0168-1702(91)90094-C","article-title":"Nucleotide sequence and coding capacity of the large (L) genomic RNA segment of Seoul 80-39 virus, a member of the hantavirus genus","volume":"19","author":"Antic","year":"1991","journal-title":"Virus Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1099\/0022-1317-73-4-829","article-title":"Cloning and sequencing of Puumala virus Sotkamo strain S and M RNA segments: Evidence for strain variation in hantaviruses and expression of the nucleocapsid protein","volume":"73","author":"Vapalahti","year":"1992","journal-title":"J. Gen. Virol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1575112","DOI":"10.3389\/fimmu.2025.1575112","article-title":"Puumala orthohantavirus: Prevalence, biology, disease, animal models and recent advances in therapeutics development and structural biology","volume":"16","author":"Tscherne","year":"2025","journal-title":"Front Immunol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-1702(97)00073-7","article-title":"Sequence analysis of the Puumala hantavirus Sotkamo strain L segment","volume":"51","author":"Piiparinen","year":"1997","journal-title":"Virus Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1006\/viro.1994.1235","article-title":"Genome structure and variability of a virus causing hantavirus pulmonary syndrome","volume":"200","author":"Spiropoulou","year":"1994","journal-title":"Virology"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Leventhal, S.S., Wilson, D., Feldmann, H., and Hawman, D.W. (2021). A Look into Bunyavirales Genomes: Functions of Non-Structural (NS) Proteins. Viruses, 13.","DOI":"10.3390\/v13020314"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"7520","DOI":"10.1128\/JVI.07204-11","article-title":"Autophagic clearance of Sin Nombre hantavirus glycoprotein Gn promotes virus replication in cells","volume":"86","author":"Hussein","year":"2012","journal-title":"J. Virol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"8132","DOI":"10.1128\/jvi.69.12.8132-8136.1995","article-title":"Complete genetic characterization and analysis of isolation of Sin Nombre virus","volume":"69","author":"Chizhikov","year":"1995","journal-title":"J. Virol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0168-1702(02)00129-6","article-title":"Complete nucleotide sequence of a Chilean hantavirus","volume":"89","author":"Meissner","year":"2002","journal-title":"Virus Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0168-1702(97)00053-1","article-title":"Genetic characterization and phylogeny of Andes virus and variants from Argentina and Chile","volume":"50","author":"Padula","year":"1997","journal-title":"Virus Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4067\/S0716-97602003000200010","article-title":"Complete sequence of the genome of the human isolate of Andes virus CHI-7913: Comparative sequence and protein structure analysis","volume":"36","author":"Tischler","year":"2003","journal-title":"Biol. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"24672","DOI":"10.1038\/s41598-025-11003-z","article-title":"Molecular evolution and reassortment dynamics of Orthohantavirus hantanense revealed through longitudinal genomic surveillance in the Republic of Korea","volume":"15","author":"Park","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s44298-024-00072-y","article-title":"Detection of divergent Orthohantavirus tulaense provides insight into wide host range and viral evolutionary patterns","volume":"2","author":"Erdin","year":"2024","journal-title":"npj Viruses"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1093\/molbev\/msaa163","article-title":"Bayesian Evaluation of Temporal Signal in Measurably Evolving Populations","volume":"37","author":"Duchene","year":"2020","journal-title":"Mol. Biol. Evol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.tim.2014.04.008","article-title":"Reconstructing the evolutionary origins and phylogeography of hantaviruses","volume":"22","author":"Bennett","year":"2014","journal-title":"Trends Microbiol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Demirev, A.V., Lee, S., Park, S., Kim, H., Cho, S., Lee, K., Kim, K., Song, J.-W., Park, M.-S., and Kim, J.I. (2024). Exploring the Genetic Diversity and Molecular Evolution of Seoul and Hantaan Orthohantaviruses. Viruses, 16.","DOI":"10.3390\/v16010105"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nrmicro.2016.46","article-title":"Reassortment in segmented RNA viruses: Mechanisms and outcomes","volume":"14","author":"McDonald","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Laenen, L., Vergote, V., Calisher, C.H., Klempa, B., Klingstr\u00f6m, J., Kuhn, J.H., and Maes, P. (2019). Hantaviridae: Current Classification and Future Perspectives. Viruses, 11.","DOI":"10.3390\/v11090788"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1007\/s11262-018-1590-z","article-title":"Reassortment events in the evolution of hantaviruses","volume":"54","author":"Klempa","year":"2018","journal-title":"Virus Genes"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Kim, J.-A., Kim, W.-K., No, J.S., Lee, S.-H., Lee, S.-Y., Kim, J.H., Kho, J.H., Lee, D., Song, D.H., and Gu, S.H. (2016). Genetic Diversity and Reassortment of Hantaan Virus Tripartite RNA Genomes in Nature, the Republic of Korea. PLoS Neglected Trop. Dis., 10.","DOI":"10.1371\/journal.pntd.0004650"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Park, K., Kim, J., Noh, J., Kim, S.G., Cho, H.K., Kim, K., Seo, Y.R., Lim, T., Lee, S., and Lee, J. (2025). Epidemiological surveillance and phylogenetic diversity of Orthohantavirus hantanense using high-fidelity nanopore sequencing, Republic of Korea. PLoS Neglected Trop. Dis., 19.","DOI":"10.1371\/journal.pntd.0012859"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"13756","DOI":"10.1128\/JVI.02341-12","article-title":"Diversity and Distribution of Hantaviruses in South America","volume":"86","author":"Firth","year":"2012","journal-title":"J. Virol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1093\/emboj\/21.6.1497","article-title":"Transfection-mediated generation of functionally competent Tula hantavirus with recombinant S RNA segment","volume":"21","author":"Plyusnin","year":"2002","journal-title":"EMBO J."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1128\/JVI.73.1.667-675.1999","article-title":"Recombination in Tula Hantavirus Evolution: Analysis of Genetic Lineages from Slovakia","volume":"73","author":"Sibold","year":"1999","journal-title":"J. Virol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1099\/vir.0.19277-0","article-title":"Phylogenetic analysis reveals a low rate of homologous recombination in negative-sense RNA viruses","volume":"84","author":"Chare","year":"2003","journal-title":"J. Gen. Virol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"11803","DOI":"10.1128\/JVI.75.23.11803-11810.2001","article-title":"Molecular evolution of Puumala hantavirus","volume":"75","author":"Sironen","year":"2001","journal-title":"J. Virol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"4454","DOI":"10.1038\/s41467-023-40126-y","article-title":"Two point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection","volume":"14","author":"Slough","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"e69708","DOI":"10.7554\/eLife.69708","article-title":"Genetic depletion studies inform receptor usage by virulent hantaviruses in human endothelial cells","volume":"10","author":"Dieterle","year":"2021","journal-title":"eLife"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e0001823","DOI":"10.1128\/msphere.00018-23","article-title":"Andes Virus Genome Mutations That Are Likely Associated with Animal Model Attenuation and Human Person-to-Person Transmission","volume":"8","author":"Bellomo","year":"2023","journal-title":"mSphere"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"e0051225","DOI":"10.1128\/jvi.00512-25","article-title":"High genomic stability of Andes virus following successive passage in vivo in Syrian hamsters","volume":"99","author":"Warner","year":"2025","journal-title":"J. Virol."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Spruill-Harrell, B., Ponce-Flores, A., Nnamani, E.I., Owen, R.D., Whitt, M.A., and Jonsson, C.B. (2026). Purifying selection constrains the evolution of Juquitiba virus in wild Oligoryzomys nigripes communities. PLoS Pathog., 22.","DOI":"10.1371\/journal.ppat.1013839"},{"key":"ref_114","first-page":"13","article-title":"The Andes Orthohantavirus NSs Protein Antagonizes the Type I Interferon Response by Inhibiting MAVS Signaling","volume":"94","author":"Solis","year":"2020","journal-title":"J. Virol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1007\/s00705-021-05159-y","article-title":"Inhibition of interferon I induction by non-structural protein NSs of Puumala virus and other vole-associated orthohantaviruses: Phenotypic plasticity of the protein and potential functional domains","volume":"166","author":"Binder","year":"2021","journal-title":"Arch. Virol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"10173","DOI":"10.1128\/JVI.05560-11","article-title":"Signatures of host mRNA 5\u2019 terminus for efficient hantavirus cap snatching","volume":"86","author":"Cheng","year":"2012","journal-title":"J. Virol."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Goodfellow, S.M., Nofchissey, R.A., Ye, C., Dunnum, J.L., Cook, J.A., and Bradfute, S.B. (2022). Use of a Novel Detection Tool to Survey Orthohantaviruses in Wild-Caught Rodent Populations. Viruses, 14.","DOI":"10.3390\/v14040682"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"105672","DOI":"10.1016\/j.jcv.2024.105672","article-title":"Hybrid capture-based next-generation sequencing of new and old world Orthohantavirus strains and wild-type Puumala isolates from humans and bank voles","volume":"172","author":"Rosenbaum","year":"2024","journal-title":"J. Clin. Virol."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Park, K., Lee, S.-H., Kim, J., Lee, J., Lee, G.-Y., Cho, S., Lee, S.H., Park, K., No, J.S., and Budhathoki, S. (2021). Multiplex PCR-Based Nanopore Sequencing and Epidemiological Surveillance of Hantaan orthohantavirus in Apodemus agrarius, Republic of Korea. Viruses, 13.","DOI":"10.3390\/v13050847"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"002169","DOI":"10.1099\/jgv.0.002169","article-title":"Amplification-free detection of zoonotic viruses using Cas13 and multiple CRISPR RNAs","volume":"106","author":"Lamb","year":"2025","journal-title":"J. Gen. Virol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"3972","DOI":"10.1038\/s41467-026-70285-7","article-title":"Prefusion-stabilized Hantaan virus glycoprotein nucleic acid vaccine elicits potent neutralizing antibody responses via germinal center activation","volume":"17","author":"Ye","year":"2026","journal-title":"Nat. Commun."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"e0253120","DOI":"10.1128\/mBio.02531-20","article-title":"Structural Basis for a Neutralizing Antibody Response Elicited by a Recombinant Hantaan Virus Gn Immunogen","volume":"12","author":"Rissanen","year":"2021","journal-title":"mBio"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Lu, S., Zhu, N., Guo, W., Wang, X., Li, K., Yan, J., Jiang, C., Han, S., Xiang, H., and Wu, X. (2020). RNA-Seq Revealed a Circular RNA-microRNA-mRNA Regulatory Network in Hantaan Virus Infection. Front. Cell. Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.00097"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"nwaa180","DOI":"10.1093\/nsr\/nwaa180","article-title":"Single-cell transcriptomic landscape of human blood cells","volume":"8","author":"Xie","year":"2021","journal-title":"Natl. Sci. Rev."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Zhang, J., Tang, K., Zhang, Y., Ma, Y., Zhang, C., Hu, H., Jia, X., Zhuang, R., Jin, B., and Wang, M. (2021). The Presence of Circulating Nucleated Red Blood Cells Is Associated with Disease Severity in Patients of Hemorrhagic Fever with Renal Syndrome. Front. Med., 8.","DOI":"10.3389\/fmed.2021.665410"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Xiao, R., Lin, M., Liu, M., and Ma, Q. (2024). Single cells and TRUST4 reveal immunological features of the HFRS transcriptome. Front. Med., 11.","DOI":"10.3389\/fmed.2024.1403335"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1419787","DOI":"10.3389\/fimmu.2024.1419787","article-title":"Maturing neutrophils of lower density associate with thrombocytopenia in Puumala orthohantavirus-caused hemorrhagic fever with renal syndrome","volume":"15","author":"Cabrera","year":"2024","journal-title":"Front Immunol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.csbj.2026.01.001","article-title":"Longitudinal omics data analysis: Approaches and applications","volume":"31","author":"Taheriyoun","year":"2026","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Hu, Y., Wu, C., Li, T., Wu, Y., Yao, K., Zhang, M., Li, P., and Bian, X. (2024). Transcriptomic analysis reveals key molecular signatures across recovery phases of hemorrhagic fever with renal syndrome. BMC Med. Genom., 17.","DOI":"10.1186\/s12920-024-02004-4"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Noack, D., van den Hout, M., Embregts, C.W.E., van IJcken, W.F.J., Koopmans, M.P.G., and Rockx, B. (2024). Species-specific responses during Seoul orthohantavirus infection in human and rat lung microvascular endothelial cells. PLoS Neglected Trop. Dis., 18.","DOI":"10.1371\/journal.pntd.0012074"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/s41467-024-44687-4","article-title":"Disparate macrophage responses are linked to infection outcome of Hantan virus in humans or rodents","volume":"15","author":"Ma","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Campbell, C.L., Torres-Perez, F., Acuna-Retamar, M., and Schountz, T. (2015). Transcriptome Markers of Viral Persistence in Naturally-Infected Andes Virus (Bunyaviridae) Seropositive Long-Tailed Pygmy Rice Rats. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0122935"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Gallo, G., Kotlik, P., Roingeard, P., Monot, M., Chevreux, G., Ulrich, R.G., Tordo, N., and Ermonval, M. (2022). Diverse susceptibilities and responses of human and rodent cells to orthohantavirus infection reveal different levels of cellular restriction. PLoS Neglected Trop. Dis., 16.","DOI":"10.1371\/journal.pntd.0010844"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Oh, T. (2026). Advances in Spatial Transcriptomics for Infectious Disease Research: Insight for Vaccine Development. Vaccines, 14.","DOI":"10.3390\/vaccines14020158"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/s41581-024-00841-1","article-title":"Spatial transcriptomics in health and disease","volume":"20","author":"Jain","year":"2024","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Sch\u00f6nrich, G., Kr\u00fcger, D.H., and Raftery, M.J. (2015). Hantavirus-induced disruption of the endothelial barrier: Neutrophils are on the payroll. Front. Microbiol., 6.","DOI":"10.3389\/fmicb.2015.00222"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3390\/v7020559","article-title":"Elevated Cytokines, Thrombin and PAI-1 in Severe HCPS Patients Due to Sin Nombre Virus","volume":"7","author":"Bondu","year":"2015","journal-title":"Viruses"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Bondu, V., Bitting, C., Poland, V.L., Hanson, J.A., Harkins, M.S., Lathrop, S., Nolte, K.B., Lawrence, D.A., and Buranda, T. (2018). Upregulation of P2Y2R, Active uPA, and PAI-1 Are Essential Components of Hantavirus Cardiopulmonary Syndrome. Front. Cell. Infect. Microbiol., 8.","DOI":"10.3389\/fcimb.2018.00169"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Maleki, K.T., Niemetz, L., Christ, W., Wigren Bystr\u00f6m, J., Thunberg, T., Ahlm, C., and Klingstr\u00f6m, J. (2025). IL-6 trans-signaling mediates cytokine secretion and barrier dysfunction in hantavirus-infected cells and correlates to severity in HFRS. PLoS Pathog., 21.","DOI":"10.1371\/journal.ppat.1013042"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"7405","DOI":"10.1128\/JVI.00576-10","article-title":"Pathogenic Hantaviruses Andes Virus and Hantaan Virus Induce Adherens Junction Disassembly by Directing Vascular Endothelial Cadherin Internalization in Human Endothelial Cells","volume":"84","author":"Gorbunova","year":"2010","journal-title":"J. Virol."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Noack, D., Goeijenbier, M., Reusken, C.B.E.M., Koopmans, M.P.G., and Rockx, B.H.G. (2020). Orthohantavirus Pathogenesis and Cell Tropism. Front. Cell. Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.00399"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1600-065X.2008.00694.x","article-title":"Hantavirus-induced immunity in rodent reservoirs and humans","volume":"225","author":"Rang","year":"2008","journal-title":"Immunol. Rev."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1128\/JVI.02397-07","article-title":"Hantaviruses direct endothelial cell permeability by sensitizing cells to the vascular permeability factor VEGF, while angiopoietin 1 and sphingosine 1-phosphate inhibit hantavirus-directed permeability","volume":"82","author":"Gavrilovskaya","year":"2008","journal-title":"J. Virol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nature19949","article-title":"Mass-spectrometric exploration of proteome structure and function","volume":"537","author":"Aebersold","year":"2016","journal-title":"Nature"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"ofy021","DOI":"10.1093\/ofid\/ofy021","article-title":"Differential Regulation of PAI-1 in Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever With Renal Syndrome","volume":"5","author":"Bellomo","year":"2018","journal-title":"Open Forum Infect. Dis."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"11227","DOI":"10.1128\/JVI.01405-10","article-title":"Andes Virus Disrupts the Endothelial Cell Barrier by Induction of Vascular Endothelial Growth Factor and Downregulation of VE-Cadherin","volume":"84","author":"Rollin","year":"2010","journal-title":"J. Virol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2217\/fvl.11.138","article-title":"Pathogenesis of the hantavirus pulmonary syndrome","volume":"7","author":"Mackow","year":"2012","journal-title":"Future Virol."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Hepojoki, J., Vaheri, A., and Strandin, T. (2014). The fundamental role of endothelial cells in hantavirus pathogenesis. Front. Microbiol., 5.","DOI":"10.3389\/fmicb.2014.00727"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cels.2020.05.012","article-title":"Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection","volume":"11","author":"Messner","year":"2020","journal-title":"Cell Syst."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1021\/acs.jproteome.4c00104","article-title":"Deep Plasma Proteomics with Data-Independent Acquisition: Clinical Study Protocol Optimization with a COVID-19 Cohort","volume":"23","author":"Ward","year":"2024","journal-title":"J. Proteome Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"e00528-19","DOI":"10.1128\/JVI.00528-19","article-title":"Phosphoproteome Analysis of Cells Infected with Adapted and Nonadapted Influenza A Virus Reveals Novel Pro- and Antiviral Signaling Networks","volume":"93","author":"Weber","year":"2019","journal-title":"J. Virol."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Lietz\u00e9n, N., \u00d6hman, T., Rintahaka, J., Julkunen, I., Aittokallio, T., Matikainen, S., and Nyman, T.A. (2011). Quantitative Subcellular Proteome and Secretome Profiling of Influenza A Virus-Infected Human Primary Macrophages. PLoS Pathog., 7.","DOI":"10.1371\/journal.ppat.1001340"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Taylor, S.L., Wahl-Jensen, V., Copeland, A.M., Jahrling, P.B., and Schmaljohn, C.S. (2013). Endothelial cell permeability during hantavirus infection involves factor XII-dependent increased activation of the kallikrein-kinin system. PLoS Pathog., 9.","DOI":"10.1371\/journal.ppat.1003470"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"e00801-15","DOI":"10.1128\/mBio.00801-15","article-title":"Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion","volume":"6","author":"Kleinfelter","year":"2015","journal-title":"mBio"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Petersen, J., Drake, M.J., Bruce, E.A., Riblett, A.M., Didigu, C.A., Wilen, C.B., Malani, N., Male, F., Lee, F.-H., and Bushman, F.D. (2014). The Major Cellular Sterol Regulatory Pathway Is Required for Andes Virus Infection. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1003911"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"849020","DOI":"10.3389\/fmicb.2022.849020","article-title":"LncRNA NEAT1 Potentiates SREBP2 Activity to Promote Inflammatory Macrophage Activation and Limit Hantaan Virus Propagation","volume":"13","author":"Yang","year":"2022","journal-title":"Front Microbiol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.freeradbiomed.2024.08.029","article-title":"25-Hydroxycholesterol inhibits Hantavirus infection by reprogramming cholesterol metabolism","volume":"224","author":"Dang","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"Kishton","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Lyon, P., Strippoli, V., Fang, B., and Cimmino, L. (2020). B Vitamins and One-Carbon Metabolism: Implications in Human Health and Disease. Nutrients, 12.","DOI":"10.3390\/nu12092867"},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Fakhrzadeh, H., Ghotbi, S., Pourebrahim, R., Nouri, M., Heshmat, R., Bandarian, F., Shafaee, A., and Larijani, B. (2006). Total plasma homocysteine, folate, and vitamin B12 status in healthy Iranian adults: The Tehran homocysteine survey (2003\u20132004)\/a cross-sectional population based study. BMC Public Health, 6.","DOI":"10.1186\/1471-2458-6-29"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s00018-014-1780-3","article-title":"Accumulating evidence for a role of oxidized phospholipids in infectious diseases","volume":"72","author":"Matt","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"519","DOI":"10.5483\/BMBRep.2022.55.11.128","article-title":"The role of immunomodulatory metabolites in shaping the inflammatory response of macrophages","volume":"55","author":"Park","year":"2022","journal-title":"BMB Rep."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1039\/D1MO00017A","article-title":"Metabolomics in infectious diseases and drug discovery","volume":"17","author":"Tounta","year":"2021","journal-title":"Mol. Omics"},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Morrow, G.B., Whyte, C.S., and Mutch, N.J. (2021). A Serpin with a Finger in Many PAIs: PAI-1\u2019s Central Function in Thromboinflammation and Cardiovascular Disease. Front. Cardiovasc. Med., 8.","DOI":"10.3389\/fcvm.2021.653655"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.thromres.2010.05.025","article-title":"Enhanced thrombin formation and fibrinolysis during acute Puumala hantavirus infection","volume":"126","author":"Laine","year":"2010","journal-title":"Thromb. Res."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"467059","DOI":"10.1155\/2012\/467059","article-title":"The Role of the Endothelium in HPS Pathogenesis and Potential Therapeutic Approaches","volume":"2012","author":"Gavrilovskaya","year":"2012","journal-title":"Adv. Virol."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Gavrilovskaya, I., Gorbunova, E., Koster, F., and Mackow, E. (2012). Elevated VEGF Levels in Pulmonary Edema Fluid and PBMCs from Patients with Acute Hantavirus Pulmonary Syndrome. PLoS Pathog., 2012.","DOI":"10.1155\/2012\/674360"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"ofu027","DOI":"10.1093\/ofid\/ofu027","article-title":"Endothelial activation and repair during hantavirus infection: Association with disease outcome","volume":"1","author":"Thunberg","year":"2014","journal-title":"Open Forum Infect. Dis."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41467-018-08015-x","article-title":"SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target","volume":"10","author":"Yuan","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Zhang, J., Zhu, Y., Wang, X., and Wang, J. (2023). 25-hydroxycholesterol: An integrator of antiviral ability and signaling. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1268104"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"240239","DOI":"10.1098\/rsob.240239","article-title":"Exploring glycolytic enzymes in disease: Potential biomarkers and therapeutic targets in neurodegeneration, cancer and parasitic infections","volume":"15","author":"Rojas","year":"2025","journal-title":"Open Biol."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Huang, S., Chaudhary, K., and Garmire, L.X. (2017). More Is Better: Recent Progress in Multi-Omics Data Integration Methods. Front. Genet., 8.","DOI":"10.3389\/fgene.2017.00084"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Jendoubi, T. (2021). Approaches to Integrating Metabolomics and Multi-Omics Data: A Primer. Metabolites, 11.","DOI":"10.20944\/preprints202101.0521.v1"},{"key":"ref_174","first-page":"e9923","article-title":"Integrated intra- and intercellular signaling knowledge for multicellular omics analysis","volume":"17","author":"Valdeolivas","year":"2021","journal-title":"Mol. Syst. Biol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: Protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Afzal, S., Ali, L., Batool, A., Afzal, M., Kanwal, N., Hassan, M., Safdar, M., Ahmad, A., and Yang, J. (2023). Hantavirus: An overview and advancements in therapeutic approaches for infection. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1233433"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"7074","DOI":"10.1073\/pnas.95.12.7074","article-title":"beta3 Integrins mediate the cellular entry of hantaviruses that cause respiratory failure","volume":"95","author":"Gavrilovskaya","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Tolomeo, M., Cavalli, A., and Cascio, A. (2022). STAT1 and Its Crucial Role in the Control of Viral Infections. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23084095"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev-immunol-032713-120231","article-title":"Interferon-Stimulated Genes: A Complex Web of Host Defenses","volume":"32","author":"Schneider","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/bs.aivir.2019.07.002","article-title":"Hantavirus entry: Perspectives and recent advances","volume":"104","author":"Mittler","year":"2019","journal-title":"Adv. Virus Res."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13059-017-1215-1","article-title":"Multi-omics approaches to disease","volume":"18","author":"Hasin","year":"2017","journal-title":"Genome Biol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"e8124","DOI":"10.15252\/msb.20178124","article-title":"Multi-Omics Factor Analysis\u2014A framework for unsupervised integration of multi-omics data sets","volume":"14","author":"Argelaguet","year":"2018","journal-title":"Mol. Syst. Biol."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Jiang, M.-Z., Aguet, F., Ardlie, K., Chen, J., Cornell, E., Cruz, D., Durda, P., Gabriel, S.B., Gerszten, R.E., and Guo, X. (2023). Canonical correlation analysis for multi-omics: Application to cross-cohort analysis. PLoS Genet., 19.","DOI":"10.1371\/journal.pgen.1010517"},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Rohart, F., Gautier, B., Singh, A., and Ka, L.C. (2017). MixOmics: An R package for \u2019omics feature selection and multiple data integration. PLoS Comput. Biol., 13.","DOI":"10.1101\/108597"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13059-020-02015-1","article-title":"MOFA+: A statistical framework for comprehensive integration of multi-modal single-cell data","volume":"21","author":"Argelaguet","year":"2020","journal-title":"Genome Biol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/S1053-8119(03)00202-7","article-title":"Dynamic causal modelling","volume":"19","author":"Friston","year":"2003","journal-title":"Neuroimage"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/s41592-021-01343-9","article-title":"Identifying temporal and spatial patterns of variation from multimodal data using MEFISTO","volume":"19","author":"Velten","year":"2022","journal-title":"Nat. Methods"},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Thaker, S.K., Ch\u2019ng, J., and Christofk, H.R. (2019). Viral hijacking of cellular metabolism. BMC Biol., 17.","DOI":"10.1186\/s12915-019-0678-9"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"e9730","DOI":"10.15252\/msb.20209730","article-title":"Causal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses","volume":"17","author":"Dugourd","year":"2021","journal-title":"Mol. Syst. Biol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.csbj.2024.04.053","article-title":"Knowledge-guided learning methods for integrative analysis of multi-omics data","volume":"23","author":"Li","year":"2024","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"LaPointe, A., Gale, M., and Kell, A.M. (2023). Orthohantavirus Replication in the Context of Innate Immunity. Viruses, 15.","DOI":"10.3390\/v15051130"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"524024","DOI":"10.1155\/2012\/524024","article-title":"Hantavirus regulation of type I interferon responses","volume":"2012","author":"Matthys","year":"2012","journal-title":"Adv. Virol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"e315","DOI":"10.1002\/mco2.315","article-title":"Applications of multi-omics analysis in human diseases","volume":"4","author":"Chen","year":"2023","journal-title":"MedComm"},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Outinen, T.K., M\u00e4kel\u00e4, S., P\u00f6rsti, I., Vaheri, A., and Mustonen, J. (2022). Severity Biomarkers in Puumala Hantavirus Infection. Viruses, 14.","DOI":"10.3390\/v14010045"},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"L\u00f3pez, R., Vial, C., Graf, J., Calvo, M., Ferr\u00e9s, M., Mertz, G., Cuiza, A., Ag\u00fcero, B., Aguilera, D., and Araya, D. (2019). Platelet Count in Patients with Mild Disease at Admission is Associated with Progression to Severe Hantavirus Cardiopulmonary Syndrome. Viruses, 11.","DOI":"10.3390\/v11080693"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1093\/infdis\/jiz005","article-title":"Serum Markers Associated with Severity and Outcome of Hantavirus Pulmonary Syndrome","volume":"219","author":"Maleki","year":"2019","journal-title":"J. Infect. Dis."},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Vlasova-St. Louis, I., Fang, D., Amer, Y., and Mohei, H. (2023). COVID-19-Omics Report: From Individual Omics Approaches to Precision Medicine. Reports, 6.","DOI":"10.3390\/reports6040045"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"101079","DOI":"10.1016\/j.xcrm.2023.101079","article-title":"Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients","volume":"4","author":"Fourati","year":"2023","journal-title":"Cell Rep. Med."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1128\/JVI.02063-13","article-title":"Mobilization of circulating endothelial progenitor cells correlates with the clinical course of hantavirus disease","volume":"88","author":"Grouls","year":"2014","journal-title":"J. Virol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/s00705-004-0306-y","article-title":"Modification of endothelial cell functions by Hantaan virus infection: Prolonged hyper-permeability induced by TNF-alpha of hantaan virus-infected endothelial cell monolayers","volume":"149","author":"Niikura","year":"2004","journal-title":"Arch. Virol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.virol.2015.02.038","article-title":"Viral activation of cellular metabolism","volume":"479\u2013480","author":"Sanchez","year":"2015","journal-title":"Virology"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.virusres.2013.12.041","article-title":"Hantavirus interferon regulation and virulence determinants","volume":"187","author":"Mackow","year":"2014","journal-title":"Virus Res."},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Easterbrook, J.D., and Klein, S.L. (2008). Immunological mechanisms mediating hantavirus persistence in rodent reservoirs. PLoS Pathog., 4.","DOI":"10.1371\/journal.ppat.1000172"},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Sol\u00e0-Riera, C., Garc\u00eda, M., Ljunggren, H.G., and Klingstr\u00f6m, J. (2020). Hantavirus inhibits apoptosis by preventing mitochondrial membrane potential loss through up-regulation of the pro-survival factor BCL-2. PLoS Pathog., 16.","DOI":"10.1371\/journal.ppat.1008297"},{"key":"ref_205","first-page":"635","article-title":"Fatty acid synthase promotes Hantaan virus infection through lipogenic regulation in the tree shrew model","volume":"47","author":"Wu","year":"2026","journal-title":"Zool. Res."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1016\/j.celrep.2019.04.061","article-title":"The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses","volume":"27","author":"Wang","year":"2019","journal-title":"Cell Rep."},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Saeidi, A., Zandi, K., Cheok, Y.Y., Saeidi, H., Wong, W.F., Lee, C.Y.Q., Cheong, H.C., Yong, Y.K., Larsson, M., and Shankar, E.M. (2018). T-Cell Exhaustion in Chronic Infections: Reversing the State of Exhaustion and Reinvigorating Optimal Protective Immune Responses. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.02569"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s11926-025-01189-6","article-title":"Biorepositories For Global Rare Disease Research: A Narrative Review","volume":"27","author":"Pellico","year":"2025","journal-title":"Curr. Rheumatol. Rep."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1089\/vim.2004.17.481","article-title":"Hantaviruses: Immunology, treatment, and prevention","volume":"17","author":"Maes","year":"2004","journal-title":"Viral Immunol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.coviro.2014.12.007","article-title":"The evolution and emergence of hantaviruses","volume":"10","author":"Holmes","year":"2015","journal-title":"Curr. Opin. Virol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.3390\/v6052214","article-title":"Immunogenetic factors affecting susceptibility of humans and rodents to hantaviruses and the clinical course of hantaviral disease in humans","volume":"6","author":"Charbonnel","year":"2014","journal-title":"Viruses"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/hmg\/ddae158","article-title":"Genetic analysis implicates ERAP1 and HLA as risk factors for severe Puumala virus infection","volume":"34","author":"Haapaniemi","year":"2025","journal-title":"Hum. Mol. Genet."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jcv.2014.08.033","article-title":"Hantaviruses\u2013globally emerging pathogens","volume":"64","author":"Kruger","year":"2015","journal-title":"J. Clin. Virol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41579-018-0020-5","article-title":"ISG15 in antiviral immunity and beyond","volume":"16","author":"Perng","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"507","DOI":"10.4161\/viru.24530","article-title":"Biomarkers of endothelial activation\/dysfunction in infectious diseases","volume":"4","author":"Page","year":"2013","journal-title":"Virulence"},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Ara\u00fajo, R., Bento, L.F.N., Fonseca, T.A.H., Von Rekowski, C.P., da Cunha, B.R., and Calado, C.R.C. (2022). Infection Biomarkers Based on Metabolomics. Metabolites, 12.","DOI":"10.3390\/metabo12020092"},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"Diray-Arce, J., Conti, M.G., Petrova, B., Kanarek, N., Angelidou, A., and Levy, O. (2020). Integrative metabolomics to identify molecular signatures of responses to vaccines and infections. Metabolites, 10.","DOI":"10.20944\/preprints202009.0004.v1"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"1177932219899051","DOI":"10.1177\/1177932219899051","article-title":"Multi-omics Data Integration, Interpretation, and Its Application","volume":"14","author":"Subramanian","year":"2020","journal-title":"Bioinform. Biol. Insights"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1016\/j.csbj.2021.06.030","article-title":"Integration strategies of multi-omics data for machine learning analysis","volume":"19","author":"Picard","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2014.12.003","article-title":"Reservoir host immune responses to emerging zoonotic viruses","volume":"160","author":"Mandl","year":"2015","journal-title":"Cell"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/s44320-025-00134-0","article-title":"Longitudinal big biological data in the AI era","volume":"21","author":"Mardinoglu","year":"2025","journal-title":"Mol. Syst. Biol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"100561","DOI":"10.1016\/j.mcpro.2023.100561","article-title":"Multi-Omics Profiling for Health","volume":"22","author":"Babu","year":"2023","journal-title":"Mol. Cell. Proteom."},{"key":"ref_223","first-page":"bbad453","article-title":"Explainable artificial intelligence for omics data: A systematic mapping study. Brief","volume":"25","author":"Toussaint","year":"2023","journal-title":"Bioinform."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s10238-025-01965-9","article-title":"AI-driven multi-omics integration in precision oncology: Bridging the data deluge to clinical decisions","volume":"26","author":"Hsu","year":"2025","journal-title":"Clin. Exp. Med."},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"Khan, S.N.N., Khan, M.W.A.A., Guarnera, L., and Akhtar, S.M.F. (2026). Multi-modal AI in precision medicine: Integrating genomics, imaging, and EHR data for clinical insights. Front. Artif. Intell., 8.","DOI":"10.3389\/frai.2025.1743921"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1038\/s41598-023-30596-x","article-title":"Machine learning identifies straightforward early warning rules for human Puumala hantavirus outbreaks","volume":"13","author":"Kazasidis","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_227","doi-asserted-by":"crossref","unstructured":"Glass, G.E. (2023). Forecasting Outbreaks of Hantaviral Disease: Future Directions in Geospatial Modeling. Viruses, 15.","DOI":"10.3390\/v15071461"},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Cintron, R., Whitmer, S.L.M., Moscoso, E., Campbell, E.M., Kelly, R., Talundzic, E., Mobley, M., Chiu, K.W., Shedroff, E., and Shankar, A. (2023). HantaNet: A New MicrobeTrace Application for Hantavirus Classification, Genomic Surveillance, Epidemiology and Outbreak Investigations. Viruses, 15.","DOI":"10.3390\/v15112208"},{"key":"ref_229","doi-asserted-by":"crossref","unstructured":"Nourani, E., Khunjush, F., and Durmu\u015f, S. (2015). Computational approaches for prediction of pathogen-host protein-protein interactions. Front. Microbiol., 6.","DOI":"10.3389\/fmicb.2015.00094"},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Guzzi, P.H., Branda, F., Scarpa, F., Ceccarelli, G., Ciccozzi, M., Giorgi, F.M., and Veltri, P. (2026). Integrated Downstream Analysis and Epidemiological Modelling of Hantavirus Infection: From Host Transcriptomics to Transmission Dynamics. Pathogens, 15.","DOI":"10.20944\/preprints202605.0831.v1"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1093\/bioinformatics\/bty1054","article-title":"DIABLO: An integrative approach for identifying key molecular drivers from multi-omics assays","volume":"35","author":"Singh","year":"2019","journal-title":"Bioinformatics"},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"Alshammari, A. (2023). Identification of novel inhibitors against hantaviruses through 2D fingerprinting and molecular modeling approaches. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1113321"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"19596","DOI":"10.1038\/s41598-026-57843-1","article-title":"A drug repurposing screen identifies antiviral compounds against Puumala Orthohantavirus","volume":"16","author":"Christ","year":"2026","journal-title":"Sci. Rep."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1021\/acs.jcim.9b00237","article-title":"Analyzing Learned Molecular Representations for Property Prediction","volume":"59","author":"Yang","year":"2019","journal-title":"J. Chem. Inf. Model."}],"updated-by":[{"DOI":"10.3390\/biotech15040085","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000}}],"container-title":["BioTech"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2673-6284\/15\/3\/58\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:15:25Z","timestamp":1790756125000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2673-6284\/15\/3\/58"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":234,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["biotech15030058"],"URL":"https:\/\/doi.org\/10.3390\/biotech15030058","relation":{},"ISSN":["2673-6284"],"issn-type":[{"value":"2673-6284","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,23]]}}}