{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T11:33:20Z","timestamp":1786361600740,"version":"build-2736575974"},"reference-count":63,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004179","name":"Ningxia Medical University","doi-asserted-by":"publisher","award":["XT2025037"],"award-info":[{"award-number":["XT2025037"]}],"id":[{"id":"10.13039\/501100004179","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004179","name":"Ningxia Medical University","doi-asserted-by":"publisher","award":["XT2025071"],"award-info":[{"award-number":["XT2025071"]}],"id":[{"id":"10.13039\/501100004179","id-type":"DOI","asserted-by":"publisher"}]},{"award":["XT2025037"],"award-info":[{"award-number":["XT2025037"]}],"id":[{"id":"https:\/\/ror.org\/02h8a1848","id-type":"ROR","asserted-by":"publisher"}]},{"award":["XT2025071"],"award-info":[{"award-number":["XT2025071"]}],"id":[{"id":"https:\/\/ror.org\/02h8a1848","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015811","name":"Natural Science Foundation of Ningxia Hui Autonomous Region","doi-asserted-by":"publisher","award":["2025AAC050076"],"award-info":[{"award-number":["2025AAC050076"]}],"id":[{"id":"10.13039\/100015811","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015811","name":"Key Research and Development Program of Ningxia Hui Autonomous Region","doi-asserted-by":"publisher","award":["2025BEH04093"],"award-info":[{"award-number":["2025BEH04093"]}],"id":[{"id":"10.13039\/100015811","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioTech"],"abstract":"<jats:p>Network pharmacology studies of medicine\u2013food homology plants have identified broad injury response pathways and hubs that cannot support compound-level or Parkinson\u2019s disease (PD)-specific claims. We developed a traceable, non-weighted framework that separates regulatory provenance, PD-context evidence, structural support, and safety\/developability liabilities. A ten-plant feasibility panel was locked before overlap with a 1631-gene PD union, yielding 382 plant-associated targets and 190 strict intersections. Leave-one-plant-out analysis retained 173\u2013190 targets, whereas disease source and threshold stress tests showed curation dependence. Whole-blood classifiers showed modest five-fold discrimination (area under the curve, 0.606\u20130.682) and were excluded from candidate decisions. Redocking-validated AutoDock Vina and protein\u2013ligand interaction fingerprints retained baicalein\u2013MMP9, baicalein\u2013AKT1, and baicalein\u2013BCL2 as caution-tagged follow-up pairs. Quercetin\u2013MMP9 was retained as a liability-tagged comparator, while KCNH2 relations were safety-only. Because no biological validation is presented, these pairs remain hypotheses for prospective MPP+-treated SH-SY5Y testing with orthogonal injury, dopaminergic phenotypes, target dependency, material confirmation and safety controls. Baicalein remains source-pending for the material chain.<\/jats:p>","DOI":"10.3390\/biotech15030066","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T10:23:50Z","timestamp":1786357430000},"page":"66","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk-Aware Computational Prioritization and Validation Route Design for Medicine\u2013Food Homology Plant Compounds in a Parkinson\u2019s Disease Context"],"prefix":"10.3390","volume":"15","author":[{"given":"Jinhao","family":"Zou","sequence":"first","affiliation":[{"name":"Key Laboratory of Dryness Syndrome in Chinese Medicine, Ministry of Education, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyi","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjiao","family":"Yong","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangyu","family":"Yan","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Hui","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Dryness Syndrome in Chinese Medicine, Ministry of Education, Ningxia Medical University, Yinchuan 750004, China"},{"name":"College of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. 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