{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:52:11Z","timestamp":1762624331928,"version":"build-2065373602"},"reference-count":60,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T00:00:00Z","timestamp":1580083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hungarian Ministry of Innovation and Technologies, New National Excellence Program","award":["\u00daNKP-19-3, \u00daNKP-19-2"],"award-info":[{"award-number":["\u00daNKP-19-3, \u00daNKP-19-2"]}]},{"name":"EMBERI ER\u0150FORR\u00c1S FEJLESZT\u00c9SI OPERAT\u00cdV PROGRAM (EFOP)","award":["EFOP-3.6.3-VEKOP-16-2017-00009"],"award-info":[{"award-number":["EFOP-3.6.3-VEKOP-16-2017-00009"]}]},{"name":"Gazdas\u00e1gfejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Operat\u00edv Program (GINOP)","award":["GINOP-2.3.2-15-2016-00043"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00043"]}]},{"name":"Hungarian Brain Research Program","award":["2017-1.2.1-NKP-2017-00002"],"award-info":[{"award-number":["2017-1.2.1-NKP-2017-00002"]}]},{"name":"SZTE \u00c1OK-KKA","award":["5S 567 (A202)"],"award-info":[{"award-number":["5S 567 (A202)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is the most common neurodegenerative dementia. Mapping the pathomechanism and providing novel therapeutic options have paramount significance. Recent studies have proposed the role of LMTK2 in AD. However, its expression pattern and association with the pathognomonic neurofibrillary tangles (NFTs) in different brain regions and neuropathological stages of AD is not clear. We performed chromogenic (CHR) LMTK2 and fluorescent phospho-tau\/LMTK2 double-labelling (FDL) immunohistochemistry (IHC) on 10\u201310 postmortem middle frontal gyrus (MFG) and anterior hippocampus (aHPC) samples with early and late neuropathological Braak tau stages of AD. MFG in early stage was our \u2018endogenous control\u2019 region as it is not affected by NFTs. Semiquantitative CHR-IHC intensity scoring revealed significantly higher (p &lt; 0.001) LMTK2 values in this group compared to NFT-affected regions. FDL-IHC demonstrated LMTK2 predominance in the endogenous control region, while phospho-tau overburden and decreased LMTK2 immunolabelling were detected in NFT-affected groups (aHPC in early and both regions in late stage). Spearman\u2019s correlation coefficient showed strong negative correlation between phospho-tau\/LMTK2 signals within each group. According to our results, LMTK2 expression is inversely proportionate to the extent of NFT pathology, and decreased LMTK2 level is not a general feature in AD brain, rather it is characteristic of the NFT-affected regions.<\/jats:p>","DOI":"10.3390\/brainsci10020068","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T11:41:57Z","timestamp":1580125317000},"page":"68","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lemur Tyrosine Kinase 2 (LMTK2) Level Inversely Correlates with Phospho-Tau in Neuropathological Stages of Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"10","author":[{"given":"J\u00e1nos","family":"Bencze","sequence":"first","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"},{"name":"MTA-DE Cerebrovascular and Neurodegenerative Research Group, Department of Neurology, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2670-5554","authenticated-orcid":false,"given":"M\u00e1t\u00e9","family":"Szarka","sequence":"additional","affiliation":[{"name":"Horvath Csaba Memorial Institute of Bioanalytical Research, Research Centre for Molecular Medicine, University of Debrecen, 4032 Debrecen, Hungary"},{"name":"Vitrolink Ltd., 4033 Debrecen, Hungary"},{"name":"Institute for Nuclear Research of the Hungarian Academy of Sciences (ATOMKI), 4026 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor","family":"Bencs","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e1ta N\u00f3ra","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"MTA-DE Cerebrovascular and Neurodegenerative Research Group, Department of Neurology, University of Debrecen, 4032 Debrecen, Hungary"},{"name":"Institute of Pathology, Faculty of Medicine, University of Szeged, 6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3 V.","family":"M\u00f3dis","sequence":"additional","affiliation":[{"name":"MTA-DE Cerebrovascular and Neurodegenerative Research Group, Department of Neurology, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dag","family":"Aarsland","sequence":"additional","affiliation":[{"name":"Department of Old Age Psychiatry, Institute of Psychiatry Psychology and Neuroscience, King\u2019s College London, London SE5 8AF, UK"},{"name":"Centre for Age-Related Medicine, SESAM, Stavanger University Hospital, 4011 Stavanger, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor","family":"Hortob\u00e1gyi","sequence":"additional","affiliation":[{"name":"MTA-DE Cerebrovascular and Neurodegenerative Research Group, Department of Neurology, University of Debrecen, 4032 Debrecen, Hungary"},{"name":"Institute of Pathology, Faculty of Medicine, University of Szeged, 6725 Szeged, Hungary"},{"name":"Department of Old Age Psychiatry, Institute of Psychiatry Psychology and Neuroscience, King\u2019s College London, London SE5 8AF, UK"},{"name":"Centre for Age-Related Medicine, SESAM, Stavanger University Hospital, 4011 Stavanger, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Alzheimer\u2019s Association (2017). 2017 Alzheimer\u2019s disease facts and figures. 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