{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T12:09:00Z","timestamp":1788178140114,"version":"build-2803163510"},"reference-count":89,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Introduction: Patients with obstructive sleep apnea (OSA) suffer from several neurocognitive disturbances. One of the neuropsychological processes most investigated in OSA patients is attention, but the results have been controversial. Here, we update the attention profile of OSA patients with the final aim to improve attention assessment, with a possible impact on clinical and medical-legal practices, in terms of which attention subdomains and parameters need consideration and which one is a high-risk OSA phenotype for attention dysfunctions. Method: For this purpose, we assessed 32 previously untreated OSA patients (26 men and 6 women) under 65 years of age (mean age 53.2 \u00b1 7.3; mean education level 10.4 \u00b1 3.4 years) suffering from moderate to severe sleep apnea and hypopnea (mean apnea-hypopnea index (AHI) 45.3 \u00b1 22.9, range 16.1\u201369.6). A control group of 34 healthy participants matched with OSA patients for age, education level, and general cognitive functioning were also enrolled. The OSA patients and healthy participants were tested through an extensive computerized battery (Test of Attentional Performance, TAP) that evaluated intensive (i.e., alertness and vigilance) and selective (i.e., divided and selective) dimensions of attention and returned different outcome parameters (i.e., reaction time, stability of performance, and various types of errors). Data analysis: The data were analyzed by ANCOVA which compared the speed and accuracy performance of the OSA and control participants (cognitive reserve was treated as a covariate). The possible mechanisms underlying attention deficits in OSA patients were examined through correlation analysis among AHI, oxygenation parameters, sleepiness scores, and TAP outcomes and by comparing the following three phenotypes of patients: severe OSA and severe nocturnal desaturators (AHI++D+), severe OSA nondesaturators (AHI++D\u2212), and moderate OSA nondesaturators (AHI+D\u2212). Results: The results suggest that the OSA patients manifest deficits in both intensive and selective attention processes and that reaction time (RT) alone is ineffective for detecting and characterizing their problems, for which error analysis and stability of performance also have to be considered. Patients with severe OSA and severe hypoxemia underperformed on alertness and vigilance attention subtests. Conclusions: The data suggest the importance of evaluating attention deficits among OSA patients through several parameters (including performance instability). Moreover, the data suggest a multifaceted mechanism underlying attention dysfunction in OSA patients.<\/jats:p>","DOI":"10.3390\/brainsci10060325","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T08:27:48Z","timestamp":1590654468000},"page":"325","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The Neuropsychological Profile of Attention Deficits of Patients with Obstructive Sleep Apnea: An Update on the Daytime Attentional Impairment"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9870-6009","authenticated-orcid":false,"given":"Paola","family":"Angelelli","sequence":"first","affiliation":[{"name":"Lab of Applied Psychology and Intervention, Department of History, Society and Human Studies, University of Salento, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Macchitella","sequence":"additional","affiliation":[{"name":"Lab of Applied Psychology and Intervention, Department of History, Society and Human Studies, University of Salento, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico Maurizio","family":"Toraldo","sequence":"additional","affiliation":[{"name":"\u201cV. Fazzi\u201d Hospital Rehabilitation Department, Respiratory Care Unit, ASL, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Abbate","sequence":"additional","affiliation":[{"name":"Lab of Applied Psychology and Intervention, Department of History, Society and Human Studies, University of Salento, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara Valeria","family":"Marinelli","sequence":"additional","affiliation":[{"name":"Lab of Applied Psychology and Intervention, Department of History, Society and Human Studies, University of Salento, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3012-3485","authenticated-orcid":false,"given":"Michele","family":"Arigliani","sequence":"additional","affiliation":[{"name":"\u201cV. Fazzi\u201d Hospital, ENT, ASL, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"De Benedetto","sequence":"additional","affiliation":[{"name":"\u201cV. Fazzi\u201d Hospital, ENT, ASL, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.5664\/jcsm.2172","article-title":"Rules for scoring respiratory events in sleep: Update of the 2007 AASM manual for the scoring of sleep and associated events","volume":"8","author":"Berry","year":"2012","journal-title":"J. Clin. Sleep Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S2213-2600(19)30198-5","article-title":"An Estimate of the Global Prevalence and Burden of Obstructive Sleep Apnoea","volume":"7","author":"Benjafield","year":"2019","journal-title":"Lancet Respir. Med."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Kendzerska, T., Gershon, A.S., Hawker, G., Leung, R.S., and Tomlinson, G. (2014). Obstructive sleep apnea and risk of cardiovascular events and all-cause mortality: A decade-long historical cohort study. PLoS Med., 11.","DOI":"10.1371\/journal.pmed.1001599"},{"key":"ref_4","first-page":"297","article-title":"Occupational accidents, work performance and obstructive sleep apnea syndrome (OSAS)","volume":"30","author":"Accattoli","year":"2008","journal-title":"Giornale italiano di medicina del lavoro ed ergonomia"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1136\/thx.2007.085464","article-title":"Risk and severity of motor vehicle crashes in patients with obstructive sleep apnoea\/hypopnoea","volume":"63","author":"Mulgrew","year":"2008","journal-title":"Thorax"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"573","DOI":"10.5664\/jcsm.27662","article-title":"Obstructive sleep apnea and risk of motor vehicle crash: Systematic review and meta-analysis","volume":"5","author":"Tregear","year":"2009","journal-title":"J. Clin. Sleep Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1177\/1479972312473134","article-title":"Obstructive sleep apnoea, motor vehicle accidents, and work performance","volume":"10","author":"Sanna","year":"2013","journal-title":"Chron. Respir. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/sleep\/26.3.298","article-title":"The neuropsychological effects of obstructive sleep apnea: A meta-analysis of norm-referenced and case-controlled data","volume":"26","author":"Beebe","year":"2003","journal-title":"Sleep"},{"key":"ref_9","first-page":"19","article-title":"Cognitive dysfunction in sleep-related breathing disorders: A meta-analysis","volume":"5","author":"Fulda","year":"2003","journal-title":"Sleep Res. Online"},{"key":"ref_10","first-page":"186","article-title":"The cognitive effects of obstructive sleep apnea: An updated meta-analysis","volume":"31","author":"Stranks","year":"2016","journal-title":"Arch. Clin. Neuropsychol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1001\/jamaneurol.2017.2180","article-title":"Association of Sleep-Disordered Breathing with Cognitive Function and Risk of Cognitive Impairment: A Systematic Review and Meta-analysis","volume":"74","author":"Leng","year":"2017","journal-title":"JAMA Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1152\/japplphysiol.01225.2004","article-title":"Functional imaging of working memory in obstructive sleep-disordered breathing","volume":"98","author":"Thomas","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"461","DOI":"10.5664\/jcsm.26665","article-title":"A review of neuroimaging in obstructive sleep apnea","volume":"2","author":"Zimmerman","year":"2006","journal-title":"J. Clin. Sleep Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1365-2869.2008.00705.x","article-title":"A combined neuropsychological and brain imaging study of obstructive sleep apnea","volume":"18","author":"Yaouhi","year":"2009","journal-title":"J. Sleep Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1164\/rccm.201005-0693OC","article-title":"Obstructive sleep apnea: Brain structural changes and neurocognitive function before and after treatment","volume":"183","author":"Canessa","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.neuroimage.2010.09.065","article-title":"Cognitive profile and brain morphological changes in obstructive sleep apnea","volume":"54","author":"Torelli","year":"2011","journal-title":"Neuroimage"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fneur.2012.00087","article-title":"Sleep apnea syndrome and cognition","volume":"3","author":"Sforza","year":"2012","journal-title":"Front. Neurol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s11325-014-1000-2","article-title":"Cognition and nocturnal disturbance in OSA: The importance of accounting for age and premorbid intelligence","volume":"19","author":"Olaithe","year":"2015","journal-title":"Sleep Breath"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1111\/resp.13140","article-title":"Reviewing the relationship between OSA and cognition: W here do we go from here?","volume":"22","author":"Bucks","year":"2017","journal-title":"Respirology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1097\/00002093-200607001-00010","article-title":"Cognitive reserve and Alzheimer disease","volume":"20","author":"Stern","year":"2006","journal-title":"Alzheimer. Dis. Assoc. Disord."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/BF03654795","article-title":"Cognitive Reserve Index questionnaire (CRIq): A new instrument for measuring cognitive reserve","volume":"24","author":"Nucci","year":"2012","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"894","DOI":"10.2967\/jnumed.112.113928","article-title":"Metabolic networks underlying cognitive reserve in prodromal Alzheimer disease: A European Alzheimer disease consortium project","volume":"54","author":"Morbelli","year":"2013","journal-title":"J. Nucl. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1177\/1533317516653826","article-title":"Cognitive reserve in healthy aging and Alzheimer\u2019s disease: A meta-analysis of fMRI studies","volume":"31","author":"Colangeli","year":"2016","journal-title":"Am. J. Alzheimer\u2019s Dis. Other Demen."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bandc.2017.07.002","article-title":"Cognitive and motor reaction times in obstructive sleep apnea syndrome: A study based on computerized measures","volume":"117","author":"Devita","year":"2017","journal-title":"Brain Cognit."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2869.2004.00436.x","article-title":"Sleep apnea related cognitive deficits and intelligence: An implication of cognitive reserve theory","volume":"14","author":"Alchanatis","year":"2005","journal-title":"J. Sleep Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3389\/fpsyt.2018.00435","article-title":"Analysis of attention subdomains in obstructive sleep apnea patients","volume":"9","author":"Padilla","year":"2018","journal-title":"Front. Psychiatry"},{"key":"ref_27","first-page":"685","article-title":"Executive function in sleep apnea: Controlling for attentional capacity in assessing executive attention","volume":"27","author":"Verstraeten","year":"2004","journal-title":"Sleep"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fsurg.2018.00035","article-title":"Impaired neurobehavioural Performance in Untreated Obstructive sleep apnea Patients Using a novel standardised Test Battery","volume":"5","author":"Field","year":"2018","journal-title":"Front. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1164\/ajrccm.163.7.2007028","article-title":"Microsleep during a simplified maintenance of wakefulness test: A validation study of the OSLER test","volume":"163","author":"Priest","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1164\/rccm.2107065","article-title":"Analysis of error profiles occurring during the OSLER test: A sensitive mean of detecting fluctuations in vigilance in patients with obstructive sleep apnea syndrome","volume":"166","author":"Mazza","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1183\/09031936.04.00091903","article-title":"Performance vigilance task and sleepiness in patients with sleep- disordered breathing","volume":"24","author":"Sforza","year":"2004","journal-title":"Eur. Respir. J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1183\/09031936.04.00011204","article-title":"Most obstructive sleep apnoea patients exhibit vigilance and attention deficits on an extended battery of tests","volume":"25","author":"Mazza","year":"2005","journal-title":"Eur. Resp. J."},{"key":"ref_33","first-page":"253","article-title":"Sustained attention performance during sleep deprivation: Evidence of state instability","volume":"139","author":"Doran","year":"2001","journal-title":"Arch. Ital. Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ijpsycho.2017.10.003","article-title":"Global cognitive profile and different components of reaction times in obstructive sleep apnea syndrome: Effects of continuous positive airway pressure over time","volume":"123","author":"Devita","year":"2018","journal-title":"Int. J. Psychophys."},{"key":"ref_35","first-page":"234","article-title":"Obstructive Sleep Apnea and Chronic Intermittent Hypoxia: A Review","volume":"49","author":"Chiang","year":"2006","journal-title":"Chin. J. Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s11325-011-0582-1","article-title":"Hypoxemia correlates with attentional dysfunction in patients with obstructive sleep apnea","volume":"16","author":"Shpirer","year":"2012","journal-title":"Sleep Breath"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00408-012-9427-3","article-title":"Obstructive sleep apnea syndrome: Blood viscosity, blood coagulation abnormalities, and early atherosclerosis","volume":"191","author":"Toraldo","year":"2013","journal-title":"Lung"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1378\/chest.14-0500","article-title":"Intermittent hypoxemia and OSA: Implications for comorbidities","volume":"147","author":"Dewan","year":"2015","journal-title":"Chest"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s11325-015-1227-6","article-title":"Obstructive sleep apnea syndrome: Coagulation anomalies and treatment with continuous positive airway pressure","volume":"20","author":"Toraldo","year":"2016","journal-title":"Sleep Breath"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.smrv.2017.03.005","article-title":"Cognitive deficits in obstructive sleep apnea: Insights from a meta-review and comparison with deficits observed in COPD, insomnia, and sleep deprivation","volume":"38","author":"Olaithe","year":"2018","journal-title":"Sleep Med. Rev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1164\/rccm.200411-1564OC","article-title":"Inducible nitric oxide synthase in long-term intermittent hypoxia","volume":"71","author":"Zhan","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1164\/rccm.200504-581OC","article-title":"NADPH oxidase mediates hypersomnolence and brain oxidative injury in a murine model of sleep apnea","volume":"172","author":"Zhan","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_43","first-page":"69","article-title":"Obstructive sleep apnoea syndrome: A new paradigm by chronic nocturnal intermittent hypoxia and sleep disruption","volume":"35","author":"Toraldo","year":"2015","journal-title":"Acta. Otorhinolaryngol. Ital."},{"key":"ref_44","unstructured":"American Academy of Sleep Medicine (2014). International Classification of Sleep Disorders, IL American Academy of Sleep Medicine. [3rd ed.]."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3389\/fneur.2018.00505","article-title":"Obstructive Sleep Apnea with or Without Excessive Daytime Sleepiness: Clinical and Experimental Data-Driven Phenotyping","volume":"9","author":"Garbarino","year":"2018","journal-title":"Front. Neurol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1164\/ajrccm.163.7.2004014","article-title":"Relation of measures of sleep-disordered breathing to neuropsychological functioning","volume":"163","author":"Adams","year":"2001","journal-title":"Am. J. Respir. Crit. Care. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1076\/jcen.26.1.43.23929","article-title":"Neurobehavioral functioning in obstructive sleep apnea: Differential effects of sleep quality, hypoxemia and subjective sleepiness","volume":"26","author":"Naismith","year":"2004","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1365-2869.2008.00707.x","article-title":"Altered brain activation during response inhibition in obstructive sleep apnea","volume":"18","author":"Ayalon","year":"2009","journal-title":"J. Sleep Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1378\/chest.100.6.1542","article-title":"Hypoxemia vs. sleep fragmentation as cause of excessive daytime sleepiness in obstructive sleep apnea","volume":"100","author":"Colt","year":"1991","journal-title":"Chest"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1164\/ajrccm.159.6.9808095","article-title":"Modeling Hypersomnolence in Sleep-disordered Breathing. A Novel Approach Using Survival Analysis","volume":"159","author":"Punjabi","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_51","unstructured":"Aloia, M.S., and Arnedt, J.T. (2016). Mechanisms of sleepiness in obstructive sleep apnea. Sleep Apnea, CRC Press."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/sleep\/27.2.194","article-title":"Long-term intermittent hypoxia in mice: Protracted hypersomnolence with oxidative injury to sleep-wake brain regions","volume":"27","author":"Veasey","year":"2004","journal-title":"Sleep"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"10060","DOI":"10.1523\/JNEUROSCI.0857-07.2007","article-title":"Selective loss of catecholaminergic wake\u2013active neurons in a murine sleep apnea model","volume":"27","author":"Zhu","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s11325-012-0733-z","article-title":"Factors associated with excessive daytime sleepiness in patients with severe obstructive sleep apnea","volume":"17","author":"Jacobsen","year":"2013","journal-title":"Sleep Breath"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11325-013-0851-2","article-title":"Nocturnal hypoxemia biomarker predicts sleepiness in patients with severe obstructive sleep apnea","volume":"18","author":"Uysal","year":"2014","journal-title":"Sleep Breath"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.sleep.2016.02.008","article-title":"A review of neurocognitive function and obstructive sleep apnea with or without daytime sleepiness","volume":"23","author":"Zhou","year":"2016","journal-title":"Sleep Med."},{"key":"ref_57","first-page":"43","article-title":"Deficits of cognitive executive functions in patients with sleep apnea syndrome","volume":"18","author":"Thouvard","year":"1995","journal-title":"Sleep"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2869.2002.00289.x","article-title":"Obstructive sleep apnea and the prefrontal cortex: Towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits","volume":"11","author":"Beebe","year":"2002","journal-title":"J. Sleep Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1378\/chest.100.2.367","article-title":"Nocturnal hypoxemia as a determinant of vigilance impairment in sleep apnea syndrome","volume":"100","author":"Montplaisir","year":"1991","journal-title":"Chest"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s11325-019-01860-0","article-title":"Do T90 and SaO2 nadir identify a different phenotype in obstructive sleep apnea?","volume":"23","author":"Labarca","year":"2019","journal-title":"Sleep Breath"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/sleep\/34.3.303","article-title":"The association between obstructive sleep apnea and neurocognitive performance\u2014The Apnea Positive Pressure Long-term Efficacy Study (APPLES)","volume":"34","author":"Quan","year":"2011","journal-title":"Sleep"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.sleep.2013.11.708","article-title":"Measuring attention deficit with dass test in children with obstructive sleep apnea","volume":"14","author":"Vaher","year":"2013","journal-title":"Sleep Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/87565649109540545","article-title":"The Mini Mental state examination: Normative study of an Italian random sample","volume":"9","author":"Measso","year":"1993","journal-title":"Dev. Neuropsychol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1046\/j.1365-2869.2000.00177.x","article-title":"Sensitivity and specificity of the multiple sleep latency test (MSLT), the maintenance of wakefulness test and the Epworth Sleepiness Scale: Failure of the MSLT as a gold standard","volume":"9","author":"Johns","year":"2000","journal-title":"J. Sleep Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","article-title":"A New Method for Measuring Daytime Sleepiness: The Epworth Sleepiness Scale","volume":"14","author":"Johns","year":"1991","journal-title":"Sleep"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/aje\/kws342","article-title":"Increased prevalence of sleep disordered breathing in adults","volume":"177","author":"Peppard","year":"2013","journal-title":"Am. J. Epidemiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1378\/chest.15-0903","article-title":"STOP-Bang questionnaire: A practical approach to screen for obstructive sleep apnea","volume":"149","author":"Chung","year":"2016","journal-title":"Chest"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"479","DOI":"10.5664\/jcsm.6506","article-title":"Clinical practice guideline for diagnostic testing for adult obstructive sleep apnea: An American Academy of Sleep Medicine clinical practice guideline","volume":"13","author":"Kapur","year":"2017","journal-title":"J. Clin. Sleep Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1378\/chest.15-1076","article-title":"Portable monitoring for the diagnosis of OSA","volume":"149","author":"Cooksey","year":"2016","journal-title":"Chest"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1164\/rccm.201612-2497OC","article-title":"Conventional polysomnography is not necessary for the management of most patients with suspected obstructive sleep apnea. Noninferiority, randomized controlled trial","volume":"196","author":"Corral","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1378\/chest.128.6.3828","article-title":"Pattern of Variables Describing Desaturator COPD Patients, as Revealed by Cluster Analysis","volume":"128","author":"Toraldo","year":"2005","journal-title":"Chest"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/S1053-8119(00)90945-5","article-title":"The functional anatomy of intrinsic and phasic alertness\u2014A PET study with auditory stimulation","volume":"11","author":"Weis","year":"2000","journal-title":"NeuroImage"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1006\/nimg.2001.0839","article-title":"On the functional neuroanatomy of intrinsic and phasic alertness","volume":"14","author":"Sturm","year":"2001","journal-title":"NeuroImage"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/713755526","article-title":"Do specific attention deficits need specific training?","volume":"7","author":"Sturm","year":"1997","journal-title":"Neuropsychol. Rehabil."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0028-3932(98)00141-9","article-title":"Functional anatomy of intrinsic alertness: Evidence for a fronto-parietal-thalamic-brainstem network in the right hemisphere","volume":"37","author":"Sturm","year":"1999","journal-title":"Neuropsychologia"},{"key":"ref_76","unstructured":"Leclercq, M., and Zimmermann, P. (2002). Neuropsychological spects of attentional functions and disturbances. Applied Neuropsychology of Attention Theory, Diagnosis and Rehabilitation, Psychology Press."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrn755","article-title":"Control of goal-directed and stimulus-driven attention in the brain","volume":"3","author":"Corbetta","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1146\/annurev-neuro-062111-150525","article-title":"The attention system of the human brain: 20 years after","volume":"35","author":"Petersen","year":"2012","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_79","unstructured":"Van Zomeren, A.H., and Brouwer, W.H. (1994). Clinical Neuropsychology of Attention, Oxford University Press."},{"key":"ref_80","unstructured":"Zimmermann, P., and Fimm, B. (1992). Testbatterie zur Aufmerksamkeitspr\u00fcfung (TAP), Psytest."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1212\/WNL.54.8.1616","article-title":"Quantifying fluctuation in dementia with Lewy bodies, Alzheimer\u2019s disease, and vascular dementia","volume":"54","author":"Walker","year":"2000","journal-title":"Neurology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1006\/nimg.2002.1252","article-title":"Dissociable contributions of prefrontal and parietal cortices to response selection","volume":"17","author":"Bunge","year":"2002","journal-title":"Neuroimage"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1006\/nimg.2002.1198","article-title":"The human prefrontal and parietal association cortices are involved in NO-GO performances: An event-related fMRI study","volume":"17","author":"Watanabe","year":"2002","journal-title":"Neuroimage"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.cogbrainres.2005.09.011","article-title":"On the neural basis of focused and divided attention","volume":"25","author":"Nebel","year":"2005","journal-title":"Cog. Brain Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/sleep\/32.3.373","article-title":"Relationship between obstructive sleep apnea severity and brain activation during a sustained attention task","volume":"32","author":"Ayalon","year":"2009","journal-title":"Sleep"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Spaccavento, S., Marinelli, C.V., Nardulli, R., Macchitella, L., Bivona, U., Piccardi, L., Zoccolotti, P., and Angelelli, P. (2019). Attention deficits in stroke patients: The role of lesion characteristics, time from stroke, and concomitant neuropsychological deficits. Behav. Neurol.","DOI":"10.1155\/2019\/7835710"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"903","DOI":"10.3389\/fpsyg.2014.00903","article-title":"Does the mean adequately represent reading performance? Evidence from a cross-linguistic study","volume":"5","author":"Marinelli","year":"2014","journal-title":"Front. Psychol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Marinelli, C.V., Romani, C., Burani, C., McGowan, V.A., and Zoccolotti, P. (2016). Costs and benefits of orthographic inconsistency in reading: Evidence from a cross-linguistic comparison. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0157457"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41386-019-0432-6","article-title":"Sleep deprivation, vigilant attention, and brain function: A review","volume":"45","author":"Hudson","year":"2020","journal-title":"Neuropsychopharmacology"}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/10\/6\/325\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:33:02Z","timestamp":1760175182000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/10\/6\/325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,27]]},"references-count":89,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["brainsci10060325"],"URL":"https:\/\/doi.org\/10.3390\/brainsci10060325","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,27]]}}}