{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T15:14:43Z","timestamp":1792336483825,"version":"4.4.0"},"reference-count":54,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CGP-14171"],"award-info":[{"award-number":["CGP-14171"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["CHRP 478470"],"award-info":[{"award-number":["CHRP 478470"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Post-hemorrhagic ventricular dilatation (PHVD) is characterized by a build-up of cerebral spinal fluid (CSF) in the ventricles, which increases intracranial pressure and compresses brain tissue. Clinical interventions (i.e., ventricular taps, VT) work to mitigate these complications through CSF drainage; however, the timing of these procedures remains imprecise. This study presents Neonatal NeuroMonitor (NNeMo), a portable optical device that combines broadband near-infrared spectroscopy (B-NIRS) and diffuse correlation spectroscopy (DCS) to provide simultaneous assessments of cerebral blood flow (CBF), tissue saturation (StO2), and the oxidation state of cytochrome c oxidase (oxCCO). In this study, NNeMo was used to monitor cerebral hemodynamics and metabolism in PHVD patients selected for a VT. Across multiple VTs in four patients, no significant changes were found in any of the three parameters: CBF increased by 14.6 \u00b1 37.6% (p = 0.09), StO2 by 1.9 \u00b1 4.9% (p = 0.2), and oxCCO by 0.4 \u00b1 0.6 \u00b5M (p = 0.09). However, removing outliers resulted in significant, but small, increases in CBF (6.0 \u00b1 7.7%) and oxCCO (0.1 \u00b1 0.1 \u00b5M). The results of this study demonstrate NNeMo\u2019s ability to provide safe, non-invasive measurements of cerebral perfusion and metabolism for neuromonitoring applications in the neonatal intensive care unit.<\/jats:p>","DOI":"10.3390\/brainsci10070452","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T10:35:18Z","timestamp":1594809318000},"page":"452","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Perfusion and Metabolic Neuromonitoring during Ventricular Taps in Infants with Post-Hemorrhagic Ventricular Dilatation"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0949-4137","authenticated-orcid":false,"given":"Ajay","family":"Rajaram","sequence":"first","affiliation":[{"name":"Imaging Program, Lawson Health Research Institute, London, ON N6A 4V2, Canada"},{"name":"Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 3K7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0014-8112","authenticated-orcid":false,"given":"Lawrence C. M.","family":"Yip","sequence":"additional","affiliation":[{"name":"Imaging Program, Lawson Health Research Institute, London, ON N6A 4V2, Canada"},{"name":"Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 3K7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3173-0834","authenticated-orcid":false,"given":"Daniel","family":"Milej","sequence":"additional","affiliation":[{"name":"Imaging Program, Lawson Health Research Institute, London, ON N6A 4V2, Canada"},{"name":"Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 3K7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Suwalski","sequence":"additional","affiliation":[{"name":"Imaging Program, Lawson Health Research Institute, London, ON N6A 4V2, Canada"},{"name":"Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 3K7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Kewin","sequence":"additional","affiliation":[{"name":"Imaging Program, Lawson Health Research Institute, London, ON N6A 4V2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Lo","sequence":"additional","affiliation":[{"name":"Imaging Program, Lawson Health Research Institute, London, ON N6A 4V2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0683-6004","authenticated-orcid":false,"given":"Jeffrey J. L.","family":"Carson","sequence":"additional","affiliation":[{"name":"Imaging Program, Lawson Health Research Institute, London, ON N6A 4V2, Canada"},{"name":"Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 3K7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, London Health Sciences Centre, London, ON N6A 3K7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soume","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, London Health Sciences Centre, London, ON N6A 3K7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamadou","family":"Diop","sequence":"additional","affiliation":[{"name":"Imaging Program, Lawson Health Research Institute, London, ON N6A 4V2, Canada"},{"name":"Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 3K7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"de Ribaupierre","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 3K7, Canada"},{"name":"Department of Clinical Neurological Sciences, London Health Sciences Centre, London, ON N6A 5W9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"St. Lawrence","sequence":"additional","affiliation":[{"name":"Imaging Program, Lawson Health Research Institute, London, ON N6A 4V2, Canada"},{"name":"Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 3K7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"key":"ref_1","unstructured":"Canadian Institute for Health Information (2020, July 10). 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