{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:31:31Z","timestamp":1792881091624,"version":"4.5.0"},"reference-count":115,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Since the end of 2019, the whole world has been struggling with the pandemic of the new Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2). Available evidence suggests that pain is a common symptom during Coronavirus Disease 2019 (COVID-19). According to the World Health Organization, many patients suffer from muscle pain (myalgia) and\/or joint pain (arthralgia), sore throat and headache. The exact mechanisms of headache and myalgia during viral infection are still unknown. Moreover, many patients with respiratory failure get admitted to the intensive care unit (ICU) for ventilatory support. Pain in ICU patients can be associated with viral disease itself (myalgia, arthralgia, peripheral neuropathies), may be caused by continuous pain and discomfort associated with ICU treatment, intermittent procedural pain and chronic pain present before admission to the ICU. Undertreatment of pain, especially when sedation and neuromuscular blocking agents are used, prone positioning during mechanical ventilation or extracorporeal membrane oxygenation (ECMO) may trigger delirium and cause peripheral neuropathies. This narrative review summarizes current knowledge regarding challenges associated with pain assessment and management in COVID-19 patients. A structured prospective evaluation should be undertaken to analyze the probability, severity, sources and adequate treatment of pain in patients with COVID-19 infection.<\/jats:p>","DOI":"10.3390\/brainsci10070465","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T10:59:38Z","timestamp":1595242778000},"page":"465","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["COVID-19: Pain Management in Patients with SARS-CoV-2 Infection\u2014Molecular Mechanisms, Challenges, and Perspectives"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4082-2696","authenticated-orcid":false,"given":"Sylwester","family":"Dro\u017cd\u017cal","sequence":"first","affiliation":[{"name":"Department of Pharmacokinetics and Monitored Therapy, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7377-4566","authenticated-orcid":false,"given":"Jakub","family":"Rosik","sequence":"additional","affiliation":[{"name":"Department of Physiology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0807-8510","authenticated-orcid":false,"given":"Kacper","family":"Lechowicz","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Intensive Therapy and Acute Intoxications, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Machaj","sequence":"additional","affiliation":[{"name":"Department of Physiology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartosz","family":"Szostak","sequence":"additional","affiliation":[{"name":"Department of Physiology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Majewski","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Therapy, Regional Specialist Hospital, 72-300 Gryfice, Department of Cardiac Surgery, Ceynowa Hospital, 84-200 Wejherowo, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwona","family":"Rotter","sequence":"additional","affiliation":[{"name":"Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8430-1369","authenticated-orcid":false,"given":"Katarzyna","family":"Kotfis","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Intensive Therapy and Acute Intoxications, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2020, June 15). General\u2019s Opening Remarks at the Media Briefing on {COVID}-19. Available online: https:\/\/www.who.int\/dg\/speeches\/detail\/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41579-018-0118-9","article-title":"Origin and evolution of pathogenic coronaviruses","volume":"17","author":"Cui","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_3","first-page":"3","article-title":"Animal coronaviruses: A brief introduction","volume":"1","author":"Wang","year":"2015","journal-title":"Anim. Coronaviruses"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.idc.2019.07.001","article-title":"Severe acute respiratory syndrome: Historical, epidemiologic, and clinical features","volume":"33","author":"Hui","year":"2019","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_5","first-page":"4956","article-title":"Middle east respiratory syndrome coronavirus (MERS-CoV) infection: Epidemiology, pathogenesis and clinical characteristics","volume":"22","author":"Nassar","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1093\/infdis\/jiaa077","article-title":"A familial cluster of infection associated with the 2019 novel coronavirus indicating potential person-to-person transmission during the incubation period","volume":"11","author":"Yu","year":"2020","journal-title":"J. Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.5114\/ait.2020.93867","article-title":"COVID-19: Gastrointestinal symptoms and potential sources of 2019-NCoV transmission","volume":"52","author":"Kotfis","year":"2020","journal-title":"Anaesthesiol. Intensive Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1053\/j.gastro.2020.02.054","article-title":"COVID-19: Gastrointestinal manifestations and potential fecal-oral transmission","volume":"158","author":"Gu","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0140-6736(20)30154-9","article-title":"Familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster","volume":"395","author":"Chan","year":"2020","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1056\/NEJMoa2001316","article-title":"Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia","volume":"382","author":"Li","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"ref_12","unstructured":"WHO (2020). Clinical Management of Severe Acute Respiratory Infection When Novel Coronavirus (NCoV) Infection Is Suspected, World Health Organization."},{"key":"ref_13","first-page":"S77","article-title":"Cardiovigilance in COVID 19","volume":"70","author":"Kishor","year":"2020","journal-title":"J. Pak. Med. Assoc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"618","DOI":"10.33963\/KP.15265","article-title":"The patient with heart failure in the face of the coronavirus disease 2019 pandemic: An Expert opinion of the heart failure working group of the polish cardiac society","volume":"78","author":"Gackowski","year":"2020","journal-title":"Kardiol. Pol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.acvd.2020.03.009","article-title":"COVID-19 in patients with cardiovascular diseases","volume":"113","author":"Hulot","year":"2020","journal-title":"Arch. Cardiovasc. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"E79","DOI":"10.1016\/j.jpainsymman.2020.04.025","article-title":"Palliative care in the time of COVID-19","volume":"60","author":"Mercadante","year":"2020","journal-title":"J. Pain Symptom Manag."},{"key":"ref_17","unstructured":"WHO (2020). Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19), World Health Organization."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s13054-020-02882-x","article-title":"COVID-19: ICU delirium management during SARS-CoV-2 pandemic","volume":"24","author":"Kotfis","year":"2020","journal-title":"Crit. Care"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"109852","DOI":"10.1016\/j.jclinane.2020.109852","article-title":"Chronic pain management in COVID-19 Era","volume":"65","author":"Piraccini","year":"2020","journal-title":"J. Clin. Anesth."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s11920-013-0421-0","article-title":"Pain and depression: An integrative review of neurobiological and psychological factors","volume":"15","author":"Goesling","year":"2013","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1097\/j.pain.0000000000001885","article-title":"Managing patients with chronic pain during the COVID-19 outbreak: Considerations for the rapid introduction of remotely supported (EHealth) pain management services","volume":"161","author":"Eccleston","year":"2020","journal-title":"Pain"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e181","DOI":"10.1016\/S1470-2045(20)30149-2","article-title":"Risk of COVID-19 for patients with cancer","volume":"21","author":"Wang","year":"2020","journal-title":"The Lancet. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/j.jpainsymman.2020.03.025","article-title":"Creating a palliative care inpatient response plan for COVID-19-The UW medicine experience","volume":"60","author":"Fausto","year":"2020","journal-title":"J. Pain Symptom Manag."},{"key":"ref_24","unstructured":"The British Pain Society (2020, June 05). Pain Management during COVID-19 Viral Infection. Available online: https:\/\/www.britishpainsociety.org\/static\/uploads\/resources\/files\/Pain_Management_during_COVID-19_viral_infection.pdf."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Boziki, M.K., Mentis, A.F.A., Shumilina, M., Makshakov, G., Evdoshenko, E., and Grigoriadis, N. (2020). COVID-19 immunopathology and the central nervous system: Implication for multiple sclerosis and other autoimmune diseases with associated demyelination. Brain Sci., 10.","DOI":"10.3390\/brainsci10060345"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/jamaneurol.2020.1127","article-title":"Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China","volume":"77","author":"Mao","year":"2020","journal-title":"JAMA Neurol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.jfma.2020.04.024","article-title":"COVID 19 infection presenting as motor peripheral neuropathy","volume":"119","author":"Abdelnour","year":"2020","journal-title":"J. Formos. Med. Assoc. Taiwan Yi Zhi"},{"key":"ref_28","first-page":"e8192","article-title":"A review of neurological complications of COVID-19","volume":"12","author":"Sheraton","year":"2020","journal-title":"Cureus"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"105921","DOI":"10.1016\/j.clineuro.2020.105921","article-title":"Neurological manifestations of COVID-19 and other coronavirus infections: A systematic review","volume":"194","author":"Montalvan","year":"2020","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1056\/NEJMc2008597","article-title":"Neurologic features in severe SARS-CoV-2 infection","volume":"382","author":"Helms","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bbi.2020.05.025","article-title":"Pain: A potential new label of COVID-19","volume":"87","author":"Su","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/jmv.25757","article-title":"COVID-19 Patients\u2019 clinical characteristics, discharge rate, and fatality rate of meta-analysis","volume":"92","author":"Li","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.pain.2010.07.018","article-title":"Mechanisms involved in IL-6-induced muscular mechanical hyperalgesia in mice","volume":"151","author":"Manjavachi","year":"2010","journal-title":"Pain"},{"key":"ref_34","first-page":"537","article-title":"Towards an artificial intelligence framework for data-driven prediction of coronavirus clinical severity","volume":"63","author":"Jiang","year":"2020","journal-title":"Comput. Mater. Contin."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1172\/JCI137244","article-title":"Clinical and immunological features of severe and moderate coronavirus disease 2019","volume":"130","author":"Chen","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1172\/JCI137647","article-title":"SARS-CoV-2: A storm is raging","volume":"130","author":"Pedersen","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Hoffmann, S., and Beyer, C. (2020). A fatal alliance between microglia, inflammasomes, and central pain. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21113764"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3389\/fncel.2014.00260","article-title":"The two-hit hypothesis for neuroinflammation: Role of exogenous atp in modulating inflammation in the brain","volume":"8","author":"Fiebich","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proil-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/sj.jcbfm.9600609","article-title":"Acute neurodegeneration and the inflammasome: Central processor for danger signals and the inflammatory response?","volume":"28","author":"Trendelenburg","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3389\/fncel.2017.00063","article-title":"NLRP3 inflammasome in neurological diseases, from functions to therapies","volume":"11","author":"Song","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"35237","DOI":"10.1074\/jbc.R114.619304","article-title":"Complexity of danger: The diverse nature of damage-associated molecular patterns","volume":"289","author":"Schaefer","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jmb.2017.09.019","article-title":"How inflammasomes inform adaptive immunity","volume":"430","author":"Evavold","year":"2018","journal-title":"J. Mol. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Solomon, I.H., Normandin, E., Bhattacharyya, S., Mukerji, S.S., Keller, K., Ali, A.S., Adams, G., Hornick, J.L., Padera, R.F., and Sabeti, P. (2020). Neuropathological features of Covid-19. N. Engl. J. Med., NEJMc2019373.","DOI":"10.1056\/NEJMc2019373"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"13435","DOI":"10.1523\/JNEUROSCI.3257-09.2009","article-title":"Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord","volume":"29","author":"Kigerl","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.yfrne.2018.11.003","article-title":"Sexual differentiation of microglia","volume":"52","author":"Villa","year":"2019","journal-title":"Front. Neuroendocrinol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jsbmb.2014.02.018","article-title":"Regulation of brain microglia by female gonadal steroids","volume":"146","author":"Habib","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"7572","DOI":"10.1074\/jbc.M112.414904","article-title":"Toll-Like receptor 2 mediates peripheral nerve injury-induced NADPH oxidase 2 expression in spinal cord microglia","volume":"288","author":"Lim","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1111\/j.1526-4610.2006.00722.x","article-title":"Elevation of CSF tumor necrosis factor \u03b1 levels in new daily persistent headache and treatment refractory chronic migraine","volume":"47","author":"Rozen","year":"2007","journal-title":"Headache J. Head Face Pain"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/S1473-3099(05)70270-X","article-title":"Understanding the symptoms of the common cold and influenza","volume":"5","author":"Eccles","year":"2005","journal-title":"Lancet. Infect. Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11481-020-09924-9","article-title":"SARS-CoV-2 Infection leads to neurological dysfunction","volume":"15","author":"Acharya","year":"2020","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1016\/j.jpainsymman.2020.04.153","article-title":"Availability of internationally controlled essential medicines in the COVID-19 pandemic","volume":"60","author":"Pettus","year":"2020","journal-title":"J. Pain Symptom Manag."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"66","DOI":"10.5603\/AIT.2017.0010","article-title":"Methods of pain assessment in adult intensive care unit patients\u2014polish version of the CPOT (Critical Care Pain Observation Tool) and BPS (Behavioral Pain Scale)","volume":"49","author":"Kotfis","year":"2017","journal-title":"Anaesthesiol. Intensive Ther."},{"key":"ref_54","first-page":"e7-17","article-title":"Behavioral and physiologic indicators during a nociceptive procedure in conscious and unconscious mechanically ventilated adults: Similar or different?","volume":"24","author":"Arbour","year":"2009","journal-title":"J. Crit. Care"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"420","DOI":"10.4037\/ajcc2006.15.4.420","article-title":"Validation of the critical-care pain observation tool in adult patients","volume":"15","author":"Fillion","year":"2006","journal-title":"Am. J. Crit. Care"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1097\/00003246-200112000-00004","article-title":"Assessing pain in critically Ill sedated patients by using a behavioral pain scale","volume":"29","author":"Payen","year":"2001","journal-title":"Crit. Care Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"132","DOI":"10.5114\/ait.2020.95164","article-title":"COVID-19: What do we need to know about ICU delirium during SARS-CoV-2 pandemic?","volume":"52","author":"Kotfis","year":"2020","journal-title":"Anaesthesiol. Intensive Ther."},{"key":"ref_58","first-page":"880","article-title":"Validation of the polish version of the critical care pain observation tool (CPOT) to assess pain intensity in adult, intubated intensive care unit patients: The POL-CPOT study","volume":"14","author":"Kotfis","year":"2018","journal-title":"Arch. Med. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e12443","DOI":"10.1097\/MD.0000000000012443","article-title":"Validation of the behavioral pain scale to assess pain intensity in adult, intubated postcardiac surgery patients: A cohort observational study\u2014POL-BPS","volume":"97","author":"Kotfis","year":"2018","journal-title":"Medicine"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1213\/ANE.0000000000004960","article-title":"Rethinking sedation during prolonged mechanical ventilation for COVID-19 respiratory failure","volume":"131","author":"Madhok","year":"2020","journal-title":"Anesth. Analg."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.1213\/ANE.0000000000004887","article-title":"Sedation of mechanically ventilated COVID-19 patients: Challenges and special considerations","volume":"131","author":"Hanidziar","year":"2020","journal-title":"Anesth. Analg."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e0139","DOI":"10.1097\/CCE.0000000000000139","article-title":"Strategies to optimize ICU liberation (A to F) bundle performance in critically Ill adults with coronavirus disease 2019","volume":"2","author":"Devlin","year":"2020","journal-title":"Crit. Care Explor."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.amjcard.2010.04.006","article-title":"AJC editor\u2019s consensus: Selective and nonselective nonsteroidal anti-inflammatory drugs and cardiovascular risk","volume":"106","author":"Friedewald","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1161\/CIRCULATIONAHA.106.181424","article-title":"Use of nonsteroidal antiinflammatory drugs: An update for clinicians: A scientific statement from the american heart association","volume":"115","author":"Antman","year":"2007","journal-title":"Circulation"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/367243a0","article-title":"The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1","volume":"367","author":"Picot","year":"1994","journal-title":"Nature"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Khan, S., Andrews, K.L., and Chin-dusting, J.P.F. (2019). Cyclo-Oxygenase (COX) inhibitors and cardiovascular risk: Are non-steroidal anti-inflammatory drugs really anti-inflammatory?. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20174262"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.3332\/ecancer.2020.1023","article-title":"COVID-19 and treatment with NSAIDs and corticosteroids: Should we be limiting their use in the clinical setting?","volume":"14","author":"Russell","year":"2020","journal-title":"Ecancermedicalscience"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"World Health Organization (2020, June 05). The Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in Patients with COVID-19. Available online: https:\/\/www.who.int\/news-room\/commentaries\/detail\/the-use-of-non-steroidal-anti-inflammatory-drugs-(nsaids)-in-patients-with-covid-19.","DOI":"10.15557\/PiMR.2020.0022"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"m1168","DOI":"10.1136\/bmj.m1168","article-title":"Covid-19: European drugs agency to review safety of ibuprofen","volume":"368","author":"Day","year":"2020","journal-title":"BMJ"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.rmed.2016.12.005","article-title":"Prehospital NSAIDs use prolong hospitalization in patients with pleuro-pulmonary infection","volume":"123","author":"Kotsiou","year":"2017","journal-title":"Respir. Med."},{"key":"ref_71","first-page":"30092","article-title":"Non-Steroidal anti-inflammatory drugs, pharmacology, and COVID-19 infection","volume":"S0040-5957","author":"Micallef","year":"2020","journal-title":"Therapie"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Yousefifard, M., Zali, A., Zarghi, A., Madani Neishaboori, A., Hosseini, M., and Safari, S. (2020). Non-Steroidal anti-inflammatory drugs in management of COVID-19: A systematic review on current evidence. Int. J. Clin. Pract., e13557.","DOI":"10.1111\/ijcp.13557"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Rinott, E., Kozer, E., Shapira, Y., Bar-Haim, A., and Youngster, I. (2020). Ibuprofen use and clinical outcomes in COVID-19 patients. Clin. Microbiol. Infect.","DOI":"10.1016\/j.cmi.2020.06.003"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1055\/a-1156-3991","article-title":"SARS-CoV-2\/COVID-19: Evidence-Based recommendations on diagnosis and therapy","volume":"80","author":"Bein","year":"2020","journal-title":"Geburtshilfe Frauenheilkd."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.3109\/03602539709002246","article-title":"Regulation of cytochromes P450 during inflammation and infection","volume":"29","author":"Morgan","year":"1997","journal-title":"Drug Metab. Rev."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1007\/s00482-014-1490-7","article-title":"Metamizole (dipyrone): Mode of action, drug-drug interactions, and risk of agranulocytosis","volume":"28","author":"Lampl","year":"2014","journal-title":"Schmerz"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Aly, O. (2020). Molecular docking reveals the potential of aliskiren, dipyridamole, mopidamol, rosuvastatin, rolitetracycline and metamizole to inhibit COVID-19 virus main protease. ChemRxiv.","DOI":"10.26434\/chemrxiv.12061302"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/S0140-6736(03)12751-1","article-title":"Dipyrone and agranulocytosis: What is the risk?","volume":"361","author":"Offerhaus","year":"2003","journal-title":"Lancet"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/anae.15076","article-title":"Caring for patients with pain during the COVID-19 pandemic: Consensus recommendations from an international expert panel","volume":"75","author":"Shanthanna","year":"2020","journal-title":"Anaesthesia"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1513\/AnnalsATS.201501-034OC","article-title":"Effects of opioids on breathlessness and exercise capacity in chronic obstructive pulmonary disease: A systematic review","volume":"12","author":"Nilsson","year":"2015","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.jpainsymman.2019.06.006","article-title":"The current practice of opioid for cancer dyspnea: The result from the nationwide survey of japanese palliative care physicians","volume":"5","author":"Yamaguchi","year":"2019","journal-title":"J. Pain Symptom Manag."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"571","DOI":"10.21037\/apm.2019.11.04","article-title":"Opioid utility for dyspnea in chronic obstructive pulmonary disease: A Complicated and controversial story","volume":"9","author":"Vozoris","year":"2020","journal-title":"Ann. Palliat. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1056\/NEJM198112313052703","article-title":"Effects of dihydrocodeine, alcohol, and caffeine on breathlessness and exercise tolerance in patients with chronic obstructive lung disease and normal blood gases","volume":"305","author":"Woodcock","year":"1981","journal-title":"N. Engl. J. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1164\/ajrccm\/139.1.126","article-title":"Effects of oral morphine on breathlessness and exercise tolerance in patients with chronic obstructive pulmonary disease","volume":"139","author":"Light","year":"1989","journal-title":"Am. Rev. Respir. Dis."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1164\/rccm.201101-0005OC","article-title":"Using laboratory models to test treatment: Morphine reduces dyspnea and hypercapnic ventilatory response","volume":"184","author":"Banzett","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Vozoris, N.T., Pequeno, P., Li, P., Austin, P.C., O\u2019Donnell, D.E., and Gershon, A.S. (2020). Predictors of opioid-related adverse pulmonary events among older adults with COPD [published online ahead of print, 2020 May 12]. Ann. Am. Thorac. Soc.","DOI":"10.1164\/ajrccm-conference.2020.201.1_MeetingAbstracts.A6266"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1183\/13993003.01967-2015","article-title":"Incident opioid drug use and adverse respiratory outcomes among older adults with COPD","volume":"48","author":"Vozoris","year":"2016","journal-title":"Eur. Respir. J."},{"key":"ref_88","first-page":"123","article-title":"Pharmacology of opioids","volume":"7","author":"Cata","year":"2017","journal-title":"Basic Sci. Anesth."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1093\/jjco\/hyy079","article-title":"Effect of continuous intravenous oxycodone infusion in opioid-na\u00efve cancer patients with dyspnea","volume":"48","author":"Yamamoto","year":"2018","journal-title":"Jpn. J. Clin. Oncol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/bph.12696","article-title":"In vivo profiling of seven common opioids for antinociception, constipation and respiratory depression: No two opioids have the same profile","volume":"172","author":"Kuo","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"ref_91","first-page":"1246","article-title":"Mechanisms of morphine-induced immunosuppression: Effect of acute morphine administration on lymphocyte trafficking","volume":"272","author":"Flores","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_92","first-page":"1336","article-title":"Immunosuppression by Morphine is mediated by central pathways","volume":"267","author":"Hernandez","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000078444","article-title":"Effects of fentanyl on natural killer cell activity and on resistance to tumor metastasis in rats. Dose and timing study","volume":"11","author":"Shavit","year":"2004","journal-title":"Neuroimmunomodulation"},{"key":"ref_94","first-page":"492","article-title":"Effects of anesthesia based on large versus small doses of fentanyl on natural killer cell cytotoxicity in the perioperative period","volume":"82","author":"Beilin","year":"1996","journal-title":"Anesth. Analg."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/EJA.0b013e32832d540e","article-title":"Does analgesia and condition influence immunity after surgery? Effects of fentanyl, ketamine and clonidine on natural killer activity at different ages","volume":"27","author":"Forget","year":"2010","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1007\/s00540-013-1597-5","article-title":"Comparative effects of flurbiprofen and fentanyl on natural killer cell cytotoxicity, lymphocyte subsets and cytokine concentrations in post-surgical intensive care unit patients: Prospective, randomized study","volume":"27","author":"Narahara","year":"2013","journal-title":"J. Anesth."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"27","DOI":"10.5055\/jom.2008.0005","article-title":"Relationship between fentanyl dosage and immune function in the postoperative period","volume":"4","author":"Yardeni","year":"2008","journal-title":"J. Opioid Manag."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"611","DOI":"10.21037\/apm.2020.01.12","article-title":"Reasons to avoid fentanyl","volume":"9","author":"Davis","year":"2020","journal-title":"Ann. Palliat. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1093\/cid\/ciy809","article-title":"Long-Acting opioid use and the risk of serious infections: A retrospective cohort study","volume":"68","author":"Wiese","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.suponc.2012.05.002","article-title":"Twelve reasons for considering buprenorphine as a frontline analgesic in the management of pain","volume":"10","author":"Davis","year":"2012","journal-title":"J. Support. Oncol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s40265-018-0953-z","article-title":"Treating chronic pain: An Overview of clinical studies centered on the buprenorphine option","volume":"78","author":"Davis","year":"2018","journal-title":"Drugs"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1093\/jac\/dkn243","article-title":"The management of coronavirus infections with particular reference to SARS","volume":"62","author":"Wong","year":"2008","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_103","first-page":"890","article-title":"A study of pulmonary inflammatory reaction induced by N-protein of SARS-CoV in rat models and effects of glucocorticoids on it","volume":"44","author":"Hao","year":"2005","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1128\/JVI.02190-07","article-title":"Cytokine responses in porcine respiratory coronavirus-infected pigs treated with corticosteroids as a model for severe acute respiratory syndrome","volume":"82","author":"Zhang","year":"2008","journal-title":"J. Virol."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Stockman, L.J., Bellamy, R., and Garner, P. (2006). SARS: Systematic review of treatment effects. PLoS Med., 3.","DOI":"10.1371\/journal.pmed.0030343"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1164\/rccm.201706-1172OC","article-title":"Corticosteroid therapy for critically Ill patients with middle east respiratory syndrome","volume":"197","author":"Arabi","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1001\/jamaneurol.2020.1065","article-title":"The spectrum of neurologic disease in the severe acute respiratory syndrome coronavirus 2 pandemic infection: Neurologists move to the frontlines","volume":"77","author":"Pleasure","year":"2020","journal-title":"JAMA Neurol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/jmv.25728","article-title":"The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients","volume":"92","author":"Li","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1213\/ANE.0000000000003936","article-title":"Systematic review of the efficacy and safety of gabapentin and pregabalin for pain in children and adolescents","volume":"128","author":"Egunsola","year":"2019","journal-title":"Anesth. Analg."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(14)70251-0","article-title":"Pharmacotherapy for neuropathic pain in adults: A systematic review and meta-analysis","volume":"14","author":"Finnerup","year":"2015","journal-title":"Lancet. Neurol."},{"key":"ref_111","first-page":"1","article-title":"Treatments for neuropathic pain","volume":"9","author":"Brooks","year":"2017","journal-title":"Clin. Pharm."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2337\/dc16-2042","article-title":"Diabetic neuropathy: A position statement by the american diabetes association","volume":"40","author":"Boulton","year":"2017","journal-title":"Diabetes Care"},{"key":"ref_113","first-page":"512","article-title":"Neuropathic pain","volume":"23","author":"Zilliox","year":"2017","journal-title":"Continuum (Minneap. Minn)"},{"key":"ref_114","unstructured":"Accord Healthcare Limited (2020, June 18). Pregabalin Accord SmPC. Available online: https:\/\/www.medicines.org.uk\/emc\/medicine\/30815."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Gomes, T., Juurlink, D.N., Antoniou, T., Mamdani, M.M., Paterson, J.M., and van den Brink, W. (2017). Gabapentin, opioids, and the risk of opioid-related death: A Population-based nested case\u2013control study. PLoS Med., 14.","DOI":"10.1371\/journal.pmed.1002396"}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/10\/7\/465\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:49:56Z","timestamp":1760176196000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/10\/7\/465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,20]]},"references-count":115,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,7]]}},"alternative-id":["brainsci10070465"],"URL":"https:\/\/doi.org\/10.3390\/brainsci10070465","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,20]]}}}