{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T02:12:16Z","timestamp":1778724736341,"version":"3.51.4"},"reference-count":37,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>False lateralization of ictal onset by scalp electroencephalogram (EEG) is an infrequent entity that has been reported in patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis (HS). In these cases, a tendency for rapid seizures that spread through the frontal-limbic system and hippocampal commissural pathways to the contralateral hemisphere has been proposed. Cerebral cavernous malformations (CCMs), which constitute a collection of abnormally configured small blood vessels with irregular structures, is a well-defined epilepsy-associated pathology. Their primary association with seizures might be explained either as a result of physiological changes affecting the cerebral cortex immediately surrounding the CCM (an epileptogenic mechanism that is relevant for both, temporal and extratemporal lesions) or as a result of promoting epileptogenicity in remote but anatomo-functionally connected brain regions, a mechanism that is particularly relevant for temporal lobe lesions. To date, there have been only two publications on falsely lateralizing ictal onsets by EEG in temporal cavernoma, but not in other regions. Here, we report a rare case of apparent false lateralization of ictal onset by scalp EEG in a patient with a left medial frontal gyrus cavernoma (supplementary motor area), and discuss some relevant pathophysiological mechanisms of false lateralization.<\/jats:p>","DOI":"10.3390\/brainsci10090584","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T10:37:32Z","timestamp":1598265452000},"page":"584","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Apparent False Lateralization of Seizure Onset by Scalp EEG in Temporal Lobe Epilepsy Associated with Cerebral Cavernous Malformation: A Case Report and Overview"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2282-066X","authenticated-orcid":false,"given":"Mariana","family":"Gaviria Carrillo","sequence":"first","affiliation":[{"name":"Department of Neurology, Fundaci\u00f3n Cardioinfantil (FCI), Bogot\u00e1 110131, Colombia"},{"name":"Escuela de Medicina y Ciencias de la Salud, GI en Neurociencias-NeURos, Universidad del Rosario, Bogot\u00e1 111221, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1376-511X","authenticated-orcid":false,"given":"Jonathan","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Universidad del Sin\u00fa, Cartagena 130001, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8100-7340","authenticated-orcid":false,"given":"Jes\u00fas","family":"Rodr\u00edguez Q.","sequence":"additional","affiliation":[{"name":"Department of Neurology, Fundaci\u00f3n Cardioinfantil (FCI), Bogot\u00e1 110131, Colombia"},{"name":"Escuela de Medicina y Ciencias de la Salud, GI en Neurociencias-NeURos, Universidad del Rosario, Bogot\u00e1 111221, Colombia"},{"name":"Department of Neurology, Hospital Universitario Mayor\u2014Mederi, Bogot\u00e1 111411, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Gaona","sequence":"additional","affiliation":[{"name":"Department of Neurology, Fundaci\u00f3n Cardioinfantil (FCI), Bogot\u00e1 110131, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Ortiz-Guerrero","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Kansas Medical Center, Kansas City, KS 66160, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Nava-Mesa","sequence":"additional","affiliation":[{"name":"Escuela de Medicina y Ciencias de la Salud, GI en Neurociencias-NeURos, Universidad del Rosario, Bogot\u00e1 111221, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.seizure.2011.01.019","article-title":"False lateralization of seizure onset by scalp EEG in neocortical temporal lobe epilepsy","volume":"20","author":"Adamolekun","year":"2011","journal-title":"Seizure"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/ana.410210408","article-title":"False lateralization by surface EEG of seizure onset in patients with temporal lobe epilepsy and gross focal cerebral lesions: False Lateralization by Surface EEG","volume":"21","author":"Sammaritano","year":"1987","journal-title":"Ann. 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