{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:08:30Z","timestamp":1793045310360,"version":"4.5.0"},"reference-count":47,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CONSEJO NACIONAL DE CIENCIA Y TECNOLOG\u00cdA (M\u00c9XICO)","award":["CB-2008-01 No. 106619"],"award-info":[{"award-number":["CB-2008-01 No. 106619"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Depression is a psychiatric disorder, and oxidative stress is a significant mechanism of damage in this mood disorder. It is characterized by an enhancement of oxidative stress markers and low concentrations of endogenous antioxidants, or antioxidants enzymes. This suggests that antioxidants could have an antidepressant effect. S-allyl cysteine (SAC) is a compound with antioxidant action or free radical scavenger capacity. The purpose of the current research was to evaluate the antidepressant-like effect as well as the antioxidant role of SAC on a preclinical test, using the Porsolt forced swim test (FST). SAC (30, 70, 120, or 250 mg\/kg, ip) was administered to male BALB\/c mice daily for 17 days, followed by the FST at day 18. Oxidative stress markers (reactive oxygen species, superoxide production, lipid peroxidation, and antioxidant enzymes activities) were analyzed in the midbrain, prefrontal cortex, and hippocampus. SAC (120 mg\/kg) attenuated the immobility scores (44%) in the FST, and protection was unrelated to changes in locomotor activity. This antidepressant-like effect was related to decreased oxidative stress, as indicated by lipid peroxidation and manganese-superoxide dismutase (Mn-SOD) activity in the hippocampus. SAC exerts an antidepressant-like effect that correlated, in part, with preventing oxidative damage in hippocampus.<\/jats:p>","DOI":"10.3390\/brainsci10090592","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T08:05:18Z","timestamp":1598515518000},"page":"592","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["S-allyl Cysteine, a Garlic Compound, Produces an Antidepressant-Like Effect and Exhibits Antioxidant Properties in Mice"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8184-0532","authenticated-orcid":false,"given":"Elizabeth","family":"Ruiz-S\u00e1nchez","sequence":"first","affiliation":[{"name":"Laboratory of Neurotoxicology, National Institute of Neurology and Neurosurgery \u201cManuel Velasco Su\u00e1rez\u201d, SS, Av. Insurgentes Sur No. 3877, Mexico City 14269, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6628-4411","authenticated-orcid":false,"given":"Jos\u00e9","family":"Pedraza-Chaverri","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica, Departamento de Biolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, CDMX 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8264-0412","authenticated-orcid":false,"given":"Omar N.","family":"Medina-Campos","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica, Departamento de Biolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, CDMX 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7629-0580","authenticated-orcid":false,"given":"Perla D.","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Laboratory of Cerebral Vascular Pathology, National Institute of Neurology and Neurosurgery \u201cManuel Velasco Su\u00e1rez\u201d, SS, Av. Insurgentes Sur No. 3877, Mexico City 14269, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9079-3267","authenticated-orcid":false,"given":"Patricia","family":"Rojas","sequence":"additional","affiliation":[{"name":"Laboratory of Neurotoxicology, National Institute of Neurology and Neurosurgery \u201cManuel Velasco Su\u00e1rez\u201d, SS, Av. Insurgentes Sur No. 3877, Mexico City 14269, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev-publhealth-031912-114409","article-title":"The Epidemiology of Depression across Cultures","volume":"34","author":"Kessler","year":"2013","journal-title":"Annu. Rev. 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