{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:22:22Z","timestamp":1792549342405,"version":"4.5.0"},"reference-count":60,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T00:00:00Z","timestamp":1599350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Transient epileptic amnesia (TEA) is a rare epileptic condition, often confused with transient global amnesia (TGA). In a real-life scenario, differential diagnosis between these two conditions can be hard. In this study we use power spectral analysis empowered by exact Low Resolution Brain Electromagnetic Tomography (eLORETA) to evidence the differences between TEA and TGA. Fifteen patients affected by TEA (64.2 \u00b1 5.2 y.o.; 11 female\/4 male; 10 left and 5 right temporal epileptic focus) and 15 patients affected by TGA (65.8 \u00b1 7.2 y.o.; 11 females\/4 males) were retrospectively identified in our clinical records. All patients recorded EEGs after symptoms offset. EEGs were analyzed with eLORETA to evidence power spectral contrast between the two conditions. We used an inverse problem solution to localize the source of spectral differences. We found a significant increase in beta band power over the affected hemisphere of TEA patients. Significant results corresponded to the uncus and para-hippocampal gyrus, respectively Brodmann\u2019s Areas: 36, 35, 28, 34. We present original evidence of an increase in beta power in the affected hemisphere (AH) of TEA as compared to TGA. These differences involve key areas of the memory network located in the mesial temporal lobe. Spectral asymmetries could be used in the future to recognize cases of amnesia with a high risk of epilepsy.<\/jats:p>","DOI":"10.3390\/brainsci10090613","type":"journal-article","created":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T23:12:49Z","timestamp":1599433969000},"page":"613","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Power Spectral Differences between Transient Epileptic and Global Amnesia: An eLORETA Quantitative EEG Study"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7217-6281","authenticated-orcid":false,"given":"Jacopo","family":"Lanzone","sequence":"first","affiliation":[{"name":"Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Universit\u00e0 Campus Bio-Medico di Roma, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8207-6919","authenticated-orcid":false,"given":"Claudio","family":"Imperatori","sequence":"additional","affiliation":[{"name":"Cognitive and Clinical Psychology Laboratory, Department of Human Sciences, European University of Rome, Via degli Aldobrandeschi 190, 00163 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3129-1982","authenticated-orcid":false,"given":"Giovanni","family":"Assenza","sequence":"additional","affiliation":[{"name":"Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Universit\u00e0 Campus Bio-Medico di Roma, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3668-469X","authenticated-orcid":false,"given":"Lorenzo","family":"Ricci","sequence":"additional","affiliation":[{"name":"Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Universit\u00e0 Campus Bio-Medico di Roma, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetto","family":"Farina","sequence":"additional","affiliation":[{"name":"Cognitive and Clinical Psychology Laboratory, Department of Human Sciences, European University of Rome, Via degli Aldobrandeschi 190, 00163 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9113-5925","authenticated-orcid":false,"given":"Vincenzo","family":"Di Lazzaro","sequence":"additional","affiliation":[{"name":"Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Universit\u00e0 Campus Bio-Medico di Roma, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Tombini","sequence":"additional","affiliation":[{"name":"Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Universit\u00e0 Campus Bio-Medico di Roma, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.2147\/NDT.S130710","article-title":"Transient global amnesia: Current perspectives","volume":"13","author":"Spiegel","year":"2017","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1093\/brain\/115.3.749","article-title":"Pure amnestic seizures in temporal lobe epilepsy: Definition, clinical symptomatology and functional anatomical considerations","volume":"115","author":"Palmini","year":"1992","journal-title":"Brain"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1136\/jnnp.64.4.435","article-title":"Transient epileptic amnesia: A description of the clinical and neuropsychological features in 10 cases and a review of the literature","volume":"64","author":"Zeman","year":"1998","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/ana.21111","article-title":"The syndrome of transient epileptic amnesia","volume":"61","author":"Butler","year":"2007","journal-title":"Ann. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1155\/2011\/602965","article-title":"The Causes and Consequences of Transient Epileptic Amnesia","volume":"24","author":"Butler","year":"2011","journal-title":"Behav. Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.yebeh.2013.10.021","article-title":"Transient epileptic amnesia: A concise review","volume":"31","year":"2014","journal-title":"Epilepsy Behav."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.yebeh.2019.06.026","article-title":"Epilepsy-associated stigma from the perspective of people with epilepsy and the community in Italy","volume":"98","author":"Tombini","year":"2019","journal-title":"Epilepsy Behav."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.yebeh.2018.07.015","article-title":"Transient epileptic and global amnesia: Real-life differential diagnosis","volume":"88","author":"Lanzone","year":"2018","journal-title":"Epilepsy Behav."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1080\/10874201003773500","article-title":"Validity and Reliability of Quantitative electroencephalography","volume":"14","author":"Thatcher","year":"2010","journal-title":"J. Neurother."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3389\/fnagi.2017.00252","article-title":"Corrigendum: Oscillatory Activities in Neurological Disorders of Elderly: Biomarkers to Target for Neuromodulation","volume":"9","author":"Assenza","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Quraan, M.A., McCormick, C., Cohn, M., Valiante, T.A., and McAndrews, M.P. (2013). Altered Resting State Brain Dynamics in Temporal Lobe Epilepsy Can Be Observed in Spectral Power, Functional Connectivity and Graph Theory Metrics. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0068609"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1177\/1550059416652055","article-title":"Slow Activity in Focal Epilepsy During Sleep and Wakefulness","volume":"48","author":"Pellegrino","year":"2017","journal-title":"Clin. EEG Neurosci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1093\/brain\/awl105","article-title":"What does transient global amnesia really mean? Review of the literature and thorough study of 142 cases","volume":"129","author":"Quinette","year":"2006","journal-title":"Brain"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1177\/1550059418780780","article-title":"Abnormal EEG Power Spectra in Acute Transient Global Amnesia: A Quantitative EEG Study","volume":"50","author":"Imperatori","year":"2019","journal-title":"Clin. EEG Neurosci."},{"key":"ref_15","first-page":"3768","article-title":"Assessing interactions in the brain with exact low-resolution electromagnetic tomography. Philosophical Transactions of the Royal Society A: Mathematical","volume":"369","author":"Lehmann","year":"2011","journal-title":"Phys. Eng. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Szabo, K., Hoyer, C., Caplan, L.R., Grassl, R., Griebe, M., Ebert, A., Platten, M., and Gass, A. (2020). Diffusion-weighted MRI in transient global amnesia and its diagnostic implications. Neurology.","DOI":"10.1212\/WNL.0000000000009783"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0013-4694(97)00106-5","article-title":"IFCN standards for digital recording of clinical EEG. International Federation of Clinical Neurophysiology","volume":"106","author":"Nuwer","year":"1998","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s10339-014-0605-5","article-title":"Modification of EEG power spectra and EEG connectivity in autobiographical memory: A sLORETA study","volume":"15","author":"Imperatori","year":"2014","journal-title":"Cogn. Process."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jneumeth.2003.10.009","article-title":"EEGLAB: An open source toolbox for analysis of single-trial EEG dynamics including independent component analysis","volume":"134","author":"Delorme","year":"2004","journal-title":"J. Neurosci. Methods"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0167-8760(84)90014-X","article-title":"Low resolution electromagnetic tomography: A new method for localizing electrical activity in the brain","volume":"18","author":"Michel","year":"1994","journal-title":"Int. J. Psychophysiol."},{"key":"ref_21","first-page":"448","article-title":"Assessing direct paths of intracortical causal information flow of oscillatory activity with the isolated effective coherence (iCoh)","volume":"8","author":"Biscay","year":"2014","journal-title":"Front. Hum. Neurosci."},{"key":"ref_22","first-page":"5","article-title":"Standardized low-resolution brain electromagnetic tomography (sLORETA): Technical details","volume":"24","year":"2002","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1109\/10.664200","article-title":"A critical analysis of linear inverse solutions to the neuroelectromagnetic inverse problem","volume":"45","year":"1998","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-0193(2000)9:1<1::AID-HBM1>3.0.CO;2-#","article-title":"Imaging the electrical activity of the brain: ELECTRA","volume":"9","author":"Morand","year":"2000","journal-title":"Hum. Brain. Mapp."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1743-0003-5-25","article-title":"Review on solving the inverse problem in EEG source analysis","volume":"5","author":"Grech","year":"2008","journal-title":"J. Neuroeng. Rehabil."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hbm.1058","article-title":"Nonparametric permutation tests for functional neuroimaging: A primer with examples","volume":"15","author":"Nichols","year":"2002","journal-title":"Hum. Brain Mapp."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neuroimage.2014.01.006","article-title":"Comparison of three-shell and simplified volume conductor models in magnetoencephalography","volume":"94","author":"Stenroos","year":"2014","journal-title":"Neuroimage"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1159\/000106055","article-title":"Effect of low-frequency rTMS on electromagnetic tomography (LORETA) and regional brain metabolism (PET) in schizophrenia patients with auditory hallucinations","volume":"55","author":"Horacek","year":"2007","journal-title":"Neuropsychobiology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1080\/10874208.2011.623093","article-title":"sLORETA and fMRI Detection of Medial Prefrontal Default Network Anomalies in Adult ADHD","volume":"15","author":"Cannon","year":"2011","journal-title":"J. Neurother."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.neulet.2011.03.074","article-title":"Transient alcohol craving suppression by rTMS of dorsal anterior cingulate: An fMRI and LORETA EEG study","volume":"496","author":"Vanneste","year":"2011","journal-title":"Neurosci. Lett."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1002\/hbm.21276","article-title":"sLORETA allows reliable distributed source reconstruction based on subdural strip and grid recordings","volume":"33","author":"Ball","year":"2012","journal-title":"Human Brain Mapp."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/jcbfm.1991.122","article-title":"Comparing functional (PET) images: The assessment of significant change","volume":"11","author":"Friston","year":"1991","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.cnp.2017.09.002","article-title":"Functional localization and effective connectivity of cortical theta and alpha oscillatory activity during an attention task","volume":"2","author":"Kitaura","year":"2017","journal-title":"Clin. Neurophysiol. Pract."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cnp.2019.01.003","article-title":"Short-term meditation modulates EEG activity in subjects with post-traumatic residual disabilities","volume":"4","author":"Hata","year":"2019","journal-title":"Clin. Neurophysiol. Pract."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cortex.2014.02.001","article-title":"Measuring forgetting: A critical review of accelerated long-term forgetting studies","volume":"54","author":"Elliott","year":"2014","journal-title":"Cortex"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nrn.2015.24","article-title":"Anterior hippocampus: The anatomy of perception, imagination and episodic memory","volume":"17","author":"Zeidman","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jneumeth.2015.08.015","article-title":"EEG source localization: Sensor density and head surface coverage","volume":"256","author":"Song","year":"2015","journal-title":"J. Neurosci. Methods"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.yebeh.2010.04.021","article-title":"Assessment of working memory in patients with mesial temporal lobe epilepsy associated with unilateral hippocampal sclerosis","volume":"18","author":"Vaz","year":"2010","journal-title":"Epilepsy Behav."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1535-7511.2006.00097.x","article-title":"Memory Loss after Left Anterior Temporal Lobectomy in Patients with Mesial Temporal Lobe Sclerosis","volume":"6","author":"Meador","year":"2006","journal-title":"Epilepsy Curr."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Park, Y.H., Kim, J.-Y., Yi, S., Lim, J.-S., Jang, J.-W., Im, C.-H., and Kim, S. (2016). Transient Global Amnesia Deteriorates the Network Efficiency of the Theta Band. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0164884"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/0013-4694(90)90134-6","article-title":"Asymmetry in delta activity in patients with focal epilepsy","volume":"75","author":"Gotman","year":"1990","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.clinph.2010.01.020","article-title":"Theta EEG source localization using LORETA in partial epilepsy patients with and without medication","volume":"121","author":"Clemens","year":"2010","journal-title":"Clin. Neurophysiol.  Off. J. Int. Fed. Clin. Neurophysiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/WCO.0000000000000178","article-title":"Resting-state functional connectivity in epilepsy: Growing relevance for clinical decision making","volume":"28","author":"Tracy","year":"2015","journal-title":"Curr. Opin. Neurol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.eplepsyres.2008.04.020","article-title":"Enhanced EEG functional connectivity in mesial temporal lobe epilepsy","volume":"81","author":"Bettus","year":"2008","journal-title":"Epilepsy Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1093\/brain\/awv130","article-title":"Global and regional functional connectivity maps of neural oscillations in focal epilepsy","volume":"138","author":"Englot","year":"2015","journal-title":"Brain"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/cercor\/12.8.877","article-title":"Oscillations in the Alpha Band (9\u201312 Hz) Increase with Memory Load during Retention in a Short-term Memory Task","volume":"12","author":"Jensen","year":"2002","journal-title":"Cereb Cortex"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.biopsycho.2013.05.020","article-title":"Effect of beta and gamma neurofeedback on memory and intelligence in the elderly","volume":"95","author":"Staufenbiel","year":"2014","journal-title":"Biol. Psychol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neuron.2016.02.028","article-title":"Gamma and Beta Bursts Underlie Working Memory","volume":"90","author":"Lundqvist","year":"2016","journal-title":"Neuron"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-017-02791-8","article-title":"Gamma and beta bursts during working memory readout suggest roles in its volitional control","volume":"9","author":"Lundqvist","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.yebeh.2014.04.014","article-title":"TEAmistaken for mild cognitive impairment? A high-density EEG study","volume":"36","author":"Broggio","year":"2014","journal-title":"Epilepsy Behav."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.yebeh.2014.10.032","article-title":"Impaired picture recognition in transient epileptic amnesia","volume":"42","author":"Dewar","year":"2015","journal-title":"Epilepsy Behav."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1037\/neu0000114","article-title":"Accelerated Long-Term Forgetting Can Become Apparent Within 3\u20138 Hours of Wakefulness in Patients with Transient Epileptic Amnesia","volume":"29","author":"Hoefeijzers","year":"2015","journal-title":"Neuropsychology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1101\/lm.024018.111","article-title":"Working memory, long-term memory, and medial temporal lobe function","volume":"19","author":"Jeneson","year":"2012","journal-title":"Learn Mem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1016\/j.neuropsychologia.2010.07.001","article-title":"Accelerated forgetting of real-life events in Transient Epileptic Amnesia","volume":"48","author":"Muhlert","year":"2010","journal-title":"Neuropsychologia"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cortex.2018.04.015","article-title":"Encoding-related brain activity and accelerated forgetting in transient epileptic amnesia","volume":"110","author":"Atherton","year":"2019","journal-title":"Cortex"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s40263-018-0557-x","article-title":"Quantitative Pharmaco-Electroencephalography in Antiepileptic Drug Research","volume":"32","author":"Helmstaedter","year":"2018","journal-title":"CNS Drugs"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Pellegrino, G., Mecarelli, O., Pulitano, P., Tombini, M., Ricci, L., Lanzone, J., Brienza, M., Davassi, C., Di Lazzaro, V., and Assenza, G. (2018). Eslicarbazepine Acetate Modulates EEG Activity and Connectivity in Focal Epilepsy. Front. Neurol., 9.","DOI":"10.3389\/fneur.2018.01054"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.eplepsyres.2014.12.003","article-title":"Hyperventilation induces sympathetic overactivation in mesial temporal epilepsy","volume":"110","author":"Assenza","year":"2015","journal-title":"Epilepsy Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.eplepsyres.2013.09.010","article-title":"Inflammation and iron metabolism in adult patients with epilepsy: Does a link exist?","volume":"107","author":"Tombini","year":"2013","journal-title":"Epilepsy Res."},{"key":"ref_60","unstructured":"Davis, F.D., Riedl, R., vom Brocke, J., L\u00e9ger, P.-M., Randolph, A., and Fischer, T. (2020). Machine Learning Based Diagnosis of Diseases Using the Unfolded EEG Spectra: Towards an Intelligent Software Sensor. Proceedings of the Information Systems and Neuroscience, Springer International Publishing."}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/10\/9\/613\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:07:22Z","timestamp":1760177242000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/10\/9\/613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,6]]},"references-count":60,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9]]}},"alternative-id":["brainsci10090613"],"URL":"https:\/\/doi.org\/10.3390\/brainsci10090613","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,6]]}}}