{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:42:36Z","timestamp":1771472556833,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T00:00:00Z","timestamp":1602979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background: Low-grade epilepsy-associated neuroepithelial tumors (LEATs) are a frequent etiology in pediatric patients with epilepsy undergoing surgery. Objective: To identify differences in clinical and post-surgical follow-up between patients with focal meningeal involvement (MI) and those without MI within our cohort of pediatric patients with LEATs. Methods: We retrospectively reviewed all pediatric patients (&lt;18 y) who underwent epilepsy surgery between 2011 and 2017 at our hospital. Cohort inclusion required histological diagnosis of LEATs and post-surgical follow-up of \u22652 y. We subsequently stratified patients according to presence of neuroradiological MI. Results: We identified 37 patients: five with MI and 32 without. Half of patients (19) were drug sensitive at surgery; similar between groups. The group with MI differed mainly for age of epilepsy-onset (0.6 vs. 7.0 y) but not for epilepsy duration (0.9 vs. 1.5 y). Post-surgery radiological follow-up (median 4.0 y; IQR 2.8\u20135.0 y) did not indicate disease progression. Seizure outcome was excellent in both groups, with 34 patients overall being both drug- and seizure-free. Conclusions: Our study identified a new subgroup of LEATs with focal MI and excellent post-surgical outcome. Moreover, this highlights the effectiveness of early surgery in pediatric LEATs.<\/jats:p>","DOI":"10.3390\/brainsci10100752","type":"journal-article","created":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T21:26:06Z","timestamp":1603056366000},"page":"752","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement"],"prefix":"10.3390","volume":"10","author":[{"given":"Luca","family":"De Palma","sequence":"first","affiliation":[{"name":"Rare and Complex Epilepsies, Department of Neurological Science, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Member of European Reference Network EpiCARE, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Pepi","sequence":"additional","affiliation":[{"name":"Rare and Complex Epilepsies, Department of Neurological Science, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Member of European Reference Network EpiCARE, 00165 Rome, Italy"},{"name":"Child Neurology and Psychiatry Unit, Systems Medicine Department, Tor Vergata University, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"De Benedictis","sequence":"additional","affiliation":[{"name":"Neurosurgery Unit, Department of Neurological Science, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Pietrafusa","sequence":"additional","affiliation":[{"name":"Rare and Complex Epilepsies, Department of Neurological Science, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Member of European Reference Network EpiCARE, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4408-2373","authenticated-orcid":false,"given":"Angela","family":"Mastronuzzi","sequence":"additional","affiliation":[{"name":"Neuro-Oncology Unit, Department of Onco-Hematology, Cell and Gene Therapy, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Cacchione","sequence":"additional","affiliation":[{"name":"Neuro-Oncology Unit, Department of Onco-Hematology, Cell and Gene Therapy, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giusy","family":"Carf\u00ec-Pavia","sequence":"additional","affiliation":[{"name":"Rare and Complex Epilepsies, Department of Neurological Science, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Member of European Reference Network EpiCARE, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Rossi-Espagnet","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, Imaging Department, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00165 Rome, Italy"},{"name":"Neuroradiology Unit, NESMOS Department, Sapienza University, 00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Diomedi-Camassei","sequence":"additional","affiliation":[{"name":"Pathology Unit\u2014Department of Laboratories, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Rossi","sequence":"additional","affiliation":[{"name":"Pathology Unit\u2014Department of Laboratories, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3258-6846","authenticated-orcid":false,"given":"Antonio","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Medical Physics Department, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5203-7855","authenticated-orcid":false,"given":"Andrea","family":"Carai","sequence":"additional","affiliation":[{"name":"Neurosurgery Unit, Department of Neurological Science, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1142-4904","authenticated-orcid":false,"given":"Giovanna Stefania","family":"Colafati","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, Imaging Department, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0097-736X","authenticated-orcid":false,"given":"Daniela","family":"Longo","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, Imaging Department, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Curatolo","sequence":"additional","affiliation":[{"name":"Child Neurology and Psychiatry Unit, Systems Medicine Department, Tor Vergata University, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Vigevano","sequence":"additional","affiliation":[{"name":"Department of Neurological Science, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Member of European Reference Network EpiCARE, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo Efisio","family":"Marras","sequence":"additional","affiliation":[{"name":"Neurosurgery Unit, Department of Neurological Science, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Specchio","sequence":"additional","affiliation":[{"name":"Rare and Complex Epilepsies, Department of Neurological Science, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Member of European Reference Network EpiCARE, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3171\/2012.11.PEDS12137","article-title":"Seizure outcome of surgical treatment of focal epilepsy associated with low-grade tumors in children","volume":"11","author":"Babini","year":"2013","journal-title":"J. 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