{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:55:54Z","timestamp":1790430954953,"version":"4.1.0"},"reference-count":50,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T00:00:00Z","timestamp":1603497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Both tinnitus and headache are very prevalent conditions in the general population, with bidirectional co-occurrence of them. A number of studies revealed a high prevalence of headache in tinnitus patients; however, most of them used self-reported symptoms, questionnaires, or health databases and were retrospective. The aim of this study was to evaluate the prevalence of different types of headache in a cohort of tinnitus patients and to assess the influence of headache on tinnitus parameters, focusing on appropriate headache and tinnitus diagnosis verified by clinical examination. This prospective study involved 286 patients diagnosed with subjective non-pulsating tinnitus. Patients\u2019 clinical information was thoroughly assessed by the multidisciplinary team, including tinnitus characteristics and severity according to the Tinnitus Handicap Inventory (THI), loudness assessed by the Visual Analogue Scale (VAS), audiometry, type of headache diagnosed according to the third edition of the International Classification of Headache Disorders, severity of headache assessed by the Numeric Rating Scale (NRS), and impact of headache using the Headache Impact Test (HIT). In total, 141 (49.3%) tinnitus patients were diagnosed with headache, most of them with tension-type headache or migraine. They were significantly younger; mostly women; had bilateral tinnitus, vertigo, and depression more frequently; and had hearing loss less frequently as compared with the non-headache group. In total, 82 (58.16%) patients had the same localization of tinnitus and headache. Younger age, female gender, higher tinnitus burden measured by THI, and coexistence of hearing loss were independent variables connected with the occurrence of headache in the tinnitus group. According to our study, headaches impact tinnitus on many different levels and may be an important co-factor for tinnitus subtyping. We recommend screening for headache coexistence in all tinnitus patients.<\/jats:p>","DOI":"10.3390\/brainsci10110776","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T02:34:54Z","timestamp":1603679694000},"page":"776","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The Prevalence of Different Types of Headache in Patients with Subjective Tinnitus and Its Influence on Tinnitus Parameters: A Prospective Clinical Study"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2304-2903","authenticated-orcid":false,"given":"Magdalena","family":"Nowaczewska","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, and Laryngological Oncology, Ludwik, Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Sk\u0142odowskiej\u2014Curie 9, 85-090 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Wici\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Sk\u0142odowskiej\u2014Curie 9, 85-090 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9811-3526","authenticated-orcid":false,"given":"Marcin","family":"Straburzy\u0144ski","sequence":"additional","affiliation":[{"name":"Headache Clinic\u2014Terapia Neurologiczna Samodzielni, Maurycego Mochnackiego 10, 02-042 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Ka\u017amierczak","sequence":"additional","affiliation":[{"name":"Department of Sensory Organs Examination, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Sk\u0142odowskiej\u2014Curie 9, 85-090 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,24]]},"reference":[{"key":"ref_1","unstructured":"(2018). Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia, 38, 1\u2013211."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/S1474-4422(18)30322-3","article-title":"Global, regional, and national burden of migraine and tension-type headache, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"17","author":"Collaborators","year":"2018","journal-title":"Lancet Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Stockdale, D., McFerran, D., Brazier, P., Pritchard, C., Kay, T., Dowrick, C., and Hoare, D.J. (2017). An economic evaluation of the healthcare cost of tinnitus management in the UK. BMC Health Serv. Res., 17.","DOI":"10.1186\/s12913-017-2527-2"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.amjoto.2007.09.004","article-title":"Migraine and audiovestibular dysfunction: is there a correlation?","volume":"29","author":"Dash","year":"2008","journal-title":"Am. J. Otolaryngol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3233\/VES-130477","article-title":"The prevalence of vestibular symptoms in migraine or tension-type headache","volume":"23","author":"Akdal","year":"2013","journal-title":"J. Vestib. Res."},{"key":"ref_6","first-page":"85","article-title":"Assessment of migraine-related cochleovestibular symptoms","volume":"122","author":"Bayazit","year":"2001","journal-title":"Rev. Laryngol. Otol. Rhinol. (Bord.)"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Deklerck, A.N., Debacker, J.M., Keppler, H., and Dhooge, I.J.M. (2020). Identifying non-otologic risk factors for tinnitus: A systematic review. Clin. Otolaryngol.","DOI":"10.1111\/coa.13592"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"8494","DOI":"10.1038\/s41598-020-65395-1","article-title":"Relationship between headaches and tinnitus in a Swedish study","volume":"10","author":"Lugo","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/01.AUD.0000100204.08771.3D","article-title":"Risk factors for tinnitus in a population of older adults: the blue mountains hearing study","volume":"24","author":"Sindhusake","year":"2003","journal-title":"Ear Hear."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1080\/14992027.2016.1185168","article-title":"The impact of tinnitus upon cognition in adults: A systematic review","volume":"55","author":"Bennett","year":"2016","journal-title":"Int. J. Audiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.5935\/0946-5448.20150006","article-title":"One-year prevalence and risk factors of tinnitus in children with otological problems","volume":"19","author":"Thirunavukkarasu","year":"2015","journal-title":"Int. Tinnitus. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1007\/s00405-014-3275-0","article-title":"Clinical observations and risk factors for tinnitus in a Sicilian cohort","volume":"272","author":"Martines","year":"2015","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"440","DOI":"10.3389\/fneur.2017.00440","article-title":"Tinnitus Patients with Comorbid Headaches: The Influence of Headache Type and Laterality on Tinnitus Characteristics","volume":"8","author":"Langguth","year":"2017","journal-title":"Front. Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1080\/14992020802233915","article-title":"Tinnitus and hearing loss in 15-16-year-old students: mental health symptoms, substance use, and exposure in school","volume":"47","author":"Brunnberg","year":"2008","journal-title":"Int. J. Audiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1002\/lary.23482","article-title":"Tinnitus in children: association with stress and trait anxiety","volume":"122","author":"Kim","year":"2012","journal-title":"Laryngoscope"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1017\/S0022215115001425","article-title":"Tinnitus and its relationship with muscle tenderness in patients with headache and facial pain","volume":"129","author":"Pezzoli","year":"2015","journal-title":"J. Laryngol. Otol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1001\/jamaoto.2018.0939","article-title":"Association of Tinnitus and Other Cochlear Disorders With a History of Migraines","volume":"144","author":"Hwang","year":"2018","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Chen, Y.C., Tsai, S.J., Chen, J.C., and Hwang, J.H. (2019). Risks of tinnitus, sensorineural hearing impairment, and sudden deafness in patients with non-migraine headache. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0222041"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1177\/0194599818764387","article-title":"Patterns of Migraine Disease in Otolaryngology: A CHEER Network Study","volume":"159","author":"Schulz","year":"2018","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/B978-0-444-64012-3.00022-8","article-title":"Sensory neurologic disorders: Tinnitus","volume":"165","author":"Chemali","year":"2019","journal-title":"Handb. Clin. Neurol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0306-4522(97)00503-4","article-title":"Direct evidence of trigeminal innervation of the cochlear blood vessels","volume":"84","author":"Vass","year":"1998","journal-title":"Neuroscience"},{"key":"ref_22","first-page":"577","article-title":"Similarities between chronic pain and tinnitus","volume":"18","year":"1997","journal-title":"Am. J. Otolaryngol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1177\/014556130808700505","article-title":"Can a disorder of the vestibular system underlie an etiology for migraine?","volume":"87","author":"Brookler","year":"2008","journal-title":"Ear Nose Throat. J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"797416","DOI":"10.1155\/2015\/797416","article-title":"Tinnitus and Headache","volume":"2015","author":"Langguth","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1526-4610.2005.05193_2.x","article-title":"Tinnitus in migraine: an allodynic symptom secondary to abnormal cortical functioning?","volume":"45","author":"Volcy","year":"2005","journal-title":"Headache"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.3389\/fpsyg.2016.01871","article-title":"Polish Translation and Validation of the Tinnitus Handicap Inventory and the Tinnitus Functional Index","volume":"7","author":"Wrzosek","year":"2016","journal-title":"Front. Psychol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1044\/1059-0889(2005\/004)","article-title":"Clinical guide for audiologic tinnitus management I: Assessment","volume":"14","author":"Henry","year":"2005","journal-title":"Am. J. Audiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1044\/2018_AJA-TTR17-18-0038","article-title":"Clinical Protocol to Promote Standardization of Basic Tinnitus Services by Audiologists","volume":"28","author":"Henry","year":"2019","journal-title":"Am. J. Audiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"725","DOI":"10.2471\/BLT.19.230367","article-title":"Hearing loss grades and the","volume":"97","author":"Olusanya","year":"2019","journal-title":"Bull. World Health Organ."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"231","DOI":"10.4081\/audiores.2019.231","article-title":"Analysis of the audiological characteristics and comorbidity in patients with chronic tinnitus","volume":"9","author":"Pavaci","year":"2019","journal-title":"Audiol. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3766\/jaaa.15.4.2","article-title":"Factors predicting severity of tinnitus: a population-based assessment","volume":"15","author":"Sindhusake","year":"2004","journal-title":"J. Am. Acad. Audiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1111\/head.12845","article-title":"Association Between Headaches and Tinnitus in Young Adults: Cross-Sectional Study","volume":"56","author":"Guichard","year":"2016","journal-title":"Headache"},{"key":"ref_33","first-page":"106","article-title":"Vestibular migraine\u2014An underdiagnosed cause of vertigo. Diagnosis and treatment","volume":"54","author":"Nowaczewska","year":"2020","journal-title":"Neurol. Neurochir. Pol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1186\/s10194-015-0557-x","article-title":"A study of cochlear and auditory pathways in patients with tension-type headache","volume":"16","author":"Shen","year":"2015","journal-title":"J. Headache Pain"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.amjoto.2011.10.008","article-title":"Assessment of cochlear and auditory pathways in patients with migraine","volume":"33","author":"Hamed","year":"2012","journal-title":"Am. J. Otolaryngol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1468-2982.2008.01534.x","article-title":"Subclinical dysfunction of cochlea and cochlear efferents in migraine: an otoacoustic emission study","volume":"28","author":"Bolay","year":"2008","journal-title":"Cephalalgia"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0306-4522(00)00521-2","article-title":"Capsaicin stimulation of the cochlea and electric stimulation of the trigeminal ganglion mediate vascular permeability in cochlear and vertebro-basilar arteries: a potential cause of inner ear dysfunction in headache","volume":"103","author":"Vass","year":"2001","journal-title":"Neuroscience"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1055\/s-0042-1748038","article-title":"Similarities between severe tinnitus and chronic pain","volume":"11","author":"Moller","year":"2000","journal-title":"J. Am. Acad. Audiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0079-6123(07)66004-X","article-title":"Tinnitus and pain","volume":"166","year":"2007","journal-title":"Prog. Brain Res."},{"key":"ref_40","first-page":"70","article-title":"Tinnitus during headache: clinical-instrumental evaluation","volume":"19","author":"Farri","year":"1999","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.otc.2020.03.003","article-title":"Heritability and Genetics Contribution to Tinnitus","volume":"53","author":"Amanat","year":"2020","journal-title":"Otolaryngol. Clin. N. Am."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/gim.2017.4","article-title":"Genetic susceptibility to bilateral tinnitus in a Swedish twin cohort","volume":"19","author":"Maas","year":"2017","journal-title":"Genet. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e416","DOI":"10.1097\/MAO.0000000000001849","article-title":"Audiometric Profiles in Patients With Normal Hearing and Bilateral or Unilateral Tinnitus","volume":"39","author":"Song","year":"2018","journal-title":"Otol. Neurotol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1080\/00016489.2016.1223343","article-title":"Comparison of characteristics observed in tinnitus patients with unilateral vs bilateral symptoms, with both normal hearing threshold and distortion-product otoacoustic emissions","volume":"137","year":"2017","journal-title":"Acta Otolaryngol."},{"key":"ref_45","first-page":"1128","article-title":"Comparison of clinical characteristics in patients with bilateral and unilateral tinnitus","volume":"135","author":"Yang","year":"2015","journal-title":"Acta Otolaryngol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3109\/00206099209072912","article-title":"Psychological and audiological correlates of perceived tinnitus severity","volume":"31","author":"Erlandsson","year":"1992","journal-title":"Audiology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10194-009-0167-6","article-title":"Tinnitus in postherpetic neuralgia","volume":"11","author":"Marinis","year":"2010","journal-title":"J. Headache Pain."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/ene.14150","article-title":"Prevalence of visual snow syndrome in the UK","volume":"27","author":"Kondziella","year":"2020","journal-title":"Eur. J. Neurol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e564","DOI":"10.1212\/WNL.0000000000008909","article-title":"Visual snow syndrome: A clinical and phenotypical description of 1100 cases","volume":"94","author":"Puledda","year":"2020","journal-title":"Neurology"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Boecking, B., von Sass, J., Sieveking, A., Schaefer, C., Brueggemann, P., Rose, M., and Mazurek, B. (2020). Tinnitus-related distress and pain perceptions in patients with chronic tinnitus - Do psychological factors constitute a link?. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0234807"}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/10\/11\/776\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:27:32Z","timestamp":1760178452000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/10\/11\/776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,24]]},"references-count":50,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11]]}},"alternative-id":["brainsci10110776"],"URL":"https:\/\/doi.org\/10.3390\/brainsci10110776","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,24]]}}}