{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:17:20Z","timestamp":1792653440960,"version":"4.5.0"},"reference-count":41,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background: We evaluated the prevalence of psychiatric disorders in mild traumatic brain injury (MTBI) patients and investigated psychiatric comorbidity in relation to subjective symptoms and return to work (RTW). Methods: We recruited 103 MTBI patients (mean age 40.8 years, SD 3.1) prospectively from University Hospital. The patients were followed up for one year. The Rivermead Post-Concussion Symptom Questionnaire (RPQ) and Extended Glasgow Outcome Scale (GOSE) were administered one month after MTBI. Three months after MTBI, any psychiatric disorders were assessed using the Structured Clinical Interview for DSM-IV Axis I Disorders. Results: Psychiatric disorders were diagnosed in 26 patients (25.2%). The most common disorders were previous\/current depression. At three months, there was no difference between patients with psychiatric disorders versus those without them in RTW (95.7% vs. 87.3%, p = 0.260) or at least in part-time work (100% vs. 94.4%, p = 0.245). In Kaplan\u2013Meier analysis, the median time to RTW was 10 days for both groups. The median RPQ score was 13.0 (Interquartile range (IQR) 6.5\u201319.0) in patients with a psychiatric disorder compared to 8.5 (IQR 2.3\u201314.0) in those without one (p = 0.021); respectively, the median GOSE was 7.0 (IQR 7.0\u20138.0) compared to 8.0 (IQR 7.0\u20138.0, p = 0.003). Conclusions: Approximately every fourth patient with MTBI had a psychiatric disorder. These patients reported more symptoms, and their functional outcome measured with GOSE at one month after MTBI was worse. However, presence of any psychiatric disorder did not affect RTW. Early contact and adequate follow-up are important when supporting the patient\u2019s return to work.<\/jats:p>","DOI":"10.3390\/brainsci10120916","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T09:16:49Z","timestamp":1606468609000},"page":"916","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prognosis after Mild Traumatic Brain Injury: Influence of Psychiatric Disorders"],"prefix":"10.3390","volume":"10","author":[{"given":"Ivan","family":"Marinkovic","sequence":"first","affiliation":[{"name":"Neurology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 4, Helsinki P.O. Box 340, FIN-00029 HUS Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harri","family":"Isokuortti","sequence":"additional","affiliation":[{"name":"Neurology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 4, Helsinki P.O. Box 340, FIN-00029 HUS Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9964-8218","authenticated-orcid":false,"given":"Antti","family":"Huovinen","sequence":"additional","affiliation":[{"name":"Neurology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 4, Helsinki P.O. Box 340, FIN-00029 HUS Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Trpeska Marinkovic","sequence":"additional","affiliation":[{"name":"Psychiatry, University of Helsinki and City of Helsinki, Nordenski\u00f6ldinkatu 20, P.O. Box 6800, FIN-00099 City of Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaisa","family":"M\u00e4ki","sequence":"additional","affiliation":[{"name":"Neuropsychology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 4, Helsinki P.O. Box 340, FIN-00029 HUS Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taina","family":"Nybo","sequence":"additional","affiliation":[{"name":"Neuropsychology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 4, Helsinki P.O. Box 340, FIN-00029 HUS Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Korvenoja","sequence":"additional","affiliation":[{"name":"HUS Medical Imaging Center, Radiology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 4, Helsinki P.O. Box 340, FIN-00029 HUS Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Rahul","sequence":"additional","affiliation":[{"name":"Neurosurgery, University of Helsinki and Helsinki University Hospital, Topeliuksenkatu 5, Helsinki P.O. Box 266, FIN-00029 HUS Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risto","family":"Vataja","sequence":"additional","affiliation":[{"name":"Psychiatry, University of Helsinki and Helsinki University Hospital, V\u00e4lsk\u00e4rinkatu 12, Helsinki P.O. Box 590, FIN-00029 HUS Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0564-9637","authenticated-orcid":false,"given":"Susanna","family":"Melkas","sequence":"additional","affiliation":[{"name":"Neurology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 4, Helsinki P.O. Box 340, FIN-00029 HUS Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S1474-4422(17)30117-5","article-title":"Early predictors of outcome after mild traumatic brain injury (UPFRONT): An observational cohort study","volume":"16","author":"Timmerman","year":"2017","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S304","DOI":"10.1016\/j.apmr.2015.03.026","article-title":"Effects of Patient Preinjury and Injury Characteristics on Acute Rehabilitation Outcomes for Traumatic Brain Injury","volume":"96","author":"Corrigan","year":"2015","journal-title":"Arch. Phys. Med. 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