{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:02:06Z","timestamp":1790622126082,"version":"4.1.0"},"reference-count":32,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000297","name":"FRAXA Research Foundation","doi-asserted-by":"publisher","award":["Postdoctoral Fellowship"],"award-info":[{"award-number":["Postdoctoral Fellowship"]}],"id":[{"id":"10.13039\/100000297","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["ZIA MH000889"],"award-info":[{"award-number":["ZIA MH000889"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Sleep abnormalities are common in patients with neurodevelopmental disorders, and it is thought that deficits in sleep may contribute to the unfolding of symptoms in these disorders. Appreciating sleep abnormalities in neurodevelopmental disorders could be important for designing a treatment for these disorders. We studied sleep duration in three mouse models by means of home-cage monitoring: Tsc2+\/\u2212 (tuberous sclerosis complex), oxytocin receptor (Oxtr) knockout (KO) (autism spectrum disorders), and Shank3 e4-9 KO (Phelan\u2013McDermid syndrome). We studied both male and female mice, and data were analyzed to examine effects of both genotype and sex. In general, we found that female mice slept less than males regardless of genotype or phase. We did not find any differences in sleep duration in either Tsc2+\/\u2212 or Oxtr KO mice, compared to controls. In Shank3 e4-9 KO mice, we found a statistically significant genotype x phase interaction (p = 0.002) with a trend that Shank3e4-9 KO mice regardless of sex slept more than control mice in the active phase. Our results have implications for the management of patients with Phelan\u2013McDermid syndrome.<\/jats:p>","DOI":"10.3390\/brainsci11010031","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T09:35:23Z","timestamp":1609320923000},"page":"31","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Sleep Duration in Mouse Models of Neurodevelopmental Disorders"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0605-5697","authenticated-orcid":false,"given":"Rachel Michelle","family":"Sar\u00e9","sequence":"first","affiliation":[{"name":"Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Section on Neuroadaptation and Protein Metabolism, Bethesda, MD 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Lemons","sequence":"additional","affiliation":[{"name":"Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Section on Neuroadaptation and Protein Metabolism, Bethesda, MD 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Section on Neuroadaptation and Protein Metabolism, Bethesda, MD 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn Beebe","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Section on Neuroadaptation and Protein Metabolism, Bethesda, MD 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3390\/brainsci4010150","article-title":"Sleep, plasticity and the pathophysiology of neurodevelopmental disorders: The potential roles of protein synthesis and other cellular processes","volume":"4","author":"Picchioni","year":"2014","journal-title":"Brain Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.nbd.2005.04.003","article-title":"Sleep disturbances in Ube3a maternal-deficient mice modeling Angelman syndrome","volume":"20","author":"Colas","year":"2005","journal-title":"Neurobiol. 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