{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T01:37:02Z","timestamp":1780623422979,"version":"3.54.1"},"reference-count":25,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>The vestibulocerebellar tract (VCT) is regarded as an important pathway of the central vestibular system. We identified the anatomical characteristics of the primary and secondary VCTs in a normal human brain using diffusion tensor imaging (DTI) tractography. Thirty-one healthy adults were recruited. A 1.5 T scanner was used for DTI tractography. A seed region of interest (ROI) was placed on the superior and medial vestibular nuclei at the pons level and a target ROI was placed on the uvula\u2013nodulus of the cerebellum for reconstructing the primary VCT. In the secondary VCTs, the seed ROI was placed on the inferior and medial vestibular nuclei at the medulla oblongata level, and target ROIs were placed on the bilateral uvula\u2013nodulus of the cerebellum. The primary VCT originated from the superior and medial vestibular nuclei at the pons level and terminated at the ipsilateral uvula\u2013nodulus of the cerebellum. The component of the secondary VCTs originated from the inferior and medial vestibular nuclei at the level of the medulla oblongata and terminated at the bilateral uvula\u2013nodulus of the cerebellum. Among them, 70.97% in the contralateral secondary VCT crossed at the vermis of the cerebellum. In addition, the fractional anisotropies (FAs) and mean diffusivity (MD) values of the primary VCT were significantly higher and lower, respectively, compared to those of the secondary VCTs (p &lt; 0.05). The contralateral secondary VCT was significantly higher and lower in the MD and tract volume, respectively (p &lt; 0.05), compared to the ipsilateral VCT. Therefore, we believe that the results will be useful for future studies of the vestibular projection pathway in the human brain injury aspect of central vestibular syndrome.<\/jats:p>","DOI":"10.3390\/brainsci11020199","type":"journal-article","created":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T14:04:13Z","timestamp":1612706653000},"page":"199","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Anatomical Location of the Vestibulocerebellar Tract in the Healthy Human Brain: A Diffusion Tensor Imaging Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6293-5579","authenticated-orcid":false,"given":"Seo Yoon","family":"Park","sequence":"first","affiliation":[{"name":"Department of Health, Graduate School, Dankook University, Cheonan-si 31116, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Seok","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, College of Health Sciences, Dankook University, Cheonan-si 31116, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Ho","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Gyeongsan-si 42415, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5627-3698","authenticated-orcid":false,"given":"In Hee","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Health, Graduate School, Dankook University, Cheonan-si 31116, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3233\/NRE-130866","article-title":"Anatomy of the vestibular system: A review","volume":"32","author":"Khan","year":"2013","journal-title":"NeuroRehabilitation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"538","DOI":"10.3389\/fneur.2017.00538","article-title":"Vestibular Deficits in Neurodegenerative Disorders: Balance, Dizziness, and Spatial Disorientation","volume":"8","author":"Cronin","year":"2017","journal-title":"Front. Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mehy.2018.06.001","article-title":"Can pre-screening vestibulocerebellar involvement followed by targeted training improve the outcomes of balance in cerebellar ataxia?","volume":"117","author":"Winser","year":"2018","journal-title":"Med. Hypotheses"},{"key":"ref_4","unstructured":"Carpenter, M.B. (1991). Core Text of Neuroanatomy. Williams & Wilkins."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.31083\/j.jin.2019.04.1168","article-title":"Purkinje cells of vestibulocerebellum play an important role in acute vestibular migraine","volume":"18","author":"Li","year":"2019","journal-title":"J. Integr. Neurosci."},{"key":"ref_6","unstructured":"Herdman, S.J., and Clendaniel, R. (2014). Vestibular Rehabilitation, F. A. Davis Company. [4th ed.]."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/bs.pbr.2019.04.010","article-title":"Computational neurology of gravity perception involving semicircular canal dysfunction in unilateral vestibular lesions","volume":"248","author":"Glasauer","year":"2019","journal-title":"Prog. Brain Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0361-9230(03)00055-8","article-title":"Central vestibular system: Vestibular nuclei and posterior cerebellum","volume":"60","author":"Barmack","year":"2003","journal-title":"Brain Res. Bull."},{"key":"ref_9","unstructured":"Mendoza, J., and Foundas, A. (2007). Clinical Neuroanatomy: A Neurobehavioral Approach, Springer."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"617","DOI":"10.2174\/1573405613666170421175932","article-title":"The Vestibulocerebellar Tract in the Human Brain: A Diffusion Tensor Tractography Study","volume":"14","author":"Jang","year":"2017","journal-title":"Curr. Med. Imaging Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/BF00238954","article-title":"Observations on the secondary vestibulocerebellar projections in the macaque monkey","volume":"58","author":"Brodal","year":"1985","journal-title":"Exp. Brain Res."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Manto, M., Schmahmann, J.D., Rossi, F., Gruol, D.L., and Koibuchi, N. (2013). Vestibulocerebellar Connections. Handbook of the Cerebellum and Cerebellar Disorders, Springer.","DOI":"10.1007\/978-94-007-1333-8"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1002\/hbm.22419","article-title":"Diffusion tensor image registration using hybrid connectivity and tensor features","volume":"35","author":"Wang","year":"2014","journal-title":"Hum. Brain Mapp."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12031-007-0029-0","article-title":"Diffusion tensor imaging (DTI)-based white matter mapping in brain research: A review","volume":"34","author":"Assaf","year":"2008","journal-title":"J. Mol. Neurosci. MN"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12938-016-0299-2","article-title":"Evaluations of diffusion tensor image registration based on fiber tractography","volume":"16","author":"Wang","year":"2017","journal-title":"Biomed. Eng. Online"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Galons, J.P. (2017). Diffusion weighted and diffusion tensor imaging: A clinical guide. J. Magn. Reson. Imaging, 46.","DOI":"10.1002\/jmri.25621"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.06.040","article-title":"Pathways Linked to Internuclear Ophthalmoplegia on Diffusion-Tensor Imaging in a Case with Midbrain Infarction","volume":"25","author":"Takeshige","year":"2016","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/cne.901840204","article-title":"The cerebellar projection of the vestibular nerve in the cat","volume":"184","author":"Korte","year":"1979","journal-title":"J. Comp. Neurol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0006-8993(84)91040-0","article-title":"Distribution of primary vestibular fibers in the brainstem and cerebellum of the monkey","volume":"294","author":"Carleton","year":"1984","journal-title":"Brain Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/cne.902160409","article-title":"The primary vestibular projection to the cerebellar cortex in the pigeon (Columba livia)","volume":"216","author":"Schwarz","year":"1983","journal-title":"J. Comp. Neurol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0304-3940(89)90006-2","article-title":"The primary vestibulocerebellar projection in the rabbit: Absence of primary afferents in the flocculus","volume":"105","author":"Gerrits","year":"1989","journal-title":"Neurosci. Lett."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/cne.903270405","article-title":"Vestibular primary afferent projection to the cerebellum of the rabbit","volume":"327","author":"Barmack","year":"1993","journal-title":"J. Comp. Neurol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/cne.902000206","article-title":"Secondary vestibulocerebellar projections to flocculonodular lobe in a prosimian primate, Galago senegalensis","volume":"200","author":"Rubertone","year":"1981","journal-title":"J. Comp. Neurol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Arslan, O.E. (2014). Neuroanatomical Basis of Clinical Neurology, Second Edition, Taylor & Francis. [2nd ed.].","DOI":"10.1201\/b17094"},{"key":"ref_25","unstructured":"Barahona, M.L., Encinas, J.P.M., Pascual, R.Q., Prado, J.A.-L., Presmanes, Y.G., and Gil, M.\u00c1.F. (2011). Structural and Functional Anatomy of Cerebellum. More than a Motor Conception, European Society of Radiology Electronic Presentation Online System."}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/11\/2\/199\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:20:13Z","timestamp":1760160013000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/11\/2\/199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,5]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["brainsci11020199"],"URL":"https:\/\/doi.org\/10.3390\/brainsci11020199","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,5]]}}}