{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:50:24Z","timestamp":1760233824085,"version":"build-2065373602"},"reference-count":68,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T00:00:00Z","timestamp":1613779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CEU-Cardenal Herrera University","award":["Teaching+Research 2016 and Teaching+Research 2017"],"award-info":[{"award-number":["Teaching+Research 2016 and Teaching+Research 2017"]}]},{"name":"Redes Tem\u00e1ticas de Investigaci\u00f3n Cooperativa en Salud (RETICS), Red de Trastornos Adictivos, Complications of stimulant disorder, Instituto de Salud Carlos III, Ministerio de Econom\u00eda, Industria y Competitividad","award":["Ref. RD16\/0017\/0024"],"award-info":[{"award-number":["Ref. RD16\/0017\/0024"]}]},{"name":"Research Foundation of the Hospital Provincial de Castell\u00f3n","award":["CAF-20-026, CAF-20-027"],"award-info":[{"award-number":["CAF-20-026, CAF-20-027"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Cocaine addiction is frequently associated with different psychiatric disorders, especially schizophrenia and antisocial personality disorder. A small number of studies have used prepulse inhibition (PPI) as a discriminating factor between these disorders. This work evaluated PPI and the phenotype of patients with cocaine-related disorder (CRD) who presented a dual diagnosis of schizophrenia or antisocial personality disorder. A total of 74 men aged 18\u201360 years were recruited for this research. The sample was divided into four groups: CRD (n = 14), CRD and schizophrenia (n = 21), CRD and antisocial personality disorder (n = 16), and a control group (n = 23). We evaluated the PPI and other possible vulnerability factors in these patients by using different assessment scales. PPI was higher in the CRD group at 30 ms (F(3, 64) = 2.972, p = 0.038). Three discriminant functions were obtained which allowed us to use the overall Hare Psychopathy Checklist Revised score, reward sensitivity, and PPI at 30 ms to predict inclusion of these patients in the different groups with a success rate of 79.7% (42.9% for CRD, 76.2% for CRD and schizophrenia, 100% for CRD and antisocial personality disorder, and 91.3% in the control group). Despite the differences we observed in PPI, this factor is of little use for discriminating between the different diagnostic groups and it acts more as a non-specific endophenotype in certain mental disorders, such as in patients with a dual diagnosis.<\/jats:p>","DOI":"10.3390\/brainsci11020269","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T22:04:15Z","timestamp":1613945055000},"page":"269","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prepulse Inhibition in Cocaine Addiction and Dual Pathologies"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1901-8804","authenticated-orcid":false,"given":"Isis","family":"Gil-Miravet","sequence":"first","affiliation":[{"name":"TXP Research Group, Universidad Cardenal Herrera-CEU, CEU Universities, 12006 Castell\u00f3n, Spain"},{"name":"Predepartamental Unit of Medicine, Universitat Jaume I, 12071 Castell\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5410-8701","authenticated-orcid":false,"given":"Alejandro","family":"Fuertes-Saiz","sequence":"additional","affiliation":[{"name":"TXP Research Group, Universidad Cardenal Herrera-CEU, CEU Universities, 12006 Castell\u00f3n, Spain"},{"name":"Psychiatry Department, Consorcio Hospitalario Provincial de Castell\u00f3n, 12002 Castell\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0785-3570","authenticated-orcid":false,"given":"Ana","family":"Benito","sequence":"additional","affiliation":[{"name":"TXP Research Group, Universidad Cardenal Herrera-CEU, CEU Universities, 12006 Castell\u00f3n, Spain"},{"name":"Torrente Mental Health Centre, Hospital General Universitario, 46014 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0580-664X","authenticated-orcid":false,"given":"Isabel","family":"Almod\u00f3var","sequence":"additional","affiliation":[{"name":"TXP Research Group, Universidad Cardenal Herrera-CEU, CEU Universities, 12006 Castell\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Ochoa","sequence":"additional","affiliation":[{"name":"Molecular Biopathology Department, Consorcio Hospitalario Provincial de Castell\u00f3n, 12002 Castell\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1299-9611","authenticated-orcid":false,"given":"Gonzalo","family":"Haro","sequence":"additional","affiliation":[{"name":"TXP Research Group, Universidad Cardenal Herrera-CEU, CEU Universities, 12006 Castell\u00f3n, Spain"},{"name":"Psychiatry Department, Consorcio Hospitalario Provincial de Castell\u00f3n, 12002 Castell\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,20]]},"reference":[{"key":"ref_1","unstructured":"(2019). European Monitoring Centre for Drugs and Drug Addiction and Europol. EU Drug Markets Report 2019, Publications Office of the European Union."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.20882\/adicciones.124","article-title":"Psychopathological comorbidity in cocaine users in outpatient treatment","volume":"26","author":"Araos","year":"2014","journal-title":"Adicciones"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.rpsm.2012.09.002","article-title":"Cocaine abuse or dependency and other pyschiatric disorders. Madrid study on dual pathology","volume":"6","author":"Arias","year":"2013","journal-title":"Rev. Psiquiatr. Salud Ment."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.addbeh.2016.06.004","article-title":"Examining the link between psychological distress, mental health disorders and sharing behaviors among cocaine users","volume":"62","author":"Roy","year":"2016","journal-title":"Addict. Behav."},{"key":"ref_5","first-page":"364","article-title":"Factors affecting completion of a 28-day inpatient substance abuse treatment programme at the University Hospital of the West Indies","volume":"57","author":"Barnaby","year":"2008","journal-title":"West. Indian Med. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1517\/13543784.2014.915312","article-title":"Drugs currently in Phase II clinical trials for cocaine addiction","volume":"23","author":"Kim","year":"2014","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"106260","DOI":"10.1016\/j.addbeh.2019.106260","article-title":"Increased cortisol levels are associated with low treatment retention in crack cocaine users","volume":"103","author":"Ligabue","year":"2020","journal-title":"Addict. Behav."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.physbeh.2014.05.028","article-title":"Capacity of novelty-induced locomotor activity and the hole-board test to predict sensitivity to the conditioned rewarding effects of cocaine","volume":"133","author":"Arenas","year":"2014","journal-title":"Physiol. Behav."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1007\/s00213-018-4959-8","article-title":"Baseline prepulse inhibition of the startle reflex predicts the sensitivity to the conditioned rewarding effects of cocaine in male and female mice","volume":"235","author":"Arenas","year":"2018","journal-title":"Psychopharmacology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00213-014-3642-y","article-title":"Higher sensitivity to the conditioned rewarding effects of cocaine and MDMA in High-Novelty-Seekers mice exposed to a cocaine binge during adolescence","volume":"232","author":"Aguilar","year":"2015","journal-title":"Psychopharmacology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.pbb.2012.03.031","article-title":"High novelty-seeking predicts greater sensitivity to the conditioned rewarding effects of cocaine","volume":"102","author":"Arenas","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s002130100810","article-title":"Human studies of prepulse inhibition of startle: Normal subjects, patient groups, and pharmacological studies","volume":"156","author":"Braff","year":"2001","journal-title":"Psychopharmacology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00213-008-1072-4","article-title":"Realistic expectations of prepulse inhibition in translational models for schizophrenia research","volume":"199","author":"Swerdlow","year":"2008","journal-title":"Psychopharmacology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1469-8986.1975.tb01284.x","article-title":"The more or less startling effects of weak prestimulation","volume":"12","author":"Graham","year":"1975","journal-title":"Psychophysiology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3758\/BF03335308","article-title":"Discordant effects of weak prestimulation on magnitude and latency of the reflex blink","volume":"5","author":"Graham","year":"1977","journal-title":"Physiol. Psychol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/1469-8986.3740409","article-title":"Automatic and controlled attentional processes in startle eyeblink modification: Effects of habituation of the prepulse","volume":"37","author":"Schell","year":"2000","journal-title":"Psychophysiology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nn1038","article-title":"Epigenetic sources of behavioral differences in mice","volume":"6","author":"Francis","year":"2003","journal-title":"Nat. Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1176\/appi.ajp.2015.15050605","article-title":"Gating deficit heritability and correlation with increased clinical severity in schizophrenia patients with positive family history","volume":"173","author":"Greenwood","year":"2016","journal-title":"Am. J. Psychiatry"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.schres.2017.12.011","article-title":"Meta-analysis on the association between genetic polymorphisms and prepulse inhibition of the acoustic startle response","volume":"198","author":"Quednow","year":"2018","journal-title":"Schizophr. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.biopsycho.2016.12.011","article-title":"Sensorimotor gating in healthy adults tested over a 15 year period","volume":"123","author":"Swerdlow","year":"2017","journal-title":"Biol. Psychol."},{"key":"ref_21","first-page":"507","article-title":"Efecto de la coca\u00edna sobre la inhibici\u00f3n por prepulso de la respuesta de sobresalto","volume":"65","author":"Arenas","year":"2017","journal-title":"Rev. Neurol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/7854_2010_61","article-title":"Prepulse inhibition of the startle reflex: A window on the brain in schizophrenia","volume":"4","author":"Braff","year":"2010","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.biopsycho.2017.07.016","article-title":"Deficient prepulse inhibition of the startle reflex in schizophrenia using a cross-modal paradigm","volume":"128","author":"Bak","year":"2017","journal-title":"Biol. Psychol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1016\/j.neubiorev.2013.06.016","article-title":"Animal models and measures of perceptual processing in schizophrenia","volume":"37","author":"Siegel","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.schres.2013.12.004","article-title":"Deficient prepulse inhibition in schizophrenia detected by the multi-site COGS","volume":"152","author":"Swerdlow","year":"2014","journal-title":"Schizophr. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.schres.2017.05.013","article-title":"Deficient prepulse inhibition in schizophrenia in a multi-site cohort: Internal replication and extension","volume":"198","author":"Swerdlow","year":"2018","journal-title":"Schizophr. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bbr.2004.08.021","article-title":"Association between violent behaviour and impaired prepulse inhibition of the startle response in antisocial personality disorder and schizophrenia","volume":"158","author":"Kumari","year":"2005","journal-title":"Behav. Brain Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.schres.2017.06.045","article-title":"Sensorimotor gating characteristics of violent men with comorbid psychosis and dissocial personality disorder: Relationship with antisocial traits and psychosocial deprivation","volume":"198","author":"Sedgwick","year":"2018","journal-title":"Schizophr. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/cbm.1906","article-title":"The startle paradigm in a forensic psychiatric setting: Elucidating psychopathy","volume":"25","author":"Loomans","year":"2015","journal-title":"Crim. Behav. Ment Heal."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Fuertes-Saiz, A., Benito, A., Mateu, C., Carratal\u00e1, S., Almod\u00f3var, I., Baquero, A., and Haro, G. (2019). Sensorimotor Gating in Cocaine-Related Disorder with Comorbid Schizophrenia or Antisocial Personality Disorder. J. Dual. Diagn., 1\u201311.","DOI":"10.1080\/15504263.2019.1633489"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1177\/026988119200600210","article-title":"The neural substrates of sensorimotor gating of the startle reflex: A review of recent findings and their implications","volume":"6","author":"Swerdlow","year":"1992","journal-title":"J. Psychopharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s002130100799","article-title":"Neural circuit regulation of prepulse inhibition of startle in the rat: Current knowledge and future challenges","volume":"156","author":"Swerdlow","year":"2001","journal-title":"Psychopharmacology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/7854_2015_5012","article-title":"Animal Models of Deficient Sensorimotor Gating in Schizophrenia: Are They Still Relevant?","volume":"28","author":"Swerdlow","year":"2016","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/oxfordjournals.schbul.a033326","article-title":"Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia","volume":"24","author":"Swerdlow","year":"1998","journal-title":"Schizophr. Bull."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s002130000369","article-title":"Role of dopamine in prepulse inhibition of acoustic startle","volume":"149","author":"Zhang","year":"2000","journal-title":"Psychopharmacology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1038\/sj.npp.1301657","article-title":"Contributions of dopamine D1, D2, and D3 receptor subtypes to the disruptive effects of cocaine on prepulse inhibition in mice","volume":"33","author":"Doherty","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"ref_37","first-page":"41","article-title":"Dual diagnosis screening interview to identify psychiatric comorbidity in substance users: Development and validation of a brief instrument","volume":"20","author":"Torrens","year":"2013","journal-title":"Eur. Addict. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1176\/appi.ajp.161.7.1231","article-title":"Diagnosing comorbid psychiatric disorders in substance abusers: Validity of the Spanish versions of the psychiatric research interview for substance and mental disorders and the structured clinical interview for DSM-IV","volume":"161","author":"Torrens","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"ref_39","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J. Clin. Psychiatry"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1037\/0022-3514.68.1.151","article-title":"Assessing Psychopathic Attributes in a Noninstitutionalized Population","volume":"68","author":"Levenson","year":"1995","journal-title":"J. Pers. Soc. Psychol."},{"key":"ref_41","unstructured":"Cutler, B., and Hare, R.D. (2013). Hare Psychopathy Checklist\u2013Revised (PCL\u2013R). Encyclopedia of Psychology and Law, SAGE Publications. [2nd ed.]."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0191-8869(00)00183-5","article-title":"The Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ) as a measure of Gray\u2019s anxiety and impulsivity dimensions","volume":"31","author":"Torrubia","year":"2001","journal-title":"Pers. Individ. Dif."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/1097-4679(199511)51:6<768::AID-JCLP2270510607>3.0.CO;2-1","article-title":"Factor structure of the barratt impulsiveness scale","volume":"51","author":"Patton","year":"1995","journal-title":"J. Clin. Psychol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/FBP.0b013e32830dc110","article-title":"Atypical antipsychotics clozapine and quetiapine attenuate prepulse inhibition deficits in dopamine transporter knockout mice","volume":"19","author":"Powell","year":"2008","journal-title":"Behav. Pharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1038\/sj.npp.1301043","article-title":"Antipsychotic effects on prepulse inhibition in normal \u201clow gating\u201d humans and rats","volume":"31","author":"Swerdlow","year":"2006","journal-title":"Neuropsychopharmacol"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.schres.2017.07.030","article-title":"The effect of antipsychotic medications on acoustic startle latency in schizophrenia","volume":"198","author":"Fargotstein","year":"2018","journal-title":"Schizophr. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1017\/S1461145706007139","article-title":"A fMRI investigation of startle gating deficits in schizophrenia patients treated with typical or atypical antipsychotics","volume":"10","author":"Kumari","year":"2007","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0149-2918(02)85018-4","article-title":"Dosing and switching strategies for quetiapine fumarate","volume":"24","author":"Cutler","year":"2002","journal-title":"Clin. Ther."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0006-3223(02)01344-6","article-title":"Effects of typical and atypical antipsychotics on prepulse inhibition and latent inhibition in chronic schizophrenia","volume":"52","author":"Leumann","year":"2002","journal-title":"Biol. Psychiatry"},{"key":"ref_50","first-page":"1","article-title":"Endophenotypes in Schizophrenia: Digging Deeper to Identify Genetic Mechanisms","volume":"4","author":"Greenwood","year":"2019","journal-title":"J. Psychiatry Brain Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jpsychires.2012.11.018","article-title":"Prepulse inhibition in psychiatric disorders-Apart from schizophrenia","volume":"47","author":"Kohl","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"G\u00f3mez-Nieto, R., Hormigo, S., and L\u00f3pez, D.E. (2020). Prepulse Inhibition of the Auditory Startle Reflex Assessment as a Hallmark of Brainstem Sensorimotor Gating Mechanisms. Brain Sci., 10.","DOI":"10.20944\/preprints202008.0356.v1"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/BF00212846","article-title":"Dopaminergic stimulation disrupts sensorimotor gating in the rat","volume":"94","author":"Mansbach","year":"1998","journal-title":"Psychopharmacology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.biopsych.2008.01.020","article-title":"The Dopamine D3 Receptor Ser9Gly Polymorphism Modulates Prepulse Inhibition of the Acoustic Startle Reflex","volume":"64","author":"Roussos","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0006-3223(86)90005-3","article-title":"Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenics","volume":"21","author":"Swerdlow","year":"1986","journal-title":"Biol. Psychiatry"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.pbb.2007.01.018","article-title":"Role of dopamine D1 and D2 receptors in CRF-induced disruption of sensorimotor gating","volume":"86","author":"Vinkers","year":"2007","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.biopsych.2012.11.017","article-title":"Presynaptic striatal dopamine dysfunction in people at ultra-high risk for psychosis: Findings in a second cohort","volume":"74","author":"Egerton","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1001\/archgenpsychiatry.2012.169","article-title":"The nature of dopamine dysfunction in schizophrenia and what this means for treatment: Meta-analysisof imaging studies","volume":"69","author":"Howes","year":"2012","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.bbr.2006.09.014","article-title":"Cocaine strongly reduces prepulse inhibition in apomorphine-susceptible rats, but not in apomorphine-unsusceptible rats: Regulation by dopamine D2 receptors","volume":"175","author":"Ellenbroek","year":"2006","journal-title":"Behav. Brain Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnbeh.2019.00296","article-title":"Prepulse Inhibition of the Startle Reflex as a Predictor of Vulnerability to Develop Locomotor Sensitization to Cocaine","volume":"13","author":"Arenas","year":"2020","journal-title":"Front. Behav. Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/npp.2009.110","article-title":"Neurocircuitry of addiction","volume":"35","author":"Koob","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"15037","DOI":"10.1073\/pnas.1010654108","article-title":"Addiction: Beyond dopamine reward circuitry","volume":"108","author":"Volkow","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.psychres.2016.10.083","article-title":"Clinical differences between cocaine-dependent patients with and without antisocial personality disorder","volume":"246","author":"Redondo","year":"2016","journal-title":"Psychiatry Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1177\/070674371005500309","article-title":"Clinical and sociodemographic profiles of male inmates with severe mental illness: A comparison with voluntarily and involuntarily hospitalized patients","volume":"55","author":"Dumais","year":"2010","journal-title":"Can. J. Psychiatry"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"93","DOI":"10.12740\/PP\/81109","article-title":"Strengths in patients with schizophrenia and healthy people\u2014similarities and differences","volume":"53","author":"Rozya","year":"2019","journal-title":"Psychiatr. Pol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/schbul\/sbx199","article-title":"The Circuitry of Dopamine System Regulation and its Disruption in Schizophrenia: Insights into Treatment and Prevention","volume":"45","author":"Grace","year":"2019","journal-title":"Schizophr. Bull."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11920-018-0906-y","article-title":"Startling Differences: Using the Acoustic Startle Response to Study Sex Differences and Neurosteroids in Affective Disorders","volume":"20","author":"Hantsoo","year":"2018","journal-title":"Curr. Psychiatry"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1080\/10826084.2018.1536721","article-title":"Heterogeneity in the Development of Drug Use Versatility: Risk Factors for Polydrug Use throughout the Life-Course","volume":"54","author":"Wojciechowski","year":"2019","journal-title":"Subst. Use Misuse"}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/11\/2\/269\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:27:06Z","timestamp":1760160426000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/11\/2\/269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,20]]},"references-count":68,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["brainsci11020269"],"URL":"https:\/\/doi.org\/10.3390\/brainsci11020269","relation":{},"ISSN":["2076-3425"],"issn-type":[{"type":"electronic","value":"2076-3425"}],"subject":[],"published":{"date-parts":[[2021,2,20]]}}}