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Sometimes serum biomarkers can point out abnormalities in presymtomatic or otherwise asymptomatic patients (e.g., carriers). More often a biomarker of INMD is evaluated by multiple clinicians other than expert in NMD before the diagnosis, because of the multisystemic involvement in INMD. The authors performed a literature search on biomarkers in inherited neuromuscular disorders to provide a practical approach to the diagnosis and the correct management of INMD. A considerable number of biomarkers have been reported that support the diagnosis of INMD, but the role of an expert clinician is crucial. Hence, the complete knowledge of such abnormalities can accelerate the diagnostic workup supporting the referral to specialists in neuromuscular disorders.<\/jats:p>","DOI":"10.3390\/brainsci11030398","type":"journal-article","created":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T22:00:37Z","timestamp":1616364037000},"page":"398","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Inherited Neuromuscular Disorders: Which Role for Serum Biomarkers?"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1499-9460","authenticated-orcid":false,"given":"Antonino","family":"Lupica","sequence":"first","affiliation":[{"name":"Department of Biomedicine, Neuroscience and advanced Diagnostic (BIND), University of Palermo, 90121 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9805-1655","authenticated-orcid":false,"given":"Vincenzo","family":"Di Stefano","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Neuroscience and advanced Diagnostic (BIND), University of Palermo, 90121 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gagliardo","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Neuroscience and advanced Diagnostic (BIND), University of Palermo, 90121 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0035-5859","authenticated-orcid":false,"given":"Salvatore","family":"Iacono","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Neuroscience and advanced Diagnostic (BIND), University of Palermo, 90121 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8883-5701","authenticated-orcid":false,"given":"Antonia","family":"Pignolo","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Neuroscience and advanced Diagnostic (BIND), University of Palermo, 90121 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Ferlisi","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Neuroscience and advanced Diagnostic (BIND), University of Palermo, 90121 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0585-8351","authenticated-orcid":false,"given":"Angelo","family":"Torrente","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Neuroscience and advanced Diagnostic (BIND), University of Palermo, 90121 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Pagano","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Neuroscience and advanced Diagnostic (BIND), University of Palermo, 90121 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Gangitano","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Neuroscience and advanced Diagnostic (BIND), University of Palermo, 90121 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Brighina","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Neuroscience and advanced Diagnostic (BIND), University of Palermo, 90121 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/S1474-4422(20)30028-4","article-title":"Advances in the Diagnosis of Inherited Neuromuscular Diseases and Implications for Therapy Development","volume":"19","author":"Thompson","year":"2020","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000334862","article-title":"Serum Levels of Matrix Metalloproteinases: Implications in Clinical Neurology","volume":"67","author":"Romi","year":"2012","journal-title":"Eur. 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