{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:51:15Z","timestamp":1791571875513,"version":"4.3.4"},"reference-count":89,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["Program Grant 1132524"],"award-info":[{"award-number":["Program Grant 1132524"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["Dementia Research Team Grant 1095127"],"award-info":[{"award-number":["Dementia Research Team Grant 1095127"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1110773"],"award-info":[{"award-number":["1110773"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["Project Grant 1121791"],"award-info":[{"award-number":["Project Grant 1121791"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1103258"],"award-info":[{"award-number":["1103258"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Centre of Excellence in Cognition and its Disorders, Australian Research Council","award":["CE11000102"],"award-info":[{"award-number":["CE11000102"]}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FT160100096"],"award-info":[{"award-number":["FT160100096"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Semantic dementia (SD) is a younger-onset neurodegenerative disease characterised by progressive deterioration of the semantic knowledge base in the context of predominantly left-lateralised anterior temporal lobe (ATL) atrophy. Mounting evidence indicates the emergence of florid socioemotional changes in SD as atrophy encroaches into right temporal regions. How lateralisation of temporal lobe pathology impacts the hedonic experience in SD remains largely unknown yet has important implications for understanding socioemotional and functional impairments in this syndrome. Here, we explored how lateralisation of temporal lobe atrophy impacts anhedonia severity on the Snaith\u2013Hamilton Pleasure Scale in 28 SD patients presenting with variable right- (SD-R) and left-predominant (SD-L) profiles of temporal lobe atrophy compared to that of 30 participants with Alzheimer\u2019s disease and 30 healthy older Control participants. Relative to Controls, SD-R but not SD-L or Alzheimer\u2019s patients showed clinically significant anhedonia, representing a clear departure from premorbid levels. Overall, anhedonia was more strongly associated with functional impairment on the Frontotemporal Dementia Functional Rating Scale and motivational changes on the Cambridge Behavioural Inventory in SD than in Alzheimer\u2019s disease patients. Voxel-based morphometry analyses revealed that anhedonia severity correlated with reduced grey matter intensity in a restricted set of regions centred on right orbitofrontal and temporopolar cortices, bilateral posterior temporal cortices, as well as the anterior cingulate gyrus and parahippocampal gyrus, bilaterally. Finally, regression and mediation analysis indicated a unique role for right temporal lobe structures in modulating anhedonia in SD. Our findings suggest that degeneration of predominantly right-hemisphere structures deleteriously impacts the capacity to experience pleasure in SD. These findings offer important insights into hemispheric lateralisation of motivational disturbances in dementia and suggest that anhedonia may emerge at different timescales in the SD disease trajectory depending on the integrity of the right hemisphere.<\/jats:p>","DOI":"10.3390\/brainsci11080998","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T11:12:52Z","timestamp":1627470772000},"page":"998","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Anhedonia in Semantic Dementia\u2014Exploring Right Hemispheric Contributions to the Loss of Pleasure"],"prefix":"10.3390","volume":"11","author":[{"given":"Siobh\u00e1n R.","family":"Shaw","sequence":"first","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, 94 Mallett Street, Sydney, NSW 2050, Australia"},{"name":"School of Psychology, The University of Sydney, Sydney, NSW 2050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2304-7277","authenticated-orcid":false,"given":"Hashim","family":"El-Omar","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, 94 Mallett Street, Sydney, NSW 2050, Australia"},{"name":"School of Psychology, The University of Sydney, Sydney, NSW 2050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8591-042X","authenticated-orcid":false,"given":"Siddharth","family":"Ramanan","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, 94 Mallett Street, Sydney, NSW 2050, Australia"},{"name":"MRC Cognition and Brain Sciences Unit, The University of Cambridge, 15 Chaucer Rd., Cambridge CB2 7EF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6696-1440","authenticated-orcid":false,"given":"Olivier","family":"Piguet","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, 94 Mallett Street, Sydney, NSW 2050, Australia"},{"name":"School of Psychology, The University of Sydney, Sydney, NSW 2050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekah M.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, 94 Mallett Street, Sydney, NSW 2050, Australia"},{"name":"Memory and Cognition Clinic, Department of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia"},{"name":"School of Medical Sciences, The University of Sydney, Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7944-2172","authenticated-orcid":false,"given":"Alexis E.","family":"Whitton","sequence":"additional","affiliation":[{"name":"Black Dog Institute, University of New South Wales, Sydney, NSW 2031, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4950-8169","authenticated-orcid":false,"given":"Muireann","family":"Irish","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, 94 Mallett Street, Sydney, NSW 2050, Australia"},{"name":"School of Psychology, The University of Sydney, Sydney, NSW 2050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4172\/2471-271X.1000120","article-title":"Dopamine: Receptors, Functions, Synthesis, Pathways, Locations and Mental Disorders: Review of Literatures","volume":"2","author":"Ayano","year":"2016","journal-title":"J. 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