{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T16:17:13Z","timestamp":1786810633121,"version":"build-2736575974"},"reference-count":36,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01HD095663"],"award-info":[{"award-number":["1R01HD095663"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Children with unilateral spastic cerebral palsy (USCP) have impairments in motor planning, impacting their ability to grasp objects. We examined the planning of digit position and force and the flexibility of the motor system in covarying these during object manipulation. Eleven children with a left hemisphere lesion (LHL), nine children with a right hemisphere lesion (RHL) and nine typically developing children (controls) participated in the study. Participants were instructed to use a precision grip with their dominant\/less affected hand to lift and keep an object level, with either a left, centered or right center of mass (COM) location. Digit positions, forces, compensatory torque and object roll where measured. Although children with USCP generated a compensatory torque and modulated digit placement by lift-off, their index finger was either collinear or higher than the thumb, regardless of COM location, leading to larger rolls after lift-off especially for the RHL group. The findings suggest that while the kinetics of grasp control is intact, the kinematics of grasp control is impaired. This study adds to the understanding of the underlying mechanisms of anticipatory planning and control of grasp in children with USCP and may provide insights on how to improve hand function in children with USCP.<\/jats:p>","DOI":"10.3390\/brainsci11091161","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T08:42:32Z","timestamp":1630399352000},"page":"1161","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Anticipatory Motor Planning and Control of Grasp in Children with Unilateral Spastic Cerebral Palsy"],"prefix":"10.3390","volume":"11","author":[{"given":"Jennifer","family":"Gutterman","sequence":"first","affiliation":[{"name":"Department of Biobehavioral Sciences, Teachers College, Columbia University, New York, NY 10027, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Lee-Miller","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Sciences, Teachers College, Columbia University, New York, NY 10027, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Friel","sequence":"additional","affiliation":[{"name":"Burke Neurological Institute, Weill Cornell Medicine, White Plains, NY 10605, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1949-0885","authenticated-orcid":false,"given":"Katherine","family":"Dimitropoulou","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation & Regenerative Medicine (Occupational Therapy), Columbia University, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Sciences, Teachers College, Columbia University, New York, NY 10027, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.ridd.2010.04.007","article-title":"Action planning in typically and atypically developing children (unilateral cerebral palsy)","volume":"31","author":"Aarts","year":"2010","journal-title":"Res. Dev. Disabil."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/dmcn.12306","article-title":"Impaired motor planning and motor imagery in children with unilateral spastic cerebral palsy: Challenges for the future of pediatric rehabilitation","volume":"55","author":"Steenbergen","year":"2013","journal-title":"Dev. Med. child Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1080\/13803395.2017.1387645","article-title":"Motor planning in children with cerebral palsy: A longitudinal perspective","volume":"40","author":"Lust","year":"2018","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"ref_4","unstructured":"Rosenbaum, D.A., Marchak, F., Barnes, H.J., Vaughan, J., Slotta, J.D., and Jorgensen, M.J. (1990). Constraints for action selection: Overhand versus underhand grips. Attention and Performance 13: Motor Representation and Control, Lawrence Erlbaum Associates, Inc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00221-005-0327-0","article-title":"Anticipatory planning deficits and task context effects in hemiparetic cerebral palsy","volume":"172","author":"Mutsaarts","year":"2006","journal-title":"Exp. Brain Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.ridd.2011.02.002","article-title":"Typical and atypical (cerebral palsy) development of unimanual and bimanual grasp planning","volume":"32","author":"Janssen","year":"2011","journal-title":"Res. Dev. Disabil."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Martinie, O., Mercier, C., Gordon, A.M., and Robert, M.T. (2021). Upper Limb Motor Planning in Individuals with Cerebral Palsy Aged between 3 and 21 Years Old: A Systematic Review. Brain Sci., 11.","DOI":"10.3390\/brainsci11070920"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/BF00227253","article-title":"Development of human precision grip","volume":"90","author":"Forssberg","year":"1992","journal-title":"Exp. Brain Res."},{"key":"ref_9","first-page":"399","article-title":"Development of human precision grip. III. Integration of visual size cues during the programming of isometric forces","volume":"90","author":"Gordon","year":"1992","journal-title":"Exp. Brain Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0166-4115(08)61272-8","article-title":"Chapter 3 Development of the Reach to Grasp Movement","volume":"105","author":"Bennett","year":"1994","journal-title":"Advances in Psychology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/BF00247522","article-title":"Coordinated isometric muscle commands adequately and erroneously programmed for the weight during lifting task with precision grip","volume":"71","author":"Johansson","year":"1988","journal-title":"Exp. Brain Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1152\/jn.1993.69.6.1789","article-title":"Memory representations underlying motor commands used during manipulation of common and novel objects","volume":"69","author":"Gordon","year":"1993","journal-title":"J. Neurophysiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.1469-8749.1992.tb14994.x","article-title":"Impaired anticipatory control of isometric forces during grasping by children with cerebral palsy","volume":"34","author":"Eliasson","year":"1992","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1469-8749.2003.tb00884.x","article-title":"Learning of grasp control in children with hemiplegic cerebral palsy","volume":"45","author":"Duff","year":"2003","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1469-8749.1999.tb00576.x","article-title":"Fingertip forces during object manipulation in children with hemiplegic cerebral palsy. I: Anticipatory scaling","volume":"41","author":"Gordon","year":"1999","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1177\/1545968309353327","article-title":"Predictive and Reactive Control of Precision Grip in Children With Congenital Hemiplegia","volume":"24","author":"Bleyenheuft","year":"2010","journal-title":"Neurorehabilit. Neural Repair"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1469-8749.1999.tb00577.x","article-title":"Fingertip forces during object manipulation in children with hemiplegic cerebral palsy. II: Bilateral coordination","volume":"41","author":"Gordon","year":"1999","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"9117","DOI":"10.1523\/JNEUROSCI.4159-09.2010","article-title":"Anticipatory Planning and Control of Grasp Positions and Forces for Dexterous Two-Digit Manipulation","volume":"30","author":"Fu","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1152\/jn.2000.84.5.2390","article-title":"Specificity of Internal Representations Underlying Grasping","volume":"84","author":"Salimi","year":"2000","journal-title":"J. Neurophysiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1152\/jn.00140.2010","article-title":"Manipulation After Object Rotation Reveals Independent Sensorimotor Memory Representations of Digit Positions and Forces","volume":"103","author":"Zhang","year":"2010","journal-title":"J. Neurophysiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1152\/jn.00754.2013","article-title":"Coordination between Digit Forces and Positions: Interactions between Anticipatory and Feedback Control","volume":"111","author":"Fu","year":"2014","journal-title":"J. Neurophysiol."},{"key":"ref_22","unstructured":"Bernstein, N.A. (1967). The co-ordination and regulation of movements, Pergamon Press."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cogbrainres.2003.11.008","article-title":"Constraints on grip selection in hemiparetic cerebral palsy: Effects of lesional side, end-point accuracy, and context","volume":"19","author":"Steenbergen","year":"2004","journal-title":"Brain Res. Cogn. Brain Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.brainres.2008.12.074","article-title":"Visual information for action planning in left and right congenital hemiparesis","volume":"1261","author":"Steenbergen","year":"2009","journal-title":"Brain Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00221-013-3687-x","article-title":"Motor planning ability is not related to lesion side or functional manual ability in children with hemiplegic cerebral palsy","volume":"231","author":"Kirkpatrick","year":"2013","journal-title":"Exp. Brain Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ridd.2018.12.002","article-title":"The development of anticipatory action planning in children with unilateral cerebral palsy","volume":"85","author":"Krajenbrink","year":"2019","journal-title":"Res. Dev. Disabil."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1203\/01.pdr.0000242370.41469.74","article-title":"Steenbergen. Fingertip Force Planning During Grasp Is Disrupted by Impaired Sensorimotor Integration in Children with Hemiplegic Cerebral Palsy","volume":"60","author":"Gordon","year":"2006","journal-title":"Pediatr. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"12765","DOI":"10.1523\/JNEUROSCI.4335-08.2008","article-title":"Anticipatory Control of Grasping: Independence of Sensorimotor Memories for Kinematics and Kinetics","volume":"28","author":"Lukos","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_29","first-page":"1","article-title":"Explicit and implicit motor learning in children with unilateral cerebral palsy","volume":"40","author":"Kamp","year":"2017","journal-title":"Disabil. Rehabil."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.3109\/09638288.2010.497035","article-title":"Implicit and explicit learning: Applications from basic research to sports for individuals with impaired movement dynamics","volume":"32","author":"Steenbergen","year":"2010","journal-title":"Disabil. Rehabil."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3389\/fnhum.2016.00461","article-title":"Digit Position and Forces Covary during Anticipatory Control of Whole-Hand Manipulation","volume":"10","author":"Marneweck","year":"2016","journal-title":"Front. Hum. Neurosci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.1523\/JNEUROSCI.4693-06.2007","article-title":"Choice of Contact Points during Multidigit Grasping: Effect of Predictability of Object Center of Mass Location","volume":"27","author":"Lukos","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1080\/00222895.2012.747482","article-title":"The effects of brain lateralization on motor control and adaptation","volume":"44","author":"Mutha","year":"2012","journal-title":"J. Mot. Behav."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0278-2626(85)90054-5","article-title":"Anterior-posterior interhemispheric differences in the loci of lesions producing visual hemineglect","volume":"4","author":"Ogden","year":"1985","journal-title":"Brain Cogn."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1435808","DOI":"10.1155\/2018\/1435808","article-title":"Impairments of Visuospatial Attention in Children with Unilateral Spastic Cerebral Palsy","volume":"2018","author":"Ickx","year":"2018","journal-title":"Neural Plast."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1152\/jn.00760.2018","article-title":"Hand forces and placement are modulated and covary during anticipatory control of bimanual manipulation","volume":"121","author":"Santello","year":"2019","journal-title":"J. Neurophysiol."}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/11\/9\/1161\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:53:28Z","timestamp":1760165608000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/11\/9\/1161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,31]]},"references-count":36,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["brainsci11091161"],"URL":"https:\/\/doi.org\/10.3390\/brainsci11091161","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,31]]}}}