{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:56:45Z","timestamp":1784717805381,"version":"3.55.0"},"reference-count":29,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T00:00:00Z","timestamp":1631923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI14C3319; HI14C2768"],"award-info":[{"award-number":["HI14C3319; HI14C2768"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>A substantial amount of amyloid-beta (A\u03b2) accumulates in the occipital cortices; however, it draws less attention. We investigated the clinical implications of A\u03b2 accumulation in the occipital lobes in the Alzheimer\u2019s disease (AD) continuum. [18F]-Florbetaben amyloid PET scans were performed in a total of 121 AD or amnestic mild cognitive impairment (aMCI) patients. Of the 121 patients, 74 A\u03b2 positive patients were divided into occipital A\u03b2 positive (OCC+) and occipital A\u03b2 negative (OCC\u2212) groups based on A\u03b2 accumulation in the bilateral occipital lobes. The OCC+ group (41\/74, 55.4%) was younger and had a younger age at onset than the OCC\u2212 group. The OCC+ group also had an increased standard uptake value ratio in the occipital lobes and greater cortical thinning in relevant areas. The OCC+ group had a higher global deterioration scale, lower performance for the copy, immediate recall, delayed recall, and recognition in Rey\u2013Osterrieth Complex Figure tests than the OCC- group, although both groups had similar disease durations. AD or aMCI patients in the OCC+ group exhibited features noted in early onset AD with relevant neuropsychological and image findings. Occipital A\u03b2 positivity in amyloid PET scans need to be considered as an underestimated marker of early onset AD continuum.<\/jats:p>","DOI":"10.3390\/brainsci11091232","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T07:52:14Z","timestamp":1632124334000},"page":"1232","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Clinical Implications of Amyloid-Beta Accumulation in Occipital Lobes in Alzheimer\u2019s Continuum"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8736-6309","authenticated-orcid":false,"given":"Jihye","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea"},{"name":"Department of Neurology, Keimyung University Daegu Dongsan Hospital, Daegu 42601, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5686-1668","authenticated-orcid":false,"given":"Chan Mi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea"},{"name":"MGH\/MIT\/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA"},{"name":"Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea"},{"name":"Department of Neurology, Gangneung Asan Hospital, Gangneung 25440, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minyoung","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1925-8103","authenticated-orcid":false,"given":"Jungsu S.","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5701-6204","authenticated-orcid":false,"given":"Young Wook","family":"Yoon","sequence":"additional","affiliation":[{"name":"Neuroscience Research Institute, Korea University College of Medicine, Seoul 02841, Korea"},{"name":"Department of Physiology, Korea University College of Medicine, Seoul 02841, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Seung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Hong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Hoon","family":"Roh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea"},{"name":"Neuroscience Research Institute, Korea University College of Medicine, Seoul 02841, Korea"},{"name":"Department of Physiology, Korea University College of Medicine, Seoul 02841, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to alzheimer\u2019s disease: Recommendations from the national institute on aging-alzheimer\u2019s association workgroups on diagnostic guidelines for alzheimer\u2019s disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement. 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