{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T19:38:44Z","timestamp":1767382724932,"version":"build-2065373602"},"reference-count":75,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T00:00:00Z","timestamp":1632441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Centro Superior de Investigaci\u00f3n en Salud P\u00fablica (CSISP)","award":["CS2003-05-05"],"award-info":[{"award-number":["CS2003-05-05"]}]},{"name":"Valencian Reginal Government Department of Health","award":["T4591000"],"award-info":[{"award-number":["T4591000"]}]},{"name":"Research Foundation of the Hospital Provincial de Castell\u00f3n","award":["CAF 15-049 and 21-026"],"award-info":[{"award-number":["CAF 15-049 and 21-026"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Genetic analysis of the association between alcohol, cocaine, and opiate addiction and variable number tandem repeat (VNTR) polymorphisms in monoamine oxidase B (MAOB) and serotonergic 5-hydroxytryptamine (serotonin) receptor 1B and 2C (HTR1B 21 and HTR2C) pathway genes was performed in a sample of 302 polyconsumers. Our genetic association analysis revealed a significant association between a 184 base pair (bp) VNTR polymorphism in the MAOB gene and addiction to cocaine and opiates. This work highlights new genetic marker associations in cocaine and opiate polyconsumer addictions. These data help to clarify and quantify the complex role of genetics in addictive disorders, as well as their future contribution to the prevention (genetic counselling), diagnosis (genetic diagnosis of vulnerability), and treatment (pharmacogenomics) of these disorders.<\/jats:p>","DOI":"10.3390\/brainsci11101265","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T20:15:32Z","timestamp":1632514532000},"page":"1265","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Association between a MAOB Variable Number Tandem Repeat Polymorphism and Cocaine and Opiate Addictions in Polyconsumers"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3063-2837","authenticated-orcid":false,"given":"C\u00e9sar","family":"Mateu","sequence":"first","affiliation":[{"name":"Unidad Salud Mental Burjassot, Hospital Arnau de Vilanova-Lliria, 46015 Valencia, Spain"},{"name":"Grupo de Investigaci\u00f3n TXP, Departamento de Medicina, Cardenal Herrera University (CEU), 12006 Castell\u00f3n de la Plana, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Rodr\u00edguez-Arias","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Psicobiolog\u00eda de las Drogodependencias, Departamento de Psicobiolog\u00eda, Facultad de Psicolog\u00eda, Universidad de Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1901-8804","authenticated-orcid":false,"given":"Isis","family":"Gil-Miravet","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n TXP, Departamento de Medicina, Cardenal Herrera University (CEU), 12006 Castell\u00f3n de la Plana, Spain"},{"name":"Unitat Predepartamental de Medicina, Universitat Jaume I, 12071 Castell\u00f3n de la Plana, Spain"},{"name":"\u00c0rea de Psicobiologia, Universitat Jaume I, 12071 Castell\u00f3n de la Plana, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0785-3570","authenticated-orcid":false,"given":"Ana","family":"Benito","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n TXP, Departamento de Medicina, Cardenal Herrera University (CEU), 12006 Castell\u00f3n de la Plana, Spain"},{"name":"Unidad Salud Mental Torrent, Hospital General de Valencia, 46014 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3424-1668","authenticated-orcid":false,"given":"Jos\u00e9 M.","family":"Tom\u00e1s","sequence":"additional","affiliation":[{"name":"Departamento de Metodolog\u00eda de las Ciencias del Comportamiento, Facultad de Psicolog\u00eda, Universidad de Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1299-9611","authenticated-orcid":false,"given":"Gonzalo","family":"Haro","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n TXP, Departamento de Medicina, Cardenal Herrera University (CEU), 12006 Castell\u00f3n de la Plana, Spain"},{"name":"Psychiatry Department, Hospital Provincial de Castell\u00f3n, 12002 Castell\u00f3n de la Plana, Spain"},{"name":"School of Medicine, Cardenal Herrera University (CEU), 12006 Castell\u00f3n de la Plana, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.drugalcdep.2007.11.023","article-title":"Drug use and dependence in cocaine dependent subjects, community-based individuals, and their siblings","volume":"95","author":"Bierut","year":"2008","journal-title":"Drug Alcohol Depend."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1300\/J069v20n04_06","article-title":"Polysubstance use among alcoholics","volume":"20","author":"Staines","year":"2001","journal-title":"J. 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