{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:01:31Z","timestamp":1791597691006,"version":"4.3.4"},"reference-count":2,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:00:00Z","timestamp":1632528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background: Practice-based evidence can inform and support clinical decision making. Case-report series about the implementation of programs in real-world clinical settings may contribute to verifying the effectiveness of interventions for treating PPA in specific contexts, as well as illustrating challenges that need to be overcome. Objective: To describe and provide practice-based evidence on the effectiveness of four cognitive rehabilitation programs designed for individuals with PPA and directed to speech and language impairments, which were implemented in a specialized outpatient clinic. Methods: Multiple single-case study. Eighteen individuals with different subtypes of PPA were each assigned to one out of four training programs based on comprehensive speech and language assessments. The treatments targeted naming deficits, sentence production, speech apraxia, and phonological deficits. Pre- and post-treatment assessments were undertaken to compare trained and untrained items. Gains were generalized to a different task in the first two types of intervention (naming and sentence production). A follow-up assessment was conducted 1\u20138 months after treatment among 7 participants. Results: All individuals presented better performance in the trained items at the post-test for each rehabilitation program accomplished, demonstrating that learning of the trained strategies was achieved during the active phase of treatment. For 13 individuals, statistical significance was reached; while for five, the results were maintained. Results about untrained items, generalization to other tasks, and follow-up assessments are presented. Conclusions: The positive results found in our sample bring some practice-based evidence for the benefits of speech and language treatment strategies for clinical management of individuals with PPA.<\/jats:p>","DOI":"10.3390\/brainsci11101268","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T01:59:47Z","timestamp":1632707987000},"page":"1268","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Cognitive Intervention Strategies Directed to Speech and Language Deficits in Primary Progressive Aphasia: Practice-Based Evidence from 18 Cases"],"prefix":"10.3390","volume":"11","author":[{"given":"Thais Helena","family":"Machado","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Aplicadas \u00e0 Sa\u00fade do Adulto, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, MG, Brazil"},{"name":"Grupo de Pesquisa em Neurologia Cognitiva e do Comportamento, Departamento de Cl\u00ednica M\u00e9dica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, MG, Brazil"},{"name":"Av Prudente de Morais, 290-Sala 1106, Belo Horizonte 30380-002, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2751-4541","authenticated-orcid":false,"given":"Maria Teresa","family":"Carthery-Goulart","sequence":"additional","affiliation":[{"name":"Grupo de Estudos em Neuroci\u00eancia da Linguagem e Cogni\u00e7\u00e3o, N\u00facleo Interdisciplinar de Neuroci\u00eancia Aplicada, Centro de Matem\u00e1tica, Computa\u00e7\u00e3o e Cogni\u00e7\u00e3o da Universidade Federal do ABC, S\u00e3o Bernardo do Campo 09210-580, SP, Brazil"},{"name":"Grupo de Neurologia Cognitiva e do Comportamento, Divis\u00e3o de Cl\u00ednica Neurol\u00f3gica, Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, SP, Brazil"},{"name":"INCT-ECCE (Instituto Nacional de Ci\u00eancia e Tecnologia sobre Comportamento, Cogni\u00e7\u00e3o e Ensino), Rodovia Washington Lu\u00eds, Km 235, S\u00e3o Carlos 13565-905, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Carvalho","family":"Campanha","sequence":"additional","affiliation":[{"name":"Grupo de Pesquisa em Neurologia Cognitiva e do Comportamento, Departamento de Cl\u00ednica M\u00e9dica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4786-6990","authenticated-orcid":false,"given":"Paulo","family":"Caramelli","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Aplicadas \u00e0 Sa\u00fade do Adulto, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, MG, Brazil"},{"name":"Grupo de Pesquisa em Neurologia Cognitiva e do Comportamento, Departamento de Cl\u00ednica M\u00e9dica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Machado, T.H., Carthery-Goulart, M.T., Campanha, A.C., and Caramelli, P. (2021). Cognitive Intervention Strategies Directed to Speech and Language Deficits in Primary Progressive Aphasia: Practice-Based Evidence from 18 Cases. Brain Sci., 11.","DOI":"10.3390\/brainsci11101268"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1590\/S1980-57642014DN83000014","article-title":"Brief intervention for agrammatism in Primary Progressive Nonfluent Aphasia: A case report","volume":"8","author":"Machado","year":"2014","journal-title":"Dement. Neuropsychol."}],"updated-by":[{"DOI":"10.3390\/brainsci12101386","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:00:00Z","timestamp":1632528000000}}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/11\/10\/1268\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T22:57:43Z","timestamp":1754261863000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/11\/10\/1268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,25]]},"references-count":2,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["brainsci11101268"],"URL":"https:\/\/doi.org\/10.3390\/brainsci11101268","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,25]]}}}