{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:54:32Z","timestamp":1791651272355,"version":"4.3.4"},"reference-count":96,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T00:00:00Z","timestamp":1632614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870935"],"award-info":[{"award-number":["81870935"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007724","name":"Wuhan University of Technology","doi-asserted-by":"publisher","award":["40122070"],"award-info":[{"award-number":["40122070"]}],"id":[{"id":"10.13039\/501100007724","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007724","name":"Wuhan University of Technology","doi-asserted-by":"publisher","award":["3120621249"],"award-info":[{"award-number":["3120621249"]}],"id":[{"id":"10.13039\/501100007724","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Acid-base homeostasis is crucial for numerous physiological processes. Na+\/HCO3\u2212 cotransporters (NBCs) belong to the solute carrier 4 (SLC4) family, which regulates intracellular pH as well as HCO3\u2212 absorption and secretion. However, knowledge of the structural functions of these proteins remains limited. Electrogenic NBC (NBCe-1) is thought to be the primary factor promoting the precise acid\u2013base equilibrium in distinct cell types for filtration and reabsorption, as well as the function of neurons and glia. NBC dysregulation is strongly linked to several diseases. As such, the need for special drugs that interfere with the transmission function of NBC is becoming increasingly urgent. In this review, we focus on the structural and functional characteristics of NBCe1, and discuss the roles of NBCe1 in the kidney, central nervous system (CNS), and related disorders, we also summarize the research on NBC inhibitors. NBCe1 and the related pathways should be further investigated, so that new medications may be developed to address the related conditions.<\/jats:p>","DOI":"10.3390\/brainsci11101276","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T01:59:47Z","timestamp":1632707987000},"page":"1276","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Understanding the Functional Expression of \r\nNa+-Coupled SLC4 Transporters in the Renal and Nervous Systems: A Review"],"prefix":"10.3390","volume":"11","author":[{"given":"Le","family":"Du","sequence":"first","affiliation":[{"name":"School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aqeela","family":"Zahra","sequence":"additional","affiliation":[{"name":"School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Jia","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"},{"name":"Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100070, China"},{"name":"National Clinical Research Center for Neurological Disease, Beijing 100070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"},{"name":"National Clinical Research Center for Neurological Disease, Beijing 100070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2684-6122","authenticated-orcid":false,"given":"Jianping","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China"},{"name":"Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"},{"name":"Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100070, China"},{"name":"National Clinical Research Center for Neurological Disease, Beijing 100070, China"},{"name":"Health Science Center, Yangtze University, Jingzhou 434023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1152\/physrev.1982.62.4.1377-r","article-title":"Intracellular pH","volume":"62","author":"Roos","year":"1982","journal-title":"Physiol. 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