{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:54:21Z","timestamp":1787500461642,"version":"build-2736575974"},"reference-count":194,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>The paper discusses and provides support for diverse processes of brain plasticity in visual function after damage in infancy and childhood in comparison with injury that occurs in the adult brain. We provide support and description of neuroplastic mechanisms in childhood that do not seemingly exist in the same way in the adult brain. Examples include the ability to foster the development of thalamocortical connectivities that can circumvent the lesion and reach their cortical destination in the occipital cortex as the developing brain is more efficient in building new connections. Supporting this claim is the fact that in those with central visual field defects we can note that the extrastriatal visual connectivities are greater when a lesion occurs earlier in life as opposed to in the neurologically mature adult. The result is a significantly more optimized system of visual and spatial exploration within the \u2018blind\u2019 field of view. The discussion is provided within the context of \u201cblindsight\u201d and the \u201cSprague Effect\u201d.<\/jats:p>","DOI":"10.3390\/brainsci11101279","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T10:39:20Z","timestamp":1632739160000},"page":"1279","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cortical Visual Impairment in Childhood: \u2018Blindsight\u2019 and the Sprague Effect Revisited"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9975-7331","authenticated-orcid":false,"given":"Gerry","family":"Leisman","sequence":"first","affiliation":[{"name":"Movement and Cognition Laboratory, Department of Physical Therapy, University of Haifa, Haifa 3498838, Israel"},{"name":"Department of Neurology, University of the Medical Sciences of Havana, Havana 10400, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0539-5844","authenticated-orcid":false,"given":"Calixto","family":"Machado","sequence":"additional","affiliation":[{"name":"Institute of Neurology and Neurosurgery, Havana 10400, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Melillo","sequence":"additional","affiliation":[{"name":"Movement and Cognition Laboratory, Department of Physical Therapy, University of Haifa, Haifa 3498838, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.survophthal.2020.03.001","article-title":"Advances in the evaluation and management of cortical\/cerebral visual impairment in children","volume":"65","author":"Chang","year":"2020","journal-title":"Surv. 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